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Items: 1 to 50 of 606

1.

Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer.

Zhang H, Schaefer A, Wang Y, Hodge RG, Blake DR, Diehl JN, Papageorge AG, Stachler MD, Liao J, Zhou J, Wu Z, Akarca FG, de Klerk LK, Derks S, Pierobon M, Hoadley KA, Wang TC, Church G, Wong KK, Petricoin EF, Cox AD, Lowy DR, Der CJ, Bass AJ.

Cancer Discov. 2019 Nov 26. pii: CD-19-0811. doi: 10.1158/2159-8290.CD-19-0811. [Epub ahead of print]

PMID:
31771969
2.

Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest.

François B, Cariou A, Clere-Jehl R, Dequin PF, Renon-Carron F, Daix T, Guitton C, Deye N, Legriel S, Plantefève G, Quenot JP, Desachy A, Kamel T, Bedon-Carte S, Diehl JL, Chudeau N, Karam E, Durand-Zaleski I, Giraudeau B, Vignon P, Le Gouge A; CRICS-TRIGGERSEP Network and the ANTHARTIC Study Group.

N Engl J Med. 2019 Nov 7;381(19):1831-1842. doi: 10.1056/NEJMoa1812379.

PMID:
31693806
3.

Impact of hyperoxia on patients hospitalized in an intensive care unit for acute heart failure.

Nael J, Ruggiu M, Bailleul C, Ortuno S, Diehl JL, Vimpère D, Augy JL, Guerot E, Danchin N, Puymirat E, Aissaoui N.

Arch Cardiovasc Dis. 2019 Dec;112(12):748-753. doi: 10.1016/j.acvd.2019.09.003. Epub 2019 Nov 2.

PMID:
31690520
4.

Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.

Hobbs GA, Baker NM, Miermont AM, Thurman RD, Pierobon M, Tran TH, Anderson AO, Waters AM, Diehl JN, Papke B, Hodge RG, Klomp JE, Goodwin CM, DeLiberty JM, Wang J, Ng RWS, Gautam P, Bryant KL, Esposito D, Campbell SL, Petricoin EF, Simanshu DK, Aguirre AJ, Wolpin BM, Wennerberg K, Rudloff U, Cox AD, Der CJ.

Cancer Discov. 2019 Oct 24. pii: CD-19-1006. doi: 10.1158/2159-8290.CD-19-1006. [Epub ahead of print]

PMID:
31649109
5.

SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors.

Yoshida A, Bu Y, Qie S, Wrangle J, Camp ER, Hazard ES, Hardiman G, de Leeuw R, Knudsen KE, Diehl JA.

Sci Adv. 2019 Sep 18;5(9):eaax6352. doi: 10.1126/sciadv.aax6352. eCollection 2019 Sep.

6.

Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis.

Siwecka N, Rozpędek W, Pytel D, Wawrzynkiewicz A, Dziki A, Dziki Ł, Diehl JA, Majsterek I.

Int J Mol Sci. 2019 Sep 5;20(18). pii: E4354. doi: 10.3390/ijms20184354. Review.

7.

CORE-REA: COPD right heart and respiratory acidosis.

Augy JL, Diehl JL, Bailleul C, Hermann B, Guerot E, Vimpere D, Aissaoui N.

Intensive Care Med. 2019 Nov;45(11):1676-1677. doi: 10.1007/s00134-019-05748-1. Epub 2019 Aug 30. No abstract available.

PMID:
31471625
8.

Obesity and ARDS: Opportunity for Highly Personalized Mechanical Ventilation?

Diehl JL, Vimpere D, Guérot E.

Respir Care. 2019 Sep;64(9):1173-1174. doi: 10.4187/respcare.07292. No abstract available.

PMID:
31467158
9.

A 2-year multicenter, observational, prospective, cohort study on extracorporeal CO2 removal in a large metropolis area.

Augy JL, Aissaoui N, Richard C, Maury E, Fartoukh M, Mekontso-Dessap A, Paulet R, Anguel N, Blayau C, Cohen Y, Chiche JD, Gaudry S, Voicu S, Demoule A, Combes A, Megarbane B, Charpentier E, Haghighat S, Panczer M, Diehl JL.

J Intensive Care. 2019 Aug 20;7:45. doi: 10.1186/s40560-019-0399-8. eCollection 2019.

10.

Repeatability of signalling traits in the avian dawn chorus.

Naguib M, Diehl J, van Oers K, Snijders L.

Front Zool. 2019 Jul 9;16:27. doi: 10.1186/s12983-019-0328-7. eCollection 2019.

11.

Author Correction: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.

Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salinas CS, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, Koumenis C.

Nat Cell Biol. 2019 Aug;21(8):1052. doi: 10.1038/s41556-019-0370-x.

PMID:
31316187
12.

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.

Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salas Salinas C, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, Koumenis C.

Nat Cell Biol. 2019 Jul;21(7):889-899. doi: 10.1038/s41556-019-0347-9. Epub 2019 Jul 1. Erratum in: Nat Cell Biol. 2019 Aug;21(8):1052.

PMID:
31263264
13.

Glutamine addiction: an Achilles heel in esophageal cancers with dysregulation of CDK4/6.

Qie S, Diehl JA.

Mol Cell Oncol. 2019 May 7;6(4):1610257. doi: 10.1080/23723556.2019.1610257. eCollection 2019.

PMID:
31211239
14.

ECCO2R patients: look out for coloured urine.

Younan R, Augy JL, Aissaoui N, Diehl JL.

Intensive Care Med. 2019 Nov;45(11):1651-1652. doi: 10.1007/s00134-019-05640-y. Epub 2019 May 17. No abstract available.

PMID:
31101960
15.

The PKR-Like Endoplasmic Reticulum Kinase Promotes the Dissemination of Myc-Induced Leukemic Cells.

Gui J, Katlinski KV, Koumenis C, Diehl JA, Fuchs SY.

Mol Cancer Res. 2019 Jul;17(7):1450-1458. doi: 10.1158/1541-7786.MCR-19-0002. Epub 2019 Mar 22.

PMID:
30902831
16.

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma.

Qie S, Yoshida A, Parnham S, Oleinik N, Beeson GC, Beeson CC, Ogretmen B, Bass AJ, Wong KK, Rustgi AK, Diehl JA.

Nat Commun. 2019 Mar 21;10(1):1296. doi: 10.1038/s41467-019-09179-w.

17.

Weaning from veno-arterial extra-corporeal membrane oxygenation: which strategy to use?

Ortuno S, Delmas C, Diehl JL, Bailleul C, Lancelot A, Naili M, Cholley B, Pirracchio R, Aissaoui N.

Ann Cardiothorac Surg. 2019 Jan;8(1):E1-E8. doi: 10.21037/acs.2018.08.05.

18.

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.

Bryant KL, Stalnecker CA, Zeitouni D, Klomp JE, Peng S, Tikunov AP, Gunda V, Pierobon M, Waters AM, George SD, Tomar G, Papke B, Hobbs GA, Yan L, Hayes TK, Diehl JN, Goode GD, Chaika NV, Wang Y, Zhang GF, Witkiewicz AK, Knudsen ES, Petricoin EF 3rd, Singh PK, Macdonald JM, Tran NL, Lyssiotis CA, Ying H, Kimmelman AC, Cox AD, Der CJ.

Nat Med. 2019 Apr;25(4):628-640. doi: 10.1038/s41591-019-0368-8. Epub 2019 Mar 4.

19.

Inhibition of the PERK-Dependent Unfolded Protein Response Signaling Pathway Involved in the Pathogenesis of Alzheimer's Disease.

Rozpędek W, Pytel D, Popławski T, Walczak A, Gradzik K, Wawrzynkiewicz A, Wojtczak R, Mucha B, Diehl JA, Majsterek I.

Curr Alzheimer Res. 2019;16(3):209-218. doi: 10.2174/1567205016666190228121157. Erratum in: Curr Alzheimer Res. 2019;16(6):575.

PMID:
30819079
20.
21.

An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.

Ortiz A, Gui J, Zahedi F, Yu P, Cho C, Bhattacharya S, Carbone CJ, Yu Q, Katlinski KV, Katlinskaya YV, Handa S, Haas V, Volk SW, Brice AK, Wals K, Matheson NJ, Antrobus R, Ludwig S, Whiteside TL, Sander C, Tarhini AA, Kirkwood JM, Lehner PJ, Guo W, Rui H, Minn AJ, Koumenis C, Diehl JA, Fuchs SY.

Cancer Cell. 2019 Jan 14;35(1):33-45.e6. doi: 10.1016/j.ccell.2018.12.001.

PMID:
30645975
22.

Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells.

Kijima T, Nakagawa H, Shimonosono M, Chandramouleeswaran PM, Hara T, Sahu V, Kasagi Y, Kikuchi O, Tanaka K, Giroux V, Muir AB, Whelan KA, Ohashi S, Naganuma S, Klein-Szanto AJ, Shinden Y, Sasaki K, Omoto I, Kita Y, Muto M, Bass AJ, Diehl JA, Ginsberg GG, Doki Y, Mori M, Uchikado Y, Arigami T, Avadhani NG, Basu D, Rustgi AK, Natsugoe S.

Cell Mol Gastroenterol Hepatol. 2018 Sep 14;7(1):73-91. doi: 10.1016/j.jcmgh.2018.09.003. eCollection 2019.

23.

CK1α Collaborates with DOUBLETIME to Regulate PERIOD Function in the Drosophila Circadian Clock.

Lam VH, Li YH, Liu X, Murphy KA, Diehl JS, Kwok RS, Chiu JC.

J Neurosci. 2018 Dec 12;38(50):10631-10643. doi: 10.1523/JNEUROSCI.0871-18.2018. Epub 2018 Oct 29.

24.

Understanding hypoxemia on ECCO2R: back to the alveolar gas equation.

Diehl JL, Mercat A, Pesenti A.

Intensive Care Med. 2019 Feb;45(2):255-256. doi: 10.1007/s00134-018-5409-0. Epub 2018 Oct 15. No abstract available.

PMID:
30324288
25.

Imaging & identification of malaria parasites using cellphone microscope with a ball lens.

Agbana TE, Diehl JC, van Pul F, Khan SM, Patlan V, Verhaegen M, Vdovin G.

PLoS One. 2018 Oct 4;13(10):e0205020. doi: 10.1371/journal.pone.0205020. eCollection 2018.

26.

Hyperoxia effects on intensive care unit mortality: a retrospective pragmatic cohort study.

Ruggiu M, Aissaoui N, Nael J, Haw-Berlemont C, Herrmann B, Augy JL, Ortuno S, Vimpère D, Diehl JL, Bailleul C, Guerot E.

Crit Care. 2018 Sep 21;22(1):218. doi: 10.1186/s13054-018-2142-6. No abstract available.

27.

Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells.

Gennaro VJ, Stanek TJ, Peck AR, Sun Y, Wang F, Qie S, Knudsen KE, Rui H, Butt T, Diehl JA, McMahon SB.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9298-E9307. doi: 10.1073/pnas.1807704115. Epub 2018 Sep 17.

28.

Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.

Wong GS, Zhou J, Bin Liu J, Wu Z, Xu X, Li T, Xu D, Schumacher SE, Puschhof J, McFarland J, Zou C, Dulak A, Henderson L, Xu P, O'Day E, Rendak R, Liao WL, Cecchi F, Hembrough T, Schwartz S, Szeto C, Rustgi AK, Wong KK, Diehl JA, Jensen K, Graziano F, Ruzzo A, Fereshetian S, Mertins P, Carr SA, Beroukhim R, Nakamura K, Oki E, Watanabe M, Baba H, Imamura Y, Catenacci D, Bass AJ.

Nat Med. 2018 Oct;24(10):1627. doi: 10.1038/s41591-018-0168-6.

PMID:
30093730
29.

BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non-Small Cell Lung Cancer.

Adeegbe DO, Liu S, Hattersley MM, Bowden M, Zhou CW, Li S, Vlahos R, Grondine M, Dolgalev I, Ivanova EV, Quinn MM, Gao P, Hammerman PS, Bradner JE, Diehl JA, Rustgi AK, Bass AJ, Tsirigos A, Freeman GJ, Chen H, Wong KK.

Cancer Immunol Res. 2018 Oct;6(10):1234-1245. doi: 10.1158/2326-6066.CIR-18-0077. Epub 2018 Aug 7.

30.

IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment.

Karakasheva TA, Lin EW, Tang Q, Qiao E, Waldron TJ, Soni M, Klein-Szanto AJ, Sahu V, Basu D, Ohashi S, Baba K, Giaccone ZT, Walker SR, Frank DA, Wileyto EP, Long Q, Dunagin MC, Raj A, Diehl JA, Wong KK, Bass AJ, Rustgi AK.

Cancer Res. 2018 Sep 1;78(17):4957-4970. doi: 10.1158/0008-5472.CAN-17-2268. Epub 2018 Jul 5.

31.

Circulating biomarkers may be unable to detect infection at the early phase of sepsis in ICU patients: the CAPTAIN prospective multicenter cohort study.

Parlato M, Philippart F, Rouquette A, Moucadel V, Puchois V, Blein S, Bedos JP, Diehl JL, Hamzaoui O, Annane D, Journois D, Ben Boutieb M, Estève L, Fitting C, Treluyer JM, Pachot A, Adib-Conquy M, Cavaillon JM, Misset B; Captain Study Group.

Intensive Care Med. 2018 Jul;44(7):1061-1070. doi: 10.1007/s00134-018-5228-3. Epub 2018 Jun 30.

PMID:
29959455
32.

Extreme hypomagnesemia: characteristics of 119 consecutive inpatients.

Cheminet G, Clain G, Jannot AS, Ranque B, Passeron A, Michon A, De Luna G, Diehl JL, Oudard S, Cellier C, Karras A, Vedié B, Prot-Bertoye C, Pouchot J, Arlet JB.

Intern Emerg Med. 2018 Dec;13(8):1201-1209. doi: 10.1007/s11739-018-1898-7. Epub 2018 Jun 27.

PMID:
29951810
33.

Cerebral infarction following cyanoacrylate endoscopic therapy of duodenal varices in a patient with a patent foramen ovale.

Abbar B, Vimpere D, Khater S, Cellier C, Diehl JL.

Intern Emerg Med. 2018 Aug;13(5):817-819. doi: 10.1007/s11739-018-1892-0. Epub 2018 Jun 13. No abstract available.

PMID:
29948836
34.

Cerebral Oximetry for Detecting High-mortality Risk Patients with Cryptococcal Meningitis.

Diehl JW, Hullsiek KH, Okirwoth M, Stephens N, Abassi M, Rhein J, Meya DB, Boulware DR, Musubire AK; ASTRO-CM Trial Team .

Open Forum Infect Dis. 2018 May 8;5(6):ofy105. doi: 10.1093/ofid/ofy105. eCollection 2018 Jun 1.

35.

Implementation of evidence-based practices for complex mood disorders in primary care safety net clinics.

Fortney JC, Pyne JM, Ward-Jones S, Bennett IM, Diehl J, Farris K, Cerimele JM, Curran GM.

Fam Syst Health. 2018 Sep;36(3):267-280. doi: 10.1037/fsh0000357. Epub 2018 May 28.

36.

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.

Wong GS, Zhou J, Liu JB, Wu Z, Xu X, Li T, Xu D, Schumacher SE, Puschhof J, McFarland J, Zou C, Dulak A, Henderson L, Xu P, O'Day E, Rendak R, Liao WL, Cecchi F, Hembrough T, Schwartz S, Szeto C, Rustgi AK, Wong KK, Diehl JA, Jensen K, Graziano F, Ruzzo A, Fereshetian S, Mertins P, Carr SA, Beroukhim R, Nakamura K, Oki E, Watanabe M, Baba H, Imamura Y, Catenacci D, Bass AJ.

Nat Med. 2018 Jul;24(7):968-977. doi: 10.1038/s41591-018-0022-x. Epub 2018 May 28. Erratum in: Nat Med. 2018 Oct;24(10):1627.

37.

MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer.

de Leeuw R, McNair C, Schiewer MJ, Neupane NP, Brand LJ, Augello MA, Li Z, Cheng LC, Yoshida A, Courtney SM, Hazard ES, Hardiman G, Hussain MH, Diehl JA, Drake JM, Kelly WK, Knudsen KE.

Clin Cancer Res. 2018 Sep 1;24(17):4201-4214. doi: 10.1158/1078-0432.CCR-18-0410. Epub 2018 May 8.

38.

The physical and cellular conditions of the human pulmonary circulation enable thrombopoiesis.

Ouzegdouh Y, Capron C, Bauer T, Puymirat E, Diehl JL, Martin JF, Cramer-Bordé E.

Exp Hematol. 2018 Jul;63:22-27.e3. doi: 10.1016/j.exphem.2018.04.001. Epub 2018 Apr 12.

PMID:
29654952
39.

Tracheotomy in the intensive care unit: Guidelines from a French expert panel: The French Intensive Care Society and the French Society of Anaesthesia and Intensive Care Medicine.

Trouillet JL, Collange O, Belafia F, Blot F, Capellier G, Cesareo E, Constantin JM, Demoule A, Diehl JL, Guinot PG, Jegoux F, L'Her E, Luyt CE, Mahjoub Y, Mayaux J, Quintard H, Ravat F, Vergez S, Amour J, Guillot M; French Intensive Care Society; French Society of Anaesthesia and Intensive Care.

Anaesth Crit Care Pain Med. 2018 Jun;37(3):281-294. doi: 10.1016/j.accpm.2018.02.012. Epub 2018 Mar 17. Review.

40.

The Long (lncRNA) and Short (miRNA) of It: TGFβ-Mediated Control of RNA-Binding Proteins and Noncoding RNAs.

Janakiraman H, House RP, Gangaraju VK, Diehl JA, Howe PH, Palanisamy V.

Mol Cancer Res. 2018 Apr;16(4):567-579. doi: 10.1158/1541-7786.MCR-17-0547. Epub 2018 Mar 19. Review.

41.

Tracheotomy in the intensive care unit: guidelines from a French expert panel.

Trouillet JL, Collange O, Belafia F, Blot F, Capellier G, Cesareo E, Constantin JM, Demoule A, Diehl JL, Guinot PG, Jegoux F, L'Her E, Luyt CE, Mahjoub Y, Mayaux J, Quintard H, Ravat F, Vergez S, Amour J, Guillot M.

Ann Intensive Care. 2018 Mar 15;8(1):37. doi: 10.1186/s13613-018-0381-y. Review.

42.

Breaking the DNA Damage Response via Serine/Threonine Kinase Inhibitors to Improve Cancer Treatment.

Rozpędek W, Pytel D, Nowak-Zduńczyk A, Lewko D, Wojtczak R, Diehl JA, Majsterek I.

Curr Med Chem. 2019;26(8):1425-1445. doi: 10.2174/0929867325666180117102233. Review.

PMID:
29345572
43.

A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.

Bu Y, Yoshida A, Chitnis N, Altman BJ, Tameire F, Oran A, Gennaro V, Armeson KE, McMahon SB, Wertheim GB, Dang CV, Ruggero D, Koumenis C, Fuchs SY, Diehl JA.

Nat Cell Biol. 2018 Jan;20(1):104-115. doi: 10.1038/s41556-017-0006-y. Epub 2017 Dec 11.

44.

Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced coagulopathy in rats.

Helms J, Clere-Jehl R, Bianchini E, Le Borgne P, Burban M, Zobairi F, Diehl JL, Grunebaum L, Toti F, Meziani F, Borgel D.

Ann Intensive Care. 2017 Dec 8;7(1):118. doi: 10.1186/s13613-017-0340-z.

45.

Addendum: A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.

Grelet S, Link LA, Howley B, Obellianne C, Palanisamy V, Gangaraju VK, Diehl JA, Howe PH.

Nat Cell Biol. 2017 Nov 29;19(12):1443. doi: 10.1038/ncb3647.

PMID:
29184176
46.

Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.

Natsuizaka M, Whelan KA, Kagawa S, Tanaka K, Giroux V, Chandramouleeswaran PM, Long A, Sahu V, Darling DS, Que J, Yang Y, Katz JP, Wileyto EP, Basu D, Kita Y, Natsugoe S, Naganuma S, Klein-Szanto AJ, Diehl JA, Bass AJ, Wong KK, Rustgi AK, Nakagawa H.

Nat Commun. 2017 Nov 24;8(1):1758. doi: 10.1038/s41467-017-01500-9.

47.

Enhanced aerobic exercise performance in women by a combination of three mineral Chelates plus two conditionally essential nutrients.

DiSilvestro RA, Hart S, Marshall T, Joseph E, Reau A, Swain CB, Diehl J.

J Int Soc Sports Nutr. 2017 Nov 13;14:42. doi: 10.1186/s12970-017-0199-2. eCollection 2017.

48.

Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulum.

McQuiston A, Diehl JA.

F1000Res. 2017 Oct 27;6:1897. doi: 10.12688/f1000research.12138.1. eCollection 2017. Review.

49.

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.

Qie S, Majumder M, Mackiewicz K, Howley BV, Peterson YK, Howe PH, Palanisamy V, Diehl JA.

Nat Commun. 2017 Nov 16;8(1):1534. doi: 10.1038/s41467-017-01199-8.

50.

CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response.

Hong F, Liu B, Wu BX, Morreall J, Roth B, Davies C, Sun S, Diehl JA, Li Z.

Nat Struct Mol Biol. 2017 Oct;24(10):834-839. doi: 10.1038/nsmb.3458. Epub 2017 Sep 4.

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