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Items: 1 to 50 of 417

1.

Single cell RNA sequencing identifies YAP1-dependent hepatic mesothelial progenitors in fibrolamellar carcinoma.

Jewell ML, Gibson JR, Guy CD, Hyun J, Du K, Oh SH, Premont RT, Hsu DS, Ribar T, Gregory SG, Diehl AM.

Am J Pathol. 2019 Oct 24. pii: S0002-9440(19)30770-9. doi: 10.1016/j.ajpath.2019.09.018. [Epub ahead of print]

PMID:
31669305
2.

Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease.

Kleiner DE, Brunt EM, Wilson LA, Behling C, Guy C, Contos M, Cummings O, Yeh M, Gill R, Chalasani N, Neuschwander-Tetri BA, Diehl AM, Dasarathy S, Terrault N, Kowdley K, Loomba R, Belt P, Tonascia J, Lavine JE, Sanyal AJ; Nonalcoholic Steatohepatitis Clinical Research Network.

JAMA Netw Open. 2019 Oct 2;2(10):e1912565. doi: 10.1001/jamanetworkopen.2019.12565.

3.

Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury.

Win S, Min RW, Chen CQ, Zhang J, Chen Y, Li M, Suzuki A, Abdelmalek MF, Wang Y, Aghajan M, Aung FW, Diehl AM, Davis RJ, Than TA, Kaplowitz N.

J Clin Invest. 2019 Oct 28. pii: 128289. doi: 10.1172/JCI128289. [Epub ahead of print]

4.

Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21.

Albadrani M, Seth RK, Sarkar S, Kimono D, Mondal A, Bose D, Porter DE, Scott GI, Brooks B, Raychoudhury S, Nagarkatti M, Nagarkatti P, Jule Y, Diehl AM, Chatterjee S.

Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1;317(4):G408-G428. doi: 10.1152/ajpgi.00061.2019. Epub 2019 Aug 8.

PMID:
31393787
5.

Nocturnal Hypoxia Activation of the Hedgehog Signaling Pathway Affects Pediatric Nonalcoholic Fatty Liver Disease Severity.

Sundaram SS, Swiderska-Syn M, Sokol RJ, Halbower AC, Capocelli KE, Pan Z, Robbins K, Graham B, Diehl AM.

Hepatol Commun. 2019 Apr 17;3(7):883-893. doi: 10.1002/hep4.1354. eCollection 2019 Jul.

6.

The Natural History of Advanced Fibrosis Due to Nonalcoholic Steatohepatitis: Data From the Simtuzumab Trials.

Sanyal AJ, Harrison SA, Ratziu V, Abdelmalek MF, Diehl AM, Caldwell S, Shiffman ML, Aguilar Schall R, Jia C, McColgan B, Djedjos CS, McHutchison JG, Subramanian GM, Myers RP, Younossi Z, Muir AJ, Afdhal NH, Bosch J, Goodman Z.

Hepatology. 2019 Apr 16. doi: 10.1002/hep.30664. [Epub ahead of print]

PMID:
30993748
7.

Disease pathways and molecular mechanisms of nonalcoholic steatohepatitis.

Wegermann K, Diehl AM, Moylan CA.

Clin Liver Dis (Hoboken). 2018 Apr 20;11(4):87-91. doi: 10.1002/cld.709. eCollection 2018 Apr. Review. No abstract available.

8.

MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma.

Dinh TA, Jewell ML, Kanke M, Francisco A, Sritharan R, Turnham RE, Lee S, Kastenhuber ER, Wauthier E, Guy CD, Yeung RS, Lowe SW, Reid LM, Scott JD, Diehl AM, Sethupathy P.

Cell Mol Gastroenterol Hepatol. 2019;7(4):803-817. doi: 10.1016/j.jcmgh.2019.01.008. Epub 2019 Feb 11.

9.

Dysregulated activation of fetal liver programme in acute liver failure.

Hyun J, Oh SH, Premont RT, Guy CD, Berg CL, Diehl AM.

Gut. 2019 Jun;68(6):1076-1087. doi: 10.1136/gutjnl-2018-317603. Epub 2019 Jan 22.

10.

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis.

Zhu C, Kim K, Wang X, Bartolome A, Salomao M, Dongiovanni P, Meroni M, Graham MJ, Yates KP, Diehl AM, Schwabe RF, Tabas I, Valenti L, Lavine JE, Pajvani UB.

Sci Transl Med. 2018 Nov 21;10(468). pii: eaat0344. doi: 10.1126/scitranslmed.aat0344.

PMID:
30463916
11.

Validation of Serum Test for Advanced Liver Fibrosis in Patients With Nonalcoholic Steatohepatitis.

Loomba R, Jain A, Diehl AM, Guy CD, Portenier D, Sudan R, Singh S, Faulkner C, Richards L, Hester KD, Okada L, Li XJ, Mimms L, Abdelmalek MF.

Clin Gastroenterol Hepatol. 2019 Aug;17(9):1867-1876.e3. doi: 10.1016/j.cgh.2018.11.004. Epub 2018 Nov 15.

PMID:
30448594
12.

Microbial nitrogen limitation in the mammalian large intestine.

Reese AT, Pereira FC, Schintlmeister A, Berry D, Wagner M, Hale LP, Wu A, Jiang S, Durand HK, Zhou X, Premont RT, Diehl AM, O'Connell TM, Alberts SC, Kartzinel TR, Pringle RM, Dunn RR, Wright JP, David LA.

Nat Microbiol. 2018 Dec;3(12):1441-1450. doi: 10.1038/s41564-018-0267-7. Epub 2018 Oct 29.

13.

Developmental Morphogens & Recovery from Alcoholic Liver Disease.

Diehl AM.

Adv Exp Med Biol. 2018;1032:145-151. doi: 10.1007/978-3-319-98788-0_11. Review.

PMID:
30362097
14.

Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study.

Wegermann K, Henao R, Diehl AM, Murphy SK, Abdelmalek MF, Moylan CA.

PLoS One. 2018 Sep 28;13(9):e0204308. doi: 10.1371/journal.pone.0204308. eCollection 2018. Erratum in: PLoS One. 2019 Feb 5;14(2):e0212144.

15.

Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent.

Dattaroy D, Seth RK, Sarkar S, Kimono D, Albadrani M, Chandrashekaran V, Hasson FA, Singh UP, Fan D, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S.

Eur J Pharmacol. 2018 Dec 15;841:33-48. doi: 10.1016/j.ejphar.2018.08.040. Epub 2018 Sep 5.

PMID:
30194936
16.

The conundrum of cryptogenic cirrhosis: Adverse outcomes without treatment options.

Younossi Z, Stepanova M, Sanyal AJ, Harrison SA, Ratziu V, Abdelmalek MF, Diehl AM, Caldwell S, Shiffman ML, Schall RA, McColgan B, Subramanian GM, Myers RP, Muir A, Afdhal NH, Bosch J, Goodman Z.

J Hepatol. 2018 Dec;69(6):1365-1370. doi: 10.1016/j.jhep.2018.08.013. Epub 2018 Aug 23.

PMID:
30144554
17.

RNA Binding Proteins Control Transdifferentiation of Hepatic Stellate Cells into Myofibroblasts.

Wang S, Jung Y, Hyun J, Friedersdorf M, Oh SH, Kim J, Premont RT, Keene JD, Diehl AM.

Cell Physiol Biochem. 2018;48(3):1215-1229. doi: 10.1159/000491987. Epub 2018 Jul 25.

18.

Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.

Naggie S, Swiderska-Syn M, Choi S, Lusk S, Lan A, Ferrari G, Syn WK, Guy CD, Diehl AM.

Open Forum Infect Dis. 2018 Jun 11;5(7):ofy138. doi: 10.1093/ofid/ofy138. eCollection 2018 Jul.

19.

Simtuzumab Is Ineffective for Patients With Bridging Fibrosis or Compensated Cirrhosis Caused by Nonalcoholic Steatohepatitis.

Harrison SA, Abdelmalek MF, Caldwell S, Shiffman ML, Diehl AM, Ghalib R, Lawitz EJ, Rockey DC, Schall RA, Jia C, McColgan BJ, McHutchison JG, Subramanian GM, Myers RP, Younossi Z, Ratziu V, Muir AJ, Afdhal NH, Goodman Z, Bosch J, Sanyal AJ; GS-US-321-0105 and GS-US-321-0106 Investigators.

Gastroenterology. 2018 Oct;155(4):1140-1153. doi: 10.1053/j.gastro.2018.07.006. Epub 2018 Jul 7.

PMID:
29990488
20.

Towards a definite mouse model of NAFLD.

Castro RE, Diehl AM.

J Hepatol. 2018 Aug;69(2):272-274. doi: 10.1016/j.jhep.2018.05.002. Epub 2018 May 29. No abstract available.

PMID:
29858042
21.

Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes.

Oh SH, Swiderska-Syn M, Jewell ML, Premont RT, Diehl AM.

J Hepatol. 2018 Aug;69(2):359-367. doi: 10.1016/j.jhep.2018.05.008. Epub 2018 May 23.

22.

Prometheus revisited.

Chen KY, Shen X, Diehl AM.

J Clin Invest. 2018 Jun 1;128(6):2192-2193. doi: 10.1172/JCI120933. Epub 2018 Apr 30.

23.

High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease.

Alhasson F, Seth RK, Sarkar S, Kimono DA, Albadrani MS, Dattaroy D, Chandrashekaran V, Scott GI, Raychoudhury S, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S.

Redox Biol. 2018 Jul;17:1-15. doi: 10.1016/j.redox.2018.04.002. Epub 2018 Apr 7.

24.

The hedgehog pathway in nonalcoholic fatty liver disease.

Verdelho Machado M, Diehl AM.

Crit Rev Biochem Mol Biol. 2018 Jun;53(3):264-278. doi: 10.1080/10409238.2018.1448752. Epub 2018 Mar 20. Review.

25.

Nonalcoholic Steatohepatitis.

Diehl AM, Day C.

N Engl J Med. 2018 Feb 22;378(8):781. doi: 10.1056/NEJMc1716786. No abstract available.

PMID:
29466150
26.

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease.

Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, Nakagawa T, Kuwabara M, Sato Y, Kang DH, Tolan DR, Sanchez-Lozada LG, Rosen HR, Lanaspa MA, Diehl AM, Johnson RJ.

J Hepatol. 2018 May;68(5):1063-1075. doi: 10.1016/j.jhep.2018.01.019. Epub 2018 Feb 2. Review.

27.

DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitis.

Loomba R, Gindin Y, Jiang Z, Lawitz E, Caldwell S, Djedjos CS, Xu R, Chung C, Myers RP, Subramanian GM, Goodman Z, Charlton M, Afdhal NH, Diehl AM.

JCI Insight. 2018 Jan 25;3(2). pii: 96685. doi: 10.1172/jci.insight.96685. eCollection 2018 Jan 25.

28.

Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.

Du K, Hyun J, Premont RT, Choi SS, Michelotti GA, Swiderska-Syn M, Dalton GD, Thelen E, Rizi BS, Jung Y, Diehl AM.

Gastroenterology. 2018 Apr;154(5):1465-1479.e13. doi: 10.1053/j.gastro.2017.12.022. Epub 2018 Jan 3.

29.

Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis.

Diehl AM, Day C.

N Engl J Med. 2017 Nov 23;377(21):2063-2072. doi: 10.1056/NEJMra1503519. Review. No abstract available.

PMID:
29166236
30.

Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease.

Perito ER, Ajmera V, Bass NM, Rosenthal P, Lavine JE, Schwimmer JB, Yates KP, Diehl AM, Molleston JP, Murray KF, Scheimann A, Gill R, Glidden D, Aouizerat B.

Hepatol Commun. 2017 Sep;1(7):609-622. doi: 10.1002/hep4.1068. Epub 2017 Jul 17.

31.

Hedgehog signalling in liver pathophysiology.

Machado MV, Diehl AM.

J Hepatol. 2018 Mar;68(3):550-562. doi: 10.1016/j.jhep.2017.10.017. Epub 2017 Oct 26. Review.

32.

Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic.

Mendrick DL, Diehl AM, Topor LS, Dietert RR, Will Y, La Merrill MA, Bouret S, Varma V, Hastings KL, Schug TT, Emeigh Hart SG, Burleson FG.

Toxicol Sci. 2018 Mar 1;162(1):36-42. doi: 10.1093/toxsci/kfx233. Review.

33.

The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial.

Loomba R, Lawitz E, Mantry PS, Jayakumar S, Caldwell SH, Arnold H, Diehl AM, Djedjos CS, Han L, Myers RP, Subramanian GM, McHutchison JG, Goodman ZD, Afdhal NH, Charlton MR; GS-US-384-1497 Investigators.

Hepatology. 2018 Feb;67(2):549-559. doi: 10.1002/hep.29514. Epub 2017 Dec 26. Erratum in: Hepatology. 2018 May;67(5):2063.

34.

Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling.

Kim J, Hyun J, Wang S, Lee C, Lee JW, Moon EY, Cha H, Diehl AM, Jung Y.

Sci Rep. 2017 Jun 19;7(1):3815. doi: 10.1038/s41598-017-03782-x.

35.

HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease.

Chandrashekaran V, Seth RK, Dattaroy D, Alhasson F, Ziolenka J, Carson J, Berger FG, Kalyanaraman B, Diehl AM, Chatterjee S.

Redox Biol. 2017 Oct;13:8-19. doi: 10.1016/j.redox.2017.05.005. Epub 2017 May 10.

36.

Reply.

Yang JD, Abdelmalek MF, Guy CD, Diehl AM, Suzuki A.

Clin Gastroenterol Hepatol. 2018 Oct;16(10):1684. doi: 10.1016/j.cgh.2017.05.003. Epub 2017 May 11. No abstract available.

PMID:
28502788
37.

Reply to Kim et al.

Patel YA, Henao R, Moylan CA, Guy CD, Piercy DL, Diehl AM, Abdelmalek MF.

Am J Gastroenterol. 2017 May;112(5):807-808. doi: 10.1038/ajg.2017.45. No abstract available.

PMID:
28469220
38.

Loss of pericyte smoothened activity in mice with genetic deficiency of leptin.

Xie G, Swiderska-Syn M, Jewell ML, Machado MV, Michelotti GA, Premont RT, Diehl AM.

BMC Cell Biol. 2017 Apr 20;18(1):20. doi: 10.1186/s12860-017-0135-y.

39.

Id2 Collaborates with Id3 To Suppress Invariant NKT and Innate-like Tumors.

Li J, Roy S, Kim YM, Li S, Zhang B, Love C, Reddy A, Rajagopalan D, Dave S, Diehl AM, Zhuang Y.

J Immunol. 2017 Apr 15;198(8):3136-3148. doi: 10.4049/jimmunol.1601935. Epub 2017 Mar 3.

40.

The diversity and plasticity of adult hepatic progenitor cells and their niche.

Chen J, Chen L, Zern MA, Theise ND, Diehl AM, Liu P, Duan Y.

Liver Int. 2017 Sep;37(9):1260-1271. doi: 10.1111/liv.13377. Epub 2017 Feb 23. Review.

41.

Timing Is Everything.

Diehl AM.

Cell Metab. 2017 Jan 10;25(1):2-4. doi: 10.1016/j.cmet.2016.12.015.

42.

TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity.

Seth RK, Das S, Dattaroy D, Chandrashekaran V, Alhasson F, Michelotti G, Nagarkatti M, Nagarkatti P, Diehl AM, Bell PD, Liedtke W, Chatterjee S.

Free Radic Biol Med. 2017 Jan;102:260-273. doi: 10.1016/j.freeradbiomed.2016.11.047. Epub 2016 Nov 29.

43.

Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis.

Patel YA, Henao R, Moylan CA, Guy CD, Piercy DL, Diehl AM, Abdelmalek MF.

Am J Gastroenterol. 2016 Nov;111(11):1591-1598. doi: 10.1038/ajg.2016.406. Epub 2016 Sep 20.

44.

Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni.

Pereira TA, Syn WK, Pereira FE, Lambertucci JR, Secor WE, Diehl AM.

Int J Parasitol. 2016 Dec;46(13-14):829-832. doi: 10.1016/j.ijpara.2016.08.004. Epub 2016 Oct 10.

45.

Osteopontin Is Upregulated in Human and Murine Acute Schistosomiasis Mansoni.

Pereira TA, Syn WK, Amâncio FF, Cunha PH, Caporali JF, Trindade GV, Santos ET, Souza MM, Andrade ZA, Witek RP, Secor WE, Pereira FE, Lambertucci JR, Diehl AM.

PLoS Negl Trop Dis. 2016 Oct 18;10(10):e0005057. doi: 10.1371/journal.pntd.0005057. eCollection 2016 Oct.

46.

Nonalcoholic Steatohepatitis.

Suzuki A, Diehl AM.

Annu Rev Med. 2017 Jan 14;68:85-98. doi: 10.1146/annurev-med-051215-031109. Epub 2016 Oct 5. Review.

PMID:
27732787
47.

Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease.

Ajmera V, Perito ER, Bass NM, Terrault NA, Yates KP, Gill R, Loomba R, Diehl AM, Aouizerat BE; NASH Clinical Research Network.

Hepatology. 2017 Jan;65(1):65-77. doi: 10.1002/hep.28776. Epub 2016 Oct 12.

48.

Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis.

Yang JD, Abdelmalek MF, Guy CD, Gill RM, Lavine JE, Yates K, Klair J, Terrault NA, Clark JM, Unalp-Arida A, Diehl AM, Suzuki A; Nonalcoholic Steatohepatitis Clinical Research Network.

Clin Gastroenterol Hepatol. 2017 Jan;15(1):127-131.e2. doi: 10.1016/j.cgh.2016.07.034. Epub 2016 Aug 12.

49.

Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Arylglycines.

Beisel T, Diehl AM, Manolikakes G.

Org Lett. 2016 Aug 19;18(16):4116-9. doi: 10.1021/acs.orglett.6b02045. Epub 2016 Aug 9.

PMID:
27505131
50.

Hypoxia of the growing liver accelerates regeneration.

Schadde E, Tsatsaris C, Swiderska-Syn M, Breitenstein S, Urner M, Schimmer R, Booy C, Z'graggen BR, Wenger RH, Spahn DR, Hertl M, Knechtle S, Diehl AM, Schläpfer M, Beck-Schimmer B.

Surgery. 2017 Mar;161(3):666-679. doi: 10.1016/j.surg.2016.05.018. Epub 2016 Jul 16.

PMID:
27436690

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