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Items: 14


LUBAC determines chemotherapy resistance in squamous cell lung cancer.

Ruiz EJ, Diefenbacher ME, Nelson JK, Sancho R, Pucci F, Chakraborty A, Moreno P, Annibaldi A, Liccardi G, Encheva V, Mitter R, Rosenfeldt M, Snijders AP, Meier P, Calzado MA, Behrens A.

J Exp Med. 2019 Feb 4;216(2):450-465. doi: 10.1084/jem.20180742. Epub 2019 Jan 14.


Fbw7 and its counteracting forces in stem cells and cancer: Oncoproteins in the balance.

Cremona CA, Sancho R, Diefenbacher ME, Behrens A.

Semin Cancer Biol. 2016 Feb;36:52-61. doi: 10.1016/j.semcancer.2015.09.006. Epub 2015 Sep 26. Review.


The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling.

Chakraborty A, Diefenbacher ME, Mylona A, Kassel O, Behrens A.

Nat Commun. 2015 Apr 8;6:6782. doi: 10.1038/ncomms7782.


Usp28 counteracts Fbw7 in intestinal homeostasis and cancer.

Diefenbacher ME, Chakraborty A, Blake SM, Mitter R, Popov N, Eilers M, Behrens A.

Cancer Res. 2015 Apr 1;75(7):1181-6. doi: 10.1158/0008-5472.CAN-14-1726. Epub 2015 Feb 25.


Dual regulation of Fbw7 function and oncogenic transformation by Usp28.

Schülein-Völk C, Wolf E, Zhu J, Xu W, Taranets L, Hellmann A, Jänicke LA, Diefenbacher ME, Behrens A, Eilers M, Popov N.

Cell Rep. 2014 Nov 6;9(3):1099-109. doi: 10.1016/j.celrep.2014.09.057. Epub 2014 Oct 30.


The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer.

Diefenbacher ME, Popov N, Blake SM, Schülein-Völk C, Nye E, Spencer-Dene B, Jaenicke LA, Eilers M, Behrens A.

J Clin Invest. 2014 Aug;124(8):3407-18. doi: 10.1172/JCI73733. Epub 2014 Jun 24.


The LIM domain protein nTRIP6 recruits the mediator complex to AP-1-regulated promoters.

Diefenbacher ME, Reich D, Dahley O, Kemler D, Litfin M, Herrlich P, Kassel O.

PLoS One. 2014 May 12;9(5):e97549. doi: 10.1371/journal.pone.0097549. eCollection 2014.


Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance.

Castellano E, Sheridan C, Thin MZ, Nye E, Spencer-Dene B, Diefenbacher ME, Moore C, Kumar MS, Murillo MM, Grönroos E, Lassailly F, Stamp G, Downward J.

Cancer Cell. 2013 Nov 11;24(5):617-30. doi: 10.1016/j.ccr.2013.09.012.


Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation.

Davies CC, Chakraborty A, Diefenbacher ME, Skehel M, Behrens A.

EMBO J. 2013 May 29;32(11):1556-67. doi: 10.1038/emboj.2013.98. Epub 2013 Apr 26.


RsfA (YbeB) proteins are conserved ribosomal silencing factors.

Häuser R, Pech M, Kijek J, Yamamoto H, Titz B, Naeve F, Tovchigrechko A, Yamamoto K, Szaflarski W, Takeuchi N, Stellberger T, Diefenbacher ME, Nierhaus KH, Uetz P.

PLoS Genet. 2012;8(7):e1002815. doi: 10.1371/journal.pgen.1002815. Epub 2012 Jul 19.


c-Jun localizes to the nucleus independent of its phosphorylation by and interaction with JNK and vice versa promotes nuclear accumulation of JNK.

Schreck I, Al-Rawi M, Mingot JM, Scholl C, Diefenbacher ME, O'Donnell P, Bohmann D, Weiss C.

Biochem Biophys Res Commun. 2011 Apr 22;407(4):735-40. doi: 10.1016/j.bbrc.2011.03.092. Epub 2011 Mar 31.


F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor.

Sancho R, Jandke A, Davis H, Diefenbacher ME, Tomlinson I, Behrens A.

Gastroenterology. 2010 Sep;139(3):929-41. doi: 10.1053/j.gastro.2010.05.078. Epub 2010 Jun 2.


The nuclear isoform of the LIM domain protein Trip6 integrates activating and repressing signals at the promoter-bound glucocorticoid receptor.

Diefenbacher ME, Litfin M, Herrlich P, Kassel O.

Mol Cell Endocrinol. 2010 May 14;320(1-2):58-66. doi: 10.1016/j.mce.2010.02.010. Epub 2010 Feb 12.


Myosin Va cooperates with PKA RIalpha to mediate maintenance of the endplate in vivo.

Röder IV, Choi KR, Reischl M, Petersen Y, Diefenbacher ME, Zaccolo M, Pozzan T, Rudolf R.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2031-6. doi: 10.1073/pnas.0914087107. Epub 2010 Jan 19.

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