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Items: 31


Connective tissue growth factor contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ.

Tang X, Muhammad H, McLean C, Miotla-Zarebska J, Fleming J, Didangelos A, Önnerfjord P, Leask A, Saklatvala J, Vincent TL.

Ann Rheum Dis. 2018 Sep;77(9):1372-1380. doi: 10.1136/annrheumdis-2018-212964. Epub 2018 Jun 20.


Immune-evasive gene switch enables regulated delivery of chondroitinase after spinal cord injury.

Burnside ER, De Winter F, Didangelos A, James ND, Andreica EC, Layard-Horsfall H, Muir EM, Verhaagen J, Bradbury EJ.

Brain. 2018 Aug 1;141(8):2362-2381. doi: 10.1093/brain/awy158.


Combined Transcriptomics, Proteomics and Bioinformatics Identify Drug Targets in Spinal Cord Injury.

Tica J, Bradbury EJ, Didangelos A.

Int J Mol Sci. 2018 May 14;19(5). pii: E1461. doi: 10.3390/ijms19051461.


Role of ADAMTS-5 in Aortic Dilatation and Extracellular Matrix Remodeling.

Fava M, Barallobre-Barreiro J, Mayr U, Lu R, Didangelos A, Baig F, Lynch M, Catibog N, Joshi A, Barwari T, Yin X, Jahangiri M, Mayr M.

Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1537-1548. doi: 10.1161/ATVBAHA.117.310562. Epub 2018 Apr 5.


Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques.

Langley SR, Willeit K, Didangelos A, Matic LP, Skroblin P, Barallobre-Barreiro J, Lengquist M, Rungger G, Kapustin A, Kedenko L, Molenaar C, Lu R, Barwari T, Suna G, Yin X, Iglseder B, Paulweber B, Willeit P, Shalhoub J, Pasterkamp G, Davies AH, Monaco C, Hedin U, Shanahan CM, Willeit J, Kiechl S, Mayr M.

J Clin Invest. 2017 Apr 3;127(4):1546-1560. doi: 10.1172/JCI86924. Epub 2017 Mar 20.


Manipulating the extracellular matrix: an animal model of the bladder pain syndrome.

Offiah I, Didangelos A, OʼReilly BA, McMahon SB.

Pain. 2017 Jan;158(1):161-170.


Persistent Alterations in Microglial Enhancers in a Model of Chronic Pain.

Denk F, Crow M, Didangelos A, Lopes DM, McMahon SB.

Cell Rep. 2016 May 24;15(8):1771-81. doi: 10.1016/j.celrep.2016.04.063. Epub 2016 May 12.


The Expression of Inflammatory Mediators in Bladder Pain Syndrome.

Offiah I, Didangelos A, Dawes J, Cartwright R, Khullar V, Bradbury EJ, O'Sullivan S, Williams D, Chessell IP, Pallas K, Graham G, O'Reilly BA, McMahon SB.

Eur Urol. 2016 Aug;70(2):283-90. doi: 10.1016/j.eururo.2016.02.058. Epub 2016 Mar 7.


High-throughput proteomics reveal alarmins as amplifiers of tissue pathology and inflammation after spinal cord injury.

Didangelos A, Puglia M, Iberl M, Sanchez-Bellot C, Roschitzki B, Bradbury EJ.

Sci Rep. 2016 Feb 22;6:21607. doi: 10.1038/srep21607.


The role of G-protein receptor 84 in experimental neuropathic pain.

Nicol LS, Dawes JM, La Russa F, Didangelos A, Clark AK, Gentry C, Grist J, Davies JB, Malcangio M, McMahon SB.

J Neurosci. 2015 Jun 10;35(23):8959-69. doi: 10.1523/JNEUROSCI.3558-14.2015.


Regulation of IL-10 by chondroitinase ABC promotes a distinct immune response following spinal cord injury.

Didangelos A, Iberl M, Vinsland E, Bartus K, Bradbury EJ.

J Neurosci. 2014 Dec 3;34(49):16424-32. doi: 10.1523/JNEUROSCI.2927-14.2014.


Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury.

Bartus K, James ND, Didangelos A, Bosch KD, Verhaagen J, Yáñez-Muñoz RJ, Rogers JH, Schneider BL, Muir EM, Bradbury EJ.

J Neurosci. 2014 Apr 2;34(14):4822-36. doi: 10.1523/JNEUROSCI.4369-13.2014.


Gene network and proteomic analyses of cardiac responses to pathological and physiological stress.

Drozdov I, Didangelos A, Yin X, Zampetaki A, Abonnenc M, Murdoch C, Zhang M, Ouzounis CA, Mayr M, Tsoka S, Shah AM.

Circ Cardiovasc Genet. 2013 Dec;6(6):588-97. doi: 10.1161/CIRCGENETICS.113.000063. Epub 2013 Nov 8.


Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M.

Circ Res. 2013 Oct 25;113(10):1138-47. doi: 10.1161/CIRCRESAHA.113.302400. Epub 2013 Sep 4.


A sequential extraction methodology for cardiac extracellular matrix prior to proteomics analysis.

Barallobre-Barreiro J, Didangelos A, Yin X, Doménech N, Mayr M.

Methods Mol Biol. 2013;1005:215-23. doi: 10.1007/978-1-62703-386-2_17.


Proteomic identification of matrix metalloproteinase substrates in the human vasculature.

Stegemann C, Didangelos A, Barallobre-Barreiro J, Langley SR, Mandal K, Jahangiri M, Mayr M.

Circ Cardiovasc Genet. 2013 Feb;6(1):106-17. doi: 10.1161/CIRCGENETICS.112.964452. Epub 2012 Dec 19.


Smooth muscle cells in human atherosclerosis: proteomic profiling reveals differences in expression of Annexin A1 and mitochondrial proteins in carotid disease.

Viiri LE, Full LE, Navin TJ, Begum S, Didangelos A, Astola N, Berge RK, Seppälä I, Shalhoub J, Franklin IJ, Perretti M, Lehtimäki T, Davies AH, Wait R, Monaco C.

J Mol Cell Cardiol. 2013 Jan;54:65-72. doi: 10.1016/j.yjmcc.2012.11.002. Epub 2012 Nov 12.


Src and fibroblast growth factor 2 independently regulate signaling and gene expression induced by experimental injury to intact articular cartilage.

Watt FE, Ismail HM, Didangelos A, Peirce M, Vincent TL, Wait R, Saklatvala J.

Arthritis Rheum. 2013 Feb;65(2):397-407. doi: 10.1002/art.37765.


Novel cardiac-specific biomarkers and the cardiovascular continuum.

Vassiliadis E, Barascuk N, Didangelos A, Karsdal MA.

Biomark Insights. 2012;7:45-57. doi: 10.4137/BMI.S9536. Epub 2012 May 2.


Novel role of ADAMTS-5 protein in proteoglycan turnover and lipoprotein retention in atherosclerosis.

Didangelos A, Mayr U, Monaco C, Mayr M.

J Biol Chem. 2012 Jun 1;287(23):19341-5. doi: 10.1074/jbc.C112.350785. Epub 2012 Apr 9.


Method for protein subfractionation of cardiovascular tissues before DIGE analysis.

Didangelos A, Yin X, Mayr M.

Methods Mol Biol. 2012;854:287-97. doi: 10.1007/978-1-61779-573-2_20.


Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.

Barallobre-Barreiro J, Didangelos A, Schoendube FA, Drozdov I, Yin X, Fernández-Caggiano M, Willeit P, Puntmann VO, Aldama-López G, Shah AM, Doménech N, Mayr M.

Circulation. 2012 Feb 14;125(6):789-802. doi: 10.1161/CIRCULATIONAHA.111.056952. Epub 2012 Jan 18.


The -omics era: proteomics and lipidomics in vascular research.

Didangelos A, Stegemann C, Mayr M.

Atherosclerosis. 2012 Mar;221(1):12-7. doi: 10.1016/j.atherosclerosis.2011.09.043. Epub 2011 Oct 2. Review.


Substrate modifications precede the development of atrial fibrillation after cardiac surgery: a proteomic study.

Kourliouros A, Yin X, Didangelos A, Hosseini MT, Valencia O, Mayr M, Jahangiri M.

Ann Thorac Surg. 2011 Jul;92(1):104-10. doi: 10.1016/j.athoracsur.2011.03.071.


Extracellular matrix composition and remodeling in human abdominal aortic aneurysms: a proteomics approach.

Didangelos A, Yin X, Mandal K, Saje A, Smith A, Xu Q, Jahangiri M, Mayr M.

Mol Cell Proteomics. 2011 Aug;10(8):M111.008128. doi: 10.1074/mcp.M111.008128. Epub 2011 May 18.


Comparative lipidomics profiling of human atherosclerotic plaques.

Stegemann C, Drozdov I, Shalhoub J, Humphries J, Ladroue C, Didangelos A, Baumert M, Allen M, Davies AH, Monaco C, Smith A, Xu Q, Mayr M.

Circ Cardiovasc Genet. 2011 Jun;4(3):232-42. doi: 10.1161/CIRCGENETICS.110.959098. Epub 2011 Apr 21.


Proteomics characterization of extracellular space components in the human aorta.

Didangelos A, Yin X, Mandal K, Baumert M, Jahangiri M, Mayr M.

Mol Cell Proteomics. 2010 Sep;9(9):2048-62. doi: 10.1074/mcp.M110.001693. Epub 2010 Jun 15.


Comparative proteomics profiling reveals role of smooth muscle progenitors in extracellular matrix production.

Simper D, Mayr U, Urbich C, Zampetaki A, Prokopi M, Didangelos A, Saje A, Mueller M, Benbow U, Newby AC, Apweiler R, Rahman S, Dimmeler S, Xu Q, Mayr M.

Arterioscler Thromb Vasc Biol. 2010 Jul;30(7):1325-32. doi: 10.1161/ATVBAHA.110.204651. Epub 2010 Apr 29.


Proteomics of acute coronary syndromes.

Didangelos A, Simper D, Monaco C, Mayr M.

Curr Atheroscler Rep. 2009 May;11(3):188-95. Review.


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