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Items: 1 to 50 of 68

1.

Amyotrophic lateral sclerosis mutant TDP-43 may cause synaptic dysfunction through altered dendritic spine function.

Jiang T, Handley E, Brizuela M, Dawkins E, Lewis KEA, Clark RM, Dickson TC, Blizzard CA.

Dis Model Mech. 2019 May 17;12(5). pii: dmm038109. doi: 10.1242/dmm.038109.

2.

Reduced Excitability and Increased Neurite Complexity of Cortical Interneurons in a Familial Mouse Model of Amyotrophic Lateral Sclerosis.

Clark RM, Brizuela M, Blizzard CA, Dickson TC.

Front Cell Neurosci. 2018 Sep 28;12:328. doi: 10.3389/fncel.2018.00328. eCollection 2018.

3.

The Microtubule-Modulating Drug Epothilone D Alters Dendritic Spine Morphology in a Mouse Model of Mild Traumatic Brain Injury.

Chuckowree JA, Zhu Z, Brizuela M, Lee KM, Blizzard CA, Dickson TC.

Front Cell Neurosci. 2018 Jul 30;12:223. doi: 10.3389/fncel.2018.00223. eCollection 2018.

4.

Epothilone D inhibits microglia-mediated spread of alpha-synuclein aggregates.

Valdinocci D, Grant GD, Dickson TC, Pountney DL.

Mol Cell Neurosci. 2018 Jun;89:80-94. doi: 10.1016/j.mcn.2018.04.006. Epub 2018 Apr 16.

PMID:
29673913
5.

Epothilone D accelerates disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis.

Clark JA, Blizzard CA, Breslin MC, Yeaman EJ, Lee KM, Chuckowree JA, Dickson TC.

Neuropathol Appl Neurobiol. 2018 Oct;44(6):590-605. doi: 10.1111/nan.12473. Epub 2018 Mar 27.

PMID:
29380402
6.

Mild and repetitive very mild axonal stretch injury triggers cystoskeletal mislocalization and growth cone collapse.

Yap YC, King AE, Guijt RM, Jiang T, Blizzard CA, Breadmore MC, Dickson TC.

PLoS One. 2017 May 4;12(5):e0176997. doi: 10.1371/journal.pone.0176997. eCollection 2017.

7.

Calretinin and Neuropeptide Y interneurons are differentially altered in the motor cortex of the SOD1G93A mouse model of ALS.

Clark RM, Blizzard CA, Young KM, King AE, Dickson TC.

Sci Rep. 2017 Mar 15;7:44461. doi: 10.1038/srep44461.

8.

Amyloid β precursor protein regulates neuron survival and maturation in the adult mouse brain.

Wang S, Bolós M, Clark R, Cullen CL, Southam KA, Foa L, Dickson TC, Young KM.

Mol Cell Neurosci. 2016 Dec;77:21-33. doi: 10.1016/j.mcn.2016.09.002. Epub 2016 Sep 21.

PMID:
27664851
9.

A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During Disease.

Clark JA, Yeaman EJ, Blizzard CA, Chuckowree JA, Dickson TC.

Front Cell Neurosci. 2016 Sep 13;10:204. doi: 10.3389/fncel.2016.00204. eCollection 2016. Review.

10.

Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies.

Handley EE, Pitman KA, Dawkins E, Young KM, Clark RM, Jiang TC, Turner BJ, Dickson TC, Blizzard CA.

Cereb Cortex. 2017 Jul 1;27(7):3630-3647. doi: 10.1093/cercor/bhw185.

PMID:
27496536
11.

Axonal degeneration, distal collateral branching and neuromuscular junction architecture alterations occur prior to symptom onset in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Clark JA, Southam KA, Blizzard CA, King AE, Dickson TC.

J Chem Neuroanat. 2016 Oct;76(Pt A):35-47. doi: 10.1016/j.jchemneu.2016.03.003. Epub 2016 Mar 30.

PMID:
27038603
12.

Inducing Chronic Excitotoxicity in the Mouse Spinal Cord to Investigate Lower Motor Neuron Degeneration.

Blizzard CA, Lee KM, Dickson TC.

Front Neurosci. 2016 Mar 2;10:76. doi: 10.3389/fnins.2016.00076. eCollection 2016.

13.

Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis - vulnerability of lower motor neurons to proximal excitotoxicity.

Blizzard CA, Southam KA, Dawkins E, Lewis KE, King AE, Clark JA, Dickson TC.

Dis Model Mech. 2015 Mar;8(3):215-24. doi: 10.1242/dmm.018606.

14.

The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to α-synuclein inclusions.

Radford R, Rcom-H'cheo-Gauthier A, Wong MB, Eaton ED, Quilty M, Blizzard C, Norazit A, Meedeniya A, Vickers JC, Gai WP, Guillemin GJ, West AK, Dickson TC, Chung R, Pountney DL.

Mol Cell Neurosci. 2015 Mar;65:68-81. doi: 10.1016/j.mcn.2015.02.015. Epub 2015 Feb 27.

PMID:
25731829
15.

The microtubule-stabilizing drug Epothilone D increases axonal sprouting following transection injury in vitro.

Brizuela M, Blizzard CA, Chuckowree JA, Dawkins E, Gasperini RJ, Young KM, Dickson TC.

Mol Cell Neurosci. 2015 May;66(Pt B):129-40. doi: 10.1016/j.mcn.2015.02.006. Epub 2015 Feb 12.

PMID:
25684676
16.

Microfluidic culture platform for studying neuronal response to mild to very mild axonal stretch injury.

Yap YC, Dickson TC, King AE, Breadmore MC, Guijt RM.

Biomicrofluidics. 2014 Jul 22;8(4):044110. doi: 10.1063/1.4891098. eCollection 2014 Jul.

17.

Neurites containing the neurofilament-triplet proteins are selectively vulnerable to cytoskeletal pathology in Alzheimer's disease and transgenic mouse models.

Mitew S, Kirkcaldie MT, Dickson TC, Vickers JC.

Front Neuroanat. 2013 Sep 26;7:30. doi: 10.3389/fnana.2013.00030. eCollection 2013.

18.

Stainless steel pinholes for fast fabrication of high-performance microchip electrophoresis devices by CO2 laser ablation.

Yap YC, Guijt RM, Dickson TC, King AE, Breadmore MC.

Anal Chem. 2013 Nov 5;85(21):10051-6. doi: 10.1021/ac402631g. Epub 2013 Oct 15.

PMID:
24063252
19.

Denervation of the olfactory bulb leads to decreased Aβ plaque load in a transgenic mouse model of Alzheimer' s disease.

Bibari O, Lee S, Dickson TC, Mitew S, Vickers JC, Chuah MI.

Curr Alzheimer Res. 2013 Sep;10(7):688-96.

PMID:
23905998
20.

Microfluidic primary culture model of the lower motor neuron-neuromuscular junction circuit.

Southam KA, King AE, Blizzard CA, McCormack GH, Dickson TC.

J Neurosci Methods. 2013 Sep 15;218(2):164-9. doi: 10.1016/j.jneumeth.2013.06.002. Epub 2013 Jun 14.

PMID:
23774648
21.

Altered synapses and gliotransmission in Alzheimer's disease and AD model mice.

Mitew S, Kirkcaldie MT, Dickson TC, Vickers JC.

Neurobiol Aging. 2013 Oct;34(10):2341-51. doi: 10.1016/j.neurobiolaging.2013.04.010. Epub 2013 Apr 30.

PMID:
23643146
22.

Cytoskeletal changes during development and aging in the cortex of neurofilament light protein knockout mice.

Liu Y, Staal JA, Canty AJ, Kirkcaldie MT, King AE, Bibari O, Mitew ST, Dickson TC, Vickers JC.

J Comp Neurol. 2013 Jun 1;521(8):1817-27. doi: 10.1002/cne.23261.

PMID:
23172043
23.

α-Synuclein protects neurons from apoptosis downstream of free-radical production through modulation of the MAPK signalling pathway.

Musgrove RE, King AE, Dickson TC.

Neurotox Res. 2013 May;23(4):358-69. doi: 10.1007/s12640-012-9352-5. Epub 2012 Aug 31.

PMID:
22936601
24.

Degeneration of axons in spinal white matter in G93A mSOD1 mouse characterized by NFL and α-internexin immunoreactivity.

King AE, Blizzard CA, Southam KA, Vickers JC, Dickson TC.

Brain Res. 2012 Jul 17;1465:90-100. doi: 10.1016/j.brainres.2012.05.018. Epub 2012 May 17.

PMID:
22609817
25.

Chronic excitotoxin-induced axon degeneration in a compartmented neuronal culture model.

Hosie KA, King AE, Blizzard CA, Vickers JC, Dickson TC.

ASN Neuro. 2012 Feb 23;4(1). pii: e00076. doi: 10.1042/AN20110031.

26.

Neuroprotective upregulation of endogenous α-synuclein precedes ubiquitination in cultured dopaminergic neurons.

Musgrove RE, King AE, Dickson TC.

Neurotox Res. 2011 May;19(4):592-602. doi: 10.1007/s12640-010-9207-x. Epub 2010 Jul 9.

PMID:
20617407
27.

Focal damage to the adult rat neocortex induces wound healing accompanied by axonal sprouting and dendritic structural plasticity.

Blizzard CA, Chuckowree JA, King AE, Hosie KA, McCormack GH, Chapman JA, Vickers JC, Dickson TC.

Cereb Cortex. 2011 Feb;21(2):281-91. doi: 10.1093/cercor/bhq091. Epub 2010 May 28.

PMID:
20511339
28.

Focal demyelination in Alzheimer's disease and transgenic mouse models.

Mitew S, Kirkcaldie MT, Halliday GM, Shepherd CE, Vickers JC, Dickson TC.

Acta Neuropathol. 2010 May;119(5):567-77. doi: 10.1007/s00401-010-0657-2. Epub 2010 Mar 3.

PMID:
20198482
29.

Association of metallothionein-III with oligodendroglial cytoplasmic inclusions in multiple system atrophy.

Pountney DL, Dickson TC, Power JH, Vickers JC, West AJ, Gai WP.

Neurotox Res. 2011 Jan;19(1):115-22. doi: 10.1007/s12640-009-9146-6. Epub 2009 Dec 29.

PMID:
20039155
30.

Initial calcium release from intracellular stores followed by calcium dysregulation is linked to secondary axotomy following transient axonal stretch injury.

Staal JA, Dickson TC, Gasperini R, Liu Y, Foa L, Vickers JC.

J Neurochem. 2010 Mar;112(5):1147-55. doi: 10.1111/j.1471-4159.2009.06531.x. Epub 2009 Dec 7.

31.

Axonal shearing in mature cortical neurons induces attempted regeneration and the reestablishment of neurite polarity.

Blizzard CA, King AE, Haas MA, O'Toole DA, Vickers JC, Dickson TC.

Brain Res. 2009 Dec 1;1300:24-36. doi: 10.1016/j.brainres.2009.08.059. Epub 2009 Aug 26.

PMID:
19715682
32.

Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system.

Vickers JC, King AE, Woodhouse A, Kirkcaldie MT, Staal JA, McCormack GH, Blizzard CA, Musgrove RE, Mitew S, Liu Y, Chuckowree JA, Bibari O, Dickson TC.

Brain Res Bull. 2009 Oct 28;80(4-5):217-23. doi: 10.1016/j.brainresbull.2009.08.004. Epub 2009 Aug 13. Review.

PMID:
19683034
33.

Neuron-glia interactions underlie ALS-like axonal cytoskeletal pathology.

King AE, Dickson TC, Blizzard CA, Woodhouse A, Foster SS, Chung RS, Vickers JC.

Neurobiol Aging. 2011 Mar;32(3):459-69. doi: 10.1016/j.neurobiolaging.2009.04.004. Epub 2009 May 7.

PMID:
19427060
34.

Disruption of the ubiquitin proteasome system following axonal stretch injury accelerates progression to secondary axotomy.

Staal JA, Dickson TC, Chung RS, Vickers JC.

J Neurotrauma. 2009 May;26(5):781-8. doi: 10.1089/neu.2008.0669.

PMID:
19416018
35.

Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease.

Woodhouse A, Shepherd CE, Sokolova A, Carroll VL, King AE, Halliday GM, Dickson TC, Vickers JC.

Acta Neuropathol. 2009 Jan;117(1):19-29. doi: 10.1007/s00401-008-0458-z. Epub 2008 Nov 18.

PMID:
19015863
36.

ERM proteins regulate growth cone responses to Sema3A.

Mintz CD, Carcea I, McNickle DG, Dickson TC, Ge Y, Salton SR, Benson DL.

J Comp Neurol. 2008 Oct 1;510(4):351-66. doi: 10.1002/cne.21799.

37.

Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging.

Woodhouse A, Vickers JC, Adlard PA, Dickson TC.

Neurobiol Aging. 2009 Jun;30(6):864-74. Epub 2007 Oct 22.

PMID:
17950493
38.

Excitotoxicity mediated by non-NMDA receptors causes distal axonopathy in long-term cultured spinal motor neurons.

King AE, Dickson TC, Blizzard CA, Foster SS, Chung RS, West AK, Chuah MI, Vickers JC.

Eur J Neurosci. 2007 Oct;26(8):2151-9. Epub 2007 Oct 1.

PMID:
17908171
39.

Cellular dynamics underlying regeneration of damaged axons differs from initial axon development.

Blizzard CA, Haas MA, Vickers JC, Dickson TC.

Eur J Neurosci. 2007 Sep;26(5):1100-8.

PMID:
17767489
40.
41.

Acute reactive and regenerative changes in mature cortical axons following injury.

Dickson TC, Chung RS, McCormack GH, Staal JA, Vickers JC.

Neuroreport. 2007 Feb 12;18(3):283-8.

PMID:
17314672
42.

Vaccination strategies for Alzheimer's disease: A new hope?

Woodhouse A, Dickson TC, Vickers JC.

Drugs Aging. 2007;24(2):107-19. Review.

PMID:
17313199
43.

Identification and characterization of a population of motile neurons in long-term cortical culture.

Haas MA, Chuckowree JA, Chung RS, Vickers JC, Dickson TC.

Cell Motil Cytoskeleton. 2007 Apr;64(4):274-87.

PMID:
17245771
44.
45.

Localization of glutamate receptors in developing cortical neurons in culture and relationship to susceptibility to excitotoxicity.

King AE, Chung RS, Vickers JC, Dickson TC.

J Comp Neurol. 2006 Sep 10;498(2):277-94.

PMID:
16856139
46.

Cytoplasmic cytochrome c immunolabelling in dystrophic neurites in Alzheimer's disease.

Woodhouse A, Vickers JC, Dickson TC.

Acta Neuropathol. 2006 Oct;112(4):429-37. Epub 2006 Jul 20.

PMID:
16855832
47.

No difference in expression of apoptosis-related proteins and apoptotic morphology in control, pathologically aged and Alzheimer's disease cases.

Woodhouse A, Dickson TC, West AK, McLean CA, Vickers JC.

Neurobiol Dis. 2006 May;22(2):323-33. Epub 2006 Jan 9.

PMID:
16406795
48.

Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection.

Quilty MC, King AE, Gai WP, Pountney DL, West AK, Vickers JC, Dickson TC.

Exp Neurol. 2006 Jun;199(2):249-56. Epub 2005 Nov 28.

PMID:
16310772
49.

Mild axonal stretch injury in vitro induces a progressive series of neurofilament alterations ultimately leading to delayed axotomy.

Chung RS, Staal JA, McCormack GH, Dickson TC, Cozens MA, Chuckowree JA, Quilty MC, Vickers JC.

J Neurotrauma. 2005 Oct;22(10):1081-91.

PMID:
16238485
50.

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