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Crystal structures of the c-di-AMP-synthesizing enzyme CdaA.

Heidemann JL, Neumann P, Dickmanns A, Ficner R.

J Biol Chem. 2019 Jul 5;294(27):10463-10470. doi: 10.1074/jbc.RA119.009246. Epub 2019 May 22.


Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence.

Bonnin E, Cabochette P, Filosa A, Jühlen R, Komatsuzaki S, Hezwani M, Dickmanns A, Martinelli V, Vermeersch M, Supply L, Martins N, Pirenne L, Ravenscroft G, Lombard M, Port S, Spillner C, Janssens S, Roets E, Van Dorpe J, Lammens M, Kehlenbach RH, Ficner R, Laing NG, Hoffmann K, Vanhollebeke B, Fahrenkrog B.

PLoS Genet. 2018 Dec 13;14(12):e1007845. doi: 10.1371/journal.pgen.1007845. eCollection 2018 Dec.


Validating Resolution Revolution.

Neumann P, Dickmanns A, Ficner R.

Structure. 2018 Dec 4;26(12):1678. doi: 10.1016/j.str.2018.10.028. No abstract available.


CDK4 inhibition diminishes p53 activation by MDM2 antagonists.

Sriraman A, Dickmanns A, Najafova Z, Johnsen SA, Dobbelstein M.

Cell Death Dis. 2018 Sep 11;9(9):918. doi: 10.1038/s41419-018-0968-0.


Validating Resolution Revolution.

Neumann P, Dickmanns A, Ficner R.

Structure. 2018 May 1;26(5):785-795.e4. doi: 10.1016/j.str.2018.03.004. Epub 2018 Mar 29. Erratum in: Structure. 2018 Dec 4;26(12):1678.


Structural basis for the regulatory interaction of the methylglyoxal synthase MgsA with the carbon flux regulator Crh in Bacillus subtilis.

Dickmanns A, Zschiedrich CP, Arens J, Parfentev I, Gundlach J, Hofele R, Neumann P, Urlaub H, Görke B, Ficner R, Stülke J.

J Biol Chem. 2018 Apr 20;293(16):5781-5792. doi: 10.1074/jbc.RA117.001289. Epub 2018 Mar 7.


Studying structure and function of spliceosomal helicases.

Ficner R, Dickmanns A, Neumann P.

Methods. 2017 Aug 1;125:63-69. doi: 10.1016/j.ymeth.2017.06.028. Epub 2017 Jun 29. Review.


Impact of the crystallization condition on importin-β conformation.

Tauchert MJ, Hémonnot C, Neumann P, Köster S, Ficner R, Dickmanns A.

Acta Crystallogr D Struct Biol. 2016 Jun;72(Pt 6):705-17. doi: 10.1107/S2059798316004940. Epub 2016 May 25.


MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.

Wienken M, Dickmanns A, Nemajerova A, Kramer D, Najafova Z, Weiss M, Karpiuk O, Kassem M, Zhang Y, Lozano G, Johnsen SA, Moll UM, Zhang X, Dobbelstein M.

Mol Cell. 2016 Jan 7;61(1):68-83. doi: 10.1016/j.molcel.2015.12.008. Epub 2015 Dec 31.


Combining dehydration, construct optimization and improved data collection to solve the crystal structure of a CRM1-RanGTP-SPN1-Nup214 quaternary nuclear export complex.

Monecke T, Dickmanns A, Weiss MS, Port SA, Kehlenbach RH, Ficner R.

Acta Crystallogr F Struct Biol Commun. 2015 Dec;71(Pt 12):1481-7. doi: 10.1107/S2053230X15021524. Epub 2015 Nov 18.


Nuclear Pore Complexes and Nucleocytoplasmic Transport: From Structure to Function to Disease.

Dickmanns A, Kehlenbach RH, Fahrenkrog B.

Int Rev Cell Mol Biol. 2015;320:171-233. doi: 10.1016/bs.ircmb.2015.07.010. Epub 2015 Aug 19. Review.


Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export.

Port SA, Monecke T, Dickmanns A, Spillner C, Hofele R, Urlaub H, Ficner R, Kehlenbach RH.

Cell Rep. 2015 Oct 27;13(4):690-702. doi: 10.1016/j.celrep.2015.09.042. Epub 2015 Oct 17.


Structural Basis of Targeting the Exportin CRM1 in Cancer.

Dickmanns A, Monecke T, Ficner R.

Cells. 2015 Sep 21;4(3):538-68. doi: 10.3390/cells4030538. Review.


MD simulations and FRET reveal an environment-sensitive conformational plasticity of importin-β.

Halder K, Dölker N, Van Q, Gregor I, Dickmanns A, Baade I, Kehlenbach RH, Ficner R, Enderlein J, Grubmüller H, Neumann H.

Biophys J. 2015 Jul 21;109(2):277-86. doi: 10.1016/j.bpj.2015.06.014.


A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP.

Commichau FM, Dickmanns A, Gundlach J, Ficner R, Stülke J.

Mol Microbiol. 2015 Jul;97(2):189-204. doi: 10.1111/mmi.13026. Epub 2015 May 9. Review.


Structural and biochemical analysis of the essential diadenylate cyclase CdaA from Listeria monocytogenes.

Rosenberg J, Dickmanns A, Neumann P, Gunka K, Arens J, Kaever V, Stülke J, Ficner R, Commichau FM.

J Biol Chem. 2015 Mar 6;290(10):6596-606. doi: 10.1074/jbc.M114.630418. Epub 2015 Jan 20.


Identification, characterization, and structure analysis of the cyclic di-AMP-binding PII-like signal transduction protein DarA.

Gundlach J, Dickmanns A, Schröder-Tittmann K, Neumann P, Kaesler J, Kampf J, Herzberg C, Hammer E, Schwede F, Kaever V, Tittmann K, Stülke J, Ficner R.

J Biol Chem. 2015 Jan 30;290(5):3069-80. doi: 10.1074/jbc.M114.619619. Epub 2014 Nov 28.


Allosteric control of the exportin CRM1 unraveled by crystal structure analysis.

Monecke T, Dickmanns A, Ficner R.

FEBS J. 2014 Sep;281(18):4179-94. doi: 10.1111/febs.12842. Epub 2014 Jun 6. Review.


The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB.

Ahmed YL, Gerke J, Park HS, Bayram Ö, Neumann P, Ni M, Dickmanns A, Kim SC, Yu JH, Braus GH, Ficner R.

PLoS Biol. 2013 Dec;11(12):e1001750. doi: 10.1371/journal.pbio.1001750. Epub 2013 Dec 31. Erratum in: PLoS Biol. 2014 Apr;12(4):e1001849.


Structural determinants and mechanism of mammalian CRM1 allostery.

Dölker N, Blanchet CE, Voß B, Haselbach D, Kappel C, Monecke T, Svergun DI, Stark H, Ficner R, Zachariae U, Grubmüller H, Dickmanns A.

Structure. 2013 Aug 6;21(8):1350-60. doi: 10.1016/j.str.2013.05.015. Epub 2013 Jul 11.


Structural basis for cooperativity of CRM1 export complex formation.

Monecke T, Haselbach D, Voß B, Russek A, Neumann P, Thomson E, Hurt E, Zachariae U, Stark H, Grubmüller H, Dickmanns A, Ficner R.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):960-5. doi: 10.1073/pnas.1215214110. Epub 2012 Dec 31.


Crystal structures of Physcomitrella patens AOC1 and AOC2: insights into the enzyme mechanism and differences in substrate specificity.

Neumann P, Brodhun F, Sauer K, Herrfurth C, Hamberg M, Brinkmann J, Scholz J, Dickmanns A, Feussner I, Ficner R.

Plant Physiol. 2012 Nov;160(3):1251-66. doi: 10.1104/pp.112.205138. Epub 2012 Sep 17.


Structural basis for the broad substrate range of the UDP-sugar pyrophosphorylase from Leishmania major.

Dickmanns A, Damerow S, Neumann P, Schulz EC, Lamerz AC, Routier FH, Ficner R.

J Mol Biol. 2011 Jan 14;405(2):461-78. doi: 10.1016/j.jmb.2010.10.057. Epub 2010 Nov 10.


Crystal structure analysis of DNA uridine endonuclease Mth212 bound to DNA.

Lakomek K, Dickmanns A, Ciirdaeva E, Schomacher L, Ficner R.

J Mol Biol. 2010 Jun 18;399(4):604-17. doi: 10.1016/j.jmb.2010.04.044. Epub 2010 Apr 29.


Mapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry.

Kühn-Hölsken E, Lenz C, Dickmanns A, Hsiao HH, Richter FM, Kastner B, Ficner R, Urlaub H.

Nucleic Acids Res. 2010 Sep;38(16):5581-93. doi: 10.1093/nar/gkq272. Epub 2010 Apr 26.


Crystal structure of an intramolecular chaperone mediating triple-beta-helix folding.

Schulz EC, Dickmanns A, Urlaub H, Schmitt A, Mühlenhoff M, Stummeyer K, Schwarzer D, Gerardy-Schahn R, Ficner R.

Nat Struct Mol Biol. 2010 Feb;17(2):210-5. doi: 10.1038/nsmb.1746. Epub 2010 Jan 31.


p63 antagonizes Wnt-induced transcription.

Drewelus I, Göpfert C, Hippel C, Dickmanns A, Damianitsch K, Pieler T, Dobbelstein M.

Cell Cycle. 2010 Feb 1;9(3):580-87.


Structural basis for the recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein EndoNF.

Schulz EC, Schwarzer D, Frank M, Stummeyer K, Mühlenhoff M, Dickmanns A, Gerardy-Schahn R, Ficner R.

J Mol Biol. 2010 Mar 19;397(1):341-51. doi: 10.1016/j.jmb.2010.01.028. Epub 2010 Jan 22.


Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography.

Lakomek K, Dickmanns A, Kettwig M, Urlaub H, Ficner R, Lübke T.

BMC Struct Biol. 2009 Aug 25;9:56. doi: 10.1186/1472-6807-9-56.


A C-terminal phosphatase module conserved in vertebrate CMP-sialic acid synthetases provides a tetramerization interface for the physiologically active enzyme.

Oschlies M, Dickmanns A, Haselhorst T, Schaper W, Stummeyer K, Tiralongo J, Weinhold B, Gerardy-Schahn R, von Itzstein M, Ficner R, Münster-Kühnel AK.

J Mol Biol. 2009 Oct 16;393(1):83-97. doi: 10.1016/j.jmb.2009.08.003. Epub 2009 Aug 8.


Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP.

Monecke T, Güttler T, Neumann P, Dickmanns A, Görlich D, Ficner R.

Science. 2009 May 22;324(5930):1087-91. doi: 10.1126/science.1173388. Epub 2009 Apr 23.


Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1.

Monecke T, Dickmanns A, Ficner R.

Nucleic Acids Res. 2009 Jul;37(12):3865-77. doi: 10.1093/nar/gkp249. Epub 2009 Apr 22.


Structure analysis of the conserved methyltransferase domain of human trimethylguanosine synthase TGS1.

Monecke T, Dickmanns A, Strasser A, Ficner R.

Acta Crystallogr D Biol Crystallogr. 2009 Apr;65(Pt 4):332-8. doi: 10.1107/S0907444909003102. Epub 2009 Mar 19.


De novo sulfur SAD phasing of the lysosomal 66.3 kDa protein from mouse.

Lakomek K, Dickmanns A, Mueller U, Kollmann K, Deuschl F, Berndt A, Lübke T, Ficner R.

Acta Crystallogr D Biol Crystallogr. 2009 Mar;65(Pt 3):220-8. doi: 10.1107/S0907444908041814. Epub 2009 Feb 20.


The yeast HtrA orthologue Ynm3 is a protease with chaperone activity that aids survival under heat stress.

Padmanabhan N, Fichtner L, Dickmanns A, Ficner R, Schulz JB, Braus GH.

Mol Biol Cell. 2009 Jan;20(1):68-77. doi: 10.1091/mbc.E08-02-0178. Epub 2008 Oct 22.


Disease-causing missense mutations affect enzymatic activity, stability and oligomerization of glutaryl-CoA dehydrogenase (GCDH).

Keyser B, Mühlhausen C, Dickmanns A, Christensen E, Muschol N, Ullrich K, Braulke T.

Hum Mol Genet. 2008 Dec 15;17(24):3854-63. doi: 10.1093/hmg/ddn284. Epub 2008 Sep 5.


Crystal structure of the RRM domain of poly(A)-specific ribonuclease reveals a novel m(7)G-cap-binding mode.

Monecke T, Schell S, Dickmanns A, Ficner R.

J Mol Biol. 2008 Oct 17;382(4):827-34. doi: 10.1016/j.jmb.2008.07.073. Epub 2008 Jul 31.


Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).

Schäfer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M.

Bioorg Med Chem. 2008 Feb 15;16(4):2011-33. Epub 2007 Nov 4.


Structural basis for RanGTP independent entry of spliceosomal U snRNPs into the nucleus.

Wohlwend D, Strasser A, Dickmanns A, Ficner R.

J Mol Biol. 2007 Dec 7;374(4):1129-38. Epub 2007 Sep 29.


Thermodynamic analysis of H1 nuclear import: receptor tuning of importinbeta/importin7.

Wohlwend D, Strasser A, Dickmanns A, Doenecke D, Ficner R.

J Biol Chem. 2007 Apr 6;282(14):10707-19. Epub 2007 Jan 26.


Expression, purification and crystallization of the ammonium transporter Amt-1 from Archaeoglobus fulgidus.

Andrade SL, Dickmanns A, Ficner R, Einsle O.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Sep 1;61(Pt 9):861-3. Epub 2005 Aug 31.


Structure of the novel alpha-amylase AmyC from Thermotoga maritima.

Dickmanns A, Ballschmiter M, Liebl W, Ficner R.

Acta Crystallogr D Biol Crystallogr. 2006 Mar;62(Pt 3):262-70. Epub 2006 Feb 22.


Crystal structure of a bacterial class 2 histone deacetylase homologue.

Nielsen TK, Hildmann C, Dickmanns A, Schwienhorst A, Ficner R.

J Mol Biol. 2005 Nov 18;354(1):107-20. Epub 2005 Oct 7.


Crystal structure of the archaeal ammonium transporter Amt-1 from Archaeoglobus fulgidus.

Andrade SL, Dickmanns A, Ficner R, Einsle O.

Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):14994-9. Epub 2005 Oct 7.


De novo calcium/sulfur SAD phasing of the human formylglycine-generating enzyme using in-house data.

Roeser D, Dickmanns A, Gasow K, Rudolph MG.

Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1057-66. Epub 2005 Jul 20.


Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1.

Strasser A, Dickmanns A, Lührmann R, Ficner R.

EMBO J. 2005 Jul 6;24(13):2235-43. Epub 2005 May 26.


Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme.

Dierks T, Dickmanns A, Preusser-Kunze A, Schmidt B, Mariappan M, von Figura K, Ficner R, Rudolph MG.

Cell. 2005 May 20;121(4):541-552. doi: 10.1016/j.cell.2005.03.001.


Crystal structure of human pFGE, the paralog of the Calpha-formylglycine-generating enzyme.

Dickmanns A, Schmidt B, Rudolph MG, Mariappan M, Dierks T, von Figura K, Ficner R.

J Biol Chem. 2005 Apr 15;280(15):15180-7. Epub 2005 Feb 1.


Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F.

Stummeyer K, Dickmanns A, Mühlenhoff M, Gerardy-Schahn R, Ficner R.

Nat Struct Mol Biol. 2005 Jan;12(1):90-6. Epub 2004 Dec 19.


Purification, crystallization and preliminary crystallographic data of the m3G cap-binding domain of human snRNP import factor snurportin 1.

Strasser A, Dickmanns A, Schmidt U, Penka E, Urlaub H, Sekine M, Lührmann R, Ficner R.

Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1628-31. Epub 2004 Aug 26.


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