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Items: 1 to 50 of 51

1.

Simultaneous remediation of nutrients from liquid anaerobic digestate and municipal wastewater by the microalga Scenedesmus sp. AMDD grown in continuous chemostats.

Dickinson KE, Bjornsson WJ, Garrison LL, Whitney CG, Park KC, Banskota AH, McGinn PJ.

J Appl Microbiol. 2015 Jan;118(1):75-83. doi: 10.1111/jam.12681. Epub 2014 Nov 27.

2.

Integration of microalgae cultivation with industrial waste remediation for biofuel and bioenergy production: opportunities and limitations.

McGinn PJ, Dickinson KE, Bhatti S, Frigon JC, Guiot SR, O'Leary SJ.

Photosynth Res. 2011 Sep;109(1-3):231-47. doi: 10.1007/s11120-011-9638-0. Epub 2011 Mar 9. Review. Erratum in: Photosynth Res. 2011 Sep;109(1-3):249.

PMID:
21461850
3.

Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain.

Li J, Chen SY, Tao S, Wang H, Li JJ, Swartz S, Musial C, Hernandez AA, Flynn N, Murphy BJ, Beehler B, Dickinson KE, Giupponi L, Grover G, Seethala R, Sleph P, Slusarchyk D, Yan M, Humphreys WG, Zhang H, Ewing WR, Robl JA, Gordon D, Tino JA.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):1825-9. doi: 10.1016/j.bmcl.2008.02.021. Epub 2008 Feb 13.

PMID:
18295486
4.

Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180).

Li J, Chen SY, Li JJ, Wang H, Hernandez AS, Tao S, Musial CM, Qu F, Swartz S, Chao ST, Flynn N, Murphy BJ, Slusarchyk DA, Seethala R, Yan M, Sleph P, Grover G, Smith MA, Beehler B, Giupponi L, Dickinson KE, Zhang H, Humphreys WG, Patel BP, Schwinden M, Stouch T, Cheng PT, Biller SA, Ewing WR, Gordon D, Robl JA, Tino JA.

J Med Chem. 2007 Nov 29;50(24):5890-3. Epub 2007 Oct 31.

PMID:
17973363
5.

Arylpropanolamines: selective beta3 agonists arising from strategies to mitigate phase I metabolic transformations.

Washburn WN, Harper TW, Wu G, Godfrey JD, McCann P, Girotra R, Shao C, Zhang H, Gavai A, Mikkilineni A, Dejneka T, Ahmed S, Caringal Y, Hangeland J, Zhang M, Cheng PT, Russell AD, Skwish S, Slusarchyk DA, Allen GT, Frohlich BH, Abboa-Offei BE, Cap M, Waldron TL, George RJ, Tesfamariam B, Dickinson KE, Seymour AA, Sher PM.

Bioorg Med Chem Lett. 2007 Aug 1;17(15):4290-6. Epub 2007 May 16.

PMID:
17533126
6.

An automated high throughput liquid chromatography-mass spectrometry process to assess the metabolic stability of drug candidates.

Drexler DM, Belcastro JV, Dickinson KE, Edinger KJ, Hnatyshyn SY, Josephs JL, Langish RA, McNaney CA, Santone KS, Shipkova PA, Tymiak AA, Zvyaga TA, Sanders M.

Assay Drug Dev Technol. 2007 Apr;5(2):247-64.

PMID:
17477833
7.

Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics.

Murugesan N, Gu Z, Fadnis L, Tellew JE, Baska RA, Yang Y, Beyer SM, Monshizadegan H, Dickinson KE, Valentine MT, Humphreys WG, Lan SJ, Ewing WR, Carlson KE, Kowala MC, Zahler R, Macor JE.

J Med Chem. 2005 Jan 13;48(1):171-9.

PMID:
15634011
8.

BMS-201620: a selective beta 3 agonist.

Washburn WN, Sun CQ, Bisacchi G, Wu G, Cheng PT, Sher PM, Ryono D, Gavai AV, Poss K, Girotra RN, McCann PJ, Mikkilineni AB, Dejneka TC, Wang TC, Merchant Z, Morella M, Arbeeny CM, Harper TW, Slusarchyk DA, Skwish S, Russell AD, Allen GT, Tesfamariam B, Frohlich BH, Abboa-Offei BE, Cap M, Waldron TL, George RJ, Young D, Dickinson KE, Seymour AA.

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3525-9.

PMID:
15177466
9.

Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists.

Murugesan N, Tellew JE, Gu Z, Kunst BL, Fadnis L, Cornelius LA, Baska RA, Yang Y, Beyer SM, Monshizadegan H, Dickinson KE, Panchal B, Valentine MT, Chong S, Morrison RA, Carlson KE, Powell JR, Moreland S, Barrish JC, Kowala MC, Macor JE.

J Med Chem. 2002 Aug 29;45(18):3829-35.

PMID:
12190306
10.

BMS-196085: a potent and selective full agonist of the human beta(3) adrenergic receptor.

Gavai AV, Sher PM, Mikkilineni AB, Poss KM, McCann PJ, Girotra RN, Fisher LG, Wu G, Bednarz MS, Mathur A, Wang TC, Sun CQ, Slusarchyk DA, Skwish S, Allen GT, Hillyer DE, Frohlich BH, Abboa-Offei BE, Cap M, Waldron TL, George RJ, Tesfamariam B, Harper TW, Ciosek CP Jr, Young DA, Dickinson KE, Seymour AA, Arbeeny CM, Washburn WN.

Bioorg Med Chem Lett. 2001 Dec 3;11(23):3041-4.

PMID:
11714606
11.

Beta 3 agonists. Part 1: evolution from inception to BMS-194449.

Washburn WN, Sher PM, Poss KM, Girotra RN, McCann PJ, Gavai AV, Mikkilineni AB, Mathur A, Cheng P, Dejneka TC, Sun CQ, Wang TC, Harper TW, Russell AD, Slusarchyk DA, Skwish S, Allen GT, Hillyer DE, Frohlich BH, Abboa-Offei BE, Cap M, Waldron TL, George RJ, Tesfamariam B, Ciosek CP Jr, Ryono D, Young DA, Dickinson KE, Seymour AA, Arbeeny CM, Gregg RE.

Bioorg Med Chem Lett. 2001 Dec 3;11(23):3035-9.

PMID:
11714605
12.

Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.

Fathi Z, Battaglino PM, Iben LG, Li H, Baker E, Zhang D, McGovern R, Mahle CD, Sutherland GR, Iismaa TP, Dickinson KE, Zimanyi IA.

Brain Res Mol Brain Res. 1998 Jul 15;58(1-2):156-69.

PMID:
9685625
13.

Identification of [3H]P1075 binding sites and P1075-activated K+ currents in ovine choroid plexus cells.

Dickinson KE, Baska RA, Cohen RB, Bryson CC, Smith MA, Schroeder K, Lodge NJ.

Eur J Pharmacol. 1998 Mar 12;345(1):97-101.

PMID:
9593600
14.

Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes: correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies.

Atwal KS, Grover GJ, Lodge NJ, Normandin DE, Traeger SC, Sleph PG, Cohen RB, Bryson CC, Dickinson KE.

J Med Chem. 1998 Jan 29;41(3):271-5. No abstract available.

PMID:
9464357
15.

Nucleotide regulation and characteristics of potassium channel opener binding to skeletal muscle membranes.

Dickinson KE, Bryson CC, Cohen RB, Rogers L, Green DW, Atwal KS.

Mol Pharmacol. 1997 Sep;52(3):473-81.

16.

Beta 3-adrenergic receptor-mediated lipolysis and oxygen consumption in brown adipocytes from cynomolgus monkeys.

Meyers DS, Skwish S, Dickinson KE, Kienzle B, Arbeeny CM.

J Clin Endocrinol Metab. 1997 Feb;82(2):395-401.

PMID:
9024225
17.

Mutational analysis of the endothelin type A receptor (ETA): interactions and model of selective ETA antagonist BMS-182874 with putative ETA receptor binding cavity.

Webb ML, Patel PS, Rose PM, Liu EC, Stein PD, Barrish J, Lach DA, Stouch T, Fisher SM, Hadjilambris O, Lee H, Skwish S, Dickinson KE, Krystek SR Jr.

Biochemistry. 1996 Feb 27;35(8):2548-56.

PMID:
8611558
18.

BMS-180560, an insurmountable inhibitor of angiotensin II-stimulated responses: comparison with losartan and EXP3174.

Dickinson KE, Cohen RB, Skwish S, Delaney CL, Serafino RP, Poss MA, Gu Z, Ryono DE, Moreland S, Powell JR.

Br J Pharmacol. 1994 Sep;113(1):179-89.

19.

The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide.

Stein PD, Hunt JT, Floyd DM, Moreland S, Dickinson KE, Mitchell C, Liu EC, Webb ML, Murugesan N, Dickey J, et al.

J Med Chem. 1994 Feb 4;37(3):329-31. No abstract available.

PMID:
8308857
20.

Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: synthesis, biological properties, and structure-activity relationships.

Kim KS, Qian L, Bird JE, Dickinson KE, Moreland S, Schaeffer TR, Waldron TL, Delaney CL, Weller HN, Miller AV.

J Med Chem. 1993 Aug 6;36(16):2335-42.

PMID:
8360878
21.

Binding and signal transduction of the cloned vascular angiotensin II (AT1a) receptor cDNA stably expressed in Chinese hamster ovary cells.

Webb ML, Monshizadegan H, Dickinson KE, Serafino R, Moreland S, Michel I, Seiler SM, Murphy TJ.

Regul Pept. 1993 Mar 19;44(2):131-9.

PMID:
8469768
22.

Peptidases and smooth muscle cell angiotensin II receptor pharmacology.

Cohen RB, Webb ML, Dickinson KE.

Peptides. 1993 Mar-Apr;14(2):345-52.

PMID:
8483812
23.

Dihydropyrimidine angiotensin II receptor antagonists.

Atwal KS, Ahmed SZ, Bird JE, Delaney CL, Dickinson KE, Ferrara FN, Hedberg A, Miller AV, Moreland S, O'Reilly BC, et al.

J Med Chem. 1992 Dec 11;35(25):4751-63.

PMID:
1469703
24.

The endothelin receptor antagonist, BQ-123, inhibits angiotensin II-induced contractions in rabbit aorta.

Webb ML, Dickinson KE, Delaney CL, Liu EC, Serafino R, Cohen RB, Monshizadegan H, Moreland S.

Biochem Biophys Res Commun. 1992 Jun 30;185(3):887-92.

PMID:
1320879
25.

Activation of T84 cell chloride channels by carbachol involves a phosphoinositide-coupled muscarinic M3 receptor.

Dickinson KE, Frizzell RA, Sekar MC.

Eur J Pharmacol. 1992 Apr 10;225(4):291-8.

PMID:
1379932
26.
27.

Vascular A10 cell membranes contain an endothelin metabolizing neutral endopeptidase.

Dickinson KE, Tymiak AA, Cohen RB, Liu EC, Webb ML, Hedberg A.

Biochem Biophys Res Commun. 1991 Apr 15;176(1):423-30.

PMID:
2018530
28.

The role of Ca2+ in the time-dependent pepsinogen secretion of frog oesophageal peptic glands stimulated by bombesin.

Hirschowitz BI, Uemura N, Matsumoto H, Dickinson KE.

Acta Physiol Scand. 1990 Nov;140(3):401-12.

PMID:
2082706
29.

Muscarinic receptor antagonist activity of diacylglycerol lipase and kinase inhibitors.

Sekar MC, Dickinson KE, Pruitt RE, Hirschowitz BI, Hokin LE.

Biochem Pharmacol. 1990 Jun 15;39(12):2069-73. No abstract available.

PMID:
2162175
30.

Decreased secretion due to a Ca2+ influx defect in frog peptic cells isolated with EGTA.

Uemura N, Dickinson KE, Horiguchi Y, Matsumoto H, Hirschowitz BI.

Am J Physiol. 1990 Apr;258(4 Pt 1):G544-51.

PMID:
2159219
31.

125I-iodopindolol binding to frog esophageal peptic cells. Detection of amine uptake and beta-adrenergic receptors coupled to pepsinogen secretion.

Dickinson KE, Anderson W, Matsumoto H, Uemura N, Hirschowitz BI.

Biochem Pharmacol. 1989 May 1;38(9):1481-9.

PMID:
2541727
32.

Somatostatin and lanthanum discriminate two Ca2+ mobilizing mechanisms regulated by bombesin receptors in peptic cells.

Uemura N, Dickinson KE, Sekar MC, Hirschowitz BI.

Biochem Biophys Res Commun. 1989 Mar 15;159(2):599-604.

PMID:
2564778
33.

Partial agonist activity of the bombesin-receptor antagonist [Leu14-psi-CH2-NH-Leu13]-bombesin in frog peptic cells.

Dickinson KE, Uemura N, Sekar MC, McDaniel HB, Anderson W, Coy DH, Hirschowitz BI.

Biochem Biophys Res Commun. 1988 Dec 30;157(3):1154-8.

PMID:
2462868
34.

Muscarinic cholinergic receptor subtype on frog esophageal peptic cells: binding and secretion studies.

Dickinson KE, Matsumoto H, Anderson W, Pruitt RE, Uemura N, Hirschowitz BI.

J Pharmacol Exp Ther. 1988 Sep;246(3):879-86.

PMID:
2901489
35.

De novo cardiac beta adrenoceptor synthesis in adult rats under normoxic and hypoxic conditions.

Winter RJ, Inkpen PM, Dickinson KE, Rudd RM, Sever PS.

Cardiovasc Res. 1988 Mar;22(3):159-62.

PMID:
2901912
36.

Pepsinogen secretion from perifused frog peptic glands: rapid transients detected with a modified pepsin assay.

Matsumoto H, Dickinson KE, Anderson W, Hirschowitz BI.

Life Sci. 1988;42(12):1237-44.

PMID:
3126374
37.

Synergism between cellular messengers and agonist combinations in pepsinogen secretion.

Matsumoto H, Dickinson KE, Shirakawa T, Komiyama K, Hirschowitz BI.

Am J Physiol. 1987 Oct;253(4 Pt 1):G557-65.

PMID:
2444114
38.

Heterogeneity between soluble human and rabbit splenic alpha 2-adrenoceptors.

McKernan RM, Dickinson KE, Miles CM, Sever PS.

Biochem Pharmacol. 1986 Oct 15;35(20):3517-23.

PMID:
2876709
39.

Characterization of vasoactive intestinal peptide (VIP) receptors in mammalian lung.

Dickinson KE, Schachter M, Miles CM, Coy DH, Sever PS.

Peptides. 1986 Sep-Oct;7(5):791-800.

PMID:
3025822
40.

Characterisation of a high-affinity VIP receptor in human lung parenchyma.

Schachter M, Dickinson KE, Miles CM, Sever PS.

FEBS Lett. 1986 Apr 7;199(1):125-9.

41.

Identification of the subunit structure of rat pineal adrenergic receptors by photoaffinity labeling.

Dickinson KE, Leeb-Lundberg LM, Strasser RH, Caron MG, Lefkowitz RJ.

J Neurochem. 1986 Apr;46(4):1153-60.

PMID:
3005506
42.
43.

Heterogeneity of mammalian alpha 2-adrenoceptors delineated by [3H]yohimbine binding.

Dickinson KE, McKernan RM, Miles CM, Leys KS, Sever PS.

Eur J Pharmacol. 1986 Jan 29;120(3):285-93.

PMID:
3005004
44.
45.

Molecular biology of adrenergic receptors in the rat and frog central nervous system.

Caron MG, Leeb-Lundberg LM, Strader CD, Dickinson KE, Pickel VM, Joh T, Lefkowitz RJ.

Hypertension. 1984 Sep-Oct;6(5 Pt 2):II22-7.

PMID:
6094345
46.

Photoaffinity cross-linking of a radioiodinated probe, 125I-A55453, into alpha 1-adrenergic receptors.

Dickinson KE, Leeb-Lundberg LM, Heald SL, Wikberg JE, DeBernardis JF, Caron MG, Lefkowitz RJ.

Mol Pharmacol. 1984 Sep;26(2):187-95.

PMID:
6090880
47.

Photoaffinity labeling of mammalian alpha 1-adrenergic receptors. Identification of the ligand binding subunit with a high affinity radioiodinated probe.

Leeb-Lundberg LM, Dickinson KE, Heald SL, Wikberg JE, Hagen PO, DeBernardis JF, Winn M, Arendsen DL, Lefkowitz RJ, Caron MG.

J Biol Chem. 1984 Feb 25;259(4):2579-87.

48.

Covalent labeling of the cerebral cortex alpha 1-adrenergic receptor with a new high affinity radioiodinated photoaffinity probe.

Leeb-Lundberg LM, Dickinson KE, Heald SL, Wikberg JE, DeBernardis JF, Winn M, Arendsen DL, Lefkowitz RJ, Caron MG.

Biochem Biophys Res Commun. 1983 Sep 30;115(3):946-51.

PMID:
6313003
49.
50.

Identification of solubilised beta 1 and beta 2 adrenoceptors in mammalian lung.

Dickinson KE, Nahorski SR.

Life Sci. 1981 Dec 14;29(24):2527-33. No abstract available.

PMID:
6275227

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