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Items: 8


RNA binding activates RIG-I by releasing an autorepressed signaling domain.

Dickey TH, Song B, Pyle AM.

Sci Adv. 2019 Oct 2;5(10):eaax3641. doi: 10.1126/sciadv.aax3641. eCollection 2019 Oct.


A minimal RNA ligand for potent RIG-I activation in living mice.

Linehan MM, Dickey TH, Molinari ES, Fitzgerald ME, Potapova O, Iwasaki A, Pyle AM.

Sci Adv. 2018 Feb 21;4(2):e1701854. doi: 10.1126/sciadv.1701854. eCollection 2018 Feb.


The SMAD3 transcription factor binds complex RNA structures with high affinity.

Dickey TH, Pyle AM.

Nucleic Acids Res. 2017 Nov 16;45(20):11980-11988. doi: 10.1093/nar/gkx846.


Tying up the Ends: Plasticity in the Recognition of Single-Stranded DNA at Telomeres.

Lloyd NR, Dickey TH, Hom RA, Wuttke DS.

Biochemistry. 2016 Sep 27;55(38):5326-40. doi: 10.1021/acs.biochem.6b00496. Epub 2016 Sep 15.


The telomeric protein Pot1 from Schizosaccharomyces pombe binds ssDNA in two modes with differing 3' end availability.

Dickey TH, Wuttke DS.

Nucleic Acids Res. 2014 Sep;42(15):9656-65. doi: 10.1093/nar/gku680. Epub 2014 Jul 29.


Single-stranded DNA-binding proteins: multiple domains for multiple functions.

Dickey TH, Altschuler SE, Wuttke DS.

Structure. 2013 Jul 2;21(7):1074-84. doi: 10.1016/j.str.2013.05.013. Review.


Nonspecific recognition is achieved in Pot1pC through the use of multiple binding modes.

Dickey TH, McKercher MA, Wuttke DS.

Structure. 2013 Jan 8;21(1):121-132. doi: 10.1016/j.str.2012.10.015. Epub 2012 Nov 29.


Schizosaccharomyces pombe protection of telomeres 1 utilizes alternate binding modes to accommodate different telomeric sequences.

Altschuler SE, Dickey TH, Wuttke DS.

Biochemistry. 2011 Sep 6;50(35):7503-13. doi: 10.1021/bi200826a. Epub 2011 Aug 16.

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