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Items: 1 to 50 of 74

1.

Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila.

Gospodaryov DV, Strilbytska OM, Semaniuk UV, Perkhulyn NV, Rovenko BM, Yurkevych IS, Barata AG, Dick TP, Lushchak OV, Jacobs HT.

Biogerontology. 2019 Nov 20. doi: 10.1007/s10522-019-09849-8. [Epub ahead of print]

PMID:
31749111
2.

A role for peroxiredoxins in H2O2- and MEKK-dependent activation of the p38 signaling pathway.

Barata AG, Dick TP.

Redox Biol. 2020 Jan;28:101340. doi: 10.1016/j.redox.2019.101340. Epub 2019 Oct 8.

3.

Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL.

Yosifov DY, Idler I, Bhattacharya N, Reichenzeller M, Close V, Ezerina D, Scheffold A, Jebaraj BMC, Kugler S, Bloehdorn J, Bahlo J, Robrecht S, Eichhorst B, Fischer K, Weigel A, Busch H, Lichter P, Döhner H, Dick TP, Stilgenbauer S, Mertens D.

Leukemia. 2020 Jan;34(1):115-127. doi: 10.1038/s41375-019-0513-x. Epub 2019 Jul 12.

PMID:
31300746
4.

Genome-wide C-SWAT library for high-throughput yeast genome tagging.

Meurer M, Duan Y, Sass E, Kats I, Herbst K, Buchmuller BC, Dederer V, Huber F, Kirrmaier D, Štefl M, Van Laer K, Dick TP, Lemberg MK, Khmelinskii A, Levy ED, Knop M.

Nat Methods. 2018 Aug;15(8):598-600. doi: 10.1038/s41592-018-0045-8. Epub 2018 Jul 9.

PMID:
29988096
5.

Rust never sleeps: The continuing story of the Iron Bolt.

van der Vliet A, Dick TP, Aust SD, Koppenol WH, Ursini F, Kettle AJ, Beckman JS, O'Donnell V, Darley-Usmar V, Lancaster J Jr, Hogg N, Davies KJA, Forman HJ, Janssen-Heininger YMW.

Free Radic Biol Med. 2018 Aug 20;124:353-357. doi: 10.1016/j.freeradbiomed.2018.06.017. Epub 2018 Jun 18. Review.

PMID:
29913216
6.

Glucose Acutely Reduces Cytosolic and Mitochondrial H2O2 in Rat Pancreatic Beta Cells.

Deglasse JP, Roma LP, Pastor-Flores D, Gilon P, Dick TP, Jonas JC.

Antioxid Redox Signal. 2019 Jan 20;30(3):297-313. doi: 10.1089/ars.2017.7287. Epub 2018 Jun 14.

PMID:
29756464
7.

N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2S and Sulfane Sulfur Production.

Ezeriņa D, Takano Y, Hanaoka K, Urano Y, Dick TP.

Cell Chem Biol. 2018 Apr 19;25(4):447-459.e4. doi: 10.1016/j.chembiol.2018.01.011. Epub 2018 Feb 8.

8.

A role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation.

Stöcker S, Maurer M, Ruppert T, Dick TP.

Nat Chem Biol. 2018 Feb;14(2):148-155. doi: 10.1038/nchembio.2536. Epub 2017 Dec 18.

9.

Redox-sensitive GFP fusions for monitoring the catalytic mechanism and inactivation of peroxiredoxins in living cells.

Staudacher V, Trujillo M, Diederichs T, Dick TP, Radi R, Morgan B, Deponte M.

Redox Biol. 2018 Apr;14:549-556. doi: 10.1016/j.redox.2017.10.017. Epub 2017 Oct 26.

10.

Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?

Heppner DE, Hristova M, Ida T, Mijuskovic A, Dustin CM, Bogdándi V, Fukuto JM, Dick TP, Nagy P, Li J, Akaike T, van der Vliet A.

Redox Biol. 2018 Apr;14:379-385. doi: 10.1016/j.redox.2017.10.006. Epub 2017 Oct 9.

11.

The Conundrum of Hydrogen Peroxide Signaling and the Emerging Role of Peroxiredoxins as Redox Relay Hubs.

Stöcker S, Van Laer K, Mijuskovic A, Dick TP.

Antioxid Redox Signal. 2018 Mar 1;28(7):558-573. doi: 10.1089/ars.2017.7162. Epub 2017 Jul 17. Review.

PMID:
28587525
12.

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.

Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P, Przybylla A, Schönberger K, Scognamiglio R, Altamura S, Florian CM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA, Stegle O, Trumpp A.

Cell. 2017 May 18;169(5):807-823.e19. doi: 10.1016/j.cell.2017.04.018. Epub 2017 May 4.

13.

Monitoring yeast mitochondria with peroxiredoxin-based redox probes: the influence of oxygen and glucose availability.

Pastor-Flores D, Becker K, Dick TP.

Interface Focus. 2017 Apr 6;7(2):20160143. doi: 10.1098/rsfs.2016.0143.

14.

Fluorescence spectroscopy of roGFP2-based redox probes responding to various physiologically relevant oxidant species in vitro.

Müller A, Schneider JF, Degrossoli A, Lupilova N, Dick TP, Leichert LI.

Data Brief. 2017 Mar 11;11:617-627. doi: 10.1016/j.dib.2017.03.015. eCollection 2017 Apr.

15.

Systematic in vitro assessment of responses of roGFP2-based probes to physiologically relevant oxidant species.

Müller A, Schneider JF, Degrossoli A, Lupilova N, Dick TP, Leichert LI.

Free Radic Biol Med. 2017 May;106:329-338. doi: 10.1016/j.freeradbiomed.2017.02.044. Epub 2017 Feb 27.

PMID:
28242229
16.

Pex35 is a regulator of peroxisome abundance.

Yofe I, Soliman K, Chuartzman SG, Morgan B, Weill U, Yifrach E, Dick TP, Cooper SJ, Ejsing CS, Schuldiner M, Zalckvar E, Thoms S.

J Cell Sci. 2017 Feb 15;130(4):791-804. doi: 10.1242/jcs.187914. Epub 2017 Jan 3.

17.

Redox sensitivity of the MyD88 immune signaling adapter.

Stottmeier B, Dick TP.

Free Radic Biol Med. 2016 Dec;101:93-101. doi: 10.1016/j.freeradbiomed.2016.10.004. Epub 2016 Oct 5.

PMID:
27720842
18.

Real-time monitoring of basal H2O2 levels with peroxiredoxin-based probes.

Morgan B, Van Laer K, Owusu TN, Ezeriņa D, Pastor-Flores D, Amponsah PS, Tursch A, Dick TP.

Nat Chem Biol. 2016 Jun;12(6):437-43. doi: 10.1038/nchembio.2067. Epub 2016 Apr 18.

PMID:
27089028
19.

Mitochondrial redox and pH signaling occurs in axonal and synaptic organelle clusters.

Breckwoldt MO, Armoundas AA, Aon MA, Bendszus M, O'Rourke B, Schwarzländer M, Dick TP, Kurz FT.

Sci Rep. 2016 Mar 22;6:23251. doi: 10.1038/srep23251.

20.

Mouse redox histology using genetically encoded probes.

Fujikawa Y, Roma LP, Sobotta MC, Rose AJ, Diaz MB, Locatelli G, Breckwoldt MO, Misgeld T, Kerschensteiner M, Herzig S, Müller-Decker K, Dick TP.

Sci Signal. 2016 Mar 15;9(419):rs1. doi: 10.1126/scisignal.aad3895.

PMID:
26980443
21.

A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems.

Dóka É, Pader I, Bíró A, Johansson K, Cheng Q, Ballagó K, Prigge JR, Pastor-Flores D, Dick TP, Schmidt EE, Arnér ES, Nagy P.

Sci Adv. 2016 Jan 22;2(1):e1500968. doi: 10.1126/sciadv.1500968. eCollection 2016 Jan.

22.

Utilizing Natural and Engineered Peroxiredoxins As Intracellular Peroxide Reporters.

Van Laer K, Dick TP.

Mol Cells. 2016 Jan;39(1):46-52. doi: 10.14348/molcells.2016.2328. Epub 2016 Jan 25. Review.

23.

A click chemistry approach identifies target proteins of xanthohumol.

Brodziak-Jarosz L, Fujikawa Y, Pastor-Flores D, Kasikci S, Jirásek P, Pitzl S, Owen RW, Klika KD, Gerhäuser C, Amslinger S, Dick TP.

Mol Nutr Food Res. 2016 Apr;60(4):737-48. doi: 10.1002/mnfr.201500613. Epub 2016 Mar 11.

PMID:
26748658
24.

Metabolic Remodeling in Times of Stress: Who Shoots Faster than His Shadow?

Dick TP, Ralser M.

Mol Cell. 2015 Aug 20;59(4):519-21. doi: 10.1016/j.molcel.2015.08.002.

25.

Dissecting Redox Biology Using Fluorescent Protein Sensors.

Schwarzländer M, Dick TP, Meyer AJ, Morgan B.

Antioxid Redox Signal. 2016 May 1;24(13):680-712. doi: 10.1089/ars.2015.6266. Epub 2015 May 27. Review.

PMID:
25867539
26.

Highlight: dynamics of thiol-based redox switches.

Herrmann JM, Becker K, Dick TP.

Biol Chem. 2015 May;396(5):385-7. doi: 10.1515/hsz-2015-0135. Review. No abstract available.

PMID:
25854941
27.

Real-time assays for monitoring the influence of sulfide and sulfane sulfur species on protein thiol redox states.

Greiner R, Dick TP.

Methods Enzymol. 2015;555:57-77. doi: 10.1016/bs.mie.2014.11.020. Epub 2015 Jan 10.

PMID:
25747475
28.

Incidence and physiological relevance of protein thiol switches.

Leichert LI, Dick TP.

Biol Chem. 2015 May;396(5):389-99. doi: 10.1515/hsz-2014-0314. Review.

PMID:
25719318
29.

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.

Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dick TP, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MA, Williams DA, Trumpp A, Milsom MD.

Nature. 2015 Apr 23;520(7548):549-52. doi: 10.1038/nature14131. Epub 2015 Feb 18.

PMID:
25707806
30.

Enhancing the anti-inflammatory activity of chalcones by tuning the Michael acceptor site.

Rücker H, Al-Rifai N, Rascle A, Gottfried E, Brodziak-Jarosz L, Gerhäuser C, Dick TP, Amslinger S.

Org Biomol Chem. 2015 Mar 14;13(10):3040-7. doi: 10.1039/c4ob02301c.

PMID:
25622264
31.

A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation.

Peralta D, Bronowska AK, Morgan B, Dóka É, Van Laer K, Nagy P, Gräter F, Dick TP.

Nat Chem Biol. 2015 Feb;11(2):156-63. doi: 10.1038/nchembio.1720. Epub 2015 Jan 12.

PMID:
25580853
32.

Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling.

Sobotta MC, Liou W, Stöcker S, Talwar D, Oehler M, Ruppert T, Scharf AN, Dick TP.

Nat Chem Biol. 2015 Jan;11(1):64-70. doi: 10.1038/nchembio.1695. Epub 2014 Nov 24.

PMID:
25402766
33.

The 'mitoflash' probe cpYFP does not respond to superoxide.

Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Müller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP.

Nature. 2014 Oct 23;514(7523):E12-4. doi: 10.1038/nature13858. No abstract available.

34.

The yeast oligopeptide transporter Opt2 is localized to peroxisomes and affects glutathione redox homeostasis.

Elbaz-Alon Y, Morgan B, Clancy A, Amoako TN, Zalckvar E, Dick TP, Schwappach B, Schuldiner M.

FEMS Yeast Res. 2014 Nov;14(7):1055-67. doi: 10.1111/1567-1364.12196. Epub 2014 Sep 22.

35.

Reactivation of oxidized PTP1B and PTEN by thioredoxin 1.

Schwertassek U, Haque A, Krishnan N, Greiner R, Weingarten L, Dick TP, Tonks NK.

FEBS J. 2014 Aug;281(16):3545-58. doi: 10.1111/febs.12898. Epub 2014 Jul 23.

36.

Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo.

Breckwoldt MO, Pfister FM, Bradley PM, Marinković P, Williams PR, Brill MS, Plomer B, Schmalz A, St Clair DK, Naumann R, Griesbeck O, Schwarzländer M, Godinho L, Bareyre FM, Dick TP, Kerschensteiner M, Misgeld T.

Nat Med. 2014 May;20(5):555-60. doi: 10.1038/nm.3520. Epub 2014 Apr 20.

PMID:
24747747
37.

Imaging dynamic redox processes with genetically encoded probes.

Ezeriņa D, Morgan B, Dick TP.

J Mol Cell Cardiol. 2014 Aug;73:43-9. doi: 10.1016/j.yjmcc.2013.12.023. Epub 2014 Jan 7. Review.

PMID:
24406687
38.

Redesign of genetically encoded biosensors for monitoring mitochondrial redox status in a broad range of model eukaryotes.

Albrecht SC, Sobotta MC, Bausewein D, Aller I, Hell R, Dick TP, Meyer AJ.

J Biomol Screen. 2014 Mar;19(3):379-86. doi: 10.1177/1087057113499634. Epub 2013 Aug 16.

PMID:
23954927
39.

In vivo imaging of H2O2 production in Drosophila.

Barata AG, Dick TP.

Methods Enzymol. 2013;526:61-82. doi: 10.1016/B978-0-12-405883-5.00004-1.

PMID:
23791094
40.

Polysulfides link H2S to protein thiol oxidation.

Greiner R, Pálinkás Z, Bäsell K, Becher D, Antelmann H, Nagy P, Dick TP.

Antioxid Redox Signal. 2013 Nov 20;19(15):1749-65. doi: 10.1089/ars.2012.5041. Epub 2013 Jun 20.

41.

Exposing cells to H2O2: a quantitative comparison between continuous low-dose and one-time high-dose treatments.

Sobotta MC, Barata AG, Schmidt U, Mueller S, Millonig G, Dick TP.

Free Radic Biol Med. 2013 Jul;60:325-35. doi: 10.1016/j.freeradbiomed.2013.02.017. Epub 2013 Feb 26.

PMID:
23485584
42.

Biosensor-expressing spheroid cultures for imaging of drug-induced effects in three dimensions.

Wittig R, Richter V, Wittig-Blaich S, Weber P, Strauss WS, Bruns T, Dick TP, Schneckenburger H.

J Biomol Screen. 2013 Jul;18(6):736-43. doi: 10.1177/1087057113480525. Epub 2013 Mar 11.

PMID:
23479354
43.

Endoplasmic reticulum: reduced and oxidized glutathione revisited.

Birk J, Meyer M, Aller I, Hansen HG, Odermatt A, Dick TP, Meyer AJ, Appenzeller-Herzog C.

J Cell Sci. 2013 Apr 1;126(Pt 7):1604-17. doi: 10.1242/jcs.117218. Epub 2013 Feb 19.

44.

Monitoring intracellular redox changes in ozone-exposed airway epithelial cells.

Gibbs-Flournoy EA, Simmons SO, Bromberg PA, Dick TP, Samet JM.

Environ Health Perspect. 2013 Mar;121(3):312-7. doi: 10.1289/ehp.1206039. Epub 2012 Dec 18.

45.

Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis.

Morgan B, Ezeriņa D, Amoako TN, Riemer J, Seedorf M, Dick TP.

Nat Chem Biol. 2013 Feb;9(2):119-25. doi: 10.1038/nchembio.1142. Epub 2012 Dec 16.

PMID:
23242256
46.

Inaccurately assembled cytochrome c oxidase can lead to oxidative stress-induced growth arrest.

Bode M, Longen S, Morgan B, Peleh V, Dick TP, Bihlmaier K, Herrmann JM.

Antioxid Redox Signal. 2013 May 1;18(13):1597-612. doi: 10.1089/ars.2012.4685. Epub 2013 Jan 15.

47.

Redox Biology on the rise.

Herrmann JM, Dick TP.

Biol Chem. 2012 Sep;393(9):999-1004. doi: 10.1515/hsz-2012-0111. Review.

PMID:
22944698
48.

Sustained submicromolar H2O2 levels induce hepcidin via signal transducer and activator of transcription 3 (STAT3).

Millonig G, Ganzleben I, Peccerella T, Casanovas G, Brodziak-Jarosz L, Breitkopf-Heinlein K, Dick TP, Seitz HK, Muckenthaler MU, Mueller S.

J Biol Chem. 2012 Oct 26;287(44):37472-82. doi: 10.1074/jbc.M112.358911. Epub 2012 Aug 29.

49.

Mitochondrial 'flashes': a radical concept repHined.

Schwarzländer M, Murphy MP, Duchen MR, Logan DC, Fricker MD, Halestrap AP, Müller FL, Rizzuto R, Dick TP, Meyer AJ, Sweetlove LJ.

Trends Cell Biol. 2012 Oct;22(10):503-8. doi: 10.1016/j.tcb.2012.07.007. Epub 2012 Aug 20. Review.

PMID:
22917552
50.

Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state.

Kojer K, Bien M, Gangel H, Morgan B, Dick TP, Riemer J.

EMBO J. 2012 Jun 15;31(14):3169-82. doi: 10.1038/emboj.2012.165.

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