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Items: 1 to 50 of 833

1.

Rifabutin is active against Mycobacterium abscessus in mice.

Dick T, Shin SJ, Koh WJ, Dartois V, Gengenbacher M.

Antimicrob Agents Chemother. 2019 Nov 25. pii: AAC.01943-19. doi: 10.1128/AAC.01943-19. [Epub ahead of print]

2.

Overexpression, purification, enzymatic and microscopic characterization of recombinant mycobacterial F-ATP synthase.

Saw WG, Wong CF, Dick T, Grüber G.

Biochem Biophys Res Commun. 2019 Nov 21. pii: S0006-291X(19)32224-7. doi: 10.1016/j.bbrc.2019.11.098. [Epub ahead of print]

PMID:
31761325
3.

Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila.

Gospodaryov DV, Strilbytska OM, Semaniuk UV, Perkhulyn NV, Rovenko BM, Yurkevych IS, Barata AG, Dick TP, Lushchak OV, Jacobs HT.

Biogerontology. 2019 Nov 20. doi: 10.1007/s10522-019-09849-8. [Epub ahead of print]

PMID:
31749111
4.

Unique structural and mechanistic properties of mycobacterial F-ATP synthases: Implications for drug design.

Kamariah N, Ragunathan P, Shin J, Saw WG, Wong CF, Dick T, Grüber G.

Prog Biophys Mol Biol. 2019 Nov 16. pii: S0079-6107(19)30192-0. doi: 10.1016/j.pbiomolbio.2019.11.006. [Epub ahead of print] Review.

PMID:
31743686
5.

Targeted protein degradation in antibacterial drug discovery?

Gopal P, Dick T.

Prog Biophys Mol Biol. 2019 Nov 16. pii: S0079-6107(19)30188-9. doi: 10.1016/j.pbiomolbio.2019.11.005. [Epub ahead of print] Review.

PMID:
31738980
6.

Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis.

Saw WG, Wu ML, Ragunathan P, Biuković G, Lau AM, Shin J, Harikishore A, Cheung CY, Hards K, Sarathy JP, Bates RW, Cook GM, Dick T, Grüber G.

Sci Rep. 2019 Nov 14;9(1):16759. doi: 10.1038/s41598-019-53107-3.

7.

TBAJ-876 displays Bedaquiline-like mycobactericidal potency without retaining the parental drug's uncoupler activity.

Sarathy JP, Ragunathan P, Cooper CB, Upton AM, Grüber G, Dick T.

Antimicrob Agents Chemother. 2019 Nov 11. pii: AAC.01540-19. doi: 10.1128/AAC.01540-19. [Epub ahead of print]

8.

Pharmacological and Molecular Mechanisms Behind the Sterilizing Activity of Pyrazinamide.

Gopal P, Grüber G, Dartois V, Dick T.

Trends Pharmacol Sci. 2019 Dec;40(12):930-940. doi: 10.1016/j.tips.2019.10.005. Epub 2019 Nov 6. Review.

9.

A role for peroxiredoxins in H2O2- and MEKK-dependent activation of the p38 signaling pathway.

Barata AG, Dick TP.

Redox Biol. 2019 Oct 8;28:101340. doi: 10.1016/j.redox.2019.101340. [Epub ahead of print]

10.

Humans falling in holes: adaptations in lower-limb joint mechanics in response to a rapid change in substrate height during human hopping.

Dick TJM, Punith LK, Sawicki GS.

J R Soc Interface. 2019 Oct 31;16(159):20190292. doi: 10.1098/rsif.2019.0292. Epub 2019 Oct 2.

PMID:
31575349
11.

Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance.

Safi H, Gopal P, Lingaraju S, Ma S, Levine C, Dartois V, Yee M, Li L, Blanc L, Ho Liang HP, Husain S, Hoque M, Soteropoulos P, Rustad T, Sherman DR, Dick T, Alland D.

Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19665-19674. doi: 10.1073/pnas.1907631116. Epub 2019 Sep 5.

PMID:
31488707
12.

Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.

Zhong W, Pasunooti KK, Balamkundu S, Wong YH, Nah Q, Gadi V, Gnanakalai S, Chionh YH, McBee ME, Gopal P, Lim SH, Olivier N, Buurman ET, Dick T, Liu CF, Lescar J, Dedon PC.

J Med Chem. 2019 Sep 12;62(17):7788-7805. doi: 10.1021/acs.jmedchem.9b00582. Epub 2019 Aug 29.

13.

Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance.

Williams JT, Haiderer ER, Coulson GB, Conner KN, Ellsworth E, Chen C, Alvarez-Cabrera N, Li W, Jackson M, Dick T, Abramovitch RB.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00547-19. doi: 10.1128/AAC.00547-19. Print 2019 Oct.

PMID:
31405862
14.

Increasing Local Excitability of Brainstem Respiratory Nuclei Reveals a Distributed Network Underlying Respiratory Motor Pattern Formation.

Dhingra RR, Furuya WI, Bautista TG, Dick TE, Galán RF, Dutschmann M.

Front Physiol. 2019 Jul 23;10:887. doi: 10.3389/fphys.2019.00887. eCollection 2019.

15.

TBAJ-876 Retains Bedaquiline's Activity against Subunits c and ε of Mycobacterium tuberculosis F-ATP Synthase.

Sarathy JP, Ragunathan P, Shin J, Cooper CB, Upton AM, Grüber G, Dick T.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e01191-19. doi: 10.1128/AAC.01191-19. Print 2019 Oct.

16.

Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL.

Yosifov DY, Idler I, Bhattacharya N, Reichenzeller M, Close V, Ezerina D, Scheffold A, Jebaraj BMC, Kugler S, Bloehdorn J, Bahlo J, Robrecht S, Eichhorst B, Fischer K, Weigel A, Busch H, Lichter P, Döhner H, Dick TP, Stilgenbauer S, Mertens D.

Leukemia. 2019 Jul 12. doi: 10.1038/s41375-019-0513-x. [Epub ahead of print]

PMID:
31300746
17.

Editorial: NTM-The New Uber-Bugs.

Dartois V, Sizemore C, Dick T.

Front Microbiol. 2019 Jun 12;10:1299. doi: 10.3389/fmicb.2019.01299. eCollection 2019. No abstract available.

18.

Repositioning rifamycins for Mycobacterium abscessus lung disease.

Ganapathy US, Dartois V, Dick T.

Expert Opin Drug Discov. 2019 Sep;14(9):867-878. doi: 10.1080/17460441.2019.1629414. Epub 2019 Jun 14.

PMID:
31195849
19.

Bedaquiline Eliminates Bactericidal Activity of β-Lactams against Mycobacterium abscessus.

Lindman M, Dick T.

Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e00827-19. doi: 10.1128/AAC.00827-19. Print 2019 Aug.

20.

Mechanics and energetics of post-stroke walking aided by a powered ankle exoskeleton with speed-adaptive myoelectric control.

McCain EM, Dick TJM, Giest TN, Nuckols RW, Lewek MD, Saul KR, Sawicki GS.

J Neuroeng Rehabil. 2019 May 15;16(1):57. doi: 10.1186/s12984-019-0523-y.

21.

Ventilatory pattern variability as a biometric for severity of acute lung injury in rats.

Young BP, Loparo KA, Dick TE, Jacono FJ.

Respir Physiol Neurobiol. 2019 Jul;265:161-171. doi: 10.1016/j.resp.2019.03.009. Epub 2019 Mar 27.

PMID:
30928542
22.

Intimate Partner Violence Experiences Among Men Living with HIV in Rural Appalachia.

Bryan N, Davidov DM, Dick T, Bassler J, Fisher M.

AIDS Behav. 2019 Nov;23(11):3002-3014. doi: 10.1007/s10461-019-02438-3.

23.

Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in Mycobacterium tuberculosis.

Negatu DA, Yamada Y, Xi Y, Go ML, Zimmerman M, Ganapathy U, Dartois V, Gengenbacher M, Dick T.

MBio. 2019 Mar 26;10(2). pii: e02781-18. doi: 10.1128/mBio.02781-18.

24.

Moving in complex environments: a biomechanical analysis of locomotion on inclined and narrow substrates.

Clemente CJ, Dick TJM, Wheatley R, Gaschk J, Nasir AFAA, Cameron SF, Wilson RS.

J Exp Biol. 2019 Mar 21;222(Pt 6). pii: jeb189654. doi: 10.1242/jeb.189654.

25.

Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption.

Shetty A, Xu Z, Lakshmanan U, Hill J, Choong ML, Chng SS, Yamada Y, Poulsen A, Dick T, Gengenbacher M.

Front Microbiol. 2018 Dec 4;9:2960. doi: 10.3389/fmicb.2018.02960. eCollection 2018.

26.

Rapid and robust restoration of breathing long after spinal cord injury.

Warren PM, Steiger SC, Dick TE, MacFarlane PM, Alilain WJ, Silver J.

Nat Commun. 2018 Nov 27;9(1):4843. doi: 10.1038/s41467-018-06937-0.

27.

Advancing Translational Science for Pulmonary Nontuberculous Mycobacterial Infections. A Road Map for Research.

Daniel-Wayman S, Abate G, Barber DL, Bermudez LE, Coler RN, Cynamon MH, Daley CL, Davidson RM, Dick T, Floto RA, Henkle E, Holland SM, Jackson M, Lee RE, Nuermberger EL, Olivier KN, Ordway DJ, Prevots DR, Sacchettini JC, Salfinger M, Sassetti CM, Sizemore CF, Winthrop KL, Zelazny AM.

Am J Respir Crit Care Med. 2019 Apr 15;199(8):947-951. doi: 10.1164/rccm.201807-1273PP. No abstract available.

PMID:
30428263
28.

Structure and function of Mycobacterium-specific components of F-ATP synthase subunits α and ε.

Bogdanović N, Sundararaman L, Kamariah N, Tyagi A, Bhushan S, Ragunathan P, Shin J, Dick T, Grüber G.

J Struct Biol. 2018 Dec;204(3):420-434. doi: 10.1016/j.jsb.2018.10.006. Epub 2018 Oct 17.

PMID:
30342092
29.

Fundamentals of leading, tools for managing, and strategies for sustaining change.

Dick TB, Ash NR, Childress BC, Diamantides EM, Grabarczyk TR, Main TD, Schuessler BL, Van Cura JD.

Am J Health Syst Pharm. 2018 Oct 1;75(19):1450-1455. doi: 10.2146/ajhp170780. No abstract available.

PMID:
30257841
30.

Mycobacterial Cell Wall Synthesis Inhibitors Cause Lethal ATP Burst.

Shetty A, Dick T.

Front Microbiol. 2018 Aug 15;9:1898. doi: 10.3389/fmicb.2018.01898. eCollection 2018.

31.

TB drug susceptibility is more than MIC.

Dick T, Dartois V.

Nat Microbiol. 2018 Sep;3(9):971-972. doi: 10.1038/s41564-018-0226-3. No abstract available.

PMID:
30143801
32.

The Mycobacterial Membrane: A Novel Target Space for Anti-tubercular Drugs.

Chen H, Nyantakyi SA, Li M, Gopal P, Aziz DB, Yang T, Moreira W, Gengenbacher M, Dick T, Go ML.

Front Microbiol. 2018 Jul 19;9:1627. doi: 10.3389/fmicb.2018.01627. eCollection 2018. Review.

33.

Impact of immunopathology on the antituberculous activity of pyrazinamide.

Blanc L, Sarathy JP, Alvarez Cabrera N, O'Brien P, Dias-Freedman I, Mina M, Sacchettini J, Savic RM, Gengenbacher M, Podell BK, Prideaux B, Ioerger T, Dick T, Dartois V.

J Exp Med. 2018 Aug 6;215(8):1975-1986. doi: 10.1084/jem.20180518. Epub 2018 Jul 17.

34.

Genome-wide C-SWAT library for high-throughput yeast genome tagging.

Meurer M, Duan Y, Sass E, Kats I, Herbst K, Buchmuller BC, Dederer V, Huber F, Kirrmaier D, Štefl M, Van Laer K, Dick TP, Lemberg MK, Khmelinskii A, Levy ED, Knop M.

Nat Methods. 2018 Aug;15(8):598-600. doi: 10.1038/s41592-018-0045-8. Epub 2018 Jul 9.

PMID:
29988096
35.
36.

Periodicity: A Characteristic of Heart Rate Variability Modified by the Type of Mechanical Ventilation After Acute Lung Injury.

Thungtong A, Knoch MF, Jacono FJ, Dick TE, Loparo KA.

Front Physiol. 2018 Jun 19;9:772. doi: 10.3389/fphys.2018.00772. eCollection 2018.

37.

Rust never sleeps: The continuing story of the Iron Bolt.

van der Vliet A, Dick TP, Aust SD, Koppenol WH, Ursini F, Kettle AJ, Beckman JS, O'Donnell V, Darley-Usmar V, Lancaster J Jr, Hogg N, Davies KJA, Forman HJ, Janssen-Heininger YMW.

Free Radic Biol Med. 2018 Aug 20;124:353-357. doi: 10.1016/j.freeradbiomed.2018.06.017. Epub 2018 Jun 18. Review.

PMID:
29913216
38.

Indolyl Azaspiroketal Mannich Bases Are Potent Antimycobacterial Agents with Selective Membrane Permeabilizing Effects and in Vivo Activity.

Nyantakyi SA, Li M, Gopal P, Zimmerman M, Dartois V, Gengenbacher M, Dick T, Go ML.

J Med Chem. 2018 Jul 12;61(13):5733-5750. doi: 10.1021/acs.jmedchem.8b00777. Epub 2018 Jun 25.

39.

Geometric models to explore mechanisms of dynamic shape change in skeletal muscle.

Dick TJM, Wakeling JM.

R Soc Open Sci. 2018 May 16;5(5):172371. doi: 10.1098/rsos.172371. eCollection 2018 May.

40.

Teicoplanin - Tigecycline Combination Shows Synergy Against Mycobacterium abscessus.

Aziz DB, Teo JWP, Dartois V, Dick T.

Front Microbiol. 2018 May 11;9:932. doi: 10.3389/fmicb.2018.00932. eCollection 2018.

41.

Glucose Acutely Reduces Cytosolic and Mitochondrial H2O2 in Rat Pancreatic Beta Cells.

Deglasse JP, Roma LP, Pastor-Flores D, Gilon P, Dick TP, Jonas JC.

Antioxid Redox Signal. 2019 Jan 20;30(3):297-313. doi: 10.1089/ars.2017.7287. Epub 2018 Jun 14.

PMID:
29756464
42.

NTM drug discovery: status, gaps and the way forward.

Wu ML, Aziz DB, Dartois V, Dick T.

Drug Discov Today. 2018 Aug;23(8):1502-1519. doi: 10.1016/j.drudis.2018.04.001. Epub 2018 Apr 7. Review.

43.

Lung-injury depresses glutamatergic synaptic transmission in the nucleus tractus solitarii via discrete age-dependent mechanisms in neonatal rats.

Litvin DG, Dick TE, Smith CB, Jacono FJ.

Brain Behav Immun. 2018 May;70:398-422. doi: 10.1016/j.bbi.2018.03.031. Epub 2018 Mar 28.

44.

Verapamil Targets Membrane Energetics in Mycobacterium tuberculosis.

Chen C, Gardete S, Jansen RS, Shetty A, Dick T, Rhee KY, Dartois V.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02107-17. doi: 10.1128/AAC.02107-17. Print 2018 May.

45.

N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2S and Sulfane Sulfur Production.

Ezeriņa D, Takano Y, Hanaoka K, Urano Y, Dick TP.

Cell Chem Biol. 2018 Apr 19;25(4):447-459.e4. doi: 10.1016/j.chembiol.2018.01.011. Epub 2018 Feb 8.

46.

The NMR solution structure of Mycobacterium tuberculosis F-ATP synthase subunit ε provides new insight into energy coupling inside the rotary engine.

Joon S, Ragunathan P, Sundararaman L, Nartey W, Kundu S, Manimekalai MSS, Bogdanović N, Dick T, Grüber G.

FEBS J. 2018 Mar;285(6):1111-1128. doi: 10.1111/febs.14392. Epub 2018 Feb 6.

47.

Does a two-element muscle model offer advantages when estimating ankle plantar flexor forces during human cycling?

Lai AKM, Arnold AS, Biewener AA, Dick TJM, Wakeling JM.

J Biomech. 2018 Feb 8;68:6-13. doi: 10.1016/j.jbiomech.2017.12.018. Epub 2017 Dec 15.

48.

1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity.

Yang X, Wedajo W, Yamada Y, Dahlroth SL, Neo JJ, Dick T, Chui WK.

Eur J Med Chem. 2018 Jan 20;144:262-276. doi: 10.1016/j.ejmech.2017.12.017. Epub 2017 Dec 7.

PMID:
29274493
49.

A role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation.

Stöcker S, Maurer M, Ruppert T, Dick TP.

Nat Chem Biol. 2018 Feb;14(2):148-155. doi: 10.1038/nchembio.2536. Epub 2017 Dec 18.

50.

Whole-Cell Screen of Fragment Library Identifies Gut Microbiota Metabolite Indole Propionic Acid as Antitubercular.

Negatu DA, Liu JJJ, Zimmerman M, Kaya F, Dartois V, Aldrich CC, Gengenbacher M, Dick T.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e01571-17. doi: 10.1128/AAC.01571-17. Print 2018 Mar.

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