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Items: 24


A bilobal model of Ca2+-dependent inactivation to probe the physiology of L-type Ca2+ channels.

Limpitikul WB, Greenstein JL, Yue DT, Dick IE, Winslow RL.

J Gen Physiol. 2018 Dec 3;150(12):1688-1701. doi: 10.1085/jgp.201812115. Epub 2018 Nov 23.


Allosteric regulators selectively prevent Ca2+-feedback of CaV and NaV channels.

Niu J, Dick IE, Yang W, Bamgboye MA, Yue DT, Tomaselli G, Inoue T, Ben-Johny M.

Elife. 2018 Sep 10;7. pii: e35222. doi: 10.7554/eLife.35222.


A Precision Medicine Approach to the Rescue of Function on Malignant Calmodulinopathic Long-QT Syndrome.

Limpitikul WB, Dick IE, Tester DJ, Boczek NJ, Limphong P, Yang W, Choi MH, Babich J, DiSilvestre D, Kanter RJ, Tomaselli GF, Ackerman MJ, Yue DT.

Circ Res. 2017 Jan 6;120(1):39-48. doi: 10.1161/CIRCRESAHA.116.309283. Epub 2016 Oct 20.


Following Optogenetic Dimerizers and Quantitative Prospects.

Niu J, Ben Johny M, Dick IE, Inoue T.

Biophys J. 2016 Sep 20;111(6):1132-1140. doi: 10.1016/j.bpj.2016.07.040. Epub 2016 Aug 17. Review.


Protein kinase A modulation of CaV1.4 calcium channels.

Sang L, Dick IE, Yue DT.

Nat Commun. 2016 Jul 26;7:12239. doi: 10.1038/ncomms12239.


An autism-associated mutation in CaV1.3 channels has opposing effects on voltage- and Ca(2+)-dependent regulation.

Limpitikul WB, Dick IE, Ben-Johny M, Yue DT.

Sci Rep. 2016 Jun 3;6:27235. doi: 10.1038/srep27235.


Arrhythmogenesis in Timothy Syndrome is associated with defects in Ca(2+)-dependent inactivation.

Dick IE, Joshi-Mukherjee R, Yang W, Yue DT.

Nat Commun. 2016 Jan 29;7:10370. doi: 10.1038/ncomms10370.


A rendezvous with the queen of ion channels: Three decades of ion channel research by David T Yue and his Calcium Signals Laboratory.

Dick IE, Limpitikul WB, Niu J, Banerjee R, Issa JB, Ben-Johny M, Adams PJ, Kang PW, Lee SR, Sang L, Yang W, Babich J, Zhang M, Bazazzi H, Yue NC, Tomaselli GF.

Channels (Austin). 2016;10(1):20-32. doi: 10.1080/19336950.2015.1051272. Epub 2015 Jul 15.


Novel fluorescence resonance energy transfer-based reporter reveals differential calcineurin activation in neonatal and adult cardiomyocytes.

Bazzazi H, Sang L, Dick IE, Joshi-Mukherjee R, Yang W, Yue DT.

J Physiol. 2015 Sep 1;593(17):3865-84. doi: 10.1113/JP270510. Epub 2015 Jul 22.


Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels.

Ben-Johny M, Dick IE, Sang L, Limpitikul WB, Kang PW, Niu J, Banerjee R, Yang W, Babich JS, Issa JB, Lee SR, Namkung H, Li J, Zhang M, Yang PS, Bazzazi H, Adams PJ, Joshi-Mukherjee R, Yue DN, Yue DT.

Curr Mol Pharmacol. 2015;8(2):188-205. Review.


David T. Yue: in memoriam.

Dick IE, Colecraft HM.

Neuron. 2015 Mar 18;85(6):1158-61. No abstract available.


Apocalmodulin itself promotes ion channel opening and Ca(2+) regulation.

Adams PJ, Ben-Johny M, Dick IE, Inoue T, Yue DT.

Cell. 2014 Oct 23;159(3):608-22. doi: 10.1016/j.cell.2014.09.047.


Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca(2+) currents and promote proarrhythmic behavior in ventricular myocytes.

Limpitikul WB, Dick IE, Joshi-Mukherjee R, Overgaard MT, George AL Jr, Yue DT.

J Mol Cell Cardiol. 2014 Sep;74:115-24. doi: 10.1016/j.yjmcc.2014.04.022. Epub 2014 May 8.


Structural and functional plasticity in long-term cultures of adult ventricular myocytes.

Joshi-Mukherjee R, Dick IE, Liu T, O'Rourke B, Yue DT, Tung L.

J Mol Cell Cardiol. 2013 Dec;65:76-87. doi: 10.1016/j.yjmcc.2013.09.009. Epub 2013 Sep 25.


Nanodomain Ca²⁺ of Ca²⁺ channels detected by a tethered genetically encoded Ca²⁺ sensor.

Tay LH, Dick IE, Yang W, Mank M, Griesbeck O, Yue DT.

Nat Commun. 2012 Apr 10;3:778. doi: 10.1038/ncomms1777.


Mechanism of local and global Ca2+ sensing by calmodulin in complex with a Ca2+ channel.

Tadross MR, Dick IE, Yue DT.

Cell. 2008 Jun 27;133(7):1228-40. doi: 10.1016/j.cell.2008.05.025.


A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels.

Dick IE, Tadross MR, Liang H, Tay LH, Yang W, Yue DT.

Nature. 2008 Feb 14;451(7180):830-4. doi: 10.1038/nature06529. Epub 2008 Jan 30.


Sodium channel blockade may contribute to the analgesic efficacy of antidepressants.

Dick IE, Brochu RM, Purohit Y, Kaczorowski GJ, Martin WJ, Priest BT.

J Pain. 2007 Apr;8(4):315-24. Epub 2006 Dec 15.


A high-capacity membrane potential FRET-based assay for NaV1.8 channels.

Liu CJ, Priest BT, Bugianesi RM, Dulski PM, Felix JP, Dick IE, Brochu RM, Knaus HG, Middleton RE, Kaczorowski GJ, Slaughter RS, Garcia ML, Köhler MG.

Assay Drug Dev Technol. 2006 Feb;4(1):37-48.


Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats.

Brochu RM, Dick IE, Tarpley JW, McGowan E, Gunner D, Herrington J, Shao PP, Ok D, Li C, Parsons WH, Stump GL, Regan CP, Lynch JJ Jr, Lyons KA, McManus OB, Clark S, Ali Z, Kaczorowski GJ, Martin WJ, Priest BT.

Mol Pharmacol. 2006 Mar;69(3):823-32. Epub 2005 Nov 21.


Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic beta-cells.

Herrington J, Sanchez M, Wunderler D, Yan L, Bugianesi RM, Dick IE, Clark SA, Brochu RM, Priest BT, Kohler MG, McManus OB.

J Physiol. 2005 Aug 15;567(Pt 1):159-75. Epub 2005 Jun 2.


Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain.

Liang J, Brochu RM, Cohen CJ, Dick IE, Felix JP, Fisher MH, Garcia ML, Kaczorowski GJ, Lyons KA, Meinke PT, Priest BT, Schmalhofer WA, Smith MM, Tarpley JW, Williams BS, Martin WJ, Parsons WH.

Bioorg Med Chem Lett. 2005 Jun 2;15(11):2943-7.


Functional assay of voltage-gated sodium channels using membrane potential-sensitive dyes.

Felix JP, Williams BS, Priest BT, Brochu RM, Dick IE, Warren VA, Yan L, Slaughter RS, Kaczorowski GJ, Smith MM, Garcia ML.

Assay Drug Dev Technol. 2004 Jun;2(3):260-8.


A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.

Priest BT, Garcia ML, Middleton RE, Brochu RM, Clark S, Dai G, Dick IE, Felix JP, Liu CJ, Reiseter BS, Schmalhofer WA, Shao PP, Tang YS, Chou MZ, Kohler MG, Smith MM, Warren VA, Williams BS, Cohen CJ, Martin WJ, Meinke PT, Parsons WH, Wafford KA, Kaczorowski GJ.

Biochemistry. 2004 Aug 3;43(30):9866-76.


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