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Items: 1 to 50 of 59

1.

RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression.

Marshall AE, Roes MV, Passos DT, DeWeerd MC, Chaikovsky AC, Sage J, Howlett CJ, Dick FA.

Mol Cell Biol. 2019 Jul 29;39(16). pii: e00105-19. doi: 10.1128/MCB.00105-19. Print 2019 Aug 15.

PMID:
31138663
2.

Drugging RB1 Deficiency: Synthetic Lethality with Aurora Kinases.

Dick FA, Li SS.

Cancer Discov. 2019 Feb;9(2):169-172. doi: 10.1158/2159-8290.CD-18-1448.

PMID:
30737214
3.

Context dependent roles for RB-E2F transcriptional regulation in tumor suppression.

Thwaites MJ, Cecchini MJ, Passos DT, Zakirova K, Dick FA.

PLoS One. 2019 Jan 31;14(1):e0203577. doi: 10.1371/journal.pone.0203577. eCollection 2019.

4.

CDK4 Inhibitors Thwart Immunity by Inhibiting Phospho-RB-NF-κB Complexes.

Kim SJ, Asfaha S, Dick FA.

Mol Cell. 2019 Jan 3;73(1):1-2. doi: 10.1016/j.molcel.2018.12.012.

PMID:
30609388
5.

Half brain irradiation in a murine model of breast cancer brain metastasis: magnetic resonance imaging and histological assessments of dose-response.

Zarghami N, Murrell DH, Jensen MD, Dick FA, Chambers AF, Foster PJ, Wong E.

Radiat Oncol. 2018 Jun 1;13(1):104. doi: 10.1186/s13014-018-1028-8.

6.

Non-canonical functions of the RB protein in cancer.

Dick FA, Goodrich DW, Sage J, Dyson NJ.

Nat Rev Cancer. 2018 Jul;18(7):442-451. doi: 10.1038/s41568-018-0008-5. Review.

7.

Immunohistochemical Detection of the Retinoblastoma Protein.

Ishak CA, Cecchini MJ, Howlett CJ, Dick FA.

Methods Mol Biol. 2018;1726:65-75. doi: 10.1007/978-1-4939-7565-5_7.

PMID:
29468544
8.

Disruption of CDK-resistant chromatin association by pRB causes DNA damage, mitotic errors, and reduces Condensin II recruitment.

Ishak CA, Coschi CH, Roes MV, Dick FA.

Cell Cycle. 2017 Aug 3;16(15):1430-1439. doi: 10.1080/15384101.2017.1338984. Epub 2017 Jul 19.

9.

Multiple molecular interactions redundantly contribute to RB-mediated cell cycle control.

Thwaites MJ, Cecchini MJ, Talluri S, Passos DT, Carnevale J, Dick FA.

Cell Div. 2017 Mar 14;12:3. doi: 10.1186/s13008-017-0029-6. eCollection 2017.

10.

A Systematic Analysis of Negative Growth Control Implicates the DREAM Complex in Cancer Cell Dormancy.

MacDonald J, Ramos-Valdes Y, Perampalam P, Litovchick L, DiMattia GE, Dick FA.

Mol Cancer Res. 2017 Apr;15(4):371-381. doi: 10.1158/1541-7786.MCR-16-0323-T. Epub 2016 Dec 28.

11.

An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences.

Ishak CA, Marshall AE, Passos DT, White CR, Kim SJ, Cecchini MJ, Ferwati S, MacDonald WA, Howlett CJ, Welch ID, Rubin SM, Mann MRW, Dick FA.

Mol Cell. 2016 Dec 15;64(6):1074-1087. doi: 10.1016/j.molcel.2016.10.021. Epub 2016 Nov 23.

12.

Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression.

Thwaites MJ, Cecchini MJ, Passos DT, Welch I, Dick FA.

Mol Cell Biol. 2017 Jan 4;37(2). pii: e00561-16. doi: 10.1128/MCB.00561-16. Print 2017 Jan 15.

13.

Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family.

Liban TJ, Thwaites MJ, Dick FA, Rubin SM.

J Mol Biol. 2016 Oct 9;428(20):3960-3971. doi: 10.1016/j.jmb.2016.08.017. Epub 2016 Aug 25.

14.

Technical Note: Immunohistochemical evaluation of mouse brain irradiation targeting accuracy with 3D-printed immobilization device.

Zarghami N, Jensen MD, Talluri S, Foster PJ, Chambers AF, Dick FA, Wong E.

Med Phys. 2015 Nov;42(11):6507-13. doi: 10.1118/1.4933200.

PMID:
26520740
15.

Loss of the retinoblastoma tumor suppressor correlates with improved outcome in patients with lung adenocarcinoma treated with surgery and chemotherapy.

Cecchini MJ, Ishak CA, Passos DT, Warner A, Palma DA, Howlett CJ, Driman DK, Dick FA.

Hum Pathol. 2015 Dec;46(12):1922-34. doi: 10.1016/j.humpath.2015.08.010. Epub 2015 Sep 11.

PMID:
26475095
16.

Cell Synchronization of Mouse Embryonic Fibroblasts.

Thwaites MJ, Coschi CH, Isaac CE, Dick FA.

Methods Mol Biol. 2016;1342:91-9. doi: 10.1007/978-1-4939-2957-3_5.

PMID:
26254919
17.

Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene.

Ishak CA, Dick FA.

Mol Cell Oncol. 2014 Oct 30;2(1):e968069. doi: 10.4161/23723548.2014.968069. eCollection 2015 Jan-Mar.

18.

Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis.

Kareta MS, Gorges LL, Hafeez S, Benayoun BA, Marro S, Zmoos AF, Cecchini MJ, Spacek D, Batista LF, O'Brien M, Ng YH, Ang CE, Vaka D, Artandi SE, Dick FA, Brunet A, Sage J, Wernig M.

Cell Stem Cell. 2015 Jan 8;16(1):39-50. doi: 10.1016/j.stem.2014.10.019. Epub 2014 Nov 13.

19.

Analyzing RB and E2F during the G1-S transition.

Thwaites MJ, Cecchini MJ, Dick FA.

Methods Mol Biol. 2014;1170:449-61. doi: 10.1007/978-1-4939-0888-2_24.

PMID:
24906329
20.

Haploinsufficiency of an RB-E2F1-Condensin II complex leads to aberrant replication and aneuploidy.

Coschi CH, Ishak CA, Gallo D, Marshall A, Talluri S, Wang J, Cecchini MJ, Martens AL, Percy V, Welch I, Boutros PC, Brown GW, Dick FA.

Cancer Discov. 2014 Jul;4(7):840-53. doi: 10.1158/2159-8290.CD-14-0215. Epub 2014 Apr 16.

21.

Loss of the mammalian DREAM complex deregulates chondrocyte proliferation.

Forristal C, Henley SA, MacDonald JI, Bush JR, Ort C, Passos DT, Talluri S, Ishak CA, Thwaites MJ, Norley CJ, Litovchick L, DeCaprio JA, DiMattia G, Holdsworth DW, Beier F, Dick FA.

Mol Cell Biol. 2014 Jun;34(12):2221-34. doi: 10.1128/MCB.01523-13. Epub 2014 Apr 7.

22.

A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice.

Cecchini MJ, Thwaites MJ, Talluri S, MacDonald JI, Passos DT, Chong JL, Cantalupo P, Stafford PM, Sáenz-Robles MT, Francis SM, Pipas JM, Leone G, Welch I, Dick FA.

Mol Cell Biol. 2014 Jun;34(11):2029-45. doi: 10.1128/MCB.01589-13. Epub 2014 Mar 24.

23.

The retinoblastoma protein and PML collaborate to organize heterochromatin and silence E2F-responsive genes during senescence.

Talluri S, Dick FA.

Cell Cycle. 2014;13(4):641-51. doi: 10.4161/cc.27527. Epub 2013 Dec 18.

PMID:
24351540
24.

Mutation of the LXCXE binding cleft of pRb facilitates transformation by ras in vitro but does not promote tumorigenesis in vivo.

Talluri S, Francis SM, Dick FA.

PLoS One. 2013 Aug 6;8(8):e72236. doi: 10.1371/journal.pone.0072236. Print 2013.

25.

Posttranslational modifications of the retinoblastoma tumor suppressor protein as determinants of function.

Macdonald JI, Dick FA.

Genes Cancer. 2012 Nov;3(11-12):619-33. doi: 10.1177/1947601912473305.

26.

Molecular mechanisms underlying RB protein function.

Dick FA, Rubin SM.

Nat Rev Mol Cell Biol. 2013 May;14(5):297-306. doi: 10.1038/nrm3567. Epub 2013 Apr 18. Review.

27.

LXCXE-independent chromatin remodeling by Rb/E2f mediates neuronal quiescence.

Andrusiak MG, Vandenbosch R, Dick FA, Park DS, Slack RS.

Cell Cycle. 2013 May 1;12(9):1416-23. doi: 10.4161/cc.24527. Epub 2013 Apr 9.

28.

Conserved region 3 of human papillomavirus 16 E7 contributes to deregulation of the retinoblastoma tumor suppressor.

Todorovic B, Hung K, Massimi P, Avvakumov N, Dick FA, Shaw GS, Banks L, Mymryk JS.

J Virol. 2012 Dec;86(24):13313-23. doi: 10.1128/JVI.01637-12. Epub 2012 Sep 26.

29.

Regulation of transcription and chromatin structure by pRB: here, there and everywhere.

Talluri S, Dick FA.

Cell Cycle. 2012 Sep 1;11(17):3189-98. doi: 10.4161/cc.21263. Epub 2012 Aug 16. Review.

30.

The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle.

Henley SA, Dick FA.

Cell Div. 2012 Mar 14;7(1):10. doi: 10.1186/1747-1028-7-10.

31.

Analysis of cell cycle position in mammalian cells.

Cecchini MJ, Amiri M, Dick FA.

J Vis Exp. 2012 Jan 21;(59). pii: 3491. doi: 10.3791/3491.

32.

Chromosome instability and deregulated proliferation: an unavoidable duo.

Coschi CH, Dick FA.

Cell Mol Life Sci. 2012 Jun;69(12):2009-24. doi: 10.1007/s00018-011-0910-4. Epub 2012 Jan 6. Review.

PMID:
22223110
33.

DNA damage signals through differentially modified E2F1 molecules to induce apoptosis.

Carnevale J, Palander O, Seifried LA, Dick FA.

Mol Cell Biol. 2012 Mar;32(5):900-12. doi: 10.1128/MCB.06286-11. Epub 2011 Dec 19.

34.

Sweet DREAMs for Hippo.

Dick FA, Mymryk JS.

Genes Dev. 2011 May 1;25(9):889-94. doi: 10.1101/gad.2050411.

35.

A context-specific role for retinoblastoma protein-dependent negative growth control in suppressing mammary tumorigenesis.

Francis SM, Chakrabarti S, Dick FA.

PLoS One. 2011 Feb 22;6(2):e16434. doi: 10.1371/journal.pone.0016434.

36.

The biochemical basis of CDK phosphorylation-independent regulation of E2F1 by the retinoblastoma protein.

Cecchini MJ, Dick FA.

Biochem J. 2011 Mar 1;434(2):297-308. doi: 10.1042/BJ20101210.

PMID:
21143199
37.

An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein.

Hirschi A, Cecchini M, Steinhardt RC, Schamber MR, Dick FA, Rubin SM.

Nat Struct Mol Biol. 2010 Sep;17(9):1051-7. doi: 10.1038/nsmb.1868. Epub 2010 Aug 8.

38.

Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive.

Coschi CH, Martens AL, Ritchie K, Francis SM, Chakrabarti S, Berube NG, Dick FA.

Genes Dev. 2010 Jul 1;24(13):1351-63. doi: 10.1101/gad.1917610. Epub 2010 Jun 15.

39.

Identification of a molecular recognition feature in the E1A oncoprotein that binds the SUMO conjugase UBC9 and likely interferes with polySUMOylation.

Yousef AF, Fonseca GJ, Pelka P, Ablack JN, Walsh C, Dick FA, Bazett-Jones DP, Shaw GS, Mymryk JS.

Oncogene. 2010 Aug 19;29(33):4693-704. doi: 10.1038/onc.2010.226. Epub 2010 Jun 14.

PMID:
20543865
40.

A cancer derived mutation in the retinoblastoma gene with a distinct defect for LXCXE dependent interactions.

Henley SA, Francis SM, Demone J, Ainsworth P, Dick FA.

Cancer Cell Int. 2010 Mar 18;10:8. doi: 10.1186/1475-2867-10-8.

41.
42.

A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence.

Talluri S, Isaac CE, Ahmad M, Henley SA, Francis SM, Martens AL, Bremner R, Dick FA.

Mol Cell Biol. 2010 Feb;30(4):948-60. doi: 10.1128/MCB.01168-09. Epub 2009 Dec 14.

43.

A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development.

Francis SM, Bergsied J, Isaac CE, Coschi CH, Martens AL, Hojilla CV, Chakrabarti S, Dimattia GE, Khoka R, Wang JY, Dick FA.

Mol Cell Biol. 2009 Aug;29(16):4455-66. doi: 10.1128/MCB.00473-09. Epub 2009 Jun 8.

44.

pRB-E2F1 complexes are resistant to adenovirus E1A-mediated disruption.

Seifried LA, Talluri S, Cecchini M, Julian LM, Mymryk JS, Dick FA.

J Virol. 2008 May;82(9):4511-20. doi: 10.1128/JVI.02713-07. Epub 2008 Feb 27.

45.

Characterization of an E2F1-specific binding domain in pRB and its implications for apoptotic regulation.

Julian LM, Palander O, Seifried LA, Foster JE, Dick FA.

Oncogene. 2008 Mar 6;27(11):1572-9. Epub 2007 Sep 24.

PMID:
17891180
47.

Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit.

Binné UK, Classon MK, Dick FA, Wei W, Rape M, Kaelin WG Jr, Näär AM, Dyson NJ.

Nat Cell Biol. 2007 Feb;9(2):225-32. Epub 2006 Dec 24. Erratum in: Nat Cell Biol. 2007 Mar;9(3):353.

PMID:
17187060
48.

The retinoblastoma protein regulates pericentric heterochromatin.

Isaac CE, Francis SM, Martens AL, Julian LM, Seifried LA, Erdmann N, Binné UK, Harrington L, Sicinski P, Bérubé NG, Dyson NJ, Dick FA.

Mol Cell Biol. 2006 May;26(9):3659-71.

50.

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