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Items: 15


Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer.

Kang YP, Torrente L, Falzone A, Elkins CM, Liu M, Asara JM, Dibble CC, DeNicola GM.

Elife. 2019 May 20;8. pii: e45572. doi: 10.7554/eLife.45572.


PI 3-Kinase Signaling: AKTing up inside the Cell.

Toker A, Dibble CC.

Mol Cell. 2018 Sep 20;71(6):875-876. doi: 10.1016/j.molcel.2018.09.006.


PI3K signaling in cancer: beyond AKT.

Lien EC, Dibble CC, Toker A.

Curr Opin Cell Biol. 2017 Apr;45:62-71. doi: 10.1016/ Epub 2017 Mar 24. Review.


Sterol Regulatory Element Binding Protein Regulates the Expression and Metabolic Functions of Wild-Type and Oncogenic IDH1.

Ricoult SJ, Dibble CC, Asara JM, Manning BD.

Mol Cell Biol. 2016 Aug 26;36(18):2384-95. doi: 10.1128/MCB.00163-16. Print 2016 Sep 15.


Regulation of mTORC1 by PI3K signaling.

Dibble CC, Cantley LC.

Trends Cell Biol. 2015 Sep;25(9):545-55. doi: 10.1016/j.tcb.2015.06.002. Epub 2015 Jul 6. Review.


Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.

Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD.

Cell. 2014 Feb 13;156(4):771-85. doi: 10.1016/j.cell.2013.11.049.


Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

Dibble CC, Manning BD.

Nat Cell Biol. 2013 Jun;15(6):555-64. doi: 10.1038/ncb2763. Review.


TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.

Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO, Manning BD.

Mol Cell. 2012 Aug 24;47(4):535-46. doi: 10.1016/j.molcel.2012.06.009. Epub 2012 Jul 12.


Oncogenic EGFR signaling activates an mTORC2-NF-κB pathway that promotes chemotherapy resistance.

Tanaka K, Babic I, Nathanson D, Akhavan D, Guo D, Gini B, Dang J, Zhu S, Yang H, De Jesus J, Amzajerdi AN, Zhang Y, Dibble CC, Dan H, Rinkenbaugh A, Yong WH, Vinters HV, Gera JF, Cavenee WK, Cloughesy TF, Manning BD, Baldwin AS, Mischel PS.

Cancer Discov. 2011 Nov;1(6):524-38. doi: 10.1158/2159-8290.CD-11-0124. Epub 2011 Sep 13.


A molecular link between AKT regulation and chemotherapeutic response.

Dibble CC, Manning BD.

Cancer Cell. 2009 Sep 8;16(3):178-80. doi: 10.1016/j.ccr.2009.08.011.


Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1.

Dibble CC, Asara JM, Manning BD.

Mol Cell Biol. 2009 Nov;29(21):5657-70. doi: 10.1128/MCB.00735-09. Epub 2009 Aug 31.


Induction of cytoplasmic accumulation of p53: a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation.

Huang Y, Zhang J, McHenry KT, Kim MM, Zeng W, Lopez-Pajares V, Dibble CC, Mizgerd JP, Yuan ZM.

Cancer Res. 2008 Nov 15;68(22):9131-6. doi: 10.1158/0008-5472.CAN-08-3025.


The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.

Huang J, Dibble CC, Matsuzaki M, Manning BD.

Mol Cell Biol. 2008 Jun;28(12):4104-15. doi: 10.1128/MCB.00289-08. Epub 2008 Apr 14.


S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD.

Mol Cell. 2006 Oct 20;24(2):185-97.


Hedgehog signaling promotes prostate xenograft tumor growth.

Fan L, Pepicelli CV, Dibble CC, Catbagan W, Zarycki JL, Laciak R, Gipp J, Shaw A, Lamm ML, Munoz A, Lipinski R, Thrasher JB, Bushman W.

Endocrinology. 2004 Aug;145(8):3961-70. Epub 2004 May 7.


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