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Items: 35


The need for improved vaccines against foot-and-mouth disease.

de Los Santos T, Diaz-San Segundo F, Rodriguez LL.

Curr Opin Virol. 2018 Apr;29:16-25. doi: 10.1016/j.coviro.2018.02.005. Epub 2018 Mar 12. Review.


Foot-and-mouth disease virus 5'-terminal S fragment is required for replication and modulation of the innate immune response in host cells.

Kloc A, Diaz-San Segundo F, Schafer EA, Rai DK, Kenney M, de Los Santos T, Rieder E.

Virology. 2017 Dec;512:132-143. doi: 10.1016/j.virol.2017.08.036.


Attenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity.

Rai DK, Diaz-San Segundo F, Campagnola G, Keith A, Schafer EA, Kloc A, de Los Santos T, Peersen O, Rieder E.

J Virol. 2017 Jul 12;91(15). pii: e00081-17. doi: 10.1128/JVI.00081-17. Print 2017 Aug 1.


Interaction between FMDV Lpro and transcription factor ADNP is required for optimal viral replication.

Medina GN, Knudsen GM, Greninger AL, Kloc A, Díaz-San Segundo F, Rieder E, Grubman MJ, DeRisi JL, de Los Santos T.

Virology. 2017 May;505:12-22. doi: 10.1016/j.virol.2017.02.010. Epub 2017 Feb 17.


Foot-and-mouth disease vaccines.

Diaz-San Segundo F, Medina GN, Stenfeldt C, Arzt J, de Los Santos T.

Vet Microbiol. 2017 Jul;206:102-112. doi: 10.1016/j.vetmic.2016.12.018. Epub 2016 Dec 19. Review.


Combination of Adt-O1Manisa and Ad5-boIFNλ3 induces early protective immunity against foot-and-mouth disease in cattle.

Diaz-San Segundo F, Montiel NA, Sturza DF, Perez-Martin E, Hickman D, Ramirez-Medina E, Grubman MJ, de Los Santos T.

Virology. 2016 Dec;499:340-349. doi: 10.1016/j.virol.2016.09.027. Epub 2016 Oct 12.


Constitutively Active IRF7/IRF3 Fusion Protein Completely Protects Swine against Foot-and-Mouth Disease.

Ramírez-Carvajal L, Diaz-San Segundo F, Ramirez-Medina E, Rodríguez LL, de Los Santos T.

J Virol. 2016 Sep 12;90(19):8809-21. doi: 10.1128/JVI.00800-16. Print 2016 Oct 1.


The Pathogenesis of Foot-and-Mouth Disease in Pigs.

Stenfeldt C, Diaz-San Segundo F, de Los Santos T, Rodriguez LL, Arzt J.

Front Vet Sci. 2016 May 23;3:41. doi: 10.3389/fvets.2016.00041. eCollection 2016. Review.


Evaluation of a Fiber-Modified Adenovirus Vector Vaccine against Foot-and-Mouth Disease in Cattle.

Medina GN, Montiel N, Diaz-San Segundo F, Sturza D, Ramirez-Medina E, Grubman MJ, de los Santos T.

Clin Vaccine Immunol. 2015 Nov 25;23(2):125-36. doi: 10.1128/CVI.00426-15.


Synonymous Deoptimization of Foot-and-Mouth Disease Virus Causes Attenuation In Vivo while Inducing a Strong Neutralizing Antibody Response.

Diaz-San Segundo F, Medina GN, Ramirez-Medina E, Velazquez-Salinas L, Koster M, Grubman MJ, de los Santos T.

J Virol. 2015 Nov 18;90(3):1298-310. doi: 10.1128/JVI.02167-15. Print 2016 Feb 1.


Treatment with interferon-alpha delays disease in swine infected with a highly virulent CSFV strain.

Fernandez-Sainz I, Ramanathan P, O'Donnell V, Diaz-San Segundo F, Velazquez-Salinas L, Sturza DF, Zhu J, de los Santos T, Borca MV.

Virology. 2015 Sep;483:284-90. doi: 10.1016/j.virol.2015.04.024. Epub 2015 May 21.


Poly ICLC increases the potency of a replication-defective human adenovirus vectored foot-and-mouth disease vaccine.

Diaz-San Segundo F, Dias CC, Moraes MP, Weiss M, Perez-Martin E, Salazar AM, Grubman MJ, de Los Santos T.

Virology. 2014 Nov;468-470:283-292. doi: 10.1016/j.virol.2014.08.012. Epub 2014 Sep 12.


Expression of porcine fusion protein IRF7/3(5D) efficiently controls foot-and-mouth disease virus replication.

Ramírez-Carvajal L, Díaz-San Segundo F, Hickman D, Long CR, Zhu J, Rodríguez LL, de los Santos T.

J Virol. 2014 Oct;88(19):11140-53. doi: 10.1128/JVI.00372-14. Epub 2014 Jul 16.


Type III interferon protects swine against foot-and-mouth disease.

Perez-Martin E, Diaz-San Segundo F, Weiss M, Sturza DF, Dias CC, Ramirez-Medina E, Grubman MJ, de los Santos T.

J Interferon Cytokine Res. 2014 Oct;34(10):810-21. doi: 10.1089/jir.2013.0112. Epub 2014 Apr 30.


An adenovirus vectored mucosal adjuvant augments protection of mice immunized intranasally with an adenovirus-vectored foot-and-mouth disease virus subunit vaccine.

Alejo DM, Moraes MP, Liao X, Dias CC, Tulman ER, Diaz-San Segundo F, Rood D, Grubman MJ, Silbart LK.

Vaccine. 2013 Apr 26;31(18):2302-9. doi: 10.1016/j.vaccine.2013.02.060. Epub 2013 Mar 13.


Venezuelan equine encephalitis replicon particles can induce rapid protection against foot-and-mouth disease virus.

Diaz-San Segundo F, Dias CC, Moraes MP, Weiss M, Perez-Martin E, Owens G, Custer M, Kamrud K, de los Santos T, Grubman MJ.

J Virol. 2013 May;87(10):5447-60. doi: 10.1128/JVI.03462-12. Epub 2013 Mar 6.


Novel antiviral therapeutics to control foot-and-mouth disease.

Dias CC, Moraes MP, Weiss M, Diaz-San Segundo F, Perez-Martin E, Salazar AM, de los Santos T, Grubman MJ.

J Interferon Cytokine Res. 2012 Oct;32(10):462-73. doi: 10.1089/jir.2012.0012. Epub 2012 Aug 27.


Bovine type III interferon significantly delays and reduces the severity of foot-and-mouth disease in cattle.

Perez-Martin E, Weiss M, Diaz-San Segundo F, Pacheco JM, Arzt J, Grubman MJ, de los Santos T.

J Virol. 2012 Apr;86(8):4477-87. doi: 10.1128/JVI.06683-11. Epub 2012 Feb 1.


Antiviral activity of bovine type III interferon against foot-and-mouth disease virus.

Díaz-San Segundo F, Weiss M, Perez-Martín E, Koster MJ, Zhu J, Grubman MJ, de los Santos T.

Virology. 2011 May 10;413(2):283-92. doi: 10.1016/j.virol.2011.02.023. Epub 2011 Mar 24.


A replication analysis of foot-and-mouth disease virus in swine lymphoid tissue might indicate a putative carrier stage in pigs.

Rodríguez-Calvo T, Díaz-San Segundo F, Sanz-Ramos M, Sevilla N.

Vet Res. 2011 Feb 7;42:22. doi: 10.1186/1297-9716-42-22.


Introduction of tag epitopes in the inter-AUG region of foot and mouth disease virus: effect on the L protein.

Piccone ME, Diaz-San Segundo F, Kramer E, Rodriguez LL, de los Santos T.

Virus Res. 2011 Jan;155(1):91-7. doi: 10.1016/j.virusres.2010.09.004. Epub 2010 Sep 16.


Interferon-induced protection against foot-and-mouth disease virus infection correlates with enhanced tissue-specific innate immune cell infiltration and interferon-stimulated gene expression.

Diaz-San Segundo F, Moraes MP, de Los Santos T, Dias CC, Grubman MJ.

J Virol. 2010 Feb;84(4):2063-77. doi: 10.1128/JVI.01874-09. Epub 2009 Dec 2.


Immunosuppression during acute infection with foot-and-mouth disease virus in swine is mediated by IL-10.

Díaz-San Segundo F, Rodríguez-Calvo T, de Avila A, Sevilla N.

PLoS One. 2009 May 21;4(5):e5659. doi: 10.1371/journal.pone.0005659.


Hidden virulence determinants in a viral quasispecies in vivo.

Sanz-Ramos M, Díaz-San Segundo F, Escarmís C, Domingo E, Sevilla N.

J Virol. 2008 Nov;82(21):10465-76. doi: 10.1128/JVI.00825-08. Epub 2008 Aug 20.


Evading the host immune response: how foot-and-mouth disease virus has become an effective pathogen.

Grubman MJ, Moraes MP, Diaz-San Segundo F, Pena L, de los Santos T.

FEMS Immunol Med Microbiol. 2008 Jun;53(1):8-17. doi: 10.1111/j.1574-695X.2008.00409.x. Epub 2008 Apr 8. Review.


Degradation of nuclear factor kappa B during foot-and-mouth disease virus infection.

de Los Santos T, Diaz-San Segundo F, Grubman MJ.

J Virol. 2007 Dec;81(23):12803-15. Epub 2007 Sep 19.


Discrimination of sheep susceptible and resistant to transmissible spongiform encephalopathies by an haplotype specific monoclonal antibody.

Bilheude JM, Brun A, Morel N, Díaz San Segundo F, Lecroix S, Espinosa JC, González L, Steele P, Grassi J, Andréoletti O, Torres JM.

J Virol Methods. 2007 Nov;145(2):169-72. Epub 2007 Jul 5.


Reduced susceptibility to bovine spongiform encephalopathy prions in transgenic mice expressing a bovine PrP with five octapeptide repeats.

Brun A, Gutiérrez-Adán A, Castilla J, Pintado B, Díaz-San Segundo F, Cano MJ, Alamillo E, Espinosa JC, Torres JM.

J Gen Virol. 2007 Jun;88(Pt 6):1842-9.


DNA vaccination can break immunological tolerance to PrP in wild-type mice and attenuates prion disease after intracerebral challenge.

Fernandez-Borges N, Brun A, Whitton JL, Parra B, Diaz-San Segundo F, Salguero FJ, Torres JM, Rodriguez F.

J Virol. 2006 Oct;80(20):9970-6.


Distribution of the cellular prion protein (PrPC) in brains of livestock and domesticated species.

Díaz-San Segundo F, Salguero FJ, de Avila A, Espinosa JC, Torres JM, Brun A.

Acta Neuropathol. 2006 Nov;112(5):587-95. Epub 2006 Sep 7.


Selective lymphocyte depletion during the early stage of the immune response to foot-and-mouth disease virus infection in swine.

Díaz-San Segundo F, Salguero FJ, de Avila A, de Marco MM, Sánchez-Martín MA, Sevilla N.

J Virol. 2006 Mar;80(5):2369-79.


Vertical transmission of bovine spongiform encephalopathy prions evaluated in a transgenic mouse model.

Castilla J, Brun A, Díaz-San Segundo F, Salguero FJ, Gutiérrez-Adán A, Pintado B, Ramírez MA, del Riego L, Torres JM.

J Virol. 2005 Jul;79(13):8665-8.


Foot-and-mouth disease virus (FMDV) causes an acute disease that can be lethal for adult laboratory mice.

Salguero FJ, Sánchez-Martín MA, Díaz-San Segundo F, de Avila A, Sevilla N.

Virology. 2005 Feb 5;332(1):384-96.


Different behavior toward bovine spongiform encephalopathy infection of bovine prion protein transgenic mice with one extra repeat octapeptide insert mutation.

Castilla J, Gutiérrez-Adán A, Brun A, Pintado B, Parra B, Ramírez MA, Salguero FJ, Díaz San Segundo F, Rábano A, Cano MJ, Torres JM.

J Neurosci. 2004 Mar 3;24(9):2156-64.


African swine fever: Expression of interleukin-1 alpha and tumour necrosis factor-alpha by pulmonary intravascular macrophages.

Carrasco L, Núñez A, Salguero FJ, Díaz San Segundo F, Sánchez-Cordón P, Gómez-Villamandos JC, Sierra MA.

J Comp Pathol. 2002 Feb-Apr;126(2-3):194-201.


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