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Items: 38

1.

The Altered Transcriptome and DNA Methylation Profiles of Docetaxel Resistance in Breast Cancer PDX Models.

Gómez-Miragaya J, Morán S, Calleja-Cervantes ME, Collado-Sole A, Paré L, Gómez A, Serra V, Dobrolecki LE, Lewis MT, Diaz-Lagares A, Eroles P, Prat A, Esteller M, González-Suárez E.

Mol Cancer Res. 2019 Oct;17(10):2063-2076. doi: 10.1158/1541-7786.MCR-19-0040. Epub 2019 Jul 18.

PMID:
31320385
2.

Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer.

Palomeras S, Diaz-Lagares Á, Viñas G, Setien F, Ferreira HJ, Oliveras G, Crujeiras AB, Hernández A, Lum DH, Welm AL, Esteller M, Puig T.

Breast Cancer Res. 2019 Jul 5;21(1):79. doi: 10.1186/s13058-019-1160-x.

3.

The role of clonal communication and heterogeneity in breast cancer.

Martín-Pardillos A, Valls Chiva Á, Bande Vargas G, Hurtado Blanco P, Piñeiro Cid R, Guijarro PJ, Hümmer S, Bejar Serrano E, Rodriguez-Casanova A, Diaz-Lagares Á, Castellvi J, Miravet-Verde S, Serrano L, Lluch-Senar M, Sebastian V, Bribian A, López-Mascaraque L, López-López R, Ramón Y Cajal S.

BMC Cancer. 2019 Jul 5;19(1):666. doi: 10.1186/s12885-019-5883-y.

4.

DNA methylation screening after roux-en Y gastric bypass reveals the epigenetic signature stems from genes related to the surgery per se.

Nicoletti CF, Pinhel MAS, Diaz-Lagares A, Casanueva FF, Jácome A, Pinhanelli VC, de Oliveira BAP, Crujeiras AB, Nonino CB.

BMC Med Genomics. 2019 May 27;12(1):72. doi: 10.1186/s12920-019-0522-7.

5.

A two-gene epigenetic signature for the prediction of response to neoadjuvant chemotherapy in triple-negative breast cancer patients.

Pineda B, Diaz-Lagares A, Pérez-Fidalgo JA, Burgués O, González-Barrallo I, Crujeiras AB, Sandoval J, Esteller M, Lluch A, Eroles P.

Clin Epigenetics. 2019 Feb 20;11(1):33. doi: 10.1186/s13148-019-0626-0.

6.

Identification of an episignature of human colorectal cancer associated with obesity by genome-wide DNA methylation analysis.

Crujeiras AB, Morcillo S, Diaz-Lagares A, Sandoval J, Castellano-Castillo D, Torres E, Hervas D, Moran S, Esteller M, Macias-Gonzalez M, Casanueva FF, Tinahones FJ.

Int J Obes (Lond). 2019 Jan;43(1):176-188. doi: 10.1038/s41366-018-0065-6. Epub 2018 May 1.

PMID:
29717273
7.

An Epigenetic Signature in Adipose Tissue Is Linked to Nicotinamide N-Methyltransferase Gene Expression.

Crujeiras AB, Pissios P, Moreno-Navarrete JM, Diaz-Lagares A, Sandoval J, Gomez A, Ricart W, Esteller M, Casanueva FF, Fernandez-Real JM.

Mol Nutr Food Res. 2018 Apr 24:e1700933. doi: 10.1002/mnfr.201700933. [Epub ahead of print]

PMID:
29688621
8.

Epigenomic signature of adrenoleukodystrophy predicts compromised oligodendrocyte differentiation.

Schlüter A, Sandoval J, Fourcade S, Díaz-Lagares A, Ruiz M, Casaccia P, Esteller M, Pujol A.

Brain Pathol. 2018 Nov;28(6):902-919. doi: 10.1111/bpa.12595. Epub 2018 Apr 10.

PMID:
29476661
9.

Liquid Biopsy: From Basic Research to Clinical Practice.

Macías M, Alegre E, Díaz-Lagares A, Patiño A, Pérez-Gracia JL, Sanmamed M, López-López R, Varo N, González A.

Adv Clin Chem. 2018;83:73-119. doi: 10.1016/bs.acc.2017.10.003. Epub 2017 Nov 23. Review.

PMID:
29304904
10.

CD137 (4-1BB) Costimulation Modifies DNA Methylation in CD8+ T Cell-Relevant Genes.

Aznar MA, Labiano S, Diaz-Lagares A, Molina C, Garasa S, Azpilikueta A, Etxeberria I, Sanchez-Paulete AR, Korman AJ, Esteller M, Sandoval J, Melero I.

Cancer Immunol Res. 2018 Jan;6(1):69-78. doi: 10.1158/2326-6066.CIR-17-0159. Epub 2017 Nov 13.

11.

Translating cancer epigenomics into the clinic: focus on lung cancer.

Mari-Alexandre J, Diaz-Lagares A, Villalba M, Juan O, Crujeiras AB, Calvo A, Sandoval J.

Transl Res. 2017 Nov;189:76-92. doi: 10.1016/j.trsl.2017.05.008. Epub 2017 Jun 2. Review.

PMID:
28644958
12.

Obesity and menopause modify the epigenomic profile of breast cancer.

Crujeiras AB, Diaz-Lagares A, Stefansson OA, Macias-Gonzalez M, Sandoval J, Cueva J, Lopez-Lopez R, Moran S, Jonasson JG, Tryggvadottir L, Olafsdottir E, Tinahones FJ, Carreira MC, Casanueva FF, Esteller M.

Endocr Relat Cancer. 2017 Jul;24(7):351-363. doi: 10.1530/ERC-16-0565. Epub 2017 Apr 25.

PMID:
28442560
13.

DNA methylation map in circulating leukocytes mirrors subcutaneous adipose tissue methylation pattern: a genome-wide analysis from non-obese and obese patients.

Crujeiras AB, Diaz-Lagares A, Sandoval J, Milagro FI, Navas-Carretero S, Carreira MC, Gomez A, Hervas D, Monteiro MP, Casanueva FF, Esteller M, Martinez JA.

Sci Rep. 2017 Feb 17;7:41903. doi: 10.1038/srep41903.

14.

Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer.

Diaz-Lagares A, Crujeiras AB, Lopez-Serra P, Soler M, Setien F, Goyal A, Sandoval J, Hashimoto Y, Martinez-Cardús A, Gomez A, Heyn H, Moutinho C, Espada J, Vidal A, Paúles M, Galán M, Sala N, Akiyama Y, Martínez-Iniesta M, Farré L, Villanueva A, Gross M, Diederichs S, Guil S, Esteller M.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7535-E7544. Epub 2016 Nov 7.

15.

Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis.

Moran S, Martínez-Cardús A, Sayols S, Musulén E, Balañá C, Estival-Gonzalez A, Moutinho C, Heyn H, Diaz-Lagares A, de Moura MC, Stella GM, Comoglio PM, Ruiz-Miró M, Matias-Guiu X, Pazo-Cid R, Antón A, Lopez-Lopez R, Soler G, Longo F, Guerra I, Fernandez S, Assenov Y, Plass C, Morales R, Carles J, Bowtell D, Mileshkin L, Sia D, Tothill R, Tabernero J, Llovet JM, Esteller M.

Lancet Oncol. 2016 Oct;17(10):1386-1395. doi: 10.1016/S1470-2045(16)30297-2. Epub 2016 Aug 27.

PMID:
27575023
16.

Genome-wide DNA methylation pattern in visceral adipose tissue differentiates insulin-resistant from insulin-sensitive obese subjects.

Crujeiras AB, Diaz-Lagares A, Moreno-Navarrete JM, Sandoval J, Hervas D, Gomez A, Ricart W, Casanueva FF, Esteller M, Fernandez-Real JM.

Transl Res. 2016 Dec;178:13-24.e5. doi: 10.1016/j.trsl.2016.07.002. Epub 2016 Jul 15.

17.

MiR-204 silencing in intraepithelial to invasive cutaneous squamous cell carcinoma progression.

Toll A, Salgado R, Espinet B, Díaz-Lagares A, Hernández-Ruiz E, Andrades E, Sandoval J, Esteller M, Pujol RM, Hernández-Muñoz I.

Mol Cancer. 2016 Jul 25;15(1):53. doi: 10.1186/s12943-016-0537-z.

18.

Epigenetic alterations leading to TMPRSS4 promoter hypomethylation and protein overexpression predict poor prognosis in squamous lung cancer patients.

Villalba M, Diaz-Lagares A, Redrado M, de Aberasturi AL, Segura V, Bodegas ME, Pajares MJ, Pio R, Freire J, Gomez-Roman J, Montuenga LM, Esteller M, Sandoval J, Calvo A.

Oncotarget. 2016 Apr 19;7(16):22752-69. doi: 10.18632/oncotarget.8045.

19.

A Novel Epigenetic Signature for Early Diagnosis in Lung Cancer.

Diaz-Lagares A, Mendez-Gonzalez J, Hervas D, Saigi M, Pajares MJ, Garcia D, Crujerias AB, Pio R, Montuenga LM, Zulueta J, Nadal E, Rosell A, Esteller M, Sandoval J.

Clin Cancer Res. 2016 Jul 1;22(13):3361-71. doi: 10.1158/1078-0432.CCR-15-2346. Epub 2016 Feb 3.

20.

MiR-221 promotes stemness of breast cancer cells by targeting DNMT3b.

Roscigno G, Quintavalle C, Donnarumma E, Puoti I, Diaz-Lagares A, Iaboni M, Fiore D, Russo V, Todaro M, Romano G, Thomas R, Cortino G, Gaggianesi M, Esteller M, Croce CM, Condorelli G.

Oncotarget. 2016 Jan 5;7(1):580-92. doi: 10.18632/oncotarget.5979.

21.

Notch1 Pathway Activation Results from the Epigenetic Abrogation of Notch-Related MicroRNAs in Mycosis Fungoides.

Gallardo F, Sandoval J, Díaz-Lagares A, Garcia R, D'Altri T, González J, Alegre V, Servitje O, Crujeiras AB, Stefánsson ÓA, Espinet B, Hernández MI, Bellosillo B, Esteller M, Pujol RM, Bigas A, Espinosa L.

J Invest Dermatol. 2015 Dec;135(12):3144-3152. doi: 10.1038/jid.2015.328. Epub 2015 Aug 24.

22.

Genome-Wide DNA Methylation Analysis Identifies Novel Hypomethylated Non-Pericentromeric Genes with Potential Clinical Implications in ICF Syndrome.

Simo-Riudalbas L, Diaz-Lagares A, Gatto S, Gagliardi M, Crujeiras AB, Matarazzo MR, Esteller M, Sandoval J.

PLoS One. 2015 Jul 10;10(7):e0132517. doi: 10.1371/journal.pone.0132517. eCollection 2015.

23.

Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA.

Léveillé N, Melo CA, Rooijers K, Díaz-Lagares A, Melo SA, Korkmaz G, Lopes R, Moqadam FA, Maia AR, Wijchers PJ, Geeven G, den Boer ML, Kalluri R, de Laat W, Esteller M, Agami R.

Nat Commun. 2015 Mar 27;6:6520. doi: 10.1038/ncomms7520.

24.

MicroRNA expression profiling and DNA methylation signature for deregulated microRNA in cutaneous T-cell lymphoma.

Sandoval J, Díaz-Lagares A, Salgado R, Servitje O, Climent F, Ortiz-Romero PL, Pérez-Ferriols A, Garcia-Muret MP, Estrach T, Garcia M, Nonell L, Esteller M, Pujol RM, Espinet B, Gallardo F.

J Invest Dermatol. 2015 Apr;135(4):1128-1137. doi: 10.1038/jid.2014.487. Epub 2014 Nov 18.

25.

Pre-treatment circulating leptin/ghrelin ratio as a non-invasive marker to identify patients likely to regain the lost weight after an energy restriction treatment.

Crujeiras AB, Díaz-Lagares A, Abete I, Goyenechea E, Amil M, Martínez JA, Casanueva FF.

J Endocrinol Invest. 2014 Feb;37(2):119-26. doi: 10.1007/s40618-013-0004-2. Epub 2014 Jan 9.

PMID:
24497210
26.

MiR-221/222 target the DNA methyltransferase MGMT in glioma cells.

Quintavalle C, Mangani D, Roscigno G, Romano G, Diaz-Lagares A, Iaboni M, Donnarumma E, Fiore D, De Marinis P, Soini Y, Esteller M, Condorelli G.

PLoS One. 2013 Sep 19;8(9):e74466. doi: 10.1371/journal.pone.0074466. eCollection 2013.

27.

Association of weight regain with specific methylation levels in the NPY and POMC promoters in leukocytes of obese men: a translational study.

Crujeiras AB, Campion J, Díaz-Lagares A, Milagro FI, Goyenechea E, Abete I, Casanueva FF, Martínez JA.

Regul Pept. 2013 Sep 10;186:1-6. doi: 10.1016/j.regpep.2013.06.012. Epub 2013 Jul 5.

PMID:
23831408
28.

In vivo identification of an HLA-G complex as ubiquitinated protein circulating in exosomes.

Alegre E, Rebmann V, Lemaoult J, Rodriguez C, Horn PA, Díaz-Lagares A, Echeveste JI, González A.

Eur J Immunol. 2013 Jul;43(7):1933-9. doi: 10.1002/eji.201343318. Epub 2013 May 17.

29.

Oxidative stress associated to dysfunctional adipose tissue: a potential link between obesity, type 2 diabetes mellitus and breast cancer.

Crujeiras AB, Díaz-Lagares A, Carreira MC, Amil M, Casanueva FF.

Free Radic Res. 2013 Apr;47(4):243-56. doi: 10.3109/10715762.2013.772604. Epub 2013 Feb 26. Review.

PMID:
23409968
30.

Evaluation of multiple serum markers in advanced melanoma.

Díaz-Lagares A, Alegre E, Arroyo A, González-Cao M, Zudaire ME, Viteri S, Martín-Algarra S, González A.

Tumour Biol. 2011 Dec;32(6):1155-61. doi: 10.1007/s13277-011-0218-x. Epub 2011 Aug 20.

PMID:
21858537
31.

Evaluation of HLA-G5 plasmatic levels during pregnancy and relationship with the 14-bp polymorphism.

Gonzalez A, Alegre E, Torres MI, Díaz-Lagares A, Lorite P, Palomeque T, Arroyo A.

Am J Reprod Immunol. 2010 Nov;64(5):367-74. doi: 10.1111/j.1600-0897.2010.00855.x.

PMID:
20482523
32.

Detection of 3-nitrotyrosine-modified human leukocyte antigen-G in biological fluids.

Díaz-Lagares A, Alegre E, Gonzalez A.

Hum Immunol. 2009 Dec;70(12):976-80. doi: 10.1016/j.humimm.2009.07.018. Epub 2009 Aug 3.

PMID:
19651177
33.

Tyrosine nitration in the human leucocyte antigen-G-binding domain of the Ig-like transcript 2 protein.

Díaz-Lagares A, Alegre E, Arroyo A, Corrales FJ, González A.

FEBS J. 2009 Aug;276(15):4233-43. doi: 10.1111/j.1742-4658.2009.07131.x. Epub 2009 Jul 3.

34.

Nitric oxide produces HLA-G nitration and induces metalloprotease-dependent shedding creating a tolerogenic milieu.

Díaz-Lagares A, Alegre E, LeMaoult J, Carosella ED, González A.

Immunology. 2009 Mar;126(3):436-45. doi: 10.1111/j.1365-2567.2008.02911.x. Epub 2008 Sep 1.

35.

Preliminary results of the combination of bevacizumab and weekly Paclitaxel in advanced melanoma.

González-Cao M, Viteri S, Díaz-Lagares A, González A, Redondo P, Nieto Y, Espinós J, Chopitea A, Ponz M, Martín-Algarra S.

Oncology. 2008;74(1-2):12-6. doi: 10.1159/000138351. Epub 2008 Jun 9.

PMID:
18536525
36.

Study of the plasmatic levels of tryptophan and kynurenine throughout pregnancy.

Alegre E, López AS, Díaz-Lagares A, González A.

Clin Chim Acta. 2008 Jul 17;393(2):132-3. doi: 10.1016/j.cca.2008.03.011. Epub 2008 Mar 20. No abstract available.

PMID:
18402779
37.

Effect of 3-hydroxyanthranilic acid in the immunosuppressive molecules indoleamine dioxygenase and HLA-G in macrophages.

López AS, Alegre E, Díaz-Lagares A, García-Girón C, Coma MJ, González A.

Immunol Lett. 2008 Apr 15;117(1):91-5. doi: 10.1016/j.imlet.2008.01.001. Epub 2008 Feb 4.

PMID:
18289708
38.

Maternal antigen presenting cells are a source of plasmatic HLA-G during pregnancy: longitudinal study during pregnancy.

Alegre E, Díaz-Lagares A, Lemaoult J, López-Moratalla N, Carosella ED, González A.

Hum Immunol. 2007 Aug;68(8):661-7. Epub 2007 May 25.

PMID:
17678720

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