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Items: 1 to 50 of 112


Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform.

Da Li, Cao T, Sun X, Jin S, Di Xie, Huang X, Yang X, Carmichael GG, Taylor HS, Diano S, Huang Y.

Nat Commun. 2020 Jan 17;11(1):342. doi: 10.1038/s41467-019-14185-z.


Brain-to-pancreas signalling axis links nicotine and diabetes.

Bruschetta G, Diano S.

Nature. 2019 Oct;574(7778):336-337. doi: 10.1038/d41586-019-02975-w. No abstract available.


Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding.

Kim JD, Yoon NA, Jin S, Diano S.

Cell Metab. 2019 Nov 5;30(5):952-962.e5. doi: 10.1016/j.cmet.2019.08.010. Epub 2019 Sep 5.


Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects.

Diano S, Horvath TL, Mor G, Register T, Adams M, Harada N, Naftolin F.

Menopause. 2018 Nov;25(11):1201-1207. doi: 10.1097/GME.0000000000001219.


Overexpression of melanocortin 2 receptor accessory protein 2 (MRAP2) in adult paraventricular MC4R neurons regulates energy intake and expenditure.

Bruschetta G, Kim JD, Diano S, Chan LF.

Mol Metab. 2018 Dec;18:79-87. doi: 10.1016/j.molmet.2018.09.010. Epub 2018 Oct 4.


Mitochondrial Dynamics and Hypothalamic Regulation of Metabolism.

Jin S, Diano S.

Endocrinology. 2018 Oct 1;159(10):3596-3604. doi: 10.1210/en.2018-00667.


A new brain circuit in feeding control.

Diano S.

Science. 2018 Jul 6;361(6397):29-30. doi: 10.1126/science.aau1419. No abstract available.


Prolyl carboxypeptidase in Agouti-related Peptide neurons modulates food intake and body weight.

Bruschetta G, Jin S, Kim JD, Diano S.

Mol Metab. 2018 Apr;10:28-38. doi: 10.1016/j.molmet.2018.02.003. Epub 2018 Feb 8.


Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons.

Suyama S, Ralevski A, Liu ZW, Dietrich MO, Yada T, Simonds SE, Cowley MA, Gao XB, Diano S, Horvath TL.

Elife. 2017 Aug 1;6. pii: e25755. doi: 10.7554/eLife.25755.


Hypothalamic Ventromedial Lin28a Enhances Glucose Metabolism in Diet-Induced Obesity.

Kim JD, Toda C, Ramírez CM, Fernández-Hernando C, Diano S.

Diabetes. 2017 Aug;66(8):2102-2111. doi: 10.2337/db16-1558. Epub 2017 May 26.


POMC Neurons: From Birth to Death.

Toda C, Santoro A, Kim JD, Diano S.

Annu Rev Physiol. 2017 Feb 10;79:209-236. doi: 10.1146/annurev-physiol-022516-034110. Review.


DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons.

Santoro A, Campolo M, Liu C, Sesaki H, Meli R, Liu ZW, Kim JD, Diano S.

Cell Metab. 2017 Mar 7;25(3):647-660. doi: 10.1016/j.cmet.2017.01.003. Epub 2017 Feb 9.


Hypothalamic and pituitary expression of ghrelin receptor message is increased during lactation.

Abizaid A, Schioavo L, Diano S.

Neurosci Lett. 2016 Sep 19;631:126. doi: 10.1016/j.neulet.2016.07.025. No abstract available.


UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness.

Toda C, Kim JD, Impellizzeri D, Cuzzocrea S, Liu ZW, Diano S.

Cell. 2016 Feb 25;164(5):872-83. doi: 10.1016/j.cell.2016.02.010.


Women in Metabolism: Part 3.

Ashcroft F, Pearce E, Partridge L, Suomalainen A, Brunet A, Schulze A, Tseng YH, Sethi JK, Reue K, Kingwell B, McNally E, Cnop M, Hevener AL, Diano S.

Cell Metab. 2015 Dec 1;22(6):949-53. doi: 10.1016/j.cmet.2015.11.005.


AgRP Neurons Regulate Bone Mass.

Kim JG, Sun BH, Dietrich MO, Koch M, Yao GQ, Diano S, Insogna K, Horvath TL.

Cell Rep. 2015 Oct 6;13(1):8-14. doi: 10.1016/j.celrep.2015.08.070. Epub 2015 Sep 24.


Prolyl Endopeptidase (PREP) is Associated With Male Reproductive Functions and Gamete Physiology in Mice.

Dotolo R, Kim JD, Pariante P, Minucci S, Diano S.

J Cell Physiol. 2016 Mar;231(3):551-7. doi: 10.1002/jcp.25178. Epub 2015 Sep 18.



Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH.

Mol Metab. 2015 Mar 21;4(6):437-60. doi: 10.1016/j.molmet.2015.03.005. eCollection 2015 Jun. Review.


Hypothalamic POMC neurons promote cannabinoid-induced feeding.

Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, Horvath TL.

Nature. 2015 Mar 5;519(7541):45-50. doi: 10.1038/nature14260. Epub 2015 Feb 18.


Hormonal regulation of the hypothalamic melanocortin system.

Kim JD, Leyva S, Diano S.

Front Physiol. 2014 Dec 9;5:480. doi: 10.3389/fphys.2014.00480. eCollection 2014. Review.


Primate phencyclidine model of schizophrenia: sex-specific effects on cognition, brain derived neurotrophic factor, spine synapses, and dopamine turnover in prefrontal cortex.

Elsworth JD, Groman SM, Jentsch JD, Leranth C, Redmond DE Jr, Kim JD, Diano S, Roth RH.

Int J Neuropsychopharmacol. 2014 Oct 31;18(6). pii: pyu048. doi: 10.1093/ijnp/pyu048.


Mitochondrial UCP2 in the central regulation of metabolism.

Toda C, Diano S.

Best Pract Res Clin Endocrinol Metab. 2014 Oct;28(5):757-64. doi: 10.1016/j.beem.2014.02.006. Epub 2014 Mar 7. Review.


PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding.

Long L, Toda C, Jeong JK, Horvath TL, Diano S.

J Clin Invest. 2014 Sep;124(9):4017-27. doi: 10.1172/JCI76220. Epub 2014 Aug 1.


Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice.

Kim JD, Toda C, D'Agostino G, Zeiss CJ, DiLeone RJ, Elsworth JD, Kibbey RG, Chan O, Harvey BK, Richie CT, Savolainen M, Myöhänen T, Jeong JK, Diano S.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11876-81. doi: 10.1073/pnas.1406000111. Epub 2014 Jul 28. Erratum in: Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):14003.


A temperature hypothesis of hypothalamus-driven obesity.

Horvath TL, Stachenfeld NS, Diano S.

Yale J Biol Med. 2014 Jun 6;87(2):149-58. eCollection 2014 Jun. Review.


Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding.

Kim JG, Suyama S, Koch M, Jin S, Argente-Arizon P, Argente J, Liu ZW, Zimmer MR, Jeong JK, Szigeti-Buck K, Gao Y, Garcia-Caceres C, Yi CX, Salmaso N, Vaccarino FM, Chowen J, Diano S, Dietrich MO, Tschöp MH, Horvath TL.

Nat Neurosci. 2014 Jul;17(7):908-10. doi: 10.1038/nn.3725. Epub 2014 Jun 1.


Palmitoylethanolamide prevents metabolic alterations and restores leptin sensitivity in ovariectomized rats.

Mattace Raso G, Santoro A, Russo R, Simeoli R, Paciello O, Di Carlo C, Diano S, Calignano A, Meli R.

Endocrinology. 2014 Apr;155(4):1291-301. doi: 10.1210/en.2013-1823. Epub 2014 Jan 15.


Role of reactive oxygen species in hypothalamic regulation of energy metabolism.

Diano S.

Endocrinol Metab (Seoul). 2013 Mar;28(1):3-5. doi: 10.3803/EnM.2013.28.1.3. Review.


Prolyl carboxypeptidase mRNA expression in the mouse brain.

Jeong JK, Diano S.

Brain Res. 2014 Jan 13;1542:85-92. doi: 10.1016/j.brainres.2013.10.031. Epub 2013 Oct 24.


Ghrelin regulates hypothalamic prolyl carboxypeptidase expression in mice.

Kwon Jeong J, Dae Kim J, Diano S.

Mol Metab. 2013 Jan 11;2(1):23-30. doi: 10.1016/j.molmet.2013.01.002. eCollection 2013.


Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses.

Matarese G, Procaccini C, Menale C, Kim JG, Kim JD, Diano S, Diano N, De Rosa V, Dietrich MO, Horvath TL.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6193-8. doi: 10.1073/pnas.1210644110. Epub 2013 Mar 25.


Prolyl carboxypeptidase and its inhibitors in metabolism.

Jeong JK, Diano S.

Trends Endocrinol Metab. 2013 Feb;24(2):61-7. doi: 10.1016/j.tem.2012.11.001. Epub 2012 Dec 12.


Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.

Brown WH, Gillum MP, Lee HY, Camporez JP, Zhang XM, Jeong JK, Alves TC, Erion DM, Guigni BA, Kahn M, Samuel VT, Cravatt BF, Diano S, Shulman GI.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14966-71. doi: 10.1073/pnas.1212887109. Epub 2012 Aug 21.


Prolyl endopeptidase-deficient mice have reduced synaptic spine density in the CA1 region of the hippocampus, impaired LTP, and spatial learning and memory.

D'Agostino G, Kim JD, Liu ZW, Jeong JK, Suyama S, Calignano A, Gao XB, Schwartz M, Diano S.

Cereb Cortex. 2013 Aug;23(8):2007-14. doi: 10.1093/cercor/bhs199. Epub 2012 Jul 5.


Influence of a novel inhibitor (UM8190) of prolylcarboxypeptidase (PRCP) on appetite and thrombosis.

Rabey FM, Gadepalli RS, Diano S, Cheng Q, Tabrizian T, Gailani D, Rimoldi JM, Shariat-Madar Z.

Curr Med Chem. 2012;19(24):4194-206.


Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity.

Jeong JK, Szabo G, Raso GM, Meli R, Diano S.

Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1502-10. doi: 10.1152/ajpendo.00544.2011. Epub 2012 Mar 27.


2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism.

Jung KM, Clapper JR, Fu J, D'Agostino G, Guijarro A, Thongkham D, Avanesian A, Astarita G, DiPatrizio NV, Frontini A, Cinti S, Diano S, Piomelli D.

Cell Metab. 2012 Mar 7;15(3):299-310. doi: 10.1016/j.cmet.2012.01.021.


Susceptibility to a parkinsonian toxin varies during primate development.

Morrow BA, Roth RH, Redmond DE Jr, Diano S, Elsworth JD.

Exp Neurol. 2012 May;235(1):273-81. doi: 10.1016/j.expneurol.2012.02.005. Epub 2012 Feb 14.


Prolyl carboxypeptidase regulates energy expenditure and the thyroid axis.

Jeong JK, Szabo G, Kelly K, Diano S.

Endocrinology. 2012 Feb;153(2):683-9. doi: 10.1210/en.2011-1399. Epub 2011 Dec 27.


Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism.

Diano S, Horvath TL.

Trends Mol Med. 2012 Jan;18(1):52-8. doi: 10.1016/j.molmed.2011.08.003. Epub 2011 Sep 12. Review.


Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity.

Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser JL, Belsham DD, Sarruf DA, Schwartz MW, Bennett AM, Shanabrough M, Mobbs CV, Yang X, Gao XB, Horvath TL.

Nat Med. 2011 Aug 28;17(9):1121-7. doi: 10.1038/nm.2421. Erratum in: Nat Med. 2011 Oct;17(10):1320.


Nicotine decreases food intake through activation of POMC neurons.

Mineur YS, Abizaid A, Rao Y, Salas R, DiLeone RJ, Gündisch D, Diano S, De Biasi M, Horvath TL, Gao XB, Picciotto MR.

Science. 2011 Jun 10;332(6035):1330-2. doi: 10.1126/science.1201889.


Effects of chronic weight perturbation on energy homeostasis and brain structure in mice.

Ravussin Y, Gutman R, Diano S, Shanabrough M, Borok E, Sarman B, Lehmann A, LeDuc CA, Rosenbaum M, Horvath TL, Leibel RL.

Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1352-62. doi: 10.1152/ajpregu.00429.2010. Epub 2011 Mar 16.


New aspects of melanocortin signaling: a role for PRCP in α-MSH degradation.

Diano S.

Front Neuroendocrinol. 2011 Jan;32(1):70-83. doi: 10.1016/j.yfrne.2010.09.001. Epub 2010 Oct 25. Review.


Corticosterone regulates synaptic input organization of POMC and NPY/AgRP neurons in adult mice.

Gyengesi E, Liu ZW, D'Agostino G, Gan G, Horvath TL, Gao XB, Diano S.

Endocrinology. 2010 Nov;151(11):5395-402. doi: 10.1210/en.2010-0681. Epub 2010 Sep 15.


Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity.

Dietrich MO, Antunes C, Geliang G, Liu ZW, Borok E, Nie Y, Xu AW, Souza DO, Gao Q, Diano S, Gao XB, Horvath TL.

J Neurosci. 2010 Sep 1;30(35):11815-25. doi: 10.1523/JNEUROSCI.2234-10.2010.


Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity.

Horvath TL, Sarman B, García-Cáceres C, Enriori PJ, Sotonyi P, Shanabrough M, Borok E, Argente J, Chowen JA, Perez-Tilve D, Pfluger PT, Brönneke HS, Levin BE, Diano S, Cowley MA, Tschöp MH.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14875-80. doi: 10.1073/pnas.1004282107. Epub 2010 Aug 2.


A sympathetic view on free radicals in diabetes.

Diano S, Horvath TL.

Neuron. 2010 Jun 24;66(6):809-11. doi: 10.1016/j.neuron.2010.06.011.


Alpha-melanocyte stimulating hormone: production and degradation.

D'Agostino G, Diano S.

J Mol Med (Berl). 2010 Dec;88(12):1195-201. doi: 10.1007/s00109-010-0651-0. Epub 2010 Jul 10. Review.


Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding.

Leinninger GM, Jo YH, Leshan RL, Louis GW, Yang H, Barrera JG, Wilson H, Opland DM, Faouzi MA, Gong Y, Jones JC, Rhodes CJ, Chua S Jr, Diano S, Horvath TL, Seeley RJ, Becker JB, Münzberg H, Myers MG Jr.

Cell Metab. 2009 Aug;10(2):89-98. doi: 10.1016/j.cmet.2009.06.011.

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