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Items: 1 to 50 of 121

1.

Cellular senescence contributes to age-dependent changes in circulating extracellular vesicle cargo and function.

Alibhai FJ, Lim F, Yeganeh A, DiStefano PV, Binesh-Marvasti T, Belfiore A, Wlodarek L, Gustafson D, Millar S, Li SH, Weisel RD, Fish JE, Li RK.

Aging Cell. 2020 Mar;19(3):e13103. doi: 10.1111/acel.13103. Epub 2020 Jan 21.

2.

VEGF signalling enhances lesion burden in KRIT1 deficient mice.

DiStefano PV, Glading AJ.

J Cell Mol Med. 2020 Jan;24(1):632-639. doi: 10.1111/jcmm.14773. Epub 2019 Nov 20.

3.

Regulation of CCL2 expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA.

Khyzha N, Khor M, DiStefano PV, Wang L, Matic L, Hedin U, Wilson MD, Maegdefessel L, Fish JE.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16410-16419. doi: 10.1073/pnas.1904108116. Epub 2019 Jul 26.

4.

Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library.

Merkouris S, Barde YA, Binley KE, Allen ND, Stepanov AV, Wu NC, Grande G, Lin CW, Li M, Nan X, Chacon-Fernandez P, DiStefano PS, Lindsay RM, Lerner RA, Xie J.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7023-E7032. doi: 10.1073/pnas.1806660115. Epub 2018 Jul 9.

5.

The transcriptional regulator CCCTC-binding factor limits oxidative stress in endothelial cells.

Roy AR, Ahmed A, DiStefano PV, Chi L, Khyzha N, Galjart N, Wilson MD, Fish JE, Delgado-Olguín P.

J Biol Chem. 2018 Jun 1;293(22):8449-8461. doi: 10.1074/jbc.M117.814699. Epub 2018 Apr 2.

6.

Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain.

Nikolaev SI, Vetiska S, Bonilla X, Boudreau E, Jauhiainen S, Rezai Jahromi B, Khyzha N, DiStefano PV, Suutarinen S, Kiehl TR, Mendes Pereira V, Herman AM, Krings T, Andrade-Barazarte H, Tung T, Valiante T, Zadeh G, Tymianski M, Rauramaa T, Ylä-Herttuala S, Wythe JD, Antonarakis SE, Frösen J, Fish JE, Radovanovic I.

N Engl J Med. 2018 Jan 18;378(3):250-261. doi: 10.1056/NEJMoa1709449. Epub 2018 Jan 3.

7.

Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.

Goitre L, DiStefano PV, Moglia A, Nobiletti N, Baldini E, Trabalzini L, Keubel J, Trapani E, Shuvaev VV, Muzykantov VR, Sarelius IH, Retta SF, Glading AJ.

Sci Rep. 2017 Aug 15;7(1):8296. doi: 10.1038/s41598-017-08373-4.

8.

Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier.

DiStefano PV, Smrcka AV, Glading AJ.

PLoS One. 2016 Sep 9;11(9):e0162338. doi: 10.1371/journal.pone.0162338. eCollection 2016.

9.

KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling.

DiStefano PV, Kuebel JM, Sarelius IH, Glading AJ.

J Biol Chem. 2014 Nov 21;289(47):33054-65. doi: 10.1074/jbc.M114.582304. Epub 2014 Oct 15.

11.

Translating the human microbiome.

Brown J, de Vos WM, DiStefano PS, Doré J, Huttenhower C, Knight R, Lawley TD, Raes J, Turnbaugh P.

Nat Biotechnol. 2013 Apr;31(4):304-8. doi: 10.1038/nbt.2543. No abstract available.

PMID:
23563424
12.

Mitochondrial ATP-sensitive potassium channel activity and hypoxic preconditioning are independent of an inwardly rectifying potassium channel subunit in Caenorhabditis elegans.

Wojtovich AP, DiStefano P, Sherman T, Brookes PS, Nehrke K.

FEBS Lett. 2012 Feb 17;586(4):428-34. doi: 10.1016/j.febslet.2012.01.021. Epub 2012 Jan 21.

13.

Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity.

Longo KA, Govek EK, Nolan A, McDonagh T, Charoenthongtrakul S, Giuliana DJ, Morgan K, Hixon J, Zhou C, Kelder B, Kopchick JJ, Saunders JO, Navia MA, Curtis R, DiStefano PS, Geddes BJ.

J Pharmacol Exp Ther. 2011 Oct;339(1):115-24. doi: 10.1124/jpet.111.183764. Epub 2011 Jul 20. Erratum in: J Pharmacol Exp Ther. 2012 Mar;340(3):810.

PMID:
21775475
14.

Incidence and clinical relevance of uncontrolled ventricular rate during atrial fibrillation in heart failure patients treated with cardiac resynchronization therapy.

Boriani G, Gasparini M, Landolina M, Lunati M, Proclemer A, Lonardi G, Iacopino S, Rahue W, Biffi M, DiStefano P, Grammatico A, Santini M; ClinicalService cardiac centres.

Eur J Heart Fail. 2011 Aug;13(8):868-76. doi: 10.1093/eurjhf/hfr046. Epub 2011 May 10.

15.

SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183.

Huber JL, McBurney MW, Distefano PS, McDonagh T.

Future Med Chem. 2010 Dec;2(12):1751-9. doi: 10.4155/fmc.10.257.

PMID:
21428798
16.

Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps.

Qi Y, Longo KA, Giuliana DJ, Gagne S, McDonagh T, Govek E, Nolan A, Zou C, Morgan K, Hixon J, Saunders JO, Distefano PS, Geddes BJ.

BMC Physiol. 2011 Jan 6;11:1. doi: 10.1186/1472-6793-11-1.

17.

The 24-hour respiratory quotient predicts energy intake and changes in body mass.

Longo KA, Charoenthongtrakul S, Giuliana DJ, Govek EK, McDonagh T, Distefano PS, Geddes BJ.

Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R747-54. doi: 10.1152/ajpregu.00476.2009. Epub 2009 Dec 16.

18.

Daily energy balance in growth hormone receptor/binding protein (GHR -/-) gene-disrupted mice is achieved through an increase in dark-phase energy efficiency.

Longo KA, Berryman DE, Kelder B, Charoenthongtrakul S, Distefano PS, Geddes BJ, Kopchick JJ.

Growth Horm IGF Res. 2010 Feb;20(1):73-9. doi: 10.1016/j.ghir.2009.08.002. Epub 2009 Sep 10.

19.

Enhanced gastrointestinal motility with orally active ghrelin receptor agonists.

Charoenthongtrakul S, Giuliana D, Longo KA, Govek EK, Nolan A, Gagne S, Morgan K, Hixon J, Flynn N, Murphy BJ, Hernández AS, Li J, Tino JA, Gordon DA, DiStefano PS, Geddes BJ.

J Pharmacol Exp Ther. 2009 Jun;329(3):1178-86. doi: 10.1124/jpet.108.150193. Epub 2009 Feb 27.

PMID:
19252061
20.

Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 expression.

Cabodi S, Morello V, Masi A, Cicchi R, Broggio C, Distefano P, Brunelli E, Silengo L, Pavone F, Arcangeli A, Turco E, Tarone G, Moro L, Defilippi P.

J Cell Physiol. 2009 Feb;218(2):294-303. doi: 10.1002/jcp.21603.

PMID:
18844239
21.

Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice.

Longo KA, Charoenthongtrakul S, Giuliana DJ, Govek EK, McDonagh T, Qi Y, DiStefano PS, Geddes BJ.

Regul Pept. 2008 Oct 9;150(1-3):55-61. doi: 10.1016/j.regpep.2008.03.011. Epub 2008 Mar 30.

PMID:
18453014
22.

Rate control in patients with pacemaker affected by brady-tachy form of sick sinus syndrome.

Boriani G, Padeletti L, Santini M, Gulizia M, Orazi S, Botto G, Capucci A, Biffi M, Martignani C, Ricci R, Vimercati M, DiStefano P, Grammatico A.

Am Heart J. 2007 Jul;154(1):193-200.

PMID:
17584576
23.

Insulin resistance, glycemic control and adiposity: key determinants of healthy lifespan.

DiStefano PS, Curtis R, Geddes BJ.

Curr Alzheimer Res. 2007 Apr;4(2):153-7. Review.

PMID:
17430240
24.

Clustering of ventricular tachyarrhythmias in heart failure patients implanted with a biventricular cardioverter defibrillator.

Lunati M, Gasparini M, Bocchiardo M, Curnis A, Landolina M, Carboni A, Luzzi G, Zanotto G, Ravazzi P, Magenta G, Denaro A, Distefano P, Grammatico A; InSync ICD Italian Registry Investigators.

J Cardiovasc Electrophysiol. 2006 Dec;17(12):1299-306.

PMID:
17239095
25.

Proapoptotic effects of NARC 1 (= PCSK9), the gene encoding a novel serine proteinase.

Bingham B, Shen R, Kotnis S, Lo CF, Ozenberger BA, Ghosh N, Kennedy JD, Jacobsen JS, Grenier JM, DiStefano PS, Chiang LW, Wood A.

Cytometry A. 2006 Nov 1;69(11):1123-31.

26.
27.

[Health effects of environmental contamination due to volcanic ash of Mount Etna in autumn 2002].

Fano V, Cernigliaro A, Scondotto S, Cuccia M, Forastiere F, Nicolosi A, Oliveri C, Scillieri R, Distefano P, Perucci CA.

Epidemiol Prev. 2005 May-Aug;29(3-4):180-7. Italian.

28.

Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage.

Solomon JM, Pasupuleti R, Xu L, McDonagh T, Curtis R, DiStefano PS, Huber LJ.

Mol Cell Biol. 2006 Jan;26(1):28-38.

29.

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

Napper AD, Hixon J, McDonagh T, Keavey K, Pons JF, Barker J, Yau WT, Amouzegh P, Flegg A, Hamelin E, Thomas RJ, Kates M, Jones S, Navia MA, Saunders JO, DiStefano PS, Curtis R.

J Med Chem. 2005 Dec 15;48(25):8045-54. Erratum in: J Med Chem. 2007 Mar 8;50(5):1086.

PMID:
16335928
30.

Microplate filtration assay for nicotinamide release from NAD using a boronic acid resin.

McDonagh T, Hixon J, DiStefano PS, Curtis R, Napper AD.

Methods. 2005 Aug;36(4):346-50.

PMID:
16085423
31.

Ageing and metabolism: drug discovery opportunities.

Curtis R, Geesaman BJ, DiStefano PS.

Nat Rev Drug Discov. 2005 Jul;4(7):569-80. Review.

PMID:
15976816
32.

Substrate-specific activation of sirtuins by resveratrol.

Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK.

J Biol Chem. 2005 Apr 29;280(17):17038-45. Epub 2005 Jan 31.

33.

The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans.

Apfeld J, O'Connor G, McDonagh T, DiStefano PS, Curtis R.

Genes Dev. 2004 Dec 15;18(24):3004-9. Epub 2004 Dec 1. Erratum in: Genes Dev. 2005 Feb 1;19(3):411. Genes Dev. 2005 Jan 1;19(1):188.

34.

Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island.

Viala J, Chaput C, Boneca IG, Cardona A, Girardin SE, Moran AP, Athman R, Mémet S, Huerre MR, Coyle AJ, DiStefano PS, Sansonetti PJ, Labigne A, Bertin J, Philpott DJ, Ferrero RL.

Nat Immunol. 2004 Nov;5(11):1166-74. Epub 2004 Oct 17.

35.

Functional characterization of Narc 1, a novel proteinase related to proteinase K.

Naureckiene S, Ma L, Sreekumar K, Purandare U, Lo CF, Huang Y, Chiang LW, Grenier JM, Ozenberger BA, Jacobsen JS, Kennedy JD, DiStefano PS, Wood A, Bingham B.

Arch Biochem Biophys. 2003 Dec 1;420(1):55-67.

PMID:
14622975
36.

Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.

Yu FH, Westenbroek RE, Silos-Santiago I, McCormick KA, Lawson D, Ge P, Ferriera H, Lilly J, DiStefano PS, Catterall WA, Scheuer T, Curtis R.

J Neurosci. 2003 Aug 20;23(20):7577-85.

37.

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan.

Girardin SE, Boneca IG, Carneiro LA, Antignac A, Jéhanno M, Viala J, Tedin K, Taha MK, Labigne A, Zähringer U, Coyle AJ, DiStefano PS, Bertin J, Sansonetti PJ, Philpott DJ.

Science. 2003 Jun 6;300(5625):1584-7.

38.

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.

Grenier JM, Wang L, Manji GA, Huang WJ, Al-Garawi A, Kelly R, Carlson A, Merriam S, Lora JM, Briskin M, DiStefano PS, Bertin J.

FEBS Lett. 2002 Oct 23;530(1-3):73-8.

39.

A requirement for CARMA1 in TCR-induced NF-kappa B activation.

Wang D, You Y, Case SM, McAllister-Lucas LM, Wang L, DiStefano PS, Nuñez G, Bertin J, Lin X.

Nat Immunol. 2002 Sep;3(9):830-5. Epub 2002 Aug 5.

PMID:
12154356
40.

TRPV3 is a calcium-permeable temperature-sensitive cation channel.

Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE.

Nature. 2002 Jul 11;418(6894):181-6. Epub 2002 Jun 23.

PMID:
12077604
41.

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing.

Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J.

J Biol Chem. 2002 Aug 16;277(33):29874-80. Epub 2002 May 17.

42.

DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein.

Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ Jr, DiStefano PS, Chiang LW, Greenberg ME.

Science. 2002 Apr 19;296(5567):530-4.

43.

Differential modulation of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 subunits.

Qu Y, Curtis R, Lawson D, Gilbride K, Ge P, DiStefano PS, Silos-Santiago I, Catterall WA, Scheuer T.

Mol Cell Neurosci. 2001 Nov;18(5):570-80.

PMID:
11922146
44.

A novel membrane potential-sensitive fluorescent dye improves cell-based assays for ion channels.

Baxter DF, Kirk M, Garcia AF, Raimondi A, Holmqvist MH, Flint KK, Bojanic D, Distefano PS, Curtis R, Xie Y.

J Biomol Screen. 2002 Feb;7(1):79-85.

PMID:
11897058
45.

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.

Razmara M, Srinivasula SM, Wang L, Poyet JL, Geddes BJ, DiStefano PS, Bertin J, Alnemri ES.

J Biol Chem. 2002 Apr 19;277(16):13952-8. Epub 2002 Jan 30.

46.

Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain.

Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, Rhodes KJ, Distefano PS, An WF.

Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):1035-40.

47.

PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B.

Manji GA, Wang L, Geddes BJ, Brown M, Merriam S, Al-Garawi A, Mak S, Lora JM, Briskin M, Jurman M, Cao J, DiStefano PS, Bertin J.

J Biol Chem. 2002 Mar 29;277(13):11570-5. Epub 2002 Jan 10.

48.

Reduced Ia-afferent-mediated Hoffman reflex in streptozotocin-induced diabetic rats.

Tonra JR, Cliffer KD, Carson SR, Lindsay RM, Bodine SC, DiStefano PS.

Exp Neurol. 2001 Nov;172(1):220-7.

PMID:
11681854
49.

A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2.

Khursigara G, Bertin J, Yano H, Moffett H, DiStefano PS, Chao MV.

J Neurosci. 2001 Aug 15;21(16):5854-63.

50.

Neurotrophin-3 is required for the survival-differentiation of subsets of developing enteric neurons.

Chalazonitis A, Pham TD, Rothman TP, DiStefano PS, Bothwell M, Blair-Flynn J, Tessarollo L, Gershon MD.

J Neurosci. 2001 Aug 1;21(15):5620-36.

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