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Items: 16


Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ.

Uehara M, McGrath MM, Ohori S, Solhjou Z, Banouni N, Routray S, Evans C, DiNitto JP, Elkhal A, Turka LA, Strom TB, Tullius SG, Winkler DG, Azzi J, Abdi R.

Nat Commun. 2017 Oct 16;8(1):951. doi: 10.1038/s41467-017-00982-x.


The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation.

Chiu H, Mallya S, Nguyen P, Mai A, Jackson LV, Winkler DG, DiNitto JP, Brophy EE, McGovern K, Kutok JL, Fruman DA.

Front Immunol. 2017 Jun 30;8:747. doi: 10.3389/fimmu.2017.00747. eCollection 2017.


Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate.

Evans CA, Liu T, Lescarbeau A, Nair SJ, Grenier L, Pradeilles JA, Glenadel Q, Tibbitts T, Rowley AM, DiNitto JP, Brophy EE, O'Hearn EL, Ali JA, Winkler DG, Goldstein SI, O'Hearn P, Martin CM, Hoyt JG, Soglia JR, Cheung C, Pink MM, Proctor JL, Palombella VJ, Tremblay MR, Castro AC.

ACS Med Chem Lett. 2016 Jul 22;7(9):862-7. doi: 10.1021/acsmedchemlett.6b00238. eCollection 2016 Sep 8.


PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models.

Winkler DG, Faia KL, DiNitto JP, Ali JA, White KF, Brophy EE, Pink MM, Proctor JL, Lussier J, Martin CM, Hoyt JG, Tillotson B, Murphy EL, Lim AR, Thomas BD, Macdougall JR, Ren P, Liu Y, Li LS, Jessen KA, Fritz CC, Dunbar JL, Porter JR, Rommel C, Palombella VJ, Changelian PS, Kutok JL.

Chem Biol. 2013 Nov 21;20(11):1364-74. doi: 10.1016/j.chembiol.2013.09.017. Epub 2013 Nov 7.


Molecular mechanisms of drug resistance in tyrosine kinases cAbl and cKit.

DiNitto JP, Wu JC.

Crit Rev Biochem Mol Biol. 2011 Aug;46(4):295-309. doi: 10.3109/10409238.2011.578612. Epub 2011 May 4. Review.


Continuous fluorescence-based method for assessing dicer cleavage efficiency reveals 3' overhang nucleotide preference.

DiNitto JP, Wang L, Wu JC.

Biotechniques. 2010 Apr;48(4):303-11. doi: 10.2144/000113402.


Specificity and membrane partitioning of Grsp1 signaling complexes with Grp1 family Arf exchange factors.

DiNitto JP, Lee MT, Malaby AW, Lambright DG.

Biochemistry. 2010 Jul 27;49(29):6083-92. doi: 10.1021/bi1000454.


Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance.

DiNitto JP, Deshmukh GD, Zhang Y, Jacques SL, Coli R, Worrall JW, Diehl W, English JM, Wu JC.

J Biochem. 2010 Apr;147(4):601-9. doi: 10.1093/jb/mvq015. Epub 2010 Feb 10.


The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay.

Tecle H, Feru F, Liu H, Kuhn C, Rennie G, Morris M, Shao J, Cheng AC, Gikunju D, Miret J, Coli R, Xi SH, Clugston SL, Low S, Kazmirski S, Ding YH, Cao Q, Johnson TL, Deshmukh GD, DiNitto JP, Wu JC, English JM.

Chem Biol Drug Des. 2009 Dec;74(6):547-59. doi: 10.1111/j.1747-0285.2009.00884.x. Epub 2009 Oct 20.


KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients.

Gajiwala KS, Wu JC, Christensen J, Deshmukh GD, Diehl W, DiNitto JP, English JM, Greig MJ, He YA, Jacques SL, Lunney EA, McTigue M, Molina D, Quenzer T, Wells PA, Yu X, Zhang Y, Zou A, Emmett MR, Marshall AG, Zhang HM, Demetri GD.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1542-7. doi: 10.1073/pnas.0812413106. Epub 2009 Jan 21.


Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors.

DiNitto JP, Delprato A, Gabe Lee MT, Cronin TC, Huang S, Guilherme A, Czech MP, Lambright DG.

Mol Cell. 2007 Nov 30;28(4):569-83.


Membrane and juxtamembrane targeting by PH and PTB domains.

DiNitto JP, Lambright DG.

Biochim Biophys Acta. 2006 Aug;1761(8):850-67. Epub 2006 May 6. Review.


Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains.

Cronin TC, DiNitto JP, Czech MP, Lambright DG.

EMBO J. 2004 Oct 1;23(19):3711-20. Epub 2004 Sep 9.


Membrane recognition and targeting by lipid-binding domains.

DiNitto JP, Cronin TC, Lambright DG.

Sci STKE. 2003 Dec 16;2003(213):re16. Review.


Mutual induced fit binding of Xenopus ribosomal protein L5 to 5S rRNA.

DiNitto JP, Huber PW.

J Mol Biol. 2003 Jul 25;330(5):979-92.


A role for aromatic amino acids in the binding of Xenopus ribosomal protein L5 to 5S rRNA.

DiNitto JP, Huber PW.

Biochemistry. 2001 Oct 23;40(42):12645-53.


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