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Items: 48

1.

Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists.

Layton ME, Kelly MJ 3rd, Rodzinak KJ, Sanderson PE, Young SD, Bednar RA, Dilella AG, McDonald TP, Wang H, Mosser SD, Fay JF, Cunningham ME, Reiss DR, Fandozzi C, Trainor N, Liang A, Lis EV, Seabrook GR, Urban MO, Yergey J, Koblan KS.

ACS Chem Neurosci. 2011 Jul 20;2(7):352-62. doi: 10.1021/cn200013d. Epub 2011 Apr 15.

2.

A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson's disease.

Le Poul E, Boléa C, Girard F, Poli S, Charvin D, Campo B, Bortoli J, Bessif A, Luo B, Koser AJ, Hodge LM, Smith KM, DiLella AG, Liverton N, Hess F, Browne SE, Reynolds IJ.

J Pharmacol Exp Ther. 2012 Oct;343(1):167-77. doi: 10.1124/jpet.112.196063. Epub 2012 Jul 11.

PMID:
22787118
3.

Molecular profiling of a 6-hydroxydopamine model of Parkinson's disease.

Na SJ, DiLella AG, Lis EV, Jones K, Levine DM, Stone DJ, Hess JF.

Neurochem Res. 2010 May;35(5):761-72. doi: 10.1007/s11064-010-0133-3. Epub 2010 Feb 19.

PMID:
20169470
4.

Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.

Yang ZQ, Barrow JC, Shipe WD, Schlegel KA, Shu Y, Yang FV, Lindsley CW, Rittle KE, Bock MG, Hartman GD, Uebele VN, Nuss CE, Fox SV, Kraus RL, Doran SM, Connolly TM, Tang C, Ballard JE, Kuo Y, Adarayan ED, Prueksaritanont T, Zrada MM, Marino MJ, Graufelds VK, DiLella AG, Reynolds IJ, Vargas HM, Bunting PB, Woltmann RF, Magee MM, Koblan KS, Renger JJ.

J Med Chem. 2008 Oct 23;51(20):6471-7. doi: 10.1021/jm800830n. Epub 2008 Sep 26.

PMID:
18817368
5.

Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist.

Liverton NJ, Bednar RA, Bednar B, Butcher JW, Claiborne CF, Claremon DA, Cunningham M, DiLella AG, Gaul SL, Libby BE, Lyle EA, Lynch JJ, McCauley JA, Mosser SD, Nguyen KT, Stump GL, Sun H, Wang H, Yergey J, Koblan KS.

J Med Chem. 2007 Feb 22;50(4):807-19. Epub 2007 Jan 24.

PMID:
17249648
6.

Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment.

Marino MJ, Williams DL Jr, O'Brien JA, Valenti O, McDonald TP, Clements MK, Wang R, DiLella AG, Hess JF, Kinney GG, Conn PJ.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13668-73. Epub 2003 Oct 30.

7.

Group III metabotropic glutamate receptor-mediated modulation of the striatopallidal synapse.

Valenti O, Marino MJ, Wittmann M, Lis E, DiLella AG, Kinney GG, Conn PJ.

J Neurosci. 2003 Aug 6;23(18):7218-26.

8.

A role for the melanocortin 4 receptor in sexual function.

Van der Ploeg LH, Martin WJ, Howard AD, Nargund RP, Austin CP, Guan X, Drisko J, Cashen D, Sebhat I, Patchett AA, Figueroa DJ, DiLella AG, Connolly BM, Weinberg DH, Tan CP, Palyha OC, Pong SS, MacNeil T, Rosenblum C, Vongs A, Tang R, Yu H, Sailer AW, Fong TM, Huang C, Tota MR, Chang RS, Stearns R, Tamvakopoulos C, Christ G, Drazen DL, Spar BD, Nelson RJ, MacIntyre DE.

Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11381-6. Epub 2002 Aug 9.

9.

Identification of genes differentially expressed in benign prostatic hyperplasia.

DiLella AG, Toner TJ, Austin CP, Connolly BM.

J Histochem Cytochem. 2001 May;49(5):669-70.

PMID:
11304808
10.

Active site cavity of herpesvirus proteases revealed by the crystal structure of herpes simplex virus protease/inhibitor complex.

Hoog SS, Smith WW, Qiu X, Janson CA, Hellmig B, McQueney MS, O'Donnell K, O'Shannessy D, DiLella AG, Debouck C, Abdel-Meguid SS.

Biochemistry. 1997 Nov 18;36(46):14023-9.

PMID:
9369473
11.

Unique fold and active site in cytomegalovirus protease.

Qiu X, Culp JS, DiLella AG, Hellmig B, Hoog SS, Janson CA, Smith WW, Abdel-Meguid SS.

Nature. 1996 Sep 19;383(6597):275-9.

PMID:
8805707
12.

Localization of the human stress responsive MAP kinase-like CSAIDs binding protein (CSBP) gene to chromosome 6q21.3/21.2.

McDonnell PC, DiLella AG, Lee JC, Young PR.

Genomics. 1995 Sep 1;29(1):301-2. No abstract available.

PMID:
8530093
13.

Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1.

Hendrickson BA, Zhang W, Craig RJ, Jin YJ, Bierer BE, Burakoff S, DiLella AG.

Gene. 1993 Dec 8;134(2):271-5.

PMID:
7505249
14.

High-level production of biologically active human cytosolic phospholipase A2 in baculovirus-infected insect cells.

Amegadzie BY, Jiampetti D, Craig RJ, Appelbaum E, Shatzman AR, Mayer RJ, DiLella AG.

Gene. 1993 Jun 30;128(2):307-8.

PMID:
8514199
15.

Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13.

DiLella AG, Hawkins A, Craig RJ, Schreiber SL, Griffin CA.

Biochem Biophys Res Commun. 1992 Dec 15;189(2):819-23.

PMID:
1281998
16.

Molecular cloning and characterization of the major endothelin receptor subtype in porcine cerebellum.

Elshourbagy NA, Lee JA, Korman DR, Nuthalaganti P, Sylvester DR, Dilella AG, Sutiphong JA, Kumar CS.

Mol Pharmacol. 1992 Mar;41(3):465-73.

PMID:
1312214
17.

Characterization of the human FKBP-12 gene and related pseudogenes.

DiLella AG, Craig RJ.

Transplant Proc. 1991 Dec;23(6):2875-9. Review. No abstract available.

PMID:
1721302
18.

Chromosomal assignment of the human immunophilin FKBP-12 gene.

DiLella AG.

Biochem Biophys Res Commun. 1991 Sep 30;179(3):1427-33.

PMID:
1930186
19.
20.

Expression of human preproendothelin-1 cDNA in COS cells results in the production of mature vasoactive endothelin-1.

DiLella AG, Ohlstein E, Elshourbagy N, Bhatnagar PK, Nambi P, DeWolf WE Jr, Caltabiano MM.

Biochem Biophys Res Commun. 1991 Mar 15;175(2):697-705.

PMID:
2018512
21.

Vectors, promoters, and expression of genes in chick embryos.

Chen HY, Garber EA, Mills E, Smith J, Kopchick JJ, DiLella AG, Smith RG.

J Reprod Fertil Suppl. 1990;41:173-82.

PMID:
2170640
22.

A bird zinc-finger protein closely related to ZFY.

DiLella AG, Page DC, Smith RG.

New Biol. 1990 Jan;2(1):49-56.

PMID:
2078552
23.

Utility of firefly luciferase as a reporter gene for promoter activity in transgenic mice.

DiLella AG, Hope DA, Chen H, Trumbauer M, Schwartz RJ, Smith RG.

Nucleic Acids Res. 1988 May 11;16(9):4159. No abstract available.

24.

Phenylalanine hydroxylase deficiency caused by a single base substitution in an exon of the human phenylalanine hydroxylase gene.

Lichter-Konecki U, Konecki DS, DiLella AG, Brayton K, Marvit J, Hahn TM, Trefz FK, Woo SL.

Biochemistry. 1988 Apr 19;27(8):2881-5.

PMID:
2840952
25.

Screening for phenylketonuria mutations by DNA amplification with the polymerase chain reaction.

DiLella AG, Huang WM, Woo SL.

Lancet. 1988 Mar 5;1(8584):497-9.

PMID:
2893918
26.

Molecular basis of phenylketonuria and its clinical applications.

DiLella AG, Woo SL.

Mol Biol Med. 1987 Aug;4(4):183-92. Review. No abstract available.

PMID:
2890077
27.

GT to AT transition at a splice donor site causes skipping of the preceding exon in phenylketonuria.

Marvit J, DiLella AG, Brayton K, Ledley FD, Robson KJ, Woo SL.

Nucleic Acids Res. 1987 Jul 24;15(14):5613-28.

28.

An amino-acid substitution involved in phenylketonuria is in linkage disequilibrium with DNA haplotype 2.

DiLella AG, Marvit J, Brayton K, Woo SL.

Nature. 1987 May 28-Jun 3;327(6120):333-6.

PMID:
2884570
29.

Polymorphic DNA haplotypes at the human phenylalanine hydroxylase locus and their relationship with phenylketonuria.

Chakraborty R, Lidsky AS, Daiger SP, Güttler F, Sullivan S, Dilella AG, Woo SL.

Hum Genet. 1987 May;76(1):40-6.

PMID:
2883110
30.

Hybridization of genomic DNA to oligonucleotide probes in the presence of tetramethylammonium chloride.

DiLella AG, Woo SL.

Methods Enzymol. 1987;152:447-51. No abstract available.

PMID:
3657583
31.

Cloning large segments of genomic DNA using cosmid vectors.

DiLella AG, Woo SL.

Methods Enzymol. 1987;152:199-212. No abstract available.

PMID:
2958679
32.

Molecular basis of phenylketonuria and recombinant DNA strategies for its therapy.

Woo SL, DiLella AG, Marvit J, Ledley FD.

Enzyme. 1987;38(1-4):207-13.

PMID:
2894302
33.

Molecular biology of phenylketonuria.

Güttler F, DiLella AG, Ledley FD, Lidsky AS, Kvok SC, Marvit J, Woo SL.

Eur J Pediatr. 1987;146 Suppl 1:A5-11. No abstract available.

PMID:
2891509
34.

Correlation between polymorphic DNA haplotypes at phenylalanine hydroxylase locus and clinical phenotypes of phenylketonuria.

Güttler F, Ledley FD, Lidsky AS, DiLella AG, Sullivan SE, Woo SL.

J Pediatr. 1987 Jan;110(1):68-71.

PMID:
2878985
35.

Tight linkage between a splicing mutation and a specific DNA haplotype in phenylketonuria.

DiLella AG, Marvit J, Lidsky AS, Güttler F, Woo SL.

Nature. 1986 Aug 28-Sep 3;322(6082):799-803.

PMID:
3018584
36.

Molecular structure and polymorphic map of the human phenylalanine hydroxylase gene.

DiLella AG, Kwok SC, Ledley FD, Marvit J, Woo SL.

Biochemistry. 1986 Feb 25;25(4):743-9.

PMID:
3008810
37.

Molecular basis of phenylketonuria and potential somatic gene therapy.

Woo SL, DiLella AG, Marvit J, Ledley FD.

Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:395-401. No abstract available.

PMID:
2884065
38.

Homology between phenylalanine and tyrosine hydroxylases reveals common structural and functional domains.

Ledley FD, DiLella AG, Kwok SC, Woo SL.

Biochemistry. 1985 Jul 2;24(14):3389-94.

PMID:
2412578
39.

Extensive restriction site polymorphism at the human phenylalanine hydroxylase locus and application in prenatal diagnosis of phenylketonuria.

Lidsky AS, Ledley FD, DiLella AG, Kwok SC, Daiger SP, Robson KJ, Woo SL.

Am J Hum Genet. 1985 Jul;37(4):619-34.

40.

Gene transfer and expression of human phenylalanine hydroxylase.

Ledley FD, Grenett HE, DiLella AG, Kwok SC, Woo SL.

Science. 1985 Apr 5;228(4695):77-9.

PMID:
3856322
41.

Nucleotide sequence of a full-length complementary DNA clone and amino acid sequence of human phenylalanine hydroxylase.

Kwok SC, Ledley FD, DiLella AG, Robson KJ, Woo SL.

Biochemistry. 1985 Jan 29;24(3):556-61.

PMID:
2986678
42.

Detection of phenylalanine hydroxylase messenger RNA in liver biopsy samples from patients with phenylketonuria.

DiLella AG, Ledley FD, Rey F, Munnich A, Woo SL.

Lancet. 1985 Jan 19;1(8421):160-1. No abstract available.

PMID:
2857230
43.

The human phenylalanine hydroxylase gene.

Woo SL, Güttler F, Ledley FD, Lidsky AS, Kwok SC, DiLella AG, Robson KJ.

Prog Clin Biol Res. 1985;177:123-35. No abstract available.

PMID:
2989834
44.

Effect of inducers and aging on rabbit liver microsomal drug-metabolizing enzymes.

Chiang JY, DiLella AG, Steggles AW.

Mol Pharmacol. 1983 Jan;23(1):244-51. No abstract available.

PMID:
6408388
45.

The quantitation of liver cytochrome P450-LM2 mRNA in rabbits of different ages and after phenobarbital treatment.

Dilella AG, Chiang JY, Steggles AW.

Mech Ageing Dev. 1982 Jun;19(2):113-25.

PMID:
7109711
46.

The partial purification of rabbit liver cytochrome P450-LM2-mRNA.

DiLella AG, Chiang JY, Steggles AW.

Biochem Biophys Res Commun. 1981 May 15;100(1):155-61. No abstract available.

PMID:
7259742
47.

Alterations in rabbit liver protein synthesis as a result of phenobarbital treatment.

DiLella AG, Roe BA, Steggles AW.

Biochem Biophys Res Commun. 1981 Feb 12;98(3):628-34. No abstract available.

PMID:
6112001
48.

The identification of cytochrome P-450-LM2 synthesized in vitro from a rabbit liver polysomal mRNA template.

DiLella AG, Chiang JY, Hutterer F, Steggles AW.

Biochim Biophys Acta. 1981 Jan 29;652(1):223-7.

PMID:
7213733

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