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Items: 14


Probing the mutational landscape of regulators of G protein signaling proteins in cancer.

DiGiacomo V, Maziarz M, Luebbers A, Norris JM, Laksono P, Garcia-Marcos M.

Sci Signal. 2020 Feb 4;13(617). pii: eaax8620. doi: 10.1126/scisignal.aax8620.


DAPLE protein inhibits nucleotide exchange on Gαs and Gαq via the same motif that activates Gαi.

Marivin A, Maziarz M, Zhao J, DiGiacomo V, Olmos Calvo I, Mann EA, Ear J, Blanco-Canosa JB, Ross EM, Ghosh P, Garcia-Marcos M.

J Biol Chem. 2020 Jan 16. pii: jbc.RA119.011648. doi: 10.1074/jbc.RA119.011648. [Epub ahead of print]


A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins.

Maziarz M, Broselid S, DiGiacomo V, Park JC, Luebbers A, Garcia-Navarrete L, Blanco-Canosa JB, Baillie GS, Garcia-Marcos M.

J Biol Chem. 2018 Nov 2;293(44):16964-16983. doi: 10.1074/jbc.RA118.003580. Epub 2018 Sep 7.


Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein.

Leyme A, Marivin A, Maziarz M, DiGiacomo V, Papakonstantinou MP, Patel PP, Blanco-Canosa JB, Walawalkar IA, Rodriguez-Davila G, Dominguez I, Garcia-Marcos M.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10319-E10328. doi: 10.1073/pnas.1707992114. Epub 2017 Nov 13.


When Heterotrimeric G Proteins Are Not Activated by G Protein-Coupled Receptors: Structural Insights and Evolutionary Conservation.

DiGiacomo V, Marivin A, Garcia-Marcos M.

Biochemistry. 2018 Jan 23;57(3):255-257. doi: 10.1021/acs.biochem.7b00845. Epub 2017 Oct 16.


The Gαi-GIV binding interface is a druggable protein-protein interaction.

DiGiacomo V, de Opakua AI, Papakonstantinou MP, Nguyen LT, Merino N, Blanco-Canosa JB, Blanco FJ, Garcia-Marcos M.

Sci Rep. 2017 Aug 17;7(1):8575. doi: 10.1038/s41598-017-08829-7.


Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.

de Opakua AI, Parag-Sharma K, DiGiacomo V, Merino N, Leyme A, Marivin A, Villate M, Nguyen LT, de la Cruz-Morcillo MA, Blanco-Canosa JB, Ramachandran S, Baillie GS, Cerione RA, Blanco FJ, Garcia-Marcos M.

Nat Commun. 2017 May 18;8:15163. doi: 10.1038/ncomms15163.


Membrane Recruitment of the Non-receptor Protein GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Is Sufficient for Activating Heterotrimeric G Protein Signaling.

Parag-Sharma K, Leyme A, DiGiacomo V, Marivin A, Broselid S, Garcia-Marcos M.

J Biol Chem. 2016 Dec 30;291(53):27098-27111. doi: 10.1074/jbc.M116.764431. Epub 2016 Nov 18.


Dominant-negative Gα subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease.

Marivin A, Leyme A, Parag-Sharma K, DiGiacomo V, Cheung AY, Nguyen LT, Dominguez I, Garcia-Marcos M.

Sci Signal. 2016 Apr 12;9(423):ra37. doi: 10.1126/scisignal.aad2429.


Evolutionary Conservation of a GPCR-Independent Mechanism of Trimeric G Protein Activation.

Coleman BD, Marivin A, Parag-Sharma K, DiGiacomo V, Kim S, Pepper JS, Casler J, Nguyen LT, Koelle MR, Garcia-Marcos M.

Mol Biol Evol. 2016 Mar;33(3):820-37. doi: 10.1093/molbev/msv336. Epub 2015 Dec 10.


The Transition of the 37-Kda Laminin Receptor (Rpsa) to Higher Molecular Weight Species: Sumoylation or Artifact?

Digiacomo V, Gando IA, Venticinque L, Hurtado A, Meruelo D.

Cell Mol Biol Lett. 2015 Dec;20(4):571-85. doi: 10.1515/cmble-2015-0031.


Looking into laminin receptor: critical discussion regarding the non-integrin 37/67-kDa laminin receptor/RPSA protein.

DiGiacomo V, Meruelo D.

Biol Rev Camb Philos Soc. 2016 May;91(2):288-310. doi: 10.1111/brv.12170. Epub 2015 Jan 28. Review.


Enhanced specific delivery and targeting of oncolytic Sindbis viral vectors by modulating vascular leakiness in tumor.

Tseng JC, Granot T, DiGiacomo V, Levin B, Meruelo D.

Cancer Gene Ther. 2010 Apr;17(4):244-55. doi: 10.1038/cgt.2009.70. Epub 2009 Oct 2.


Buerger's disease in women. A case report with critical approach to the literature.

Cavallaro A, Meloni F, Sciacca V, Transi MG, DiGiacomo V.

Angiology. 1985 Mar;36(3):191-6.


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