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Items: 1 to 50 of 164

1.

Human iPSC modeling of a familial form of atrial fibrillation reveals a gain of function of If and ICaL in patient-derived cardiomyocytes.

Benzoni P, Campostrini G, Landi S, Bertini V, Marchina E, Iascone M, Ahlberg G, Olesen MS, Crescini E, Mora C, Bisleri G, Muneretto C, Ronca R, Presta M, Poliani PL, Piovani G, Verardi R, Pasquale ED, Consiglio A, Raya A, Torre E, Lodrini AM, Milanesi R, Rocchetti M, Baruscotti M, DiFrancesco D, Memo M, Barbuti A, Dell'Era P.

Cardiovasc Res. 2019 Aug 28. pii: cvz217. doi: 10.1093/cvr/cvz217. [Epub ahead of print]

PMID:
31504264
2.

Comparing pathways for long-term heart rate modulation by the funny current.

DiFrancesco D.

J Gen Physiol. 2019 Sep 2;151(9):1066-1069. doi: 10.1085/jgp.201912409. Epub 2019 Aug 20. No abstract available.

PMID:
31431492
3.

HCN ion channels and accessory proteins in epilepsy: genetic analysis of a large cohort of patients and review of the literature.

DiFrancesco JC, Castellotti B, Milanesi R, Ragona F, Freri E, Canafoglia L, Franceschetti S, Ferrarese C, Magri S, Taroni F, Costa C, Labate A, Gambardella A, Solazzi R, Binda A, Rivolta I, Di Gennaro G, Casciato S, D'Incerti L, Barbuti A, DiFrancesco D, Granata T, Gellera C.

Epilepsy Res. 2019 Jul;153:49-58. doi: 10.1016/j.eplepsyres.2019.04.004. Epub 2019 Apr 8. Review.

PMID:
30986657
4.

HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond.

Marini C, Porro A, Rastetter A, Dalle C, Rivolta I, Bauer D, Oegema R, Nava C, Parrini E, Mei D, Mercer C, Dhamija R, Chambers C, Coubes C, Thévenon J, Kuentz P, Julia S, Pasquier L, Dubourg C, Carré W, Rosati A, Melani F, Pisano T, Giardino M, Innes AM, Alembik Y, Scheidecker S, Santos M, Figueiroa S, Garrido C, Fusco C, Frattini D, Spagnoli C, Binda A, Granata T, Ragona F, Freri E, Franceschetti S, Canafoglia L, Castellotti B, Gellera C, Milanesi R, Mancardi MM, Clark DR, Kok F, Helbig KL, Ichikawa S, Sadler L, Neupauerová J, Laššuthova P, Šterbová K, Laridon A, Brilstra E, Koeleman B, Lemke JR, Zara F, Striano P, Soblet J, Smits G, Deconinck N, Barbuti A, DiFrancesco D, LeGuern E, Guerrini R, Santoro B, Hamacher K, Thiel G, Moroni A, DiFrancesco JC, Depienne C.

Brain. 2018 Nov 1;141(11):3160-3178. doi: 10.1093/brain/awy263.

5.

A Loss-of-Function HCN4 Mutation Associated With Familial Benign Myoclonic Epilepsy in Infancy Causes Increased Neuronal Excitability.

Campostrini G, DiFrancesco JC, Castellotti B, Milanesi R, Gnecchi-Ruscone T, Bonzanni M, Bucchi A, Baruscotti M, Ferrarese C, Franceschetti S, Canafoglia L, Ragona F, Freri E, Labate A, Gambardella A, Costa C, Gellera C, Granata T, Barbuti A, DiFrancesco D.

Front Mol Neurosci. 2018 Aug 6;11:269. doi: 10.3389/fnmol.2018.00269. eCollection 2018.

6.

A novel de novo HCN1 loss-of-function mutation in genetic generalized epilepsy causing increased neuronal excitability.

Bonzanni M, DiFrancesco JC, Milanesi R, Campostrini G, Castellotti B, Bucchi A, Baruscotti M, Ferrarese C, Franceschetti S, Canafoglia L, Ragona F, Freri E, Labate A, Gambardella A, Costa C, Rivolta I, Gellera C, Granata T, Barbuti A, DiFrancesco D.

Neurobiol Dis. 2018 Oct;118:55-63. doi: 10.1016/j.nbd.2018.06.012. Epub 2018 Jun 21.

7.

A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

Saponaro A, Cantini F, Porro A, Bucchi A, DiFrancesco D, Maione V, Donadoni C, Introini B, Mesirca P, Mangoni ME, Thiel G, Banci L, Santoro B, Moroni A.

Elife. 2018 Jun 20;7. pii: e35753. doi: 10.7554/eLife.35753.

8.

Generation of human induced pluripotent stem cells (EURACi001-A, EURACi002-A, EURACi003-A) from peripheral blood mononuclear cells of three patients carrying mutations in the CAV3 gene.

Meraviglia V, Benzoni P, Landi S, Murano C, Langione M, Motta BM, Baratto S, Silipigni R, Di Segni M, Pramstaller PP, DiFrancesco D, Gazzerro E, Barbuti A, Rossini A.

Stem Cell Res. 2018 Mar;27:25-29. doi: 10.1016/j.scr.2017.12.012. Epub 2017 Dec 18.

9.

Preferential myofibroblast differentiation of cardiac mesenchymal progenitor cells in the presence of atrial fibrillation.

Gambini E, Perrucci GL, Bassetti B, Spaltro G, Campostrini G, Lionetti MC, Pilozzi A, Martinelli F, Farruggia A, DiFrancesco D, Barbuti A, Pompilio G.

Transl Res. 2018 Feb;192:54-67. doi: 10.1016/j.trsl.2017.11.003. Epub 2017 Nov 27.

10.

Mammalian γ2 AMPK regulates intrinsic heart rate.

Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG, Tarasova YS, Baban D, Sahgal N, Lockstone H, Puliyadi R, de Bono J, Siggs OM, Gomes J, Muskett H, Maguire ML, Beglov Y, Kelly M, Dos Santos PPN, Bright NJ, Woods A, Gehmlich K, Isackson H, Douglas G, Ferguson DJP, Schneider JE, Tinker A, Wolkenhauer O, Channon KM, Cornall RJ, Sternick EB, Paterson DJ, Redwood CS, Carling D, Proenza C, David R, Baruscotti M, DiFrancesco D, Lakatta EG, Watkins H, Ashrafian H.

Nat Commun. 2017 Nov 2;8(1):1258. doi: 10.1038/s41467-017-01342-5.

11.

The expression of the rare caveolin-3 variant T78M alters cardiac ion channels function and membrane excitability.

Campostrini G, Bonzanni M, Lissoni A, Bazzini C, Milanesi R, Vezzoli E, Francolini M, Baruscotti M, Bucchi A, Rivolta I, Fantini M, Severi S, Cappato R, Crotti L, J Schwartz P, DiFrancesco D, Barbuti A.

Cardiovasc Res. 2017 Aug 1;113(10):1256-1265. doi: 10.1093/cvr/cvx122.

12.

A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus Tachycardia.

Baruscotti M, Bucchi A, Milanesi R, Paina M, Barbuti A, Gnecchi-Ruscone T, Bianco E, Vitali-Serdoz L, Cappato R, DiFrancesco D.

Eur Heart J. 2017 Jan 21;38(4):280-288. doi: 10.1093/eurheartj/ehv582. No abstract available.

PMID:
28182231
13.

Mutation in S6 domain of HCN4 channel in patient with suspected Brugada syndrome modifies channel function.

Biel S, Aquila M, Hertel B, Berthold A, Neumann T, DiFrancesco D, Moroni A, Thiel G, Kauferstein S.

Pflugers Arch. 2016 Oct;468(10):1663-71. doi: 10.1007/s00424-016-1870-1. Epub 2016 Aug 23.

PMID:
27553229
14.

How integrated are neurology and palliative care services? Results of a multicentre mapping exercise.

van Vliet LM, Gao W, DiFrancesco D, Crosby V, Wilcock A, Byrne A, Al-Chalabi A, Chaudhuri KR, Evans C, Silber E, Young C, Malik F, Quibell R, Higginson IJ; OPTCARE Neuro.

BMC Neurol. 2016 May 10;16:63. doi: 10.1186/s12883-016-0583-6.

15.

HCN4, Sinus Bradycardia and Atrial Fibrillation.

DiFrancesco D.

Arrhythm Electrophysiol Rev. 2015 May;4(1):9-13. doi: 10.15420/aer.2015.4.1.9. Epub 2015 Mar 15.

16.

Current understanding of the pathophysiological mechanisms responsible for inappropriate sinus tachycardia: role of the If "funny" current.

Baruscotti M, Bianco E, Bucchi A, DiFrancesco D.

J Interv Card Electrophysiol. 2016 Jun;46(1):19-28. doi: 10.1007/s10840-015-0097-y. Epub 2016 Jan 18. Review.

PMID:
26781742
17.

Cell-specific Dynamic Clamp analysis of the role of funny If current in cardiac pacemaking.

Ravagli E, Bucchi A, Bartolucci C, Paina M, Baruscotti M, DiFrancesco D, Severi S.

Prog Biophys Mol Biol. 2016 Jan;120(1-3):50-66. doi: 10.1016/j.pbiomolbio.2015.12.004. Epub 2015 Dec 21.

PMID:
26718599
18.

Higher cardiogenic potential of iPSCs derived from cardiac versus skin stromal cells.

Meraviglia V, Wen J, Piacentini L, Campostrini G, Wang C, Florio MC, Azzimato V, Fassina L, Langes M, Wong J, Miragoli M, Gaetano C, Pompilio G, Barbuti A, DiFrancesco D, Mascalzoni D, Pramstaller PP, Colombo GI, Chen HS, Rossini A.

Front Biosci (Landmark Ed). 2016 Jan 1;21:719-43.

PMID:
26709802
19.

Anacardic acid and thyroid hormone enhance cardiomyocytes production from undifferentiated mouse ES cells along functionally distinct pathways.

Re A, Nanni S, Aiello A, Granata S, Colussi C, Campostrini G, Spallotta F, Mattiussi S, Pantisano V, D'Angelo C, Biroccio A, Rossini A, Barbuti A, DiFrancesco D, Trimarchi F, Pontecorvi A, Gaetano C, Farsetti A.

Endocrine. 2016 Sep;53(3):681-8. doi: 10.1007/s12020-015-0751-2. Epub 2015 Nov 7.

PMID:
26547215
20.

Dysfunctional HCN ion channels in neurological diseases.

DiFrancesco JC, DiFrancesco D.

Front Cell Neurosci. 2015 Mar 10;6:174. doi: 10.3389/fncel.2015.00071. eCollection 2015.

21.

LEONARDO DA VINCI AND THE ORIGIN OF SEMEN.

Noble D, DiFrancesco D, Zancani D.

Notes Rec R Soc Lond. 2014 Dec 20;68(4):391-402.

22.

Exercise training reduces resting heart rate via downregulation of the funny channel HCN4.

D'Souza A, Bucchi A, Johnsen AB, Logantha SJ, Monfredi O, Yanni J, Prehar S, Hart G, Cartwright E, Wisloff U, Dobryznski H, DiFrancesco D, Morris GM, Boyett MR.

Nat Commun. 2014 May 13;5:3775. doi: 10.1038/ncomms4775.

23.

Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.

Lolicato M, Bucchi A, Arrigoni C, Zucca S, Nardini M, Schroeder I, Simmons K, Aquila M, DiFrancesco D, Bolognesi M, Schwede F, Kashin D, Fishwick CW, Johnson AP, Thiel G, Moroni A.

Nat Chem Biol. 2014 Jun;10(6):457-62. doi: 10.1038/nchembio.1521. Epub 2014 Apr 28. Erratum in: Nat Chem Biol. 2014 Aug;10(8):692.

24.

The 'funny' side of sepsis.

Barbuti A, DiFrancesco D.

J Physiol. 2014 Mar 15;592(6):1171. doi: 10.1113/jphysiol.2014.271171. No abstract available.

25.

Multifactorial impact of channel beta-subunit gene mutation on automaticity.

Difrancesco D, Nawathe PA, Robinson RB.

J Cardiovasc Electrophysiol. 2013 Dec;24(12):E26-7. doi: 10.1111/jce.12235. Epub 2013 Sep 9. No abstract available.

PMID:
24015862
26.

Embryonic stem cell-derived CD166+ precursors develop into fully functional sinoatrial-like cells.

Scavone A, Capilupo D, Mazzocchi N, Crespi A, Zoia S, Campostrini G, Bucchi A, Milanesi R, Baruscotti M, Benedetti S, Antonini S, Messina G, DiFrancesco D, Barbuti A.

Circ Res. 2013 Aug 2;113(4):389-98. doi: 10.1161/CIRCRESAHA.113.301283. Epub 2013 Jun 10.

27.

An LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardia.

Nawathe PA, Kryukova Y, Oren RV, Milanesi R, Clancy CE, Lu JT, Moss AJ, Difrancesco D, Robinson RB.

J Cardiovasc Electrophysiol. 2013 Sep;24(9):1021-7. doi: 10.1111/jce.12163. Epub 2013 Apr 30.

28.

Funny channel gene mutations associated with arrhythmias.

DiFrancesco D.

J Physiol. 2013 Sep 1;591(17):4117-24. doi: 10.1113/jphysiol.2013.253765. Epub 2013 Mar 18. Review.

29.

Identification of the molecular site of ivabradine binding to HCN4 channels.

Bucchi A, Baruscotti M, Nardini M, Barbuti A, Micheloni S, Bolognesi M, DiFrancesco D.

PLoS One. 2013;8(1):e53132. doi: 10.1371/journal.pone.0053132. Epub 2013 Jan 4.

30.

In vitro epigenetic reprogramming of human cardiac mesenchymal stromal cells into functionally competent cardiovascular precursors.

Vecellio M, Meraviglia V, Nanni S, Barbuti A, Scavone A, DiFrancesco D, Farsetti A, Pompilio G, Colombo GI, Capogrossi MC, Gaetano C, Rossini A.

PLoS One. 2012;7(12):e51694. doi: 10.1371/journal.pone.0051694. Epub 2012 Dec 17.

31.

Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models.

Bucchi A, Barbuti A, Difrancesco D, Baruscotti M.

Front Physiol. 2012 Jul 2;3:240. doi: 10.3389/fphys.2012.00240. eCollection 2012.

32.

An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation.

Severi S, Fantini M, Charawi LA, DiFrancesco D.

J Physiol. 2012 Sep 15;590(18):4483-99. doi: 10.1113/jphysiol.2012.229435. Epub 2012 Jun 18.

33.

A caveolin-binding domain in the HCN4 channels mediates functional interaction with caveolin proteins.

Barbuti A, Scavone A, Mazzocchi N, Terragni B, Baruscotti M, Difrancesco D.

J Mol Cell Cardiol. 2012 Aug;53(2):187-95. doi: 10.1016/j.yjmcc.2012.05.013. Epub 2012 May 31.

34.

Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy.

DiFrancesco JC, Barbuti A, Milanesi R, Coco S, Bucchi A, Bottelli G, Ferrarese C, Franceschetti S, Terragni B, Baruscotti M, DiFrancesco D.

J Neurosci. 2011 Nov 30;31(48):17327-37. doi: 10.1523/JNEUROSCI.3727-11.2011.

35.

Rebuttal: "The funny current in the context of the coupled clock pacemaker cell system".

DiFrancesco D, Noble D.

Heart Rhythm. 2012 Mar;9(3):457-8. doi: 10.1016/j.hrthm.2011.09.023. Epub 2011 Sep 16. No abstract available.

PMID:
21925135
36.

The funny current has a major pacemaking role in the sinus node.

DiFrancesco D, Noble D.

Heart Rhythm. 2012 Feb;9(2):299-301. doi: 10.1016/j.hrthm.2011.09.021. Epub 2011 Sep 16. No abstract available.

PMID:
21925134
37.

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

Quinn TA, Granite S, Allessie MA, Antzelevitch C, Bollensdorff C, Bub G, Burton RA, Cerbai E, Chen PS, Delmar M, Difrancesco D, Earm YE, Efimov IR, Egger M, Entcheva E, Fink M, Fischmeister R, Franz MR, Garny A, Giles WR, Hannes T, Harding SE, Hunter PJ, Iribe G, Jalife J, Johnson CR, Kass RS, Kodama I, Koren G, Lord P, Markhasin VS, Matsuoka S, McCulloch AD, Mirams GR, Morley GE, Nattel S, Noble D, Olesen SP, Panfilov AV, Trayanova NA, Ravens U, Richard S, Rosenbaum DS, Rudy Y, Sachs F, Sachse FB, Saint DA, Schotten U, Solovyova O, Taggart P, Tung L, Varró A, Volders PG, Wang K, Weiss JN, Wettwer E, White E, Wilders R, Winslow RL, Kohl P.

Prog Biophys Mol Biol. 2011 Oct;107(1):4-10. doi: 10.1016/j.pbiomolbio.2011.07.001. Epub 2011 Jul 6.

38.

Human cord blood CD34+ progenitor cells acquire functional cardiac properties through a cell fusion process.

Avitabile D, Crespi A, Brioschi C, Parente V, Toietta G, Devanna P, Baruscotti M, Truffa S, Scavone A, Rusconi F, Biondi A, D'Alessandra Y, Vigna E, Difrancesco D, Pesce M, Capogrossi MC, Barbuti A.

Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1875-84. doi: 10.1152/ajpheart.00523.2010. Epub 2011 Feb 25.

39.

Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4.

Baruscotti M, Bucchi A, Viscomi C, Mandelli G, Consalez G, Gnecchi-Rusconi T, Montano N, Casali KR, Micheloni S, Barbuti A, DiFrancesco D.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1705-10. doi: 10.1073/pnas.1010122108. Epub 2011 Jan 10.

40.

Human cardiac and bone marrow stromal cells exhibit distinctive properties related to their origin.

Rossini A, Frati C, Lagrasta C, Graiani G, Scopece A, Cavalli S, Musso E, Baccarin M, Di Segni M, Fagnoni F, Germani A, Quaini E, Mayr M, Xu Q, Barbuti A, DiFrancesco D, Pompilio G, Quaini F, Gaetano C, Capogrossi MC.

Cardiovasc Res. 2011 Feb 15;89(3):650-60. doi: 10.1093/cvr/cvq290. Epub 2010 Sep 10.

PMID:
20833652
41.

Multinucleated giant cells with an osteoclast phenotype derived from caprine peripheral blood mononuclear cells.

Pisoni G, D'Amelio P, Sassi F, Manarolla G, Scaccabarozzi L, Locatelli C, Mazzocchi N, Baruscotti M, DiFrancesco D, Moroni P.

Vet J. 2011 Sep;189(3):361-3. doi: 10.1016/j.tvjl.2010.07.016. Epub 2010 Sep 6.

42.

HCN-related channelopathies.

Baruscotti M, Bottelli G, Milanesi R, DiFrancesco JC, DiFrancesco D.

Pflugers Arch. 2010 Jul;460(2):405-15. doi: 10.1007/s00424-010-0810-8. Epub 2010 Mar 8. Review.

PMID:
20213494
43.

The role of the funny current in pacemaker activity.

DiFrancesco D.

Circ Res. 2010 Feb 19;106(3):434-46. doi: 10.1161/CIRCRESAHA.109.208041. Review.

PMID:
20167941
44.

Funny channel-based pacemaking.

DiFrancesco D.

Heart Rhythm. 2010;7(2):276-9. doi: 10.1016/j.hrthm.2009.10.030. Epub 2009 Oct 27. Review. No abstract available.

PMID:
20022815
45.

More seafood to control heart rate?

DiFrancesco D.

Heart Rhythm. 2009 Oct;6(10):1493-4. doi: 10.1016/j.hrthm.2009.08.019. Epub 2009 Aug 21. No abstract available.

PMID:
19968930
46.

Mesoangioblasts from ventricular vessels can differentiate in vitro into cardiac myocytes with sinoatrial-like properties.

Barbuti A, Galvez BG, Crespi A, Scavone A, Baruscotti M, Brioschi C, Cossu G, DiFrancesco D.

J Mol Cell Cardiol. 2010 Feb;48(2):415-23. doi: 10.1016/j.yjmcc.2009.10.006. Epub 2009 Oct 22.

PMID:
19837079
47.

Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node.

Brioschi C, Micheloni S, Tellez JO, Pisoni G, Longhi R, Moroni P, Billeter R, Barbuti A, Dobrzynski H, Boyett MR, DiFrancesco D, Baruscotti M.

J Mol Cell Cardiol. 2009 Aug;47(2):221-7. doi: 10.1016/j.yjmcc.2009.04.009. Epub 2009 Apr 24.

PMID:
19394343
48.

What keeps us ticking: a funny current, a calcium clock, or both?

Lakatta EG, DiFrancesco D.

J Mol Cell Cardiol. 2009 Aug;47(2):157-70. doi: 10.1016/j.yjmcc.2009.03.022. Epub 2009 Apr 8. Review. No abstract available.

49.

Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker.

Chandler NJ, Greener ID, Tellez JO, Inada S, Musa H, Molenaar P, Difrancesco D, Baruscotti M, Longhi R, Anderson RH, Billeter R, Sharma V, Sigg DC, Boyett MR, Dobrzynski H.

Circulation. 2009 Mar 31;119(12):1562-75. doi: 10.1161/CIRCULATIONAHA.108.804369. Epub 2009 Mar 16.

PMID:
19289639
50.

Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.

Barbuti A, Crespi A, Capilupo D, Mazzocchi N, Baruscotti M, DiFrancesco D.

J Mol Cell Cardiol. 2009 Mar;46(3):343-51. doi: 10.1016/j.yjmcc.2008.12.001. Epub 2008 Dec 11.

PMID:
19135060

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