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Items: 20


Antifungal Phenothiazines: Optimization, Characterization of Mechanism, and Modulation of Neuroreceptor Activity.

Montoya MC, DiDone L, Heier RF, Meyers MJ, Krysan DJ.

ACS Infect Dis. 2018 Apr 13;4(4):499-507. doi: 10.1021/acsinfecdis.7b00157. Epub 2017 Nov 2.


The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.

Koselny K, Green J, DiDone L, Halterman JP, Fothergill AW, Wiederhold NP, Patterson TF, Cushion MT, Rappelye C, Wellington M, Krysan DJ.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7115-7127. Print 2016 Dec.


Complex Haploinsufficiency-Based Genetic Analysis of the NDR/Lats Kinase Cbk1 Provides Insight into Its Multiple Functions in Candida albicans.

Saputo S, Norman KL, Murante T, Horton BN, Diaz Jde L, DiDone L, Colquhoun J, Schroeder JW, Simmons LA, Kumar A, Krysan DJ.

Genetics. 2016 Jul;203(3):1217-33. doi: 10.1534/genetics.116.188029. Epub 2016 May 20.


Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase.

Koselny K, Green J, Favazzo L, Glazier VE, DiDone L, Ransford S, Krysan DJ.

ACS Infect Dis. 2016 Apr 8;2(4):268-280. Epub 2016 Feb 23.


High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling.

Hartland K, Pu J, Palmer M, Dandapani S, Moquist PN, Munoz B, DiDone L, Schreiber SL, Krysan DJ.

ACS Infect Dis. 2016 Jan 8;2(1):93-102. Epub 2015 Nov 6.


A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis.

Forbes L, Ebsworth-Mojica K, DiDone L, Li SG, Freundlich JS, Connell N, Dunman PM, Krysan DJ.

PLoS One. 2015 Jun 22;10(6):e0129234. doi: 10.1371/journal.pone.0129234. eCollection 2015.


Structure-activity relationships for the antifungal activity of selective estrogen receptor antagonists related to tamoxifen.

Butts A, Martin JA, DiDone L, Bradley EK, Mutz M, Krysan DJ.

PLoS One. 2015 May 27;10(5):e0125927. doi: 10.1371/journal.pone.0125927. eCollection 2015.


Discovery and Evaluation of Fungicidal Anti-Cryptococcal Molecules.

Hartland CL, Pu J, Krysan D, Didone L, Moquist PN, Dandapani S, Munoz B, Palmer M, Schreiber S.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2014 Apr 15 [updated 2015 Jan 16].


Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo.

Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, DiDone L, Tabroff J, Childers WE Jr, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ.

MBio. 2014 Feb 11;5(1):e00765-13. doi: 10.1128/mBio.00765-13.


A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis.

Butts A, DiDone L, Koselny K, Baxter BK, Chabrier-Rosello Y, Wellington M, Krysan DJ.

Eukaryot Cell. 2013 Feb;12(2):278-87. doi: 10.1128/EC.00314-12. Epub 2012 Dec 14.


Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes.

Chabrier-Roselló Y, Gerik KJ, Koselny K, DiDone L, Lodge JK, Krysan DJ.

Eukaryot Cell. 2013 Jan;12(1):12-22. doi: 10.1128/EC.00235-12. Epub 2012 Oct 19.


Adenylate kinase release as a high-throughput-screening-compatible reporter of bacterial lysis for identification of antibacterial agents.

Jacobs AC, Didone L, Jobson J, Sofia MK, Krysan D, Dunman PM.

Antimicrob Agents Chemother. 2013 Jan;57(1):26-36. doi: 10.1128/AAC.01640-12. Epub 2012 Oct 1.


Ergonomic assessment of porridge roaming sale system.

Braga J, Cardoso V, Abreu A, Didoné L, Evangelista M, Serra F.

Work. 2012;41 Suppl 1:5532-5. doi: 10.3233/WOR-2012-0873-5532.


A novel assay of biofilm antifungal activity reveals that amphotericin B and caspofungin lyse Candida albicans cells in biofilms.

DiDone L, Oga D, Krysan DJ.

Yeast. 2011 Aug;28(8):561-8. doi: 10.1002/yea.1860. Epub 2011 Jun 15.


Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules.

Baxter BK, DiDone L, Ogu D, Schor S, Krysan DJ.

ACS Chem Biol. 2011 May 20;6(5):502-10. doi: 10.1021/cb100399x. Epub 2011 Feb 22.


A high-throughput assay of yeast cell lysis for drug discovery and genetic analysis.

DiDone L, Scrimale T, Baxter BK, Krysan DJ.

Nat Protoc. 2010 Jun;5(6):1107-14. doi: 10.1038/nprot.2010.47. Epub 2010 May 27.


Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization.

Dolan K, Montgomery S, Buchheit B, Didone L, Wellington M, Krysan DJ.

Antimicrob Agents Chemother. 2009 Aug;53(8):3337-46. doi: 10.1128/AAC.01564-08. Epub 2009 Jun 1.


The unfolded protein response is induced by the cell wall integrity mitogen-activated protein kinase signaling cascade and is required for cell wall integrity in Saccharomyces cerevisiae.

Scrimale T, Didone L, de Mesy Bentley KL, Krysan DJ.

Mol Biol Cell. 2009 Jan;20(1):164-75. doi: 10.1091/mbc.E08-08-0809. Epub 2008 Oct 29.


A high-throughput screening assay for small molecules that disrupt yeast cell integrity.

Krysan DJ, Didone L.

J Biomol Screen. 2008 Aug;13(7):657-64. doi: 10.1177/1087057108320713. Epub 2008 Jul 14.


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