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Items: 1 to 50 of 89

1.

Withdrawal: Suppression of NF-κB survival signaling by nitrosylcobalamin sensitizes neoplasms to the anti-tumor effects of Apo2L/TRAIL.

Chawla-Sarkar M, Bauer JA, Lupica JA, Morrison BH, Tang Z, Oates RK, Almasan A, DiDonato JA, Borden EC, Lindner DJ.

J Biol Chem. 2019 Nov 29;294(48):18518. doi: 10.1074/jbc.W119.011721. No abstract available.

2.

Circulating Gut Microbiota Metabolite Trimethylamine N-Oxide (TMAO) and Changes in Bone Density in Response to Weight Loss Diets: The POUNDS Lost Trial.

Zhou T, Heianza Y, Chen Y, Li X, Sun D, DiDonato JA, Pei X, LeBoff MS, Bray GA, Sacks FM, Qi L.

Diabetes Care. 2019 Aug;42(8):1365-1371. doi: 10.2337/dc19-0134. Epub 2019 May 21.

PMID:
31332027
3.

Impaired Ribosomal Biogenesis by Noncanonical Degradation of β-Catenin during Hyperammonemia.

Davuluri G, Giusto M, Chandel R, Welch N, Alsabbagh K, Kant S, Kumar A, Kim A, Gangadhariah M, Ghosh PK, Tran U, Krajcik DM, Vasu K, DiDonato AJ, DiDonato JA, Willard B, Monga SP, Wang Y, Fox PL, Stark GR, Wessely O, Esser KA, Dasarathy S.

Mol Cell Biol. 2019 Jul 29;39(16). pii: e00451-18. doi: 10.1128/MCB.00451-18. Print 2019 Aug 15.

PMID:
31138664
4.

l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans.

Koeth RA, Lam-Galvez BR, Kirsop J, Wang Z, Levison BS, Gu X, Copeland MF, Bartlett D, Cody DB, Dai HJ, Culley MK, Li XS, Fu X, Wu Y, Li L, DiDonato JA, Tang WHW, Garcia-Garcia JC, Hazen SL.

J Clin Invest. 2019 Jan 2;129(1):373-387. doi: 10.1172/JCI94601. Epub 2018 Dec 10.

5.

Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential.

Skye SM, Zhu W, Romano KA, Guo CJ, Wang Z, Jia X, Kirsop J, Haag B, Lang JM, DiDonato JA, Tang WHW, Lusis AJ, Rey FE, Fischbach MA, Hazen SL.

Circ Res. 2018 Oct 26;123(10):1164-1176. doi: 10.1161/CIRCRESAHA.118.313142.

6.

Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential.

Roberts AB, Gu X, Buffa JA, Hurd AG, Wang Z, Zhu W, Gupta N, Skye SM, Cody DB, Levison BS, Barrington WT, Russell MW, Reed JM, Duzan A, Lang JM, Fu X, Li L, Myers AJ, Rachakonda S, DiDonato JA, Brown JM, Gogonea V, Lusis AJ, Garcia-Garcia JC, Hazen SL.

Nat Med. 2018 Sep;24(9):1407-1417. doi: 10.1038/s41591-018-0128-1. Epub 2018 Aug 6.

7.

Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk.

Zhu W, Buffa JA, Wang Z, Warrier M, Schugar R, Shih DM, Gupta N, Gregory JC, Org E, Fu X, Li L, DiDonato JA, Lusis AJ, Brown JM, Hazen SL.

J Thromb Haemost. 2018 Sep;16(9):1857-1872. doi: 10.1111/jth.14234. Epub 2018 Aug 9.

8.

Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial.

Heianza Y, Sun D, Li X, DiDonato JA, Bray GA, Sacks FM, Qi L.

Gut. 2019 Feb;68(2):263-270. doi: 10.1136/gutjnl-2018-316155. Epub 2018 Jun 2.

PMID:
29860242
9.

Plasma levels of high density lipoprotein cholesterol and outcomes in chronic thromboembolic pulmonary hypertension.

Khirfan G, Tejwani V, Wang X, Li M, DiDonato J, Dweik RA, Smedira N, Heresi GA.

PLoS One. 2018 May 29;13(5):e0197700. doi: 10.1371/journal.pone.0197700. eCollection 2018.

10.

Structural control of caspase-generated glutamyl-tRNA synthetase by appended noncatalytic WHEP domains.

Halawani D, Gogonea V, DiDonato JA, Pipich V, Yao P, China A, Topbas C, Vasu K, Arif A, Hazen SL, Fox PL.

J Biol Chem. 2018 Jun 8;293(23):8843-8860. doi: 10.1074/jbc.M117.807503. Epub 2018 Apr 11.

11.

Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk.

Li XS, Wang Z, Cajka T, Buffa JA, Nemet I, Hurd AG, Gu X, Skye SM, Roberts AB, Wu Y, Li L, Shahen CJ, Wagner MA, Hartiala JA, Kerby RL, Romano KA, Han Y, Obeid S, Lüscher TF, Allayee H, Rey FE, DiDonato JA, Fiehn O, Tang WHW, Hazen SL.

JCI Insight. 2018 Mar 22;3(6). pii: 99096. doi: 10.1172/jci.insight.99096.

12.

Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer.

Zamanian-Daryoush M, Lindner DJ, DiDonato JA, Wagner M, Buffa J, Rayman P, Parks JS, Westerterp M, Tall AR, Hazen SL.

Oncotarget. 2017 Jun 27;8(42):71965-71980. doi: 10.18632/oncotarget.18666. eCollection 2017 Sep 22.

13.

Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo.

Lin H, Levison BS, Buffa JA, Huang Y, Fu X, Wang Z, Gogonea V, DiDonato JA, Hazen SL.

Free Radic Biol Med. 2017 Mar;104:20-31. doi: 10.1016/j.freeradbiomed.2017.01.006. Epub 2017 Jan 6.

14.

Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma.

Wang Z, DiDonato JA, Buffa J, Comhair SA, Aronica MA, Dweik RA, Lee NA, Lee JJ, Thomassen MJ, Kavuru M, Erzurum SC, Hazen SL.

J Biol Chem. 2016 Oct 14;291(42):22118-22135. Epub 2016 Sep 1.

15.

Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo.

Iqbal AJ, Barrett TJ, Taylor L, McNeill E, Manmadhan A, Recio C, Carmineri A, Brodermann MH, White GE, Cooper D, DiDonato JA, Zamanian-Daryoush M, Hazen SL, Channon KM, Greaves DR, Fisher EA.

Elife. 2016 Aug 30;5. pii: e15190. doi: 10.7554/eLife.15190.

16.

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.

Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, Sartor RB, McIntyre TM, Silverstein RL, Tang WHW, DiDonato JA, Brown JM, Lusis AJ, Hazen SL.

Cell. 2016 Mar 24;165(1):111-124. doi: 10.1016/j.cell.2016.02.011. Epub 2016 Mar 10.

17.

Brief Report: Intestinal Microbiota-Produced Trimethylamine-N-Oxide and Its Association With Coronary Stenosis and HIV Serostatus.

Miller PE, Haberlen SA, Brown TT, Margolick JB, DiDonato JA, Hazen SL, Witt MD, Kingsley LA, Palella FJ Jr, Budoff M, Jacobson LP, Post WS, Sears CL.

J Acquir Immune Defic Syndr. 2016 May 1;72(1):114-8. doi: 10.1097/QAI.0000000000000937.

18.

A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein.

Gu X, Wu Z, Huang Y, Wagner MA, Baleanu-Gogonea C, Mehl RA, Buffa JA, DiDonato AJ, Hazen LB, Fox PL, Gogonea V, Parks JS, DiDonato JA, Hazen SL.

J Biol Chem. 2016 Mar 18;291(12):6386-95. doi: 10.1074/jbc.M115.696088. Epub 2016 Jan 21.

19.

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis.

Wang Z, Roberts AB, Buffa JA, Levison BS, Zhu W, Org E, Gu X, Huang Y, Zamanian-Daryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, Lusis AJ, Hazen SL.

Cell. 2015 Dec 17;163(7):1585-95. doi: 10.1016/j.cell.2015.11.055.

20.

Apolipoprotein A-I and Cancer.

Zamanian-Daryoush M, DiDonato JA.

Front Pharmacol. 2015 Nov 12;6:265. doi: 10.3389/fphar.2015.00265. eCollection 2015. Review.

21.

Identification of Critical Paraoxonase 1 Residues Involved in High Density Lipoprotein Interaction.

Gu X, Huang Y, Levison BS, Gerstenecker G, DiDonato AJ, Hazen LB, Lee J, Gogonea V, DiDonato JA, Hazen SL.

J Biol Chem. 2016 Jan 22;291(4):1890-904. doi: 10.1074/jbc.M115.678334. Epub 2015 Nov 13.

22.

Transmission of atherosclerosis susceptibility with gut microbial transplantation.

Gregory JC, Buffa JA, Org E, Wang Z, Levison BS, Zhu W, Wagner MA, Bennett BJ, Li L, DiDonato JA, Lusis AJ, Hazen SL.

J Biol Chem. 2015 Feb 27;290(9):5647-60. doi: 10.1074/jbc.M114.618249. Epub 2014 Dec 30.

23.

γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO.

Koeth RA, Levison BS, Culley MK, Buffa JA, Wang Z, Gregory JC, Org E, Wu Y, Li L, Smith JD, Tang WHW, DiDonato JA, Lusis AJ, Hazen SL.

Cell Metab. 2014 Nov 4;20(5):799-812. doi: 10.1016/j.cmet.2014.10.006. Epub 2014 Nov 4.

24.

Cancer stem cell-specific scavenger receptor CD36 drives glioblastoma progression.

Hale JS, Otvos B, Sinyuk M, Alvarado AG, Hitomi M, Stoltz K, Wu Q, Flavahan W, Levison B, Johansen ML, Schmitt D, Neltner JM, Huang P, Ren B, Sloan AE, Silverstein RL, Gladson CL, DiDonato JA, Brown JM, McIntyre T, Hazen SL, Horbinski C, Rich JN, Lathia JD.

Stem Cells. 2014 Jul;32(7):1746-58. doi: 10.1002/stem.1716.

25.

Site-specific nitration of apolipoprotein A-I at tyrosine 166 is both abundant within human atherosclerotic plaque and dysfunctional.

DiDonato JA, Aulak K, Huang Y, Wagner M, Gerstenecker G, Topbas C, Gogonea V, DiDonato AJ, Tang WH, Mehl RA, Fox PL, Plow EF, Smith JD, Fisher EA, Hazen SL.

J Biol Chem. 2014 Apr 11;289(15):10276-92. doi: 10.1074/jbc.M114.556506. Epub 2014 Feb 20.

26.

An abundant dysfunctional apolipoprotein A1 in human atheroma.

Huang Y, DiDonato JA, Levison BS, Schmitt D, Li L, Wu Y, Buffa J, Kim T, Gerstenecker GS, Gu X, Kadiyala CS, Wang Z, Culley MK, Hazen JE, Didonato AJ, Fu X, Berisha SZ, Peng D, Nguyen TT, Liang S, Chuang CC, Cho L, Plow EF, Fox PL, Gogonea V, Tang WH, Parks JS, Fisher EA, Smith JD, Hazen SL.

Nat Med. 2014 Feb;20(2):193-203. doi: 10.1038/nm.3459. Epub 2014 Jan 26.

27.

Effects of native and myeloperoxidase-modified apolipoprotein a-I on reverse cholesterol transport and atherosclerosis in mice.

Hewing B, Parathath S, Barrett T, Chung WK, Astudillo YM, Hamada T, Ramkhelawon B, Tallant TC, Yusufishaq MS, Didonato JA, Huang Y, Buffa J, Berisha SZ, Smith JD, Hazen SL, Fisher EA.

Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):779-89. doi: 10.1161/ATVBAHA.113.303044. Epub 2014 Jan 9.

28.

Function and distribution of apolipoprotein A1 in the artery wall are markedly distinct from those in plasma.

DiDonato JA, Huang Y, Aulak KS, Even-Or O, Gerstenecker G, Gogonea V, Wu Y, Fox PL, Tang WH, Plow EF, Smith JD, Fisher EA, Hazen SL.

Circulation. 2013 Oct 8;128(15):1644-55. doi: 10.1161/CIRCULATIONAHA.113.002624. Epub 2013 Aug 22.

29.

Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex.

Huang Y, Wu Z, Riwanto M, Gao S, Levison BS, Gu X, Fu X, Wagner MA, Besler C, Gerstenecker G, Zhang R, Li XM, DiDonato AJ, Gogonea V, Tang WH, Smith JD, Plow EF, Fox PL, Shih DM, Lusis AJ, Fisher EA, DiDonato JA, Landmesser U, Hazen SL.

J Clin Invest. 2013 Sep;123(9):3815-28. doi: 10.1172/JCI67478. Epub 2013 Aug 1.

30.

The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.

Zamanian-Daryoush M, Lindner D, Tallant TC, Wang Z, Buffa J, Klipfell E, Parker Y, Hatala D, Parsons-Wingerter P, Rayman P, Yusufishaq MS, Fisher EA, Smith JD, Finke J, DiDonato JA, Hazen SL.

J Biol Chem. 2013 Jul 19;288(29):21237-52. doi: 10.1074/jbc.M113.468967. Epub 2013 May 17.

31.

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis.

Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL.

Nat Med. 2013 May;19(5):576-85. doi: 10.1038/nm.3145. Epub 2013 Apr 7.

32.

Paradoxical association of enhanced cholesterol efflux with increased incident cardiovascular risks.

Li XM, Tang WH, Mosior MK, Huang Y, Wu Y, Matter W, Gao V, Schmitt D, Didonato JA, Fisher EA, Smith JD, Hazen SL.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1696-705. doi: 10.1161/ATVBAHA.113.301373. Epub 2013 Mar 21.

33.

Quantification of fatty acid oxidation products using online high-performance liquid chromatography tandem mass spectrometry.

Levison BS, Zhang R, Wang Z, Fu X, DiDonato JA, Hazen SL.

Free Radic Biol Med. 2013 Jun;59:2-13. doi: 10.1016/j.freeradbiomed.2013.03.001. Epub 2013 Mar 14.

34.

The low-resolution structure of nHDL reconstituted with DMPC with and without cholesterol reveals a mechanism for particle expansion.

Gogonea V, Gerstenecker GS, Wu Z, Lee X, Topbas C, Wagner MA, Tallant TC, Smith JD, Callow P, Pipich V, Malet H, Schoehn G, DiDonato JA, Hazen SL.

J Lipid Res. 2013 Apr;54(4):966-83. doi: 10.1194/jlr.M032763. Epub 2013 Jan 23.

35.

NF-κB and the link between inflammation and cancer.

DiDonato JA, Mercurio F, Karin M.

Immunol Rev. 2012 Mar;246(1):379-400. doi: 10.1111/j.1600-065X.2012.01099.x. Review.

PMID:
22435567
36.

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.

Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SL.

Nature. 2011 Apr 7;472(7341):57-63. doi: 10.1038/nature09922.

37.

Urinary bromotyrosine measures asthma control and predicts asthma exacerbations in children.

Wedes SH, Wu W, Comhair SA, McDowell KM, DiDonato JA, Erzurum SC, Hazen SL.

J Pediatr. 2011 Aug;159(2):248-55.e1. doi: 10.1016/j.jpeds.2011.01.029. Epub 2011 Mar 10.

38.

The low resolution structure of ApoA1 in spherical high density lipoprotein revealed by small angle neutron scattering.

Wu Z, Gogonea V, Lee X, May RP, Pipich V, Wagner MA, Undurti A, Tallant TC, Baleanu-Gogonea C, Charlton F, Ioffe A, DiDonato JA, Rye KA, Hazen SL.

J Biol Chem. 2011 Apr 8;286(14):12495-508. doi: 10.1074/jbc.M110.209130. Epub 2011 Feb 3.

39.

An hTERT-immortalized human urothelial cell line that responds to anti-proliferative factor.

Kim J, Ji M, DiDonato JA, Rackley RR, Kuang M, Sadhukhan PC, Mauney JR, Keay SK, Freeman MR, Liou LS, Adam RM.

In Vitro Cell Dev Biol Anim. 2011 Jan;47(1):2-9. doi: 10.1007/s11626-010-9350-y. Epub 2010 Dec 7.

40.

Congruency between biophysical data from multiple platforms and molecular dynamics simulation of the double-super helix model of nascent high-density lipoprotein.

Gogonea V, Wu Z, Lee X, Pipich V, Li XM, Ioffe AI, Didonato JA, Hazen SL.

Biochemistry. 2010 Aug 31;49(34):7323-43. doi: 10.1021/bi100588a.

41.

Plasma levels of high-density lipoprotein cholesterol and outcomes in pulmonary arterial hypertension.

Heresi GA, Aytekin M, Newman J, DiDonato J, Dweik RA.

Am J Respir Crit Care Med. 2010 Sep 1;182(5):661-8. doi: 10.1164/rccm.201001-0007OC. Epub 2010 May 6.

42.

Double superhelix model of high density lipoprotein.

Wu Z, Gogonea V, Lee X, Wagner MA, Li XM, Huang Y, Undurti A, May RP, Haertlein M, Moulin M, Gutsche I, Zaccai G, Didonato JA, Hazen SL.

J Biol Chem. 2009 Dec 25;284(52):36605-19. doi: 10.1074/jbc.M109.039537. Epub 2009 Oct 7.

43.

Modification of high density lipoprotein by myeloperoxidase generates a pro-inflammatory particle.

Undurti A, Huang Y, Lupica JA, Smith JD, DiDonato JA, Hazen SL.

J Biol Chem. 2009 Nov 6;284(45):30825-35. doi: 10.1074/jbc.M109.047605. Epub 2009 Sep 2.

44.

An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models.

Burdelya LG, Krivokrysenko VI, Tallant TC, Strom E, Gleiberman AS, Gupta D, Kurnasov OV, Fort FL, Osterman AL, Didonato JA, Feinstein E, Gudkov AV.

Science. 2008 Apr 11;320(5873):226-30. doi: 10.1126/science.1154986.

45.

Nitrosylcobalamin potentiates the anti-neoplastic effects of chemotherapeutic agents via suppression of survival signaling.

Bauer JA, Lupica JA, Schmidt H, Morrison BH, Haney RM, Masci RK, Lee RM, Didonato JA, Lindner DJ.

PLoS One. 2007 Dec 12;2(12):e1313.

46.

Protein carbamylation links inflammation, smoking, uremia and atherogenesis.

Wang Z, Nicholls SJ, Rodriguez ER, Kummu O, Hörkkö S, Barnard J, Reynolds WF, Topol EJ, DiDonato JA, Hazen SL.

Nat Med. 2007 Oct;13(10):1176-84. Epub 2007 Sep 9.

PMID:
17828273
47.

Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation.

Morrison BH, Bauer JA, Lupica JA, Tang Z, Schmidt H, DiDonato JA, Lindner DJ.

J Biol Chem. 2007 May 25;282(21):15349-56. Epub 2007 Mar 22.

48.

Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice.

Saadane A, Masters S, DiDonato J, Li J, Berger M.

Am J Respir Cell Mol Biol. 2007 Jun;36(6):728-36. Epub 2007 Feb 1.

49.

Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification.

Yao J, Kim TW, Qin J, Jiang Z, Qian Y, Xiao H, Lu Y, Qian W, Gulen MF, Sizemore N, DiDonato J, Sato S, Akira S, Su B, Li X.

J Biol Chem. 2007 Mar 2;282(9):6075-89. Epub 2006 Dec 29.

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