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15-Lipoxygenase 1 in nasal polyps promotes CCL26/eotaxin 3 expression through extracellular signal-regulated kinase activation.

Li Z, Zeng M, Deng Y, Zhao J, Zhou X, Trudeau JB, Goldschmidt E, Moore JA, Chu H, Zhang W, Yin S, Liu Z, Di YP, Lee SE, Wenzel SE.

J Allergy Clin Immunol. 2019 Jul 11. pii: S0091-6749(19)30905-4. doi: 10.1016/j.jaci.2019.06.037. [Epub ahead of print]


Inhibition of Pseudomonas aeruginosa biofilm formation and expression of virulence genes by selective epimerization in the peptide Esculentin-1a(1-21)NH2.

Casciaro B, Lin Q, Afonin S, Loffredo MR, de Turris V, Middel V, Ulrich AS, Di YP, Mangoni ML.

FEBS J. 2019 May 30. doi: 10.1111/febs.14940. [Epub ahead of print]


Poly(lactide- co-glycolide) Nanoparticles for Prolonged Therapeutic Efficacy of Esculentin-1a-Derived Antimicrobial Peptides against Pseudomonas aeruginosa Lung Infection: in Vitro and in Vivo Studies.

Casciaro B, d'Angelo I, Zhang X, Loffredo MR, Conte G, Cappiello F, Quaglia F, Di YP, Ungaro F, Mangoni ML.

Biomacromolecules. 2019 May 13;20(5):1876-1888. doi: 10.1021/acs.biomac.8b01829. Epub 2019 Apr 23.


The effect of BPIFA1/SPLUNC1 genetic variation on its expression and function in asthmatic airway epithelium.

Schaefer N, Li X, Seibold MA, Jarjour NN, Denlinger LC, Castro M, Coverstone AM, Teague WG, Boomer J, Bleecker ER, Meyers DA, Moore WC, Hawkins GA, Fahy J, Phillips BR, Mauger DT, Dakhama A, Gellatly S, Pavelka N, Berman R, Di YP, Wenzel SE, Chu HW.

JCI Insight. 2019 Apr 18;4(8). pii: 127237. doi: 10.1172/jci.insight.127237. eCollection 2019 Apr 18.


Antibacterial Properties and Efficacy of a Novel SPLUNC1-Derived Antimicrobial Peptide, α4-Short, in a Murine Model of Respiratory Infection.

Jiang S, Deslouches B, Chen C, Di ME, Di YP.

MBio. 2019 Apr 9;10(2). pii: e00226-19. doi: 10.1128/mBio.00226-19.


Enhanced biofilm prevention activity of a SPLUNC1-derived antimicrobial peptide against Staphylococcus aureus.

Yu Z, Deslouches B, Walton WG, Redinbo MR, Di YP.

PLoS One. 2018 Sep 14;13(9):e0203621. doi: 10.1371/journal.pone.0203621. eCollection 2018.


Antimicrobial Peptides: A Potential Therapeutic Option for Surgical Site Infections.

Deslouches B, Di YP.

Clin Surg. 2017 Nov;2. pii: 1740. Epub 2017 Nov 16.


Urinary Bladder Matrix Protects Host in a Murine Model of Bacterial-Induced Lung Infection.

Chen C, Zhang X, Lin Q, Remlinger NT, Gilbert TW, Di YP.

Tissue Eng Part A. 2019 Feb;25(3-4):257-270. doi: 10.1089/ten.TEA.2018.0080. Epub 2018 Sep 19.


Prevention of ESKAPE pathogen biofilm formation by antimicrobial peptides WLBU2 and LL37.

Lin Q, Deslouches B, Montelaro RC, Di YP.

Int J Antimicrob Agents. 2018 Nov;52(5):667-672. doi: 10.1016/j.ijantimicag.2018.04.019. Epub 2018 May 10.


Caveolin-1 promotes the tumor suppressor properties of oncogene-induced cellular senescence.

Volonte D, Vyas AR, Chen C, Dacic S, Stabile LP, Kurland BF, Abberbock SR, Burns TF, Herman JG, Di YP, Galbiati F.

J Biol Chem. 2018 Feb 2;293(5):1794-1809. doi: 10.1074/jbc.M117.815902. Epub 2017 Dec 15.


Latent Membrane Protein 1 Is a Novel Determinant of Epstein-Barr Virus Genome Persistence and Reactivation.

Caves EA, Butch RM, Cook SA, Wasil LR, Chen C, Di YP, Lee N, Shair KHY.

mSphere. 2017 Nov 8;2(6). pii: e00453-17. doi: 10.1128/mSphereDirect.00453-17. eCollection 2017 Nov-Dec.


Enhanced efficacy of the engineered antimicrobial peptide WLBU2 via direct airway delivery in a murine model of Pseudomonas aeruginosa pneumonia.

Chen C, Deslouches B, Montelaro RC, Di YP.

Clin Microbiol Infect. 2018 May;24(5):547.e1-547.e8. doi: 10.1016/j.cmi.2017.08.029. Epub 2017 Sep 4.


In vivo therapeutic efficacy of frog skin-derived peptides against Pseudomonas aeruginosa-induced pulmonary infection.

Chen C, Mangoni ML, Di YP.

Sci Rep. 2017 Aug 17;7(1):8548. doi: 10.1038/s41598-017-08361-8.


Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications.

Deslouches B, Di YP.

Oncotarget. 2017 Jul 11;8(28):46635-46651. doi: 10.18632/oncotarget.16743. Review.


Esculentin-1a-Derived Peptides Promote Clearance of Pseudomonas aeruginosa Internalized in Bronchial Cells of Cystic Fibrosis Patients and Lung Cell Migration: Biochemical Properties and a Plausible Mode of Action.

Cappiello F, Di Grazia A, Segev-Zarko LA, Scali S, Ferrera L, Galietta L, Pini A, Shai Y, Di YP, Mangoni ML.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7252-7262. Print 2016 Dec.


Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1.

Walton WG, Ahmad S, Little MS, Kim CS, Tyrrell J, Lin Q, Di YP, Tarran R, Redinbo MR.

Biochemistry. 2016 May 31;55(21):2979-91. doi: 10.1021/acs.biochem.6b00271. Epub 2016 May 17.


Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs.

Phinney DG, Di Giuseppe M, Njah J, Sala E, Shiva S, St Croix CM, Stolz DB, Watkins SC, Di YP, Leikauf GD, Kolls J, Riches DW, Deiuliis G, Kaminski N, Boregowda SV, McKenna DH, Ortiz LA.

Nat Commun. 2015 Oct 7;6:8472. doi: 10.1038/ncomms9472.


Differential Susceptibilities of Human Lung Primary Cells to H1N1 Influenza Viruses.

Travanty E, Zhou B, Zhang H, Di YP, Alcorn JF, Wentworth DE, Mason R, Wang J.

J Virol. 2015 Dec;89(23):11935-44. doi: 10.1128/JVI.01792-15. Epub 2015 Sep 16.


D-Amino acids incorporation in the frog skin-derived peptide esculentin-1a(1-21)NH2 is beneficial for its multiple functions.

Di Grazia A, Cappiello F, Cohen H, Casciaro B, Luca V, Pini A, Di YP, Shai Y, Mangoni ML.

Amino Acids. 2015 Dec;47(12):2505-19. doi: 10.1007/s00726-015-2041-y. Epub 2015 Jul 11.


Influenza-induced type I interferon enhances susceptibility to gram-negative and gram-positive bacterial pneumonia in mice.

Lee B, Robinson KM, McHugh KJ, Scheller EV, Mandalapu S, Chen C, Di YP, Clay ME, Enelow RI, Dubin PJ, Alcorn JF.

Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15;309(2):L158-67. doi: 10.1152/ajplung.00338.2014. Epub 2015 May 22.


Analysis of clinical and biological samples using microsphere-based multiplexing Luminex system.

Zhang Y, Birru R, Di YP.

Methods Mol Biol. 2014;1105:43-57. doi: 10.1007/978-1-62703-739-6_4.


Assessment of pathological and physiological changes in mouse lung through bronchoalveolar lavage.

Di YP.

Methods Mol Biol. 2014;1105:33-42. doi: 10.1007/978-1-62703-739-6_3.


Increased susceptibility to pulmonary Pseudomonas infection in Splunc1 knockout mice.

Liu Y, Di ME, Chu HW, Liu X, Wang L, Wenzel S, Di YP.

J Immunol. 2013 Oct 15;191(8):4259-68. doi: 10.4049/jimmunol.1202340. Epub 2013 Sep 18.


Dual acute proinflammatory and antifibrotic pulmonary effects of short palate, lung, and nasal epithelium clone-1 after exposure to carbon nanotubes.

Di YP, Tkach AV, Yanamala N, Stanley S, Gao S, Shurin MR, Kisin ER, Kagan VE, Shvedova A.

Am J Respir Cell Mol Biol. 2013 Nov;49(5):759-67. doi: 10.1165/rcmb.2012-0435OC.


Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence.

Volonte D, Liu Z, Musille PM, Stoppani E, Wakabayashi N, Di YP, Lisanti MP, Kensler TW, Galbiati F.

Mol Biol Cell. 2013 Jun;24(12):1852-62. doi: 10.1091/mbc.E12-09-0666. Epub 2013 May 1.


Functional genomic assessment of phosgene-induced acute lung injury in mice.

Leikauf GD, Concel VJ, Bein K, Liu P, Berndt A, Martin TM, Ganguly K, Jang AS, Brant KA, Dopico RA Jr, Upadhyay S, Cario C, Di YP, Vuga LJ, Kostem E, Eskin E, You M, Kaminski N, Prows DR, Knoell DL, Fabisiak JP.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):368-83. doi: 10.1165/rcmb.2012-0337OC.


SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection.

Liu Y, Bartlett JA, Di ME, Bomberger JM, Chan YR, Gakhar L, Mallampalli RK, McCray PB Jr, Di YP.

Am J Pathol. 2013 May;182(5):1519-31. doi: 10.1016/j.ajpath.2013.01.050. Epub 2013 Mar 15.


Multifunctional role of human SPLUNC1 in Pseudomonas aeruginosa infection.

Sayeed S, Nistico L, St Croix C, Di YP.

Infect Immun. 2013 Jan;81(1):285-91. doi: 10.1128/IAI.00500-12. Epub 2012 Nov 6.


Pathogenic mechanism of second hand smoke induced inflammation and COPD.

Birru RL, Di YP.

Front Physiol. 2012 Aug 28;3:348. doi: 10.3389/fphys.2012.00348. eCollection 2012.


Effects of second hand smoke on airway secretion and mucociliary clearance.

Liu Y, Di YP.

Front Physiol. 2012 Aug 28;3:342. doi: 10.3389/fphys.2012.00342. eCollection 2012.


Cigarette smoke induces MUC5AC protein expression through the activation of Sp1.

Di YP, Zhao J, Harper R.

J Biol Chem. 2012 Aug 10;287(33):27948-58. doi: 10.1074/jbc.M111.334375. Epub 2012 Jun 14.


Integrative assessment of chlorine-induced acute lung injury in mice.

Leikauf GD, Pope-Varsalona H, Concel VJ, Liu P, Bein K, Berndt A, Martin TM, Ganguly K, Jang AS, Brant KA, Dopico RA Jr, Upadhyay S, Di YP, Li Q, Hu Z, Vuga LJ, Medvedovic M, Kaminski N, You M, Alexander DC, McDunn JE, Prows DR, Knoell DL, Fabisiak JP.

Am J Respir Cell Mol Biol. 2012 Aug;47(2):234-44. doi: 10.1165/rcmb.2012-0026OC. Epub 2012 Mar 23.


Negative control of TLR3 signaling by TICAM1 down-regulation.

Tao S, Zhu L, Lee P, Lee WM, Knox K, Chen J, Di YP, Chen Y.

Am J Respir Cell Mol Biol. 2012 May;46(5):660-7. doi: 10.1165/rcmb.2011-0340OC. Epub 2011 Dec 28.


K-ras mutations in lung tumors from NNK-treated mice with lipopolysaccharide-elicited lung inflammation.

Keohavong P, Kahkonen B, Kinchington E, Yin J, Jin J, Liu X, Siegfried JM, DI YP.

Anticancer Res. 2011 Sep;31(9):2877-82.


Functional roles of SPLUNC1 in the innate immune response against Gram-negative bacteria.

Di YP.

Biochem Soc Trans. 2011 Aug;39(4):1051-5. doi: 10.1042/BST0391051. Review.


Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection.

Lukinskiene L, Liu Y, Reynolds SD, Steele C, Stripp BR, Leikauf GD, Kolls JK, Di YP.

J Immunol. 2011 Jul 1;187(1):382-90. doi: 10.4049/jimmunol.1001769. Epub 2011 Jun 1.


SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice.

Gally F, Di YP, Smith SK, Minor MN, Liu Y, Bratton DL, Frasch SC, Michels NM, Case SR, Chu HW.

Am J Pathol. 2011 May;178(5):2159-67. doi: 10.1016/j.ajpath.2011.01.026.


Differential effects of nicotine and tobacco smoke condensate on human annulus fibrosus cell metabolism.

Vo N, Wang D, Sowa G, Witt W, Ngo K, Coelho P, Bedison R, Byer B, Studer R, Lee J, Di YP, Kang J.

J Orthop Res. 2011 Oct;29(10):1585-91. doi: 10.1002/jor.21417. Epub 2011 Mar 29.


Prospective study of epidermal growth factor receptor tyrosine kinase inhibitors concurrent with individualized radiotherapy for patients with locally advanced or metastatic non-small-cell lung cancer.

Wang J, Xia TY, Wang YJ, Li HQ, Li P, Wang JD, Chang DS, Liu LY, Di YP, Wang X, Wu WZ.

Int J Radiat Oncol Biol Phys. 2011 Nov 1;81(3):e59-65. doi: 10.1016/j.ijrobp.2010.12.035. Epub 2011 Feb 23.


Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.

Leikauf GD, Concel VJ, Liu P, Bein K, Berndt A, Ganguly K, Jang AS, Brant KA, Dietsch M, Pope-Varsalona H, Dopico RA Jr, Di YP, Li Q, Vuga LJ, Medvedovic M, Kaminski N, You M, Prows DR.

Am J Respir Crit Care Med. 2011 Jun 1;183(11):1499-509. doi: 10.1164/rccm.201006-0912OC. Epub 2011 Feb 4.


Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation.

Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC.

J Exp Med. 2010 Nov 22;207(12):2595-607. doi: 10.1084/jem.20100786. Epub 2010 Oct 25.


Functional genomics of chlorine-induced acute lung injury in mice.

Leikauf GD, Pope-Varsalona H, Concel VJ, Liu P, Bein K, Brant KA, Dopico RA, Di YP, Jang AS, Dietsch M, Medvedovic M, Li Q, Vuga LJ, Kaminski N, You M, Prows DR.

Proc Am Thorac Soc. 2010 Jul;7(4):294-6. doi: 10.1513/pats.201001-005SM.


Endothelial dysfunction and claudin 5 regulation during acrolein-induced lung injury.

Jang AS, Concel VJ, Bein K, Brant KA, Liu S, Pope-Varsalona H, Dopico RA Jr, Di YP, Knoell DL, Barchowsky A, Leikauf GD.

Am J Respir Cell Mol Biol. 2011 Apr;44(4):483-90. doi: 10.1165/rcmb.2009-0391OC. Epub 2010 Jun 4.


Identification of multiple MAPK-mediated transcription factors regulated by tobacco smoke in airway epithelial cells.

Zhao J, Harper R, Barchowsky A, Di YP.

Am J Physiol Lung Cell Mol Physiol. 2007 Aug;293(2):L480-90. Epub 2007 May 11.


Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease.

Ning W, Li CJ, Kaminski N, Feghali-Bostwick CA, Alber SM, Di YP, Otterbein SL, Song R, Hayashi S, Zhou Z, Pinsky DJ, Watkins SC, Pilewski JM, Sciurba FC, Peters DG, Hogg JC, Choi AM.

Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14895-900. Epub 2004 Oct 5.


[Replication and encapsidation of HBV mutants with the truncated C gene].

Han JQ, Hu DR, Xiong JH, Hu XL, Fan GR, Li J, Liu CY, Di YP, Wu YP.

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2004 Mar;18(1):39-42. Chinese.


Regulation of thioredoxin gene expression by vitamin A in human airway epithelial cells.

Chang WH, Reddy SP, Di YP, Yoneda K, Harper R, Wu R.

Am J Respir Cell Mol Biol. 2002 May;26(5):627-35.


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