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Items: 27

1.

Rational design of agonists for bitter taste receptor TAS2R14: from modeling to bench and back.

Di Pizio A, Waterloo LAW, Brox R, Löber S, Weikert D, Behrens M, Gmeiner P, Niv MY.

Cell Mol Life Sci. 2019 Jun 24. doi: 10.1007/s00018-019-03194-2. [Epub ahead of print]

PMID:
31236627
2.

A bioinspired in vitro bioelectronic tongue with human T2R38 receptor for high-specificity detection of N-C=S-containing compounds.

Qin C, Qin Z, Zhao D, Pan Y, Zhuang L, Wan H, Di Pizio A, Malach E, Niv MY, Huang L, Hu N, Wang P.

Talanta. 2019 Jul 1;199:131-139. doi: 10.1016/j.talanta.2019.02.021. Epub 2019 Feb 6.

PMID:
30952236
3.

Beyond the Flavour: The Potential Druggability of Chemosensory G Protein-Coupled Receptors.

Di Pizio A, Behrens M, Krautwurst D.

Int J Mol Sci. 2019 Mar 20;20(6). pii: E1402. doi: 10.3390/ijms20061402. Review.

4.

Author Correction: RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells.

Qutob N, Masuho I, Alon M, Emmanuel R, Cohen I, Di Pizio A, Madore J, Elkahloun A, Ziv T, Levy R, Gartner JJ, Hill VK, Lin JC, Hevroni Y, Greenberg P, Brodezki A, Rosenberg SA, Kosloff M, Hayward NK, Admon A, Niv MY, Scolyer RA, Martemyanov KA, Samuels Y.

Sci Rep. 2019 Mar 9;9(1):4523. doi: 10.1038/s41598-018-37932-6.

5.

Allostery in Its Many Disguises: From Theory to Applications.

Wodak SJ, Paci E, Dokholyan NV, Berezovsky IN, Horovitz A, Li J, Hilser VJ, Bahar I, Karanicolas J, Stock G, Hamm P, Stote RH, Eberhardt J, Chebaro Y, Dejaegere A, Cecchini M, Changeux JP, Bolhuis PG, Vreede J, Faccioli P, Orioli S, Ravasio R, Yan L, Brito C, Wyart M, Gkeka P, Rivalta I, Palermo G, McCammon JA, Panecka-Hofman J, Wade RC, Di Pizio A, Niv MY, Nussinov R, Tsai CJ, Jang H, Padhorny D, Kozakov D, McLeish T.

Structure. 2019 Apr 2;27(4):566-578. doi: 10.1016/j.str.2019.01.003. Epub 2019 Feb 7. Review.

6.

RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma.

Arafeh R, Di Pizio A, Elkahloun AG, Dym O, Niv MY, Samuels Y.

Oncogene. 2019 Mar;38(13):2432-2434. doi: 10.1038/s41388-018-0578-4. Epub 2018 Nov 26. No abstract available.

PMID:
30478445
7.

BitterDB: taste ligands and receptors database in 2019.

Dagan-Wiener A, Di Pizio A, Nissim I, Bahia MS, Dubovski N, Margulis E, Niv MY.

Nucleic Acids Res. 2019 Jan 8;47(D1):D1179-D1185. doi: 10.1093/nar/gky974.

8.

Bitterless guaifenesin prodrugs-design, synthesis, characterization, in vitro kinetics, and bitterness studies.

Thawabteh A, Lelario F, Scrano L, Bufo SA, Nowak S, Behrens M, Di Pizio A, Niv MY, Karaman R.

Chem Biol Drug Des. 2019 Mar;93(3):262-271. doi: 10.1111/cbdd.13409. Epub 2018 Nov 2.

PMID:
30276968
9.

Corrigendum: Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes.

Xue AY, Di Pizio A, Levit A, Yarnitzky T, Penn O, Pupko T, Niv MY.

Front Mol Biosci. 2018 Sep 11;5:84. doi: 10.3389/fmolb.2018.00084. eCollection 2018.

10.

Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14.

Nowak S, Di Pizio A, Levit A, Niv MY, Meyerhof W, Behrens M.

Biochim Biophys Acta Gen Subj. 2018 Oct;1862(10):2162-2173. doi: 10.1016/j.bbagen.2018.07.009. Epub 2018 Jul 19.

PMID:
30009876
11.

Bitter and sweet tasting molecules: It's complicated.

Di Pizio A, Ben Shoshan-Galeczki Y, Hayes JE, Niv MY.

Neurosci Lett. 2019 May 1;700:56-63. doi: 10.1016/j.neulet.2018.04.027. Epub 2018 Apr 19. Review.

PMID:
29679682
12.

Locally translated mTOR controls axonal local translation in nerve injury.

Terenzio M, Koley S, Samra N, Rishal I, Zhao Q, Sahoo PK, Urisman A, Marvaldi L, Oses-Prieto JA, Forester C, Gomes C, Kalinski AL, Di Pizio A, Doron-Mandel E, Perry RB, Koppel I, Twiss JL, Burlingame AL, Fainzilber M.

Science. 2018 Mar 23;359(6382):1416-1421. doi: 10.1126/science.aan1053.

13.

Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes.

Xue AY, Di Pizio A, Levit A, Yarnitzky T, Penn O, Pupko T, Niv MY.

Front Mol Biosci. 2018 Mar 2;5:9. doi: 10.3389/fmolb.2018.00009. eCollection 2018. Erratum in: Front Mol Biosci. 2018 Sep 11;5:84.

14.

Molecular Features Underlying Selectivity in Chicken Bitter Taste Receptors.

Di Pizio A, Shy N, Behrens M, Meyerhof W, Niv MY.

Front Mol Biosci. 2018 Jan 31;5:6. doi: 10.3389/fmolb.2018.00006. eCollection 2018.

15.

RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells.

Qutob N, Masuho I, Alon M, Emmanuel R, Cohen I, Di Pizio A, Madore J, Elkahloun A, Ziv T, Levy R, Gartner JJ, Hill VK, Lin JC, Hevroni Y, Greenberg P, Brodezki A, Rosenberg SA, Kosloff M, Hayward NK, Admon A, Niv MY, Scolyer RA, Martemyanov KA, Samuels Y.

Sci Rep. 2018 Jan 12;8(1):653. doi: 10.1038/s41598-017-18851-4. Erratum in: Sci Rep. 2019 Mar 9;9(1):4523.

16.

Ligand binding modes from low resolution GPCR models and mutagenesis: chicken bitter taste receptor as a test-case.

Di Pizio A, Kruetzfeldt LM, Cheled-Shoval S, Meyerhof W, Behrens M, Niv MY.

Sci Rep. 2017 Aug 15;7(1):8223. doi: 10.1038/s41598-017-08344-9.

17.

From Cell to Beak: In-Vitro and In-Vivo Characterization of Chicken Bitter Taste Thresholds.

Cheled-Shoval S, Behrens M, Korb A, Di Pizio A, Meyerhof W, Uni Z, Niv MY.

Molecules. 2017 May 17;22(5). pii: E821. doi: 10.3390/molecules22050821.

18.

Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity.

Tauro M, Laghezza A, Loiodice F, Piemontese L, Caradonna A, Capelli D, Montanari R, Pochetti G, Di Pizio A, Agamennone M, Campestre C, Tortorella P.

J Enzyme Inhib Med Chem. 2016;31(sup4):25-37. Epub 2016 Aug 24.

PMID:
27556138
19.

Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios.

Di Pizio A, Levit A, Slutzki M, Behrens M, Karaman R, Niv MY.

Methods Cell Biol. 2016;132:401-27. doi: 10.1016/bs.mcb.2015.10.005. Epub 2015 Dec 24.

PMID:
26928553
20.

Probing the Binding Pocket of the Broadly Tuned Human Bitter Taste Receptor TAS2R14 by Chemical Modification of Cognate Agonists.

Karaman R, Nowak S, Di Pizio A, Kitaneh H, Abu-Jaish A, Meyerhof W, Niv MY, Behrens M.

Chem Biol Drug Des. 2016 Jul;88(1):66-75. doi: 10.1111/cbdd.12734. Epub 2016 Feb 17.

PMID:
26825540
21.

Recurrent inactivating RASA2 mutations in melanoma.

Arafeh R, Qutob N, Emmanuel R, Keren-Paz A, Madore J, Elkahloun A, Wilmott JS, Gartner JJ, Di Pizio A, Winograd-Katz S, Sindiri S, Rotkopf R, Dutton-Regester K, Johansson P, Pritchard AL, Waddell N, Hill VK, Lin JC, Hevroni Y, Rosenberg SA, Khan J, Ben-Dor S, Niv MY, Ulitsky I, Mann GJ, Scolyer RA, Hayward NK, Samuels Y.

Nat Genet. 2015 Dec;47(12):1408-10. doi: 10.1038/ng.3427. Epub 2015 Oct 26.

22.

Non-Zinc-Binding Inhibitors of MMP-13: GRID-Based Approaches to Rationalize the Binding Process.

Di Pizio A, Agamennone M, Tortorella P.

Curr Top Med Chem. 2016;16(4):449-59. Review.

PMID:
26268339
23.

Promiscuity and selectivity of bitter molecules and their receptors.

Di Pizio A, Niv MY.

Bioorg Med Chem. 2015 Jul 15;23(14):4082-91. doi: 10.1016/j.bmc.2015.04.025. Epub 2015 Apr 16.

PMID:
25934224
24.

Ac-tLeu-Asp-H is the minimal and highly effective human caspase-3 inhibitor: biological and in silico studies.

Ferrucci A, Leboffe L, Agamennone M, Di Pizio A, Fiocchetti M, Marino M, Ascenzi P, Luisi G.

Amino Acids. 2015 Jan;47(1):153-62. doi: 10.1007/s00726-014-1855-3. Epub 2014 Oct 21.

PMID:
25331424
25.

Probing the S1' site for the identification of non-zinc-binding MMP-2 inhibitors.

Di Pizio A, Laghezza A, Tortorella P, Agamennone M.

ChemMedChem. 2013 Sep;8(9):1475-82, 1421. doi: 10.1002/cmdc.201300186. Epub 2013 Jul 19.

PMID:
23873724
26.

Amino Acid derivatives as new zinc binding groups for the design of selective matrix metalloproteinase inhibitors.

Giustiniano M, Tortorella P, Agamennone M, Di Pizio A, Rossello A, Nuti E, Gomez-Monterrey I, Novellino E, Campiglia P, Vernieri E, Sala M, Bertamino A, Carotenuto A.

J Amino Acids. 2013;2013:178381. doi: 10.1155/2013/178381. Epub 2013 Mar 10.

27.

An integrated computational approach to rationalize the activity of non-zinc-binding MMP-2 inhibitors.

Di Pizio A, Agamennone M, Aschi M.

PLoS One. 2012;7(11):e47774. doi: 10.1371/journal.pone.0047774. Epub 2012 Nov 8.

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