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Items: 1 to 50 of 412

1.

N-Palmitoylethanolamide-Oxazoline Protects against Middle Cerebral Artery Occlusion Injury in Diabetic Rats by Regulating the SIRT1 Pathway.

Fusco R, Scuto M, Cordaro M, D'Amico R, Gugliandolo E, Siracusa R, Peritore AF, Crupi R, Impellizzeri D, Cuzzocrea S, Di Paola R.

Int J Mol Sci. 2019 Sep 29;20(19). pii: E4845. doi: 10.3390/ijms20194845.

2.

The neuroprotective effects of micronized PEA (PEA-m) formulation on diabetic peripheral neuropathy in mice.

Impellizzeri D, Peritore AF, Cordaro M, Gugliandolo E, Siracusa R, Crupi R, D'Amico R, Fusco R, Evangelista M, Cuzzocrea S, Di Paola R.

FASEB J. 2019 Oct;33(10):11364-11380. doi: 10.1096/fj.201900538R. Epub 2019 Jul 25.

PMID:
31344333
3.

Co-ultraPEALut: Role in Preclinical and Clinical Delirium Manifestations.

Lunardelli ML, Crupi R, Siracusa R, Cocuzza G, Cordaro M, Martini E, Impellizzeri D, Di Paola R, Cuzzocrea S.

CNS Neurol Disord Drug Targets. 2019 Jun 17. doi: 10.2174/1871527318666190617162041. [Epub ahead of print]

PMID:
31244434
4.

Association of a homozygous GCK missense mutation with mild diabetes.

Marucci A, Biagini T, Di Paola R, Menzaghi C, Fini G, Castellana S, Cardinale GM, Mazza T, Trischitta V.

Mol Genet Genomic Med. 2019 Jul;7(7):e00728. doi: 10.1002/mgg3.728. Epub 2019 Jun 14.

5.

GALNT2 as a novel modulator of adipogenesis and adipocyte insulin signaling.

Marucci A, Antonucci A, De Bonis C, Mangiacotti D, Scarale MG, Trischitta V, Di Paola R.

Int J Obes (Lond). 2019 Apr 30. doi: 10.1038/s41366-019-0367-3. [Epub ahead of print]

PMID:
31040393
6.

Formyl peptide receptor 1 signalling promotes experimental colitis in mice.

Di Paola R, Fusco R, Gugliandolo E, D'Amico R, Cordaro M, Impellizzeri D, Perretti M, Cuzzocrea S.

Pharmacol Res. 2019 Mar;141:591-601. doi: 10.1016/j.phrs.2019.01.041. Epub 2019 Jan 31.

PMID:
30711419
7.

Treatment With a Flavonoid-Rich Fraction of Bergamot Juice Improved Lipopolysaccharide-Induced Periodontitis in Rats.

Gugliandolo E, Fusco R, D'Amico R, Peditto M, Oteri G, Di Paola R, Cuzzocrea S, Navarra M.

Front Pharmacol. 2019 Jan 17;9:1563. doi: 10.3389/fphar.2018.01563. eCollection 2018.

8.

Functional and endocrine-metabolic oligomenorrhea: proposal of a new diagnostic assessment tool for differential diagnosis in adolescence.

Baggio S, Di Paola R, Zaffagnini S, Fino S, Raffaelli R, Franchi M.

J Pediatr Endocrinol Metab. 2019 Feb 25;32(2):135-142. doi: 10.1515/jpem-2018-0351.

PMID:
30685743
9.

Effects of a new compound containing Palmitoylethanolamide and Baicalein in myocardial ischaemia/reperfusion injury in vivo.

D'amico R, Fusco R, Gugliandolo E, Cordaro M, Siracusa R, Impellizzeri D, Peritore AF, Crupi R, Cuzzocrea S, Di Paola R.

Phytomedicine. 2019 Feb 15;54:27-42. doi: 10.1016/j.phymed.2018.09.191. Epub 2018 Sep 19.

PMID:
30668378
10.

N-Palmitoylethanolamine-oxazoline (PEA-OXA): A new therapeutic strategy to reduce neuroinflammation, oxidative stress associated to vascular dementia in an experimental model of repeated bilateral common carotid arteries occlusion.

Impellizzeri D, Siracusa R, Cordaro M, Crupi R, Peritore AF, Gugliandolo E, D'Amico R, Petrosino S, Evangelista M, Di Paola R, Cuzzocrea S.

Neurobiol Dis. 2019 May;125:77-91. doi: 10.1016/j.nbd.2019.01.007. Epub 2019 Jan 17.

PMID:
30660740
11.

Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post-ischemia/reperfusion injury.

Voisin MB, Leoni G, Woodfin A, Loumagne L, Patel NS, Di Paola R, Cuzzocrea S, Thiemermann C, Perretti M, Nourshargh S.

J Pathol. 2019 May;248(1):88-102. doi: 10.1002/path.5234. Epub 2019 Mar 22.

PMID:
30632166
12.

Selective CB2 inverse agonist JTE907 drives T cell differentiation towards a Treg cell phenotype and ameliorates inflammation in a mouse model of inflammatory bowel disease.

Gentili M, Ronchetti S, Ricci E, Di Paola R, Gugliandolo E, Cuzzocrea S, Bereshchenko O, Migliorati G, Riccardi C.

Pharmacol Res. 2019 Mar;141:21-31. doi: 10.1016/j.phrs.2018.12.005. Epub 2018 Dec 12.

PMID:
30552973
13.

Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis.

Riva B, Griglio A, Serafini M, Cordero-Sanchez C, Aprile S, Di Paola R, Gugliandolo E, Alansary D, Biocotino I, Lim D, Grosa G, Galli U, Niemeyer B, Sorba G, Canonico PL, Cuzzocrea S, Genazzani AA, Pirali T.

J Med Chem. 2018 Nov 8;61(21):9756-9783. doi: 10.1021/acs.jmedchem.8b01512. Epub 2018 Oct 30.

PMID:
30347159
14.

Pharmacodynamical effects of orally administered exenatide nanoparticles embedded in gastro-resistant microparticles.

Soudry-Kochavi L, Naraykin N, Di Paola R, Gugliandolo E, Peritore A, Cuzzocrea S, Ziv E, Nassar T, Benita S.

Eur J Pharm Biopharm. 2018 Dec;133:214-223. doi: 10.1016/j.ejpb.2018.10.013. Epub 2018 Oct 18.

PMID:
30342089
15.

Are we choosing the correct FSH starting dose during controlled ovarian stimulation for intrauterine insemination cycles? Potential application of a nomogram based on woman's age and markers of ovarian reserve.

Di Paola R, Garzon S, Giuliani S, Laganà AS, Noventa M, Parissone F, Zorzi C, Raffaelli R, Ghezzi F, Franchi M, Zaffagnini S.

Arch Gynecol Obstet. 2018 Nov;298(5):1029-1035. doi: 10.1007/s00404-018-4906-2. Epub 2018 Sep 21.

PMID:
30242498
16.

Effect of PEA-OXA on neuropathic pain and functional recovery after sciatic nerve crush.

Gugliandolo E, D'amico R, Cordaro M, Fusco R, Siracusa R, Crupi R, Impellizzeri D, Cuzzocrea S, Di Paola R.

J Neuroinflammation. 2018 Sep 14;15(1):264. doi: 10.1186/s12974-018-1303-5.

17.

Topical Application of Adelmidrol + Trans-Traumatic Acid Enhances Skin Wound Healing in a Streptozotocin-Induced Diabetic Mouse Model.

Siracusa R, Impellizzeri D, Cordaro M, Gugliandolo E, Peritore AF, Di Paola R, Cuzzocrea S.

Front Pharmacol. 2018 Aug 23;9:871. doi: 10.3389/fphar.2018.00871. eCollection 2018.

18.

Absence of formyl peptide receptor 1 causes endometriotic lesion regression in a mouse model of surgically-induced endometriosis.

Fusco R, D'amico R, Cordaro M, Gugliandolo E, Siracusa R, Peritore AF, Crupi R, Impellizzeri D, Cuzzocrea S, Di Paola R.

Oncotarget. 2018 Jul 31;9(59):31355-31366. doi: 10.18632/oncotarget.25823. eCollection 2018 Jul 31.

19.

Micronized palmitoylethanolamide reduces joint pain and glial cell activation.

Bartolucci ML, Marini I, Bortolotti F, Impellizzeri D, Di Paola R, Bruschetta G, Crupi R, Portelli M, Militi A, Oteri G, Esposito E, Cuzzocrea S.

Inflamm Res. 2018 Oct;67(10):891-901. doi: 10.1007/s00011-018-1179-y. Epub 2018 Aug 18.

PMID:
30121836
20.

Neuroprotective Effect of Artesunate in Experimental Model of Traumatic Brain Injury.

Gugliandolo E, D'Amico R, Cordaro M, Fusco R, Siracusa R, Crupi R, Impellizzeri D, Cuzzocrea S, Di Paola R.

Front Neurol. 2018 Jul 31;9:590. doi: 10.3389/fneur.2018.00590. eCollection 2018.

21.

Is There Really a Paradoxical Effect of Obesity on Mortality Rate in High-Risk Patients? It Is Time for Large Mendelian Randomization Studies.

Trischitta V, Di Paola R.

Am J Cardiol. 2018 Sep 1;122(5):910. doi: 10.1016/j.amjcard.2018.04.063. Epub 2018 Jun 2. No abstract available.

PMID:
30049458
22.

Correction: Effect of a new formulation of micronized and ultramicronized N-palmitoylethanolamine in a tibia fracture mouse model of complex regional pain syndrome.

Fusco R, Gugliandolo E, Campolo M, Evangelista M, Di Paola R, Cuzzocrea S.

PLoS One. 2018 Jul 25;13(7):e0201501. doi: 10.1371/journal.pone.0201501. eCollection 2018.

23.

Therapeutic potential of dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice by targeting IL-1β and IL-18.

Impellizzeri D, Siracusa R, Cordaro M, Peritore AF, Gugliandolo E, Mancuso G, Midiri A, Di Paola R, Cuzzocrea S.

Biochem Pharmacol. 2018 Sep;155:150-161. doi: 10.1016/j.bcp.2018.06.029. Epub 2018 Jun 28.

PMID:
29963998
24.

Adelmidrol + sodium hyaluronate in IC/BPS or conditions associated to chronic urothelial inflammation. A translational study.

Ostardo E, Impellizzeri D, Cervigni M, Porru D, Sommariva M, Cordaro M, Siracusa R, Fusco R, Gugliandolo E, Crupi R, Schievano C, Inferrera A, Di Paola R, Cuzzocrea S; Urology Study Group.

Pharmacol Res. 2018 Aug;134:16-30. doi: 10.1016/j.phrs.2018.05.013. Epub 2018 May 22.

PMID:
29800607
25.

2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease.

Cordaro M, Siracusa R, Crupi R, Impellizzeri D, Peritore AF, D'Amico R, Gugliandolo E, Di Paola R, Cuzzocrea S.

Mol Neurobiol. 2018 Dec;55(12):9251-9266. doi: 10.1007/s12035-018-1064-2. Epub 2018 Apr 14.

PMID:
29656363
26.

Involvement of TLR4 and PPAR-α Receptors in Host Response and NLRP3 Inflammasome Activation, Against Pulmonary Infection With Pseudomonas Aeruginosa.

Gugliandolo E, Fusco R, Ginestra G, D'amico R, Bisignano C, Mandalari G, Cuzzocrea S, Di Paola R.

Shock. 2019 Feb;51(2):221-227. doi: 10.1097/SHK.0000000000001137.

PMID:
29547450
27.

The Antioxidant Activity of Pistachios Reduces Cardiac Tissue Injury of Acute Ischemia/Reperfusion (I/R) in Diabetic Streptozotocin (STZ)-Induced Hyperglycaemic Rats.

Di Paola R, Fusco R, Gugliandolo E, D'Amico R, Campolo M, Latteri S, Carughi A, Mandalari G, Cuzzocrea S.

Front Pharmacol. 2018 Feb 6;9:51. doi: 10.3389/fphar.2018.00051. eCollection 2018.

28.

Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer's disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms.

Trovato Salinaro A, Pennisi M, Di Paola R, Scuto M, Crupi R, Cambria MT, Ontario ML, Tomasello M, Uva M, Maiolino L, Calabrese EJ, Cuzzocrea S, Calabrese V.

Immun Ageing. 2018 Feb 14;15:8. doi: 10.1186/s12979-017-0108-1. eCollection 2018. Review.

29.

Anti-inflammatory effect of ATB-352, a H2S -releasing ketoprofen derivative, on lipopolysaccharide-induced periodontitis in rats.

Gugliandolo E, Fusco R, D'Amico R, Militi A, Oteri G, Wallace JL, Di Paola R, Cuzzocrea S.

Pharmacol Res. 2018 Jun;132:220-231. doi: 10.1016/j.phrs.2017.12.022. Epub 2017 Dec 26.

PMID:
29287688
30.

Middle Cerebral Artery Occlusion by an Intraluminal Suture Method.

Crupi R, Di Paola R, Esposito E, Cuzzocrea S.

Methods Mol Biol. 2018;1727:393-401. doi: 10.1007/978-1-4939-7571-6_31.

PMID:
29222799
31.

Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis.

Calabrese V, Santoro A, Monti D, Crupi R, Di Paola R, Latteri S, Cuzzocrea S, Zappia M, Giordano J, Calabrese EJ, Franceschi C.

Free Radic Biol Med. 2018 Feb 1;115:80-91. doi: 10.1016/j.freeradbiomed.2017.10.379. Epub 2017 Nov 25. Review.

PMID:
29080843
32.

A novel composite formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain models.

Britti D, Crupi R, Impellizzeri D, Gugliandolo E, Fusco R, Schievano C, Morittu VM, Evangelista M, Di Paola R, Cuzzocrea S.

BMC Vet Res. 2017 Aug 2;13(1):229. doi: 10.1186/s12917-017-1151-z.

33.

Pharmacogenetics of oral antidiabetes drugs: evidence for diverse signals at the IRS1 locus.

Prudente S, Di Paola R, Pezzilli S, Garofolo M, Lamacchia O, Filardi T, Mannino GC, Mercuri L, Alberico F, Scarale MG, Sesti G, Morano S, Penno G, Cignarelli M, Copetti M, Trischitta V.

Pharmacogenomics J. 2018 May 22;18(3):431-435. doi: 10.1038/tpj.2017.32. Epub 2017 Jul 11.

PMID:
28696414
34.

Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury.

Gugliandolo E, Fusco R, Biundo F, D'Amico R, Benedetto F, Di Paola R, Cuzzocrea S.

Pharmacol Res. 2017 Sep;123:83-92. doi: 10.1016/j.phrs.2017.06.014. Epub 2017 Jul 1.

PMID:
28676456
35.

AQX-1125, small molecule SHIP1 activator inhibits bleomycin-induced pulmonary fibrosis.

Cross J, Stenton GR, Harwig C, Szabo C, Genovese T, Di Paola R, Esposito E, Cuzzocrea S, Mackenzie LF.

Br J Pharmacol. 2017 Sep;174(18):3045-3057. doi: 10.1111/bph.13934. Epub 2017 Aug 11.

36.

Effects of a co-micronized composite containing palmitoylethanolamide and polydatin in an experimental model of benign prostatic hyperplasia.

Cordaro M, Impellizzeri D, Siracusa R, Gugliandolo E, Fusco R, Inferrera A, Esposito E, Di Paola R, Cuzzocrea S.

Toxicol Appl Pharmacol. 2017 Aug 15;329:231-240. doi: 10.1016/j.taap.2017.06.005. Epub 2017 Jun 10.

PMID:
28610993
37.

Effect of a new formulation of micronized and ultramicronized N-palmitoylethanolamine in a tibia fracture mouse model of complex regional pain syndrome.

Fusco R, Gugliandolo E, Campolo M, Evangelista M, Di Paola R, Cuzzocrea S.

PLoS One. 2017 Jun 8;12(6):e0178553. doi: 10.1371/journal.pone.0178553. eCollection 2017. Erratum in: PLoS One. 2018 Jul 25;13(7):e0201501.

38.

Inhibition of inflammasome activation improves lung acute injury induced by carrageenan in a mouse model of pleurisy.

Fusco R, Gugliandolo E, Biundo F, Campolo M, Di Paola R, Cuzzocrea S.

FASEB J. 2017 Aug;31(8):3497-3511. doi: 10.1096/fj.201601349R. Epub 2017 May 1.

PMID:
28461340
39.

Liver X receptors activation, through TO901317 binding, reduces neuroinflammation in Parkinson's disease.

Paterniti I, Campolo M, Siracusa R, Cordaro M, Di Paola R, Calabrese V, Navarra M, Cuzzocrea S, Esposito E.

PLoS One. 2017 Apr 3;12(4):e0174470. doi: 10.1371/journal.pone.0174470. eCollection 2017.

40.

Monogenic Diabetes Accounts for 6.3% of Cases Referred to 15 Italian Pediatric Diabetes Centers During 2007 to 2012.

Delvecchio M, Mozzillo E, Salzano G, Iafusco D, Frontino G, Patera PI, Rabbone I, Cherubini V, Grasso V, Tinto N, Giglio S, Contreas G, Di Paola R, Salina A, Cauvin V, Tumini S, d'Annunzio G, Iughetti L, Mantovani V, Maltoni G, Toni S, Marigliano M, Barbetti F; Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetes (ISPED).

J Clin Endocrinol Metab. 2017 Jun 1;102(6):1826-1834. doi: 10.1210/jc.2016-2490.

PMID:
28323911
41.

Suggestive evidence of a multi-cytokine resistin pathway in humans and its role on cardiovascular events in high-risk individuals.

Menzaghi C, Marucci A, Antonucci A, De Bonis C, Ortega Moreno L, Salvemini L, Copetti M, Trischitta V, Di Paola R.

Sci Rep. 2017 Mar 14;7:44337. doi: 10.1038/srep44337.

42.

FeTPPS Reduces Secondary Damage and Improves Neurobehavioral Functions after Traumatic Brain Injury.

Bruschetta G, Impellizzeri D, Campolo M, Casili G, Di Paola R, Paterniti I, Esposito E, Cuzzocrea S.

Front Neurosci. 2017 Feb 7;11:6. doi: 10.3389/fnins.2017.00006. eCollection 2017.

43.

Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity.

Travelli C, Aprile S, Rahimian R, Grolla AA, Rogati F, Bertolotti M, Malagnino F, di Paola R, Impellizzeri D, Fusco R, Mercalli V, Massarotti A, Stortini G, Terrazzino S, Del Grosso E, Fakhfouri G, Troiani MP, Alisi MA, Grosa G, Sorba G, Canonico PL, Orsomando G, Cuzzocrea S, Genazzani AA, Galli U, Tron GC.

J Med Chem. 2017 Mar 9;60(5):1768-1792. doi: 10.1021/acs.jmedchem.6b01392. Epub 2017 Feb 22.

PMID:
28165742
44.

GALNT2 effect on HDL-cholesterol and triglycerides levels in humans: Evidence of pleiotropy?

Di Paola R, Marucci A, Trischitta V.

Nutr Metab Cardiovasc Dis. 2017 Apr;27(4):281-282. doi: 10.1016/j.numecd.2016.11.006. Epub 2016 Nov 23.

PMID:
28153384
45.

Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats.

Di Paola R, Fusco R, Impellizzeri D, Cordaro M, Britti D, Morittu VM, Evangelista M, Cuzzocrea S.

Arthritis Res Ther. 2016 Dec 12;18(1):291.

46.

Hormesis, cellular stress response and neuroinflammation in schizophrenia: Early onset versus late onset state.

Calabrese V, Giordano J, Crupi R, Di Paola R, Ruggieri M, Bianchini R, Ontario ML, Cuzzocrea S, Calabrese EJ.

J Neurosci Res. 2017 May;95(5):1182-1193. doi: 10.1002/jnr.23967. Epub 2016 Nov 29. Review.

PMID:
27898171
47.

Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease.

Pennisi M, Crupi R, Di Paola R, Ontario ML, Bella R, Calabrese EJ, Crea R, Cuzzocrea S, Calabrese V.

J Neurosci Res. 2017 Jul;95(7):1360-1372. doi: 10.1002/jnr.23986. Epub 2016 Nov 8. Review.

PMID:
27862176
48.

Clinical application of a nomogram based on age, serum FSH and AMH to select the FSH starting dose in IVF/ICSI cycles: a retrospective two-centres study.

Papaleo E, Zaffagnini S, Munaretto M, Vanni VS, Rebonato G, Grisendi V, Di Paola R, La Marca A.

Eur J Obstet Gynecol Reprod Biol. 2016 Dec;207:94-99. doi: 10.1016/j.ejogrb.2016.10.021. Epub 2016 Oct 26.

PMID:
27835829
49.

Co-micronized Palmitoylethanolamide/Polydatin Treatment Causes Endometriotic Lesion Regression in a Rodent Model of Surgically Induced Endometriosis.

Di Paola R, Fusco R, Gugliandolo E, Crupi R, Evangelista M, Granese R, Cuzzocrea S.

Front Pharmacol. 2016 Oct 14;7:382. eCollection 2016.

50.

PARP inhibition treatment in a nonconventional experimental mouse model of chronic asthma.

Zaffini R, Di Paola R, Cuzzocrea S, Menegazzi M.

Naunyn Schmiedebergs Arch Pharmacol. 2016 Dec;389(12):1301-1313. Epub 2016 Sep 7.

PMID:
27604227

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