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Items: 1 to 50 of 105

1.

MyD88 as a therapeutic target for inflammatory lung diseases.

Di Padova F, Quesniaux VFJ, Ryffel B.

Expert Opin Ther Targets. 2018 May;22(5):401-408. doi: 10.1080/14728222.2018.1464139. Epub 2018 Apr 20. Review.

PMID:
29658361
2.

Neutralization of either IL-17A or IL-17F is sufficient to inhibit house dust mite induced allergic asthma in mice.

Chenuet P, Fauconnier L, Madouri F, Marchiol T, Rouxel N, Ledru A, Mauny P, Lory R, Uttenhove C, van Snick J, Iwakura Y, di Padova F, Quesniaux V, Togbe D, Ryffel B.

Clin Sci (Lond). 2017 Oct 12;131(20):2533-2548. doi: 10.1042/CS20171034. Print 2017 Oct 15.

PMID:
29026003
3.

Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells.

Li C, Maillet I, Mackowiak C, Viala C, Di Padova F, Li M, Togbe D, Quesniaux V, Lai Y, Ryffel B.

Cell Death Dis. 2017 Apr 6;8(4):e2735. doi: 10.1038/cddis.2017.90.

4.

Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization.

Segueni N, Tritto E, Bourigault ML, Rose S, Erard F, Le Bert M, Jacobs M, Di Padova F, Stiehl DP, Moulin P, Brees D, Chibout SD, Ryffel B, Kammüller M, Quesniaux VF.

Sci Rep. 2016 Nov 17;6:36923. doi: 10.1038/srep36923.

5.

IL-1R1-MyD88 axis elicits papain-induced lung inflammation.

Agoro R, Piotet-Morin J, Palomo J, Michaudel C, Vigne S, Maillet I, Chenuet P, Guillou N, Le Bérichel J, Kisielow M, Flodby P, Borok Z, Crandall ED, Le Bert M, Quesniaux V, Muller M, Di Padova F, Ryffel B, Gabay C, Couturier-Maillard A.

Eur J Immunol. 2016 Nov;46(11):2531-2541. doi: 10.1002/eji.201646366. Epub 2016 Sep 22.

6.

Targeting IL-17A in multiple myeloma: a potential novel therapeutic approach in myeloma.

Prabhala RH, Fulciniti M, Pelluru D, Rashid N, Nigroiu A, Nanjappa P, Pai C, Lee S, Prabhala NS, Bandi RL, Smith R, Lazo-Kallanian SB, Valet S, Raje N, Gold JS, Richardson PG, Daley JF, Anderson KC, Ettenberg SA, Di Padova F, Munshi NC.

Leukemia. 2016 Feb;30(2):379-89. doi: 10.1038/leu.2015.228. Epub 2015 Aug 21.

7.

Antibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPS.

Gomery K, Müller-Loennies S, Brooks CL, Brade L, Kosma P, Di Padova F, Brade H, Evans SV.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20877-82. doi: 10.1073/pnas.1209253109. Epub 2012 Nov 26.

8.

Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy.

Nindl V, Maier R, Ratering D, De Giuli R, Züst R, Thiel V, Scandella E, Di Padova F, Kopf M, Rudin M, Rülicke T, Ludewig B.

Eur J Immunol. 2012 Sep;42(9):2311-21. doi: 10.1002/eji.201142209. Epub 2012 Jul 13.

9.

T cell lessons from the rheumatoid arthritis synovium SCID mouse model: CD3-rich synovium lacks response to CTLA-4Ig but is successfully treated by interleukin-17 neutralization.

Koenders MI, Marijnissen RJ, Joosten LA, Abdollahi-Roodsaz S, Di Padova FE, van de Loo FA, Dulos J, van den Berg WB, Boots AM.

Arthritis Rheum. 2012 Jun;64(6):1762-70. doi: 10.1002/art.34352. Epub 2011 Dec 27.

10.

Enhanced Th17-cell responses render CCR2-deficient mice more susceptible for autoimmune arthritis.

Rampersad RR, Tarrant TK, Vallanat CT, Quintero-Matthews T, Weeks MF, Esserman DA, Clark J, Di Padova F, Patel DD, Fong AM, Liu P.

PLoS One. 2011;6(10):e25833. doi: 10.1371/journal.pone.0025833. Epub 2011 Oct 4.

11.

IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis.

Gasse P, Riteau N, Vacher R, Michel ML, Fautrel A, di Padova F, Fick L, Charron S, Lagente V, Eberl G, Le Bert M, Quesniaux VF, Huaux F, Leite-de-Moraes M, Ryffel B, Couillin I.

PLoS One. 2011;6(8):e23185. doi: 10.1371/journal.pone.0023185. Epub 2011 Aug 16.

12.

Immunization with an anti-idiotypic antibody against the broadly lipopolysaccharide-reactive antibody WN1 222-5 induces Escherichia coli R3-core-type specific antibodies in rabbits.

Brade L, Heine H, Raina S, Klein G, Di Padova F, Brade H, Müller-Loennies S.

Innate Immun. 2012 Apr;18(2):279-93. doi: 10.1177/1753425911401055. Epub 2011 Aug 15.

PMID:
21844130
13.

The anti-CD20 antibody rituximab reduces the Th17 cell response.

van de Veerdonk FL, Lauwerys B, Marijnissen RJ, Timmermans K, Di Padova F, Koenders MI, Gutierrez-Roelens I, Durez P, Netea MG, van der Meer JW, van den Berg WB, Joosten LA.

Arthritis Rheum. 2011 Jun;63(6):1507-16. doi: 10.1002/art.30314.

14.

Th17 cells, not IL-17+ γδ T cells, drive arthritic bone destruction in mice and humans.

Pöllinger B, Junt T, Metzler B, Walker UA, Tyndall A, Allard C, Bay S, Keller R, Raulf F, Di Padova F, O'Reilly T, Horwood NJ, Patel DD, Littlewood-Evans A.

J Immunol. 2011 Feb 15;186(4):2602-12. doi: 10.4049/jimmunol.1003370. Epub 2011 Jan 7.

15.

Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis.

Hueber W, Patel DD, Dryja T, Wright AM, Koroleva I, Bruin G, Antoni C, Draelos Z, Gold MH; Psoriasis Study Group, Durez P, Tak PP, Gomez-Reino JJ; Rheumatoid Arthritis Study Group, Foster CS, Kim RY, Samson CM, Falk NS, Chu DS, Callanan D, Nguyen QD; Uveitis Study Group, Rose K, Haider A, Di Padova F.

Sci Transl Med. 2010 Oct 6;2(52):52ra72. doi: 10.1126/scitranslmed.3001107.

16.

Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice.

Koenders MI, Devesa I, Marijnissen RJ, Abdollahi-Roodsaz S, Boots AM, Walgreen B, di Padova FE, Nicklin MJ, Joosten LA, van den Berg WB.

Arthritis Rheum. 2008 Nov;58(11):3461-70. doi: 10.1002/art.23957.

17.

Interleukin-17 acts independently of TNF-alpha under arthritic conditions.

Koenders MI, Lubberts E, van de Loo FA, Oppers-Walgreen B, van den Bersselaar L, Helsen MM, Kolls JK, Di Padova FE, Joosten LA, van den Berg WB.

J Immunol. 2006 May 15;176(10):6262-9.

18.

Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity.

Revesz L, Blum E, Di Padova FE, Buhl T, Feifel R, Gram H, Hiestand P, Manning U, Neumann U, Rucklin G.

Bioorg Med Chem Lett. 2006 Jan 15;16(2):262-6. Epub 2005 Oct 24.

PMID:
16249085
19.

Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.

Koenders MI, Lubberts E, Oppers-Walgreen B, van den Bersselaar L, Helsen MM, Di Padova FE, Boots AM, Gram H, Joosten LA, van den Berg WB.

Am J Pathol. 2005 Jul;167(1):141-9.

20.

Dual effects of p38 MAPK on TNF-dependent bronchoconstriction and TNF-independent neutrophil recruitment in lipopolysaccharide-induced acute respiratory distress syndrome.

Schnyder-Candrian S, Quesniaux VF, Di Padova F, Maillet I, Noulin N, Couillin I, Moser R, Erard F, Vargaftig BB, Ryffel B, Schnyder B.

J Immunol. 2005 Jul 1;175(1):262-9.

21.

Involvement of microRNA in AU-rich element-mediated mRNA instability.

Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, Chen J, Di Padova F, Lin SC, Gram H, Han J.

Cell. 2005 Mar 11;120(5):623-34.

22.

SAR of benzoylpyridines and benzophenones as p38alpha MAP kinase inhibitors with oral activity.

Revesz L, Blum E, Di Padova FE, Buhl T, Feifel R, Gram H, Hiestand P, Manning U, Rucklin G.

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3601-5.

PMID:
15177483
23.

Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis.

Revesz L, Blum E, Di Padova FE, Buhl T, Feifel R, Gram H, Hiestand P, Manning U, Rucklin G.

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3595-9.

PMID:
15177482
24.

Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation.

Schuler W, Bigaud M, Brinkmann V, Di Padova F, Geisse S, Gram H, Hungerford V, Kleuser B, Kristofic C, Menninger K, Tees R, Wieczorek G, Wilt C, Wioland C, Zurini M.

Transplantation. 2004 Mar 15;77(5):717-26.

PMID:
15021835
25.

A novel Pd-catalyzed cyclization reaction of ureas for the synthesis of dihydroquinazolinone p38 kinase inhibitors.

Schlapbach A, Heng R, Di Padova F.

Bioorg Med Chem Lett. 2004 Jan 19;14(2):357-60.

PMID:
14698158
26.

Effects of a mitogen-activated protein kinase inhibitor on allergic airways inflammation in the rat studied by magnetic resonance imaging.

Tigani B, Di Padova F, Zurbrügg S, Schaeublin E, Revesz L, Fozard JR, Beckmann N.

Eur J Pharmacol. 2003 Dec 15;482(1-3):319-24.

PMID:
14660038
27.

Identification of a cross-reactive epitope widely present in lipopolysaccharide from enterobacteria and recognized by the cross-protective monoclonal antibody WN1 222-5.

Muller-Loennies S, Brade L, MacKenzie CR, Di Padova FE, Brade H.

J Biol Chem. 2003 Jul 11;278(28):25618-27. Epub 2003 Apr 25.

28.

SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.

Revesz L, Di Padova FE, Buhl T, Feifel R, Gram H, Hiestand P, Manning U, Wolf R, Zimmerlin AG.

Bioorg Med Chem Lett. 2002 Aug 19;12(16):2109-12.

PMID:
12127515
29.

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.

Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J.

Science. 2002 Feb 15;295(5558):1291-4.

30.

Critical role of lipopolysaccharide-binding protein and CD14 in immune responses against gram-negative bacteria.

Le Roy D, Di Padova F, Adachi Y, Glauser MP, Calandra T, Heumann D.

J Immunol. 2001 Sep 1;167(5):2759-65.

31.

Gene suppression by tristetraprolin and release by the p38 pathway.

Zhu W, Brauchle MA, Di Padova F, Gram H, New L, Ono K, Downey JS, Han J.

Am J Physiol Lung Cell Mol Physiol. 2001 Aug;281(2):L499-508.

32.

Independent role of p38 and ERK1/2 mitogen-activated kinases in the upregulation of matrix metalloproteinase-1.

Brauchle M, Glück D, Di Padova F, Han J, Gram H.

Exp Cell Res. 2000 Jul 10;258(1):135-44.

PMID:
10912795
33.

SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors.

Revesz L, Di Padova FE, Buhl T, Feifel R, Gram H, Hiestand P, Manning U, Zimmerlin AG.

Bioorg Med Chem Lett. 2000 Jun 5;10(11):1261-4.

PMID:
10866395
34.

Regulation of TNF expression by multiple mitogen-activated protein kinase pathways.

Zhu W, Downey JS, Gu J, Di Padova F, Gram H, Han J.

J Immunol. 2000 Jun 15;164(12):6349-58.

35.

Coordinate activation of endogenous p38alpha, beta, gamma, and delta by inflammatory stimuli.

Fearns C, Kline L, Gram H, Di Padova F, Zurini M, Han J, Ulevitch RJ.

J Leukoc Biol. 2000 May;67(5):705-11.

PMID:
10811012
36.
37.

All three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complex.

Heilker R, Freuler F, Pulfer R, Di Padova F, Eder J.

Eur J Biochem. 1999 Jan;259(1-2):253-61.

38.

Regulation of the MEF2 family of transcription factors by p38.

Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, Olson EN, Ulevitch RJ, Han J.

Mol Cell Biol. 1999 Jan;19(1):21-30.

39.

Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta.

Jiang Y, Gram H, Zhao M, New L, Gu J, Feng L, Di Padova F, Ulevitch RJ, Han J.

J Biol Chem. 1997 Nov 28;272(48):30122-8.

40.

Dual effects of LPS antibodies on cellular uptake of LPS and LPS-induced proinflammatory functions.

Pollack M, Ohl CA, Golenbock DT, Di Padova F, Wahl LM, Koles NL, Guelde G, Monks BG.

J Immunol. 1997 Oct 1;159(7):3519-30.

PMID:
9317151
41.

Monoclonal antibody to endotoxin attenuates hemorrhage-induced lung injury and mortality in rats.

Bahrami S, Yao YM, Leichtfried G, Redl H, Schlag G, Di Padova FE.

Crit Care Med. 1997 Jun;25(6):1030-6.

PMID:
9201057
42.

Role of repetitive antigen patterns for induction of antibodies against antibodies.

Fehr T, Bachmann MF, Bucher E, Kalinke U, Di Padova FE, Lang AB, Hengartner H, Zinkernagel RM.

J Exp Med. 1997 May 19;185(10):1785-92.

43.

Lack of type 2 T cell-independent B cell responses and defect in isotype switching in TNF-lymphotoxin alpha-deficient mice.

Ryffel B, Di Padova F, Schreier MH, Le Hir M, Eugster HP, Quesniaux VF.

J Immunol. 1997 Mar 1;158(5):2126-33.

PMID:
9036957
44.

Detection and quantification of cyclosporine in body fluids using an interleukin-2 reporter-gene assay.

Wenner PR, Di Padova F, Keown PA.

J Immunol Methods. 1997 Feb 14;201(1):125-35.

PMID:
9032415
45.

Similarities and disparities between core-specific and O-side-chain-specific antilipopolysaccharide monoclonal antibodies in models of endotoxemia and bacteremia in mice.

Bailat S, Heumann D, Le Roy D, Baumgartner JD, Rietschel ET, Glauser MP, Di Padova F.

Infect Immun. 1997 Feb;65(2):811-4.

46.

Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling.

Le Hir M, Bluethmann H, Kosco-Vilbois MH, Müller M, di Padova F, Moore M, Ryffel B, Eugster HP.

J Exp Med. 1996 May 1;183(5):2367-72.

47.

Correction or transfer of immunodeficiency due to TNF-LT alpha deletion by bone marrow transplantation.

Müller M, Eugster HP, Le Hir M, Shakhov A, Di Padova F, Maurer C, Quesniaux VF, Ryffel B.

Mol Med. 1996 Mar;2(2):247-55.

48.

Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxification.

Rietschel ET, Brade H, Holst O, Brade L, Müller-Loennies S, Mamat U, Zähringer U, Beckmann F, Seydel U, Brandenburg K, Ulmer AJ, Mattern T, Heine H, Schletter J, Loppnow H, Schönbeck U, Flad HD, Hauschildt S, Schade UF, Di Padova F, Kusumoto S, Schumann RR.

Curr Top Microbiol Immunol. 1996;216:39-81. Review. No abstract available.

PMID:
8791735
49.

Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice.

Eugster HP, Muller M, Karrer U, Car BD, Schnyder B, Eng VM, Woerly G, Le Hir M, di Padova F, Aguet M, Zinkernagel R, Bluethmann H, Ryffel B.

Int Immunol. 1996 Jan;8(1):23-36.

PMID:
8671586
50.

Allergen-specific IgE production of committed B cells from allergic patients in vitro.

Steinberger P, Bohle B, di Padova F, Wrann M, Liehl E, Scheiner O, Kraft D, Valenta R.

J Allergy Clin Immunol. 1995 Aug;96(2):209-18.

PMID:
7543502

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