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Items: 47

1.

Aldara-induced dermatitis is associated with development of liver fibrosis in mice.

Maybury CM, Di Meglio P, Smith CH.

Br J Dermatol. 2018 Jul;179(1):9-10. doi: 10.1111/bjd.16693. No abstract available.

PMID:
30156283
2.

An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target.

Mahil SK, Catapano M, Di Meglio P, Dand N, Ahlfors H, Carr IM, Smith CH, Trembath RC, Peakman M, Wright J, Ciccarelli FD, Barker JN, Capon F.

Sci Transl Med. 2017 Oct 11;9(411). pii: eaan2514. doi: 10.1126/scitranslmed.aan2514. Erratum in: Sci Transl Med. 2017 Dec 13;9(420):.

3.

AP1S3 Mutations Cause Skin Autoinflammation by Disrupting Keratinocyte Autophagy and Up-Regulating IL-36 Production.

Mahil SK, Twelves S, Farkas K, Setta-Kaffetzi N, Burden AD, Gach JE, Irvine AD, Képíró L, Mockenhaupt M, Oon HH, Pinner J, Ranki A, Seyger MMB, Soler-Palacin P, Storan ER, Tan ES, Valeyrie-Allanore L, Young HS, Trembath RC, Choon SE, Szell M, Bata-Csorgo Z, Smith CH, Di Meglio P, Barker JN, Capon F.

J Invest Dermatol. 2016 Nov;136(11):2251-2259. doi: 10.1016/j.jid.2016.06.618. Epub 2016 Jul 5.

4.

Targeting CD8(+) T cells prevents psoriasis development.

Di Meglio P, Villanova F, Navarini AA, Mylonas A, Tosi I, Nestle FO, Conrad C.

J Allergy Clin Immunol. 2016 Jul;138(1):274-276.e6. doi: 10.1016/j.jaci.2015.10.046. Epub 2016 Jan 9. No abstract available.

5.

The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis.

Roederer M, Quaye L, Mangino M, Beddall MH, Mahnke Y, Chattopadhyay P, Tosi I, Napolitano L, Terranova Barberio M, Menni C, Villanova F, Di Meglio P, Spector TD, Nestle FO.

Cell. 2015 Apr 9;161(2):387-403. doi: 10.1016/j.cell.2015.02.046. Epub 2015 Mar 12.

6.

IL-22 fate reporter reveals origin and control of IL-22 production in homeostasis and infection.

Ahlfors H, Morrison PJ, Duarte JH, Li Y, Biro J, Tolaini M, Di Meglio P, Potocnik AJ, Stockinger B.

J Immunol. 2014 Nov 1;193(9):4602-13. doi: 10.4049/jimmunol.1401244. Epub 2014 Sep 26.

7.

Psoriasis.

Di Meglio P, Villanova F, Nestle FO.

Cold Spring Harb Perspect Med. 2014 Aug 1;4(8). pii: a015354. doi: 10.1101/cshperspect.a015354. Review.

8.

Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions.

Di Meglio P, Duarte JH, Ahlfors H, Owens ND, Li Y, Villanova F, Tosi I, Hirota K, Nestle FO, Mrowietz U, Gilchrist MJ, Stockinger B.

Immunity. 2014 Jun 19;40(6):989-1001. doi: 10.1016/j.immuni.2014.04.019. Epub 2014 Jun 5.

9.

The aryl hydrocarbon receptor: multitasking in the immune system.

Stockinger B, Di Meglio P, Gialitakis M, Duarte JH.

Annu Rev Immunol. 2014;32:403-32. doi: 10.1146/annurev-immunol-032713-120245. Review.

PMID:
24655296
10.

Characterization of innate lymphoid cells in human skin and blood demonstrates increase of NKp44+ ILC3 in psoriasis.

Villanova F, Flutter B, Tosi I, Grys K, Sreeneebus H, Perera GK, Chapman A, Smith CH, Di Meglio P, Nestle FO.

J Invest Dermatol. 2014 Apr;134(4):984-991. doi: 10.1038/jid.2013.477. Epub 2013 Nov 11.

11.

Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo.

Duarte JH, Di Meglio P, Hirota K, Ahlfors H, Stockinger B.

PLoS One. 2013 Nov 14;8(11):e79819. doi: 10.1371/journal.pone.0079819. eCollection 2013.

12.

An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element.

Clop A, Bertoni A, Spain SL, Simpson MA, Pullabhatla V, Tonda R, Hundhausen C, Di Meglio P, De Jong P, Hayday AC, Nestle FO, Barker JN, Bell RJ, Capon F, Trembath RC.

PLoS One. 2013 Aug 19;8(8):e71690. doi: 10.1371/journal.pone.0071690. eCollection 2013.

13.

Gene expression changes with age in skin, adipose tissue, blood and brain.

Glass D, Viñuela A, Davies MN, Ramasamy A, Parts L, Knowles D, Brown AA, Hedman AK, Small KS, Buil A, Grundberg E, Nica AC, Di Meglio P, Nestle FO, Ryten M; UK Brain Expression consortium; MuTHER consortium, Durbin R, McCarthy MI, Deloukas P, Dermitzakis ET, Weale ME, Bataille V, Spector TD.

Genome Biol. 2013 Jul 26;14(7):R75. doi: 10.1186/gb-2013-14-7-r75.

14.

Integration of lyoplate based flow cytometry and computational analysis for standardized immunological biomarker discovery.

Villanova F, Di Meglio P, Inokuma M, Aghaeepour N, Perucha E, Mollon J, Nomura L, Hernandez-Fuentes M, Cope A, Prevost AT, Heck S, Maino V, Lord G, Brinkman RR, Nestle FO.

PLoS One. 2013 Jul 3;8(7):e65485. doi: 10.1371/journal.pone.0065485. Print 2013.

15.

The IL23R A/Gln381 allele promotes IL-23 unresponsiveness in human memory T-helper 17 cells and impairs Th17 responses in psoriasis patients.

Di Meglio P, Villanova F, Napolitano L, Tosi I, Terranova Barberio M, Mak RK, Nutland S, Smith CH, Barker JNWN, Todd JA, Nestle FO.

J Invest Dermatol. 2013 Oct;133(10):2381-2389. doi: 10.1038/jid.2013.170. Epub 2013 Apr 5. Erratum in: J Invest Dermatol. 2014 Jun;134(6):1779. Barberio, Manuela Terranova [corrected to Terranova Barberio, Manuela].

16.

Biomarkers in psoriasis and psoriatic arthritis.

Villanova F, Di Meglio P, Nestle FO.

Ann Rheum Dis. 2013 Apr;72 Suppl 2:ii104-10. doi: 10.1136/annrheumdis-2012-203037. Review.

PMID:
23532439
17.

CD8 T Cells and IFN-γ emerge as critical players for psoriasis in a novel model of mouse psoriasiform skin inflammation.

Di Meglio P, Duarte JH.

J Invest Dermatol. 2013 Apr;133(4):871-4. doi: 10.1038/jid.2012.426.

18.

Mapping cis- and trans-regulatory effects across multiple tissues in twins.

Grundberg E, Small KS, Hedman ÅK, Nica AC, Buil A, Keildson S, Bell JT, Yang TP, Meduri E, Barrett A, Nisbett J, Sekowska M, Wilk A, Shin SY, Glass D, Travers M, Min JL, Ring S, Ho K, Thorleifsson G, Kong A, Thorsteindottir U, Ainali C, Dimas AS, Hassanali N, Ingle C, Knowles D, Krestyaninova M, Lowe CE, Di Meglio P, Montgomery SB, Parts L, Potter S, Surdulescu G, Tsaprouni L, Tsoka S, Bataille V, Durbin R, Nestle FO, O'Rahilly S, Soranzo N, Lindgren CM, Zondervan KT, Ahmadi KR, Schadt EE, Stefansson K, Smith GD, McCarthy MI, Deloukas P, Dermitzakis ET, Spector TD; Multiple Tissue Human Expression Resource (MuTHER) Consortium.

Nat Genet. 2012 Oct;44(10):1084-9. doi: 10.1038/ng.2394. Epub 2012 Sep 2.

19.

Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation.

Chu CC, Ali N, Karagiannis P, Di Meglio P, Skowera A, Napolitano L, Barinaga G, Grys K, Sharif-Paghaleh E, Karagiannis SN, Peakman M, Lombardi G, Nestle FO.

J Exp Med. 2012 May 7;209(5):935-45. doi: 10.1084/jem.20112583. Epub 2012 Apr 30.

20.

The multitasking organ: recent insights into skin immune function.

Di Meglio P, Perera GK, Nestle FO.

Immunity. 2011 Dec 23;35(6):857-69. doi: 10.1016/j.immuni.2011.12.003. Review.

21.

Allele-specific cytokine responses at the HLA-C locus: implications for psoriasis.

Hundhausen C, Bertoni A, Mak RK, Botti E, Di Meglio P, Clop A, Laggner U, Chimenti S, Hayday AC, Barker JN, Trembath RC, Capon F, Nestle FO.

J Invest Dermatol. 2012 Mar;132(3 Pt 1):635-41. doi: 10.1038/jid.2011.378. Epub 2011 Nov 24.

22.

Psoriasis.

Perera GK, Di Meglio P, Nestle FO.

Annu Rev Pathol. 2012;7:385-422. doi: 10.1146/annurev-pathol-011811-132448. Epub 2011 Nov 4. Review.

PMID:
22054142
23.

Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis.

Onoufriadis A, Simpson MA, Pink AE, Di Meglio P, Smith CH, Pullabhatla V, Knight J, Spain SL, Nestle FO, Burden AD, Capon F, Trembath RC, Barker JN.

Am J Hum Genet. 2011 Sep 9;89(3):432-7. doi: 10.1016/j.ajhg.2011.07.022. Epub 2011 Aug 11.

24.

Identification of a novel proinflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasis.

Laggner U, Di Meglio P, Perera GK, Hundhausen C, Lacy KE, Ali N, Smith CH, Hayday AC, Nickoloff BJ, Nestle FO.

J Immunol. 2011 Sep 1;187(5):2783-93. doi: 10.4049/jimmunol.1100804. Epub 2011 Aug 3.

25.

The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans.

Di Meglio P, Di Cesare A, Laggner U, Chu CC, Napolitano L, Villanova F, Tosi I, Capon F, Trembath RC, Peris K, Nestle FO.

PLoS One. 2011 Feb 22;6(2):e17160. doi: 10.1371/journal.pone.0017160.

26.

The architecture of gene regulatory variation across multiple human tissues: the MuTHER study.

Nica AC, Parts L, Glass D, Nisbet J, Barrett A, Sekowska M, Travers M, Potter S, Grundberg E, Small K, Hedman AK, Bataille V, Tzenova Bell J, Surdulescu G, Dimas AS, Ingle C, Nestle FO, di Meglio P, Min JL, Wilk A, Hammond CJ, Hassanali N, Yang TP, Montgomery SB, O'Rahilly S, Lindgren CM, Zondervan KT, Soranzo N, Barroso I, Durbin R, Ahmadi K, Deloukas P, McCarthy MI, Dermitzakis ET, Spector TD; MuTHER Consortium.

PLoS Genet. 2011 Feb 3;7(2):e1002003. doi: 10.1371/journal.pgen.1002003.

27.

Harnessing dendritic cells in inflammatory skin diseases.

Chu CC, Di Meglio P, Nestle FO.

Semin Immunol. 2011 Feb;23(1):28-41. doi: 10.1016/j.smim.2011.01.006. Epub 2011 Feb 4. Review.

28.

A model for harmonizing flow cytometry in clinical trials.

Maecker HT, McCoy JP Jr; FOCIS Human Immunophenotyping Consortium, Amos M, Elliott J, Gaigalas A, Wang L, Aranda R, Banchereau J, Boshoff C, Braun J, Korin Y, Reed E, Cho J, Hafler D, Davis M, Fathman CG, Robinson W, Denny T, Weinhold K, Desai B, Diamond B, Gregersen P, Di Meglio P, Nestle FO, Peakman M, Villanova F, Ferbas J, Field E, Kantor A, Kawabata T, Komocsar W, Lotze M, Nepom J, Ochs H, O'Lone R, Phippard D, Plevy S, Rich S, Roederer M, Rotrosen D, Yeh JH.

Nat Immunol. 2010 Nov;11(11):975-8. doi: 10.1038/ni1110-975. Erratum in: Nat Immunol. 2010 Nov;11(11):979. DiMeglio, Paola [corrected to Di Meglio, Paola]; Nestle, Frank [corrected to Nestle, Frank O]; Villnova, Federica [corrected to Villanova, Federica]. Nat Immunol. 2011 Mar;12(3):271.

29.

Cutting edge: A critical functional role for IL-23 in psoriasis.

Tonel G, Conrad C, Laggner U, Di Meglio P, Grys K, McClanahan TK, Blumenschein WM, Qin JZ, Xin H, Oldham E, Kastelein R, Nickoloff BJ, Nestle FO.

J Immunol. 2010 Nov 15;185(10):5688-91. doi: 10.4049/jimmunol.1001538. Epub 2010 Oct 18.

30.

The role of IL-23 in the immunopathogenesis of psoriasis.

Di Meglio P, Nestle FO.

F1000 Biol Rep. 2010 May 24;2. pii: 40. doi: 10.3410/B2-40.

31.

The I{kappa}B kinase inhibitor nuclear factor-{kappa}B essential modulator-binding domain peptide for inhibition of injury-induced neointimal formation.

Grassia G, Maddaluno M, Musilli C, De Stefano D, Carnuccio R, Di Lauro MV, Parratt CA, Kennedy S, Di Meglio P, Ianaro A, Maffia P, Parenti A, Ialenti A.

Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2458-66. doi: 10.1161/ATVBAHA.110.215467. Epub 2010 Oct 7.

PMID:
20930169
32.

Skin immune sentinels in health and disease.

Nestle FO, Di Meglio P, Qin JZ, Nickoloff BJ.

Nat Rev Immunol. 2009 Oct;9(10):679-91. doi: 10.1038/nri2622. Epub 2009 Sep 18. Review.

33.

The IL-23/Th17 axis in the immunopathogenesis of psoriasis.

Di Cesare A, Di Meglio P, Nestle FO.

J Invest Dermatol. 2009 Jun;129(6):1339-50. doi: 10.1038/jid.2009.59. Epub 2009 Mar 26. Review.

34.

A role for Th17 cells in the immunopathogenesis of atopic dermatitis?

Di Cesare A, Di Meglio P, Nestle FO.

J Invest Dermatol. 2008 Nov;128(11):2569-71. doi: 10.1038/jid.2008.283.

35.

Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.

Capon F, Di Meglio P, Szaub J, Prescott NJ, Dunster C, Baumber L, Timms K, Gutin A, Abkevic V, Burden AD, Lanchbury J, Barker JN, Trembath RC, Nestle FO.

Hum Genet. 2007 Sep;122(2):201-6. Epub 2007 Jun 22.

PMID:
17587057
36.

Neutralization of interleukin-18 inhibits neointimal formation in a rat model of vascular injury.

Maffia P, Grassia G, Di Meglio P, Carnuccio R, Berrino L, Garside P, Ianaro A, Ialenti A.

Circulation. 2006 Aug 1;114(5):430-7. Epub 2006 Jul 24.

PMID:
16864728
37.

A novel lipid A from Halomonas magadiensis inhibits enteric LPS-induced human monocyte activation.

Ialenti A, Di Meglio P, Grassia G, Maffia P, Di Rosa M, Lanzetta R, Molinaro A, Silipo A, Grant W, Ianaro A.

Eur J Immunol. 2006 Feb;36(2):354-60.

38.

Discovery and biological evaluation of the novel naturally occurring diterpene pepluanone as antiinflammatory agent.

Corea G, Fattorusso E, Lanzotti V, Di Meglio P, Maffia P, Grassia G, Ialenti A, Ianaro A.

J Med Chem. 2005 Nov 3;48(22):7055-62.

PMID:
16250665
39.

New sesquiterpene lactones from Laurus nobilis leaves as inhibitors of nitric oxide production.

De Marino S, Borbone N, Zollo F, Ianaro A, Di Meglio P, Iorizzi M.

Planta Med. 2005 Aug;71(8):706-10.

PMID:
16142632
40.

Hydroxytyrosol, a phenolic compound from virgin olive oil, prevents macrophage activation.

Maiuri MC, De Stefano D, Di Meglio P, Irace C, Savarese M, Sacchi R, Cinelli MP, Carnuccio R.

Naunyn Schmiedebergs Arch Pharmacol. 2005 Jun;371(6):457-65. Epub 2005 Jul 16.

PMID:
16025269
41.
42.

Inhibition of cyclooxygenase-2 gene expression by the heat shock response in J774 murine macrophages.

Ialenti A, Di Meglio P, D'Acquisto F, Pisano B, Maffia P, Grassia G, Di Rosa M, Ianaro A.

Eur J Pharmacol. 2005 Feb 21;509(2-3):89-96.

PMID:
15733543
43.

Mechanism of the anti-inflammatory effect of thiazolidinediones: relationship with the glucocorticoid pathway.

Ialenti A, Grassia G, Di Meglio P, Maffia P, Di Rosa M, Ianaro A.

Mol Pharmacol. 2005 May;67(5):1620-8. Epub 2005 Jan 31.

PMID:
15684043
44.

Megastigmane and phenolic components from Laurus nobilis L. leaves and their inhibitory effects on nitric oxide production.

De Marino S, Borbone N, Zollo F, Ianaro A, Di Meglio P, Iorizzi M.

J Agric Food Chem. 2004 Dec 15;52(25):7525-31.

PMID:
15675799
45.

Cloricromene in endotoxemia: role of NF-kappaB.

Ianaro A, Maffia P, Grassia G, Di Meglio P, Sorrentino R, di Villa Bianca Rd, Di Rosa M, Ialenti A.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):140-5. Epub 2004 Jul 30.

PMID:
15322736
46.

Polychlorinated androstanes from the burrowing sponge Cliona nigricans.

Fattorusso E, Taglialatela-Scafati O, Petrucci F, Bavestrello G, Calcinai B, Cerrano C, Di Meglio P, Ianaro A.

Org Lett. 2004 May 13;6(10):1633-5.

PMID:
15128254
47.

Anti-inflammatory activity of 15-deoxy-delta12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response.

Ianaro A, Ialenti A, Maffia P, Di Meglio P, Di Rosa M, Santoro MG.

Mol Pharmacol. 2003 Jul;64(1):85-93.

PMID:
12815164

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