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Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome.

Di Marzo V, Silvestri C.

Nutrients. 2019 Aug 20;11(8). pii: E1956. doi: 10.3390/nu11081956. Review.


Altered Metabolism of Phospholipases, Diacylglycerols, Endocannabinoids, and N-Acylethanolamines in Patients with Mastocytosis.

Ferrara AL, Piscitelli F, Petraroli A, Parente R, Galdiero MR, Varricchi G, Marone G, Triggiani M, Di Marzo V, Loffredo S.

J Immunol Res. 2019 Jul 1;2019:5836476. doi: 10.1155/2019/5836476. eCollection 2019.


Cannabidiol improves vocal learning-dependent recovery from, and reduces magnitude of deficits following, damage to a cortical-like brain region in a songbird pre-clinical animal model.

Alalawi A, Dodu JC, Woolley-Roberts M, Brodie J, Di Marzo V, Soderstrom K.

Neuropharmacology. 2019 Jul 17;158:107716. doi: 10.1016/j.neuropharm.2019.107716. [Epub ahead of print]


Structure-activity relationships of thiazole and benzothiazole derivatives as selective cannabinoid CB2 agonists with in vivo anti-inflammatory properties.

Ghonim AE, Ligresti A, Rabbito A, Mahmoud AM, Di Marzo V, Osman NA, Abadi AH.

Eur J Med Chem. 2019 Jul 2;180:154-170. doi: 10.1016/j.ejmech.2019.07.002. [Epub ahead of print]


Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment.

Montanari S, Mahmoud AM, Pruccoli L, Rabbito A, Naldi M, Petralla S, Moraleda I, Bartolini M, Monti B, Iriepa I, Belluti F, Gobbi S, Di Marzo V, Bisi A, Tarozzi A, Ligresti A, Rampa A.

Eur J Med Chem. 2019 Sep 15;178:243-258. doi: 10.1016/j.ejmech.2019.05.080. Epub 2019 May 31.


Cannabidivarin completely rescues cognitive deficits and delays neurological and motor defects in male Mecp2 mutant mice.

Zamberletti E, Gabaglio M, Piscitelli F, Brodie JS, Woolley-Roberts M, Barbiero I, Tramarin M, Binelli G, Landsberger N, Kilstrup-Nielsen C, Rubino T, Di Marzo V, Parolaro D.

J Psychopharmacol. 2019 Jul;33(7):894-907. doi: 10.1177/0269881119844184. Epub 2019 May 14.


Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier.

Tunisi L, Forte N, Fernández-Rilo AC, Mavaro I, Capasso R, D'Angelo L, Milić N, Cristino L, Di Marzo V, Palomba L.

Front Endocrinol (Lausanne). 2019 Apr 10;10:219. doi: 10.3389/fendo.2019.00219. eCollection 2019.


Oleoyl glycine: interference with the aversive effects of acute naloxone-precipitated MWD, but not morphine reward, in male Sprague-Dawley rats.

Petrie GN, Wills KL, Piscitelli F, Smoum R, Limebeer CL, Rock EM, Humphrey AE, Sheppard-Perkins M, Lichtman AH, Mechoulam R, Di Marzo V, Parker LA.

Psychopharmacology (Berl). 2019 Sep;236(9):2623-2633. doi: 10.1007/s00213-019-05237-9. Epub 2019 Apr 16.


Altered gut microbiota and endocannabinoid system tone in vitamin D deficiency-mediated chronic pain.

Guida F, Boccella S, Belardo C, Iannotta M, Piscitelli F, De Filippis F, Paino S, Ricciardi F, Siniscalco D, Marabese I, Luongo L, Ercolini D, Di Marzo V, Maione S.

Brain Behav Immun. 2019 Apr 3. pii: S0889-1591(18)31247-9. doi: 10.1016/j.bbi.2019.04.006. [Epub ahead of print]


In Silico Identification and Experimental Validation of (-)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator.

D'Aniello E, Iannotti FA, Falkenberg LG, Martella A, Gentile A, De Maio F, Ciavatta ML, Gavagnin M, Waxman JS, Di Marzo V, Amodeo P, Vitale RM.

Mar Drugs. 2019 Feb 12;17(2). pii: E110. doi: 10.3390/md17020110.


Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis.

Everard A, Plovier H, Rastelli M, Van Hul M, de Wouters d'Oplinter A, Geurts L, Druart C, Robine S, Delzenne NM, Muccioli GG, de Vos WM, Luquet S, Flamand N, Di Marzo V, Cani PD.

Nat Commun. 2019 Jan 28;10(1):457. doi: 10.1038/s41467-018-08051-7.


Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach.

D'Aniello E, Fellous T, Iannotti FA, Gentile A, Allarà M, Balestrieri F, Gray R, Amodeo P, Vitale RM, Di Marzo V.

Biochim Biophys Acta Gen Subj. 2019 Mar;1863(3):586-597. doi: 10.1016/j.bbagen.2019.01.002. Epub 2019 Jan 3.


Systemic administration of serotonin exacerbates abdominal pain and colitis via interaction with the endocannabinoid system.

Salaga M, Binienda A, Piscitelli F, Mokrowiecka A, Cygankiewicz AI, Verde R, Malecka-Panas E, Kordek R, Krajewska WM, Di Marzo V, Fichna J.

Biochem Pharmacol. 2019 Mar;161:37-51. doi: 10.1016/j.bcp.2019.01.001. Epub 2019 Jan 3.


Effects of diisononyl phthalate (DiNP) on the endocannabinoid and reproductive systems of male gilthead sea bream (Sparus aurata) during the spawning season.

Forner-Piquer I, Mylonas CC, Fakriadis I, Papadaki M, Piscitelli F, Di Marzo V, Calduch-Giner J, Pérez-Sánchez J, Carnevali O.

Arch Toxicol. 2019 Mar;93(3):727-741. doi: 10.1007/s00204-018-2378-6. Epub 2019 Jan 2.


Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia.

Stark T, Ruda-Kucerova J, Iannotti FA, D'Addario C, Di Marco R, Pekarik V, Drazanova E, Piscitelli F, Bari M, Babinska Z, Giurdanella G, Di Bartolomeo M, Salomone S, Sulcova A, Maccarrone M, Wotjak CT, Starcuk Z Jr, Drago F, Mechoulam R, Di Marzo V, Micale V.

Neuropharmacology. 2019 Mar 1;146:212-221. doi: 10.1016/j.neuropharm.2018.11.035. Epub 2018 Nov 26.


Fishing for Targets of Alien Metabolites: A Novel Peroxisome Proliferator-Activated Receptor (PPAR) Agonist from a Marine Pest.

Vitale RM, D'Aniello E, Gorbi S, Martella A, Silvestri C, Giuliani ME, Fellous T, Gentile A, Carbone M, Cutignano A, Grauso L, Magliozzi L, Polese G, D'Aniello B, Defranoux F, Felline S, Terlizzi A, Calignano A, Regoli F, Di Marzo V, Amodeo P, Mollo E.

Mar Drugs. 2018 Nov 3;16(11). pii: E431. doi: 10.3390/md16110431.


Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease.

Mugnaini C, Rabbito A, Brizzi A, Palombi N, Petrosino S, Verde R, Di Marzo V, Ligresti A, Corelli F.

Eur J Med Chem. 2019 Jan 1;161:239-251. doi: 10.1016/j.ejmech.2018.09.070. Epub 2018 Oct 13.


Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway.

Boccella S, Cristiano C, Romano R, Iannotta M, Belardo C, Farina A, Guida F, Piscitelli F, Palazzo E, Mazzitelli M, Imperatore R, Tunisi L, de Novellis V, Cristino L, Di Marzo V, Calignano A, Maione S, Luongo L.

Neurobiol Dis. 2019 Jan;121:106-119. doi: 10.1016/j.nbd.2018.09.023. Epub 2018 Sep 25.


Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy.

Iannotti FA, Pagano E, Guardiola O, Adinolfi S, Saccone V, Consalvi S, Piscitelli F, Gazzerro E, Busetto G, Carrella D, Capasso R, Puri PL, Minchiotti G, Di Marzo V.

Nat Commun. 2018 Sep 27;9(1):3950. doi: 10.1038/s41467-018-06267-1.


FAAH-Catalyzed C-C Bond Cleavage of a New Multitarget Analgesic Drug.

Ligresti A, Silvestri C, Vitale RM, Martos JL, Piscitelli F, Wang JW, Allarà M, Carling RW, Luongo L, Guida F, Illiano A, Amoresano A, Maione S, Amodeo P, Woodward DF, Di Marzo V, Marino G.

ACS Chem Neurosci. 2019 Jan 16;10(1):424-437. doi: 10.1021/acschemneuro.8b00315. Epub 2018 Oct 4.


Reversal of albuminuria by combined AM6545 and perindopril therapy in experimental diabetic nephropathy.

Barutta F, Bellini S, Mastrocola R, Gambino R, Piscitelli F, di Marzo V, Corbetta B, Vemuri VK, Makriyannis A, Annaratone L, Bruno G, Gruden G.

Br J Pharmacol. 2018 Dec;175(23):4371-4385. doi: 10.1111/bph.14495. Epub 2018 Nov 6.


Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists.

Schiano Moriello A, López Chinarro S, Novo Fernández O, Eras J, Amodeo P, Canela-Garayoa R, Vitale RM, Di Marzo V, De Petrocellis L.

J Med Chem. 2018 Sep 27;61(18):8255-8281. doi: 10.1021/acs.jmedchem.8b00734. Epub 2018 Sep 14.


Δ9-tetrahydrocannabivarin impairs epithelial calcium transport through inhibition of TRPV5 and TRPV6.

Janssens A, Silvestri C, Martella A, Vanoevelen JM, Di Marzo V, Voets T.

Pharmacol Res. 2018 Oct;136:83-89. doi: 10.1016/j.phrs.2018.08.021. Epub 2018 Aug 28.


New approaches and challenges to targeting the endocannabinoid system.

Di Marzo V.

Nat Rev Drug Discov. 2018 Sep;17(9):623-639. doi: 10.1038/nrd.2018.115. Epub 2018 Aug 17. Review. Erratum in: Nat Rev Drug Discov. 2018 Aug 30;17(9):688.


Overlapping Distribution of Orexin and Endocannabinoid Receptors and Their Functional Interaction in the Brain of Adult Zebrafish.

Imperatore R, D'Angelo L, Safari O, Motlagh HA, Piscitelli F, de Girolamo P, Cristino L, Varricchio E, di Marzo V, Paolucci M.

Front Neuroanat. 2018 Jul 30;12:62. doi: 10.3389/fnana.2018.00062. eCollection 2018.


Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain.

Brindisi M, Borrelli G, Brogi S, Grillo A, Maramai S, Paolino M, Benedusi M, Pecorelli A, Valacchi G, Di Cesare Mannelli L, Ghelardini C, Allarà M, Ligresti A, Minetti P, Campiani G, di Marzo V, Butini S, Gemma S.

ChemMedChem. 2018 Oct 8;13(19):2090-2103. doi: 10.1002/cmdc.201800397. Epub 2018 Aug 30.


Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice.

Iannotti FA, Pagano E, Moriello AS, Alvino FG, Sorrentino NC, D'Orsi L, Gazzerro E, Capasso R, De Leonibus E, De Petrocellis L, Di Marzo V.

Br J Pharmacol. 2019 May;176(10):1568-1584. doi: 10.1111/bph.14460. Epub 2018 Sep 9.


CB1 receptor activation induces intracellular Ca2+ mobilization and 2-arachidonoylglycerol release in rodent spinal cord astrocytes.

Hegyi Z, Oláh T, Kőszeghy Á, Piscitelli F, Holló K, Pál B, Csernoch L, Di Marzo V, Antal M.

Sci Rep. 2018 Jul 12;8(1):10562. doi: 10.1038/s41598-018-28763-6. Erratum in: Sci Rep. 2018 Sep 7;8(1):13715.


Endocrine disruptors in the diet of male Sparus aurata: Modulation of the endocannabinoid system at the hepatic and central level by Di-isononyl phthalate and Bisphenol A.

Forner-Piquer I, Mylonas CC, Calduch-Giner J, Maradonna F, Gioacchini G, Allarà M, Piscitelli F, Di Marzo V, Pérez-Sánchez J, Carnevali O.

Environ Int. 2018 Oct;119:54-65. doi: 10.1016/j.envint.2018.06.011. Epub 2018 Jun 19.


Experimental ischemia/reperfusion model impairs endocannabinoid signaling and Na+/K+ ATPase expression and activity in kidney proximal tubule cells.

Sampaio LS, Iannotti FA, Veneziani L, Borelli-Tôrres RT, De Maio F, Piscitelli F, Reis RAM, Di Marzo V, Einicker-Lamas M.

Biochem Pharmacol. 2018 Aug;154:482-491. doi: 10.1016/j.bcp.2018.06.005. Epub 2018 Jun 8.


Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate.

Forner-Piquer I, Santangeli S, Maradonna F, Rabbito A, Piscitelli F, Habibi HR, Di Marzo V, Carnevali O.

Environ Pollut. 2018 Oct;241:1-8. doi: 10.1016/j.envpol.2018.05.007. Epub 2018 May 21.


Role of Bisphenol A on the Endocannabinoid System at central and peripheral levels: Effects on adult female zebrafish.

Forner-Piquer I, Santangeli S, Maradonna F, Verde R, Piscitelli F, di Marzo V, Habibi HR, Carnevali O.

Chemosphere. 2018 Aug;205:118-125. doi: 10.1016/j.chemosphere.2018.04.078. Epub 2018 Apr 14.


Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis.

Petrosino S, Verde R, Vaia M, Allarà M, Iuvone T, Di Marzo V.

J Pharmacol Exp Ther. 2018 Jun;365(3):652-663. doi: 10.1124/jpet.117.244368. Epub 2018 Apr 9.


Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect.

Petrosino S, Cordaro M, Verde R, Schiano Moriello A, Marcolongo G, Schievano C, Siracusa R, Piscitelli F, Peritore AF, Crupi R, Impellizzeri D, Esposito E, Cuzzocrea S, Di Marzo V.

Front Pharmacol. 2018 Mar 20;9:249. doi: 10.3389/fphar.2018.00249. eCollection 2018.


N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice.

Donvito G, Piscitelli F, Muldoon P, Jackson A, Vitale RM, D'Aniello E, Giordano C, Ignatowska-Jankowska BM, Mustafa MA, Guida F, Petrie GN, Parker L, Smoum R, Sim-Selley L, Maione S, Lichtman AH, Damaj MI, Di Marzo V, Mechoulam R.

Neuropharmacology. 2019 Apr;148:320-331. doi: 10.1016/j.neuropharm.2018.03.020. Epub 2018 Mar 19.


Endocannabinoid Tone Regulates Human Sebocyte Biology.

Zákány N, Oláh A, Markovics A, Takács E, Aranyász A, Nicolussi S, Piscitelli F, Allarà M, Pór Á, Kovács I, Zouboulis CC, Gertsch J, Di Marzo V, Bíró T, Szabó T.

J Invest Dermatol. 2018 Aug;138(8):1699-1706. doi: 10.1016/j.jid.2018.02.022. Epub 2018 Mar 6.


Effects of repeated long-term psychosocial stress and acute cannabinoid exposure on mouse corticostriatal circuitries: Implications for neuropsychiatric disorders.

Tomas-Roig J, Piscitelli F, Gil V, Quintana E, Ramió-Torrentà LL, Del Río JA, Moore TP, Agbemenyah H, Salinas G, Pommerenke C, Lorenzen S, Beißbarth T, Hoyer-Fender S, Di Marzo V, Havemann-Reinecke U.

CNS Neurosci Ther. 2018 Jun;24(6):528-538. doi: 10.1111/cns.12810. Epub 2018 Jan 31.


Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse.

Roviezzo F, Rossi A, Caiazzo E, Orlando P, Riemma MA, Iacono VM, Guarino A, Ialenti A, Cicala C, Peritore A, Capasso R, Di Marzo V, Izzo AA.

Front Pharmacol. 2017 Dec 12;8:857. doi: 10.3389/fphar.2017.00857. eCollection 2017.


Polymorphism rs1761667 in the CD36 Gene Is Associated to Changes in Fatty Acid Metabolism and Circulating Endocannabinoid Levels Distinctively in Normal Weight and Obese Subjects.

Melis M, Carta G, Pintus S, Pintus P, Piras CA, Murru E, Manca C, Di Marzo V, Banni S, Tomassini Barbarossa I.

Front Physiol. 2017 Dec 6;8:1006. doi: 10.3389/fphys.2017.01006. eCollection 2017.


Peripheral Endocannabinoid Responses to Hedonic Eating in Binge-Eating Disorder.

Monteleone AM, Piscitelli F, Dalle Grave R, El Ghoch M, Di Marzo V, Maj M, Monteleone P.

Nutrients. 2017 Dec 20;9(12). pii: E1377. doi: 10.3390/nu9121377.


The Involvement of the Endocannabinoid System in the Peripheral Antinociceptive Action of Ketamine.

Ferreira RCM, Castor MGM, Piscitelli F, Di Marzo V, Duarte IDG, Romero TRL.

J Pain. 2018 May;19(5):487-495. doi: 10.1016/j.jpain.2017.12.002. Epub 2017 Dec 13.


Characterization of endocannabinoids and related acylethanolamides in the synovial fluid of dogs with osteoarthritis: a pilot study.

Valastro C, Campanile D, Marinaro M, Franchini D, Piscitelli F, Verde R, Di Marzo V, Di Bello A.

BMC Vet Res. 2017 Nov 6;13(1):309. doi: 10.1186/s12917-017-1245-7.


Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish.

Forner-Piquer I, Maradonna F, Gioacchini G, Santangeli S, Allarà M, Piscitelli F, Habibi HR, Di Marzo V, Carnevali O.

Endocrinology. 2017 Oct 1;158(10):3462-3476. doi: 10.1210/en.2017-00458.


Effects of curcumin and curcumin analogues on TRP channels.

Nalli M, Ortar G, Schiano Moriello A, Di Marzo V, De Petrocellis L.

Fitoterapia. 2017 Oct;122:126-131. doi: 10.1016/j.fitote.2017.09.007. Epub 2017 Sep 10. Review.


Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice.

Guida F, Turco F, Iannotta M, De Gregorio D, Palumbo I, Sarnelli G, Furiano A, Napolitano F, Boccella S, Luongo L, Mazzitelli M, Usiello A, De Filippis F, Iannotti FA, Piscitelli F, Ercolini D, de Novellis V, Di Marzo V, Cuomo R, Maione S.

Brain Behav Immun. 2018 Jan;67:230-245. doi: 10.1016/j.bbi.2017.09.001. Epub 2017 Sep 7.


Techniques for the Cellular and Subcellular Localization of Endocannabinoid Receptors and Enzymes in the Mammalian Brain.

Cristino L, Imperatore R, Di Marzo V.

Methods Enzymol. 2017;593:61-98. doi: 10.1016/bs.mie.2017.05.003. Epub 2017 Jul 3.


Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT).

Bashashati M, Fichna J, Piscitelli F, Capasso R, Izzo AA, Sibaev A, Timmermans JP, Cenac N, Vergnolle N, Di Marzo V, Storr M.

Neurogastroenterol Motil. 2017 Dec;29(12). doi: 10.1111/nmo.13148. Epub 2017 Jul 11.


Hedonic eating in Prader-Willi syndrome is associated with blunted PYY secretion.

Rigamonti AE, Bini S, Piscitelli F, Lauritano A, Di Marzo V, Vanetti C, Agosti F, De Col A, Lucchetti E, Grugni G, Sartorio A.

Food Nutr Res. 2017 May 2;61(1):1297553. doi: 10.1080/16546628.2017.1297553. eCollection 2017.


A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover.

Malenczyk K, Girach F, Szodorai E, Storm P, Segerstolpe Å, Tortoriello G, Schnell R, Mulder J, Romanov RA, Borók E, Piscitelli F, Di Marzo V, Szabó G, Sandberg R, Kubicek S, Lubec G, Hökfelt T, Wagner L, Groop L, Harkany T.

EMBO J. 2017 Jul 14;36(14):2107-2125. doi: 10.15252/embj.201695347. Epub 2017 Jun 21.


2-Pentadecyl-2-Oxazoline, the Oxazoline of Pea, Modulates Carrageenan-Induced Acute Inflammation.

Petrosino S, Campolo M, Impellizzeri D, Paterniti I, Allarà M, Gugliandolo E, D'Amico R, Siracusa R, Cordaro M, Esposito E, Di Marzo V, Cuzzocrea S.

Front Pharmacol. 2017 May 30;8:308. doi: 10.3389/fphar.2017.00308. eCollection 2017.

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