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Items: 1 to 50 of 685

1.

New approaches and challenges to targeting the endocannabinoid system.

Di Marzo V.

Nat Rev Drug Discov. 2018 Aug 17. doi: 10.1038/nrd.2018.115. [Epub ahead of print] Review.

PMID:
30116049
2.

Overlapping Distribution of Orexin and Endocannabinoid Receptors and Their Functional Interaction in the Brain of Adult Zebrafish.

Imperatore R, D'Angelo L, Safari O, Motlagh HA, Piscitelli F, de Girolamo P, Cristino L, Varricchio E, di Marzo V, Paolucci M.

Front Neuroanat. 2018 Jul 30;12:62. doi: 10.3389/fnana.2018.00062. eCollection 2018.

3.

Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain.

Brindisi M, Borrelli G, Brogi S, Grillo A, Maramai S, Paolino M, Benedusi M, Pecorelli A, Valacchi G, Di Cesare Mannelli L, Ghelardini C, Allarà M, Ligresti A, Minetti P, Campiani G, Butini S, di Marzo V, Gemma S.

ChemMedChem. 2018 Aug 7. doi: 10.1002/cmdc.201800397. [Epub ahead of print]

PMID:
30085402
4.

Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice.

Iannotti FA, Pagano E, Moriello AS, Alvino FG, Sorrentino NC, D'Orsi L, Gazzerro E, Capasso R, De Leonibus E, De Petrocellis L, Di Marzo V.

Br J Pharmacol. 2018 Aug 3. doi: 10.1111/bph.14460. [Epub ahead of print]

PMID:
30074247
5.

CB1 receptor activation induces intracellular Ca2+ mobilization and 2-arachidonoylglycerol release in rodent spinal cord astrocytes.

Hegyi Z, Oláh T, Kőszeghy Á, Pisticelli F, Holló K, Pál B, Csernoch L, Di Marzo V, Antal M.

Sci Rep. 2018 Jul 12;8(1):10562. doi: 10.1038/s41598-018-28763-6.

6.

Endocrine disruptors in the diet of male Sparus aurata: Modulation of the endocannabinoid system at the hepatic and central level by Di-isononyl phthalate and Bisphenol A.

Forner-Piquer I, Mylonas CC, Calduch-Giner J, Maradonna F, Gioacchini G, Allarà M, Piscitelli F, Di Marzo V, Pérez-Sánchez J, Carnevali O.

Environ Int. 2018 Jun 19;119:54-65. doi: 10.1016/j.envint.2018.06.011. [Epub ahead of print]

PMID:
29933238
7.

Experimental ischemia/reperfusion model impairs endocannabinoid signaling and Na+/K+ ATPase expression and activity in kidney proximal tubule cells.

Sampaio LS, Iannotti FA, Veneziani L, Borelli-Tôrres RT, De Maio F, Piscitelli F, Reis RAM, Di Marzo V, Einicker-Lamas M.

Biochem Pharmacol. 2018 Aug;154:482-491. doi: 10.1016/j.bcp.2018.06.005. Epub 2018 Jun 8.

PMID:
29890144
8.

Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate.

Forner-Piquer I, Santangeli S, Maradonna F, Rabbito A, Piscitelli F, Habibi HR, Di Marzo V, Carnevali O.

Environ Pollut. 2018 Oct;241:1-8. doi: 10.1016/j.envpol.2018.05.007. Epub 2018 May 21.

PMID:
29793103
9.

Role of Bisphenol A on the Endocannabinoid System at central and peripheral levels: Effects on adult female zebrafish.

Forner-Piquer I, Santangeli S, Maradonna F, Verde R, Piscitelli F, di Marzo V, Habibi HR, Carnevali O.

Chemosphere. 2018 Aug;205:118-125. doi: 10.1016/j.chemosphere.2018.04.078. Epub 2018 Apr 14.

PMID:
29689525
10.

Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis.

Petrosino S, Verde R, Vaia M, Allarà M, Iuvone T, Di Marzo V.

J Pharmacol Exp Ther. 2018 Jun;365(3):652-663. doi: 10.1124/jpet.117.244368. Epub 2018 Apr 9.

PMID:
29632236
11.

Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect.

Petrosino S, Cordaro M, Verde R, Schiano Moriello A, Marcolongo G, Schievano C, Siracusa R, Piscitelli F, Peritore AF, Crupi R, Impellizzeri D, Esposito E, Cuzzocrea S, Di Marzo V.

Front Pharmacol. 2018 Mar 20;9:249. doi: 10.3389/fphar.2018.00249. eCollection 2018.

12.

N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice.

Donvito G, Piscitelli F, Muldoon P, Jackson A, Vitale RM, D'Aniello E, Giordano C, Ignatowska-Jankowska BM, Mustafa MA, Guida F, Petrie GN, Parker L, Smoum R, Sim-Selley L, Maione S, Lichtman AH, Damaj MI, Di Marzo V, Mechoulam R.

Neuropharmacology. 2018 Mar 19. pii: S0028-3908(18)30131-X. doi: 10.1016/j.neuropharm.2018.03.020. [Epub ahead of print]

PMID:
29567093
13.

Endocannabinoid Tone Regulates Human Sebocyte Biology.

Zákány N, Oláh A, Markovics A, Takács E, Aranyász A, Nicolussi S, Piscitelli F, Allarà M, Pór Á, Kovács I, Zouboulis CC, Gertsch J, Di Marzo V, Bíró T, Szabó T.

J Invest Dermatol. 2018 Aug;138(8):1699-1706. doi: 10.1016/j.jid.2018.02.022. Epub 2018 Mar 6.

PMID:
29501385
14.

Effects of repeated long-term psychosocial stress and acute cannabinoid exposure on mouse corticostriatal circuitries: Implications for neuropsychiatric disorders.

Tomas-Roig J, Piscitelli F, Gil V, Quintana E, Ramió-Torrentà LL, Del Río JA, Moore TP, Agbemenyah H, Salinas G, Pommerenke C, Lorenzen S, Beißbarth T, Hoyer-Fender S, Di Marzo V, Havemann-Reinecke U.

CNS Neurosci Ther. 2018 Jun;24(6):528-538. doi: 10.1111/cns.12810. Epub 2018 Jan 31.

15.

Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse.

Roviezzo F, Rossi A, Caiazzo E, Orlando P, Riemma MA, Iacono VM, Guarino A, Ialenti A, Cicala C, Peritore A, Capasso R, Di Marzo V, Izzo AA.

Front Pharmacol. 2017 Dec 12;8:857. doi: 10.3389/fphar.2017.00857. eCollection 2017.

16.

Polymorphism rs1761667 in the CD36 Gene Is Associated to Changes in Fatty Acid Metabolism and Circulating Endocannabinoid Levels Distinctively in Normal Weight and Obese Subjects.

Melis M, Carta G, Pintus S, Pintus P, Piras CA, Murru E, Manca C, Di Marzo V, Banni S, Tomassini Barbarossa I.

Front Physiol. 2017 Dec 6;8:1006. doi: 10.3389/fphys.2017.01006. eCollection 2017.

17.

Peripheral Endocannabinoid Responses to Hedonic Eating in Binge-Eating Disorder.

Monteleone AM, Piscitelli F, Dalle Grave R, El Ghoch M, Di Marzo V, Maj M, Monteleone P.

Nutrients. 2017 Dec 20;9(12). pii: E1377. doi: 10.3390/nu9121377.

18.

The Involvement of the Endocannabinoid System in the Peripheral Antinociceptive Action of Ketamine.

Ferreira RCM, Castor MGM, Piscitelli F, Di Marzo V, Duarte IDG, Romero TRL.

J Pain. 2018 May;19(5):487-495. doi: 10.1016/j.jpain.2017.12.002. Epub 2017 Dec 13.

PMID:
29247851
19.

Characterization of endocannabinoids and related acylethanolamides in the synovial fluid of dogs with osteoarthritis: a pilot study.

Valastro C, Campanile D, Marinaro M, Franchini D, Piscitelli F, Verde R, Di Marzo V, Di Bello A.

BMC Vet Res. 2017 Nov 6;13(1):309. doi: 10.1186/s12917-017-1245-7.

20.

Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish.

Forner-Piquer I, Maradonna F, Gioacchini G, Santangeli S, Allarà M, Piscitelli F, Habibi HR, Di Marzo V, Carnevali O.

Endocrinology. 2017 Oct 1;158(10):3462-3476. doi: 10.1210/en.2017-00458.

PMID:
28938452
21.

Effects of curcumin and curcumin analogues on TRP channels.

Nalli M, Ortar G, Schiano Moriello A, Di Marzo V, De Petrocellis L.

Fitoterapia. 2017 Oct;122:126-131. doi: 10.1016/j.fitote.2017.09.007. Epub 2017 Sep 10. Review.

PMID:
28903060
22.

Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice.

Guida F, Turco F, Iannotta M, De Gregorio D, Palumbo I, Sarnelli G, Furiano A, Napolitano F, Boccella S, Luongo L, Mazzitelli M, Usiello A, De Filippis F, Iannotti FA, Piscitelli F, Ercolini D, de Novellis V, Di Marzo V, Cuomo R, Maione S.

Brain Behav Immun. 2018 Jan;67:230-245. doi: 10.1016/j.bbi.2017.09.001. Epub 2017 Sep 7.

PMID:
28890155
23.

Techniques for the Cellular and Subcellular Localization of Endocannabinoid Receptors and Enzymes in the Mammalian Brain.

Cristino L, Imperatore R, Di Marzo V.

Methods Enzymol. 2017;593:61-98. doi: 10.1016/bs.mie.2017.05.003. Epub 2017 Jul 3.

PMID:
28750816
24.

Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT).

Bashashati M, Fichna J, Piscitelli F, Capasso R, Izzo AA, Sibaev A, Timmermans JP, Cenac N, Vergnolle N, Di Marzo V, Storr M.

Neurogastroenterol Motil. 2017 Dec;29(12). doi: 10.1111/nmo.13148. Epub 2017 Jul 11.

PMID:
28695708
25.

Hedonic eating in Prader-Willi syndrome is associated with blunted PYY secretion.

Rigamonti AE, Bini S, Piscitelli F, Lauritano A, Di Marzo V, Vanetti C, Agosti F, De Col A, Lucchetti E, Grugni G, Sartorio A.

Food Nutr Res. 2017 May 2;61(1):1297553. doi: 10.1080/16546628.2017.1297553. eCollection 2017.

26.

A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover.

Malenczyk K, Girach F, Szodorai E, Storm P, Segerstolpe Å, Tortoriello G, Schnell R, Mulder J, Romanov RA, Borók E, Piscitelli F, Di Marzo V, Szabó G, Sandberg R, Kubicek S, Lubec G, Hökfelt T, Wagner L, Groop L, Harkany T.

EMBO J. 2017 Jul 14;36(14):2107-2125. doi: 10.15252/embj.201695347. Epub 2017 Jun 21.

27.

2-Pentadecyl-2-Oxazoline, the Oxazoline of Pea, Modulates Carrageenan-Induced Acute Inflammation.

Petrosino S, Campolo M, Impellizzeri D, Paterniti I, Allarà M, Gugliandolo E, D'Amico R, Siracusa R, Cordaro M, Esposito E, Di Marzo V, Cuzzocrea S.

Front Pharmacol. 2017 May 30;8:308. doi: 10.3389/fphar.2017.00308. eCollection 2017.

28.

Role of N-Arachidonoyl-Serotonin (AA-5-HT) in Sleep-Wake Cycle Architecture, Sleep Homeostasis, and Neurotransmitters Regulation.

Murillo-Rodríguez E, Di Marzo V, Machado S, Rocha NB, Veras AB, Neto GAM, Budde H, Arias-Carrión O, Arankowsky-Sandoval G.

Front Mol Neurosci. 2017 May 30;10:152. doi: 10.3389/fnmol.2017.00152. eCollection 2017.

29.

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.

van Esbroeck ACM, Janssen APA, Cognetta AB 3rd, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H, Allarà M, Fezza F, Lin Z, van der Wel T, Soethoudt M, Mock ED, den Dulk H, Baak IL, Florea BI, Hendriks G, De Petrocellis L, Overkleeft HS, Hankemeier T, De Zeeuw CI, Di Marzo V, Maccarrone M, Cravatt BF, Kushner SA, van der Stelt M.

Science. 2017 Jun 9;356(6342):1084-1087. doi: 10.1126/science.aaf7497.

30.

Endocannabinoid-dependent disinhibition of orexinergic neurons: Electrophysiological evidence in leptin-knockout obese mice.

Becker TM, Favero M, Di Marzo V, Cristino L, Busetto G.

Mol Metab. 2017 Apr 22;6(6):594-601. doi: 10.1016/j.molmet.2017.04.005. eCollection 2017 Jun.

31.

Participants with Normal Weight or with Obesity Show Different Relationships of 6-n-Propylthiouracil (PROP) Taster Status with BMI and Plasma Endocannabinoids.

Carta G, Melis M, Pintus S, Pintus P, Piras CA, Muredda L, Demurtas D, Di Marzo V, Banni S, Barbarossa IT.

Sci Rep. 2017 May 2;7(1):1361. doi: 10.1038/s41598-017-01562-1.

32.

Dual therapy targeting the endocannabinoid system prevents experimental diabetic nephropathy.

Barutta F, Grimaldi S, Gambino R, Vemuri K, Makriyannis A, Annaratone L, di Marzo V, Bruno G, Gruden G.

Nephrol Dial Transplant. 2017 Oct 1;32(10):1655-1665. doi: 10.1093/ndt/gfx010.

PMID:
28387811
33.

Development of a Rapid LC-MS/MS Method for the Quantification of Cannabidiol, Cannabidivarin, Δ9-Tetrahydrocannabivarin, and Cannabigerol in Mouse Peripheral Tissues.

Piscitelli F, Pagano E, Lauritano A, Izzo AA, Di Marzo V.

Anal Chem. 2017 Apr 18;89(8):4749-4755. doi: 10.1021/acs.analchem.7b01094. Epub 2017 Apr 3.

PMID:
28343385
34.

Sex-dependent effects of neonatal maternal deprivation on endocannabinoid levels in the adipose tissue: influence of diet.

Mela V, Piscitelli F, Berzal AL, Chowen J, Silvestri C, Viveros MP, Di Marzo V.

J Physiol Biochem. 2016 Aug;73(3):349-357. doi: 10.1007/s13105-017-0558-0. Epub 2017 Mar 23. Erratum in: J Physiol Biochem. 2017 Oct 5;:.

PMID:
28337718
35.

Palmitoylethanolamide induces microglia changes associated with increased migration and phagocytic activity: involvement of the CB2 receptor.

Guida F, Luongo L, Boccella S, Giordano ME, Romano R, Bellini G, Manzo I, Furiano A, Rizzo A, Imperatore R, Iannotti FA, D'Aniello E, Piscitelli F, Sca Rossi F, Cristino L, Di Marzo V, de Novellis V, Maione S.

Sci Rep. 2017 Mar 23;7(1):375. doi: 10.1038/s41598-017-00342-1.

36.

Exercise training and high-fat diet elicit endocannabinoid system modifications in the rat hypothalamus and hippocampus.

Gamelin FX, Aucouturier J, Iannotti FA, Piscitelli F, Mazzarella E, Aveta T, Leriche M, Dupont E, Cieniewski-Bernard C, Leclair E, Bastide B, Di Marzo V, Heyman E.

J Physiol Biochem. 2016 Aug;73(3):335-347. doi: 10.1007/s13105-017-0557-1. Epub 2017 Mar 10. Erratum in: J Physiol Biochem. 2017 Oct 5;:.

PMID:
28283967
37.

Allodynia Lowering Induced by Cannabinoids and Endocannabinoids (ALICE).

Luongo L, Starowicz K, Maione S, Di Marzo V.

Pharmacol Res. 2017 May;119:272-277. doi: 10.1016/j.phrs.2017.02.019. Epub 2017 Feb 22. Review.

PMID:
28237514
38.

Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis.

Pagano E, Borrelli F, Orlando P, Romano B, Monti M, Morbidelli L, Aviello G, Imperatore R, Capasso R, Piscitelli F, Buono L, Di Marzo V, Izzo AA.

Pharmacol Res. 2017 May;119:227-236. doi: 10.1016/j.phrs.2017.02.002. Epub 2017 Feb 11.

PMID:
28193521
39.

Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome.

Cremon C, Stanghellini V, Barbaro MR, Cogliandro RF, Bellacosa L, Santos J, Vicario M, Pigrau M, Alonso Cotoner C, Lobo B, Azpiroz F, Bruley des Varannes S, Neunlist M, DeFilippis D, Iuvone T, Petrosino S, Di Marzo V, Barbara G.

Aliment Pharmacol Ther. 2017 Apr;45(7):909-922. doi: 10.1111/apt.13958. Epub 2017 Feb 6.

PMID:
28164346
40.

Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor.

Romero-Parra J, Chung H, Tapia RA, Faúndez M, Morales-Verdejo C, Lorca M, Lagos CF, Di Marzo V, David Pessoa-Mahana C, Mella J.

Eur J Pharm Sci. 2017 Apr 1;101:1-10. doi: 10.1016/j.ejps.2017.01.037. Epub 2017 Jan 28.

PMID:
28137469
41.
42.

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.

Soethoudt M, Grether U, Fingerle J, Grim TW, Fezza F, de Petrocellis L, Ullmer C, Rothenhäusler B, Perret C, van Gils N, Finlay D, MacDonald C, Chicca A, Gens MD, Stuart J, de Vries H, Mastrangelo N, Xia L, Alachouzos G, Baggelaar MP, Martella A, Mock ED, Deng H, Heitman LH, Connor M, Di Marzo V, Gertsch J, Lichtman AH, Maccarrone M, Pacher P, Glass M, van der Stelt M.

Nat Commun. 2017 Jan 3;8:13958. doi: 10.1038/ncomms13958.

43.

Plasma palmitoylethanolamide (PEA) as a potential biomarker for impaired coronary function.

Quercioli A, Carbone F, Bonaventura A, Liberale L, Pataky Z, Thomas A, Lenglet S, Lauer E, Golay A, Dallegri F, Di Marzo V, Schindler TH, Montecucco F.

Int J Cardiol. 2017 Mar 15;231:1-5. doi: 10.1016/j.ijcard.2016.12.023. Epub 2016 Dec 13.

PMID:
27989579
44.

Role of the endocannabinoid system in the control of mouse myometrium contractility during the menstrual cycle.

Pagano E, Orlando P, Finizio S, Rossi A, Buono L, Iannotti FA, Piscitelli F, Izzo AA, Di Marzo V, Borrelli F.

Biochem Pharmacol. 2017 Jan 15;124:83-93. doi: 10.1016/j.bcp.2016.11.023. Epub 2016 Nov 27.

PMID:
27899300
45.

Palmitoylethanolamide reduces inflammation and itch in a mouse model of contact allergic dermatitis.

Vaia M, Petrosino S, De Filippis D, Negro L, Guarino A, Carnuccio R, Di Marzo V, Iuvone T.

Eur J Pharmacol. 2016 Nov 15;791:669-674. doi: 10.1016/j.ejphar.2016.10.005. Epub 2016 Oct 5.

PMID:
27720681
46.

Treatment with the GPR55 antagonist CID16020046 increases neutrophil activation in mouse atherogenesis.

Montecucco F, Bondarenko AI, Lenglet S, Burger F, Piscitelli F, Carbone F, Roth A, Liberale L, Dallegri F, Brandt KJ, Fraga-Silva RA, Stergiopulos N, Di Marzo V, Mach F.

Thromb Haemost. 2016 Oct 28;116(5):987-997. Epub 2016 Jul 28.

PMID:
27465665
47.

CB1 Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal.

Saravia R, Flores Á, Plaza-Zabala A, Busquets-Garcia A, Pastor A, de la Torre R, Di Marzo V, Marsicano G, Ozaita A, Maldonado R, Berrendero F.

Biol Psychiatry. 2017 Apr 1;81(7):625-634. doi: 10.1016/j.biopsych.2016.07.007. Epub 2016 Jul 16.

PMID:
27737762
48.

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology.

Ligresti A, De Petrocellis L, Di Marzo V.

Physiol Rev. 2016 Oct;96(4):1593-659. doi: 10.1152/physrev.00002.2016. Review.

49.

Important role of endocannabinoid signaling in the development of functional vision and locomotion in zebrafish.

Martella A, Sepe RM, Silvestri C, Zang J, Fasano G, Carnevali O, De Girolamo P, Neuhauss SC, Sordino P, Di Marzo V.

FASEB J. 2016 Dec;30(12):4275-4288. Epub 2016 Sep 13.

PMID:
27623930
50.

Chronic exposure to cannabinoids during adolescence causes long-lasting behavioral deficits in adult mice.

Tomas-Roig J, Benito E, Agis-Balboa RC, Piscitelli F, Hoyer-Fender S, Di Marzo V, Havemann-Reinecke U.

Addict Biol. 2017 Nov;22(6):1778-1789. doi: 10.1111/adb.12446. Epub 2016 Aug 31.

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