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Items: 1 to 50 of 75

1.

Kras/ADAM17-dependent Jag1-ICD reverse signalling sustains colorectal cancer progression and chemoresistance.

Pelullo M, Nardozza F, Zema S, Quaranta R, Nicoletti C, Besharat ZM, Felli MP, Cerbelli B, d'Amati G, Palermo R, Capalbo C, Talora C, Di Marcotullio L, Giannini G, Checquolo S, Screpanti I, Bellavia D.

Cancer Res. 2019 Sep 10. pii: canres.0145.2019. doi: 10.1158/0008-5472.CAN-19-0145. [Epub ahead of print]

PMID:
31506332
2.

1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma.

D'Alessandro G, Quaglio D, Monaco L, Lauro C, Ghirga F, Ingallina C, De Martino M, Fucile S, Porzia A, Di Castro MA, Bellato F, Mastrotto F, Mori M, Infante P, Turano P, Salmaso S, Caliceti P, Di Marcotullio L, Botta B, Ghini V, Limatola C.

Cell Commun Signal. 2019 Aug 28;17(1):108. doi: 10.1186/s12964-019-0421-8.

3.

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP.

Bufalieri F, Infante P, Bernardi F, Caimano M, Romania P, Moretti M, Lospinoso Severini L, Talbot J, Melaiu O, Tanori M, Di Magno L, Bellavia D, Capalbo C, Puget S, De Smaele E, Canettieri G, Guardavaccaro D, Busino L, Peschiaroli A, Pazzaglia S, Giannini G, Melino G, Locatelli F, Gulino A, Ayrault O, Fruci D, Di Marcotullio L.

Nat Commun. 2019 Jul 24;10(1):3304. doi: 10.1038/s41467-019-11093-0.

4.

Targeting Hedgehog Signalling through the Ubiquitylation Process: The Multiple Roles of the HECT-E3 Ligase Itch.

Infante P, Lospinoso Severini L, Bernardi F, Bufalieri F, Di Marcotullio L.

Cells. 2019 Jan 29;8(2). pii: E98. doi: 10.3390/cells8020098. Review.

5.

P300/CBP-associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation.

Savoia M, Cencioni C, Mori M, Atlante S, Zaccagnini G, Devanna P, Di Marcotullio L, Botta B, Martelli F, Zeiher AM, Pontecorvi A, Farsetti A, Spallotta F, Gaetano C.

FASEB J. 2019 Mar;33(3):4107-4123. doi: 10.1096/fj.201800788R. Epub 2018 Dec 10.

PMID:
30526058
6.

Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation.

Antonucci L, Di Magno L, D'Amico D, Manni S, Serrao SM, Di Pastena F, Bordone R, Yurtsever ZN, Caimano M, Petroni M, Giorgi A, Schininà ME, Yates Iii JR, Di Marcotullio L, De Smaele E, Checquolo S, Capalbo C, Agostinelli E, Maroder M, Coni S, Canettieri G.

Int J Oncol. 2019 Feb;54(2):505-514. doi: 10.3892/ijo.2018.4638. Epub 2018 Nov 19.

7.

MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors.

Petroni M, Sardina F, Infante P, Bartolazzi A, Locatelli E, Fabretti F, Di Giulio S, Capalbo C, Cardinali B, Coppa A, Tessitore A, Colicchia V, Sahùn Roncero M, Belardinilli F, Di Marcotullio L, Soddu S, Comes Franchini M, Petricci E, Gulino A, Giannini G.

Cell Death Dis. 2018 Aug 30;9(9):895. doi: 10.1038/s41419-018-0924-z.

8.

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold.

Berardozzi S, Bernardi F, Infante P, Ingallina C, Toscano S, De Paolis E, Alfonsi R, Caimano M, Botta B, Mori M, Di Marcotullio L, Ghirga F.

Eur J Med Chem. 2018 Aug 5;156:554-562. doi: 10.1016/j.ejmech.2018.07.017. Epub 2018 Jul 9.

PMID:
30025349
9.

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.

Infante P, Faedda R, Bernardi F, Bufalieri F, Lospinoso Severini L, Alfonsi R, Mazzà D, Siler M, Coni S, Po A, Petroni M, Ferretti E, Mori M, De Smaele E, Canettieri G, Capalbo C, Maroder M, Screpanti I, Kool M, Pfister SM, Guardavaccaro D, Gulino A, Di Marcotullio L.

Nat Commun. 2018 Mar 7;9(1):976. doi: 10.1038/s41467-018-03339-0.

10.

Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61.

Calcaterra A, Iovine V, Botta B, Quaglio D, D'Acquarica I, Ciogli A, Iazzetti A, Alfonsi R, Lospinoso Severini L, Infante P, Di Marcotullio L, Mori M, Ghirga F.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):349-358. doi: 10.1080/14756366.2017.1419221.

11.

Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.

De Mori R, Romani M, D'Arrigo S, Zaki MS, Lorefice E, Tardivo S, Biagini T, Stanley V, Musaev D, Fluss J, Micalizzi A, Nuovo S, Illi B, Chiapparini L, Di Marcotullio L, Issa MY, Anello D, Casella A, Ginevrino M, Leggins AS, Roosing S, Alfonsi R, Rosati J, Schot R, Mancini GMS, Bertini E, Dobyns WB, Mazza T, Gleeson JG, Valente EM.

Am J Hum Genet. 2017 Oct 5;101(4):552-563. doi: 10.1016/j.ajhg.2017.08.017. Epub 2017 Sep 28.

12.

Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway.

Quaranta R, Pelullo M, Zema S, Nardozza F, Checquolo S, Lauer DM, Bufalieri F, Palermo R, Felli MP, Vacca A, Talora C, Di Marcotullio L, Screpanti I, Bellavia D.

Cell Death Dis. 2017 Jul 20;8(7):e2942. doi: 10.1038/cddis.2017.326.

13.

β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells.

Miele E, Po A, Begalli F, Antonucci L, Mastronuzzi A, Marras CE, Carai A, Cucchi D, Abballe L, Besharat ZM, Catanzaro G, Infante P, Di Marcotullio L, Canettieri G, De Smaele E, Screpanti I, Locatelli F, Ferretti E.

BMC Cancer. 2017 Jul 17;17(1):488. doi: 10.1186/s12885-017-3477-0.

14.

Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.

Coni S, Mancuso AB, Di Magno L, Sdruscia G, Manni S, Serrao SM, Rotili D, Spiombi E, Bufalieri F, Petroni M, Kusio-Kobialka M, De Smaele E, Ferretti E, Capalbo C, Mai A, Niewiadomski P, Screpanti I, Di Marcotullio L, Canettieri G.

Sci Rep. 2017 Apr 21;7:46645. doi: 10.1038/srep46645. No abstract available.

15.

Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma.

Po A, Silvano M, Miele E, Capalbo C, Eramo A, Salvati V, Todaro M, Besharat ZM, Catanzaro G, Cucchi D, Coni S, Di Marcotullio L, Canettieri G, Vacca A, Stassi G, De Smaele E, Tartaglia M, Screpanti I, De Maria R, Ferretti E.

Oncogene. 2017 Aug 10;36(32):4641-4652. doi: 10.1038/onc.2017.91. Epub 2017 Apr 3.

16.

Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.

Coni S, Mancuso AB, Di Magno L, Sdruscia G, Manni S, Serrao SM, Rotili D, Spiombi E, Bufalieri F, Petroni M, Kusio-Kobialka M, De Smaele E, Ferretti E, Capalbo C, Mai A, Niewiadomski P, Screpanti I, Di Marcotullio L, Canettieri G.

Sci Rep. 2017 Mar 9;7:44079. doi: 10.1038/srep44079. Erratum in: Sci Rep. 2017 Apr 21;7:46645.

17.

Design, Palladium-Catalyzed Synthesis, and Biological Investigation of 2-Substituted 3-Aroylquinolin-4(1H)-ones as Inhibitors of the Hedgehog Signaling Pathway.

Alfonsi R, Botta B, Cacchi S, Di Marcotullio L, Fabrizi G, Faedda R, Goggiamani A, Iazzetti A, Mori M.

J Med Chem. 2017 Feb 23;60(4):1469-1477. doi: 10.1021/acs.jmedchem.6b01135. Epub 2017 Feb 10.

PMID:
28122186
18.

Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype.

Infante P, Alfonsi R, Ingallina C, Quaglio D, Ghirga F, D'Acquarica I, Bernardi F, Di Magno L, Canettieri G, Screpanti I, Gulino A, Botta B, Mori M, Di Marcotullio L.

Cell Death Dis. 2016 Sep 22;7(9):e2376. doi: 10.1038/cddis.2016.195.

19.

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer.

Signoretti S, Di Marcotullio L, Richardson A, Ramaswamy S, Isaac B, Rue M, Monti F, Loda M, Pagano M.

J Clin Invest. 2016 Nov 1;126(11):4387. doi: 10.1172/JCI90690. Epub 2016 Nov 1. No abstract available.

20.

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.

Raducu M, Fung E, Serres S, Infante P, Barberis A, Fischer R, Bristow C, Thézénas ML, Finta C, Christianson JC, Buffa FM, Kessler BM, Sibson NR, Di Marcotullio L, Toftgård R, D'Angiolella V.

EMBO J. 2016 Jul 1;35(13):1400-16. doi: 10.15252/embj.201593374. Epub 2016 May 27.

21.

MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against Medulloblastoma and Basal Cell Carcinoma.

Filocamo G, Brunetti M, Colaceci F, Sasso R, Tanori M, Pasquali E, Alfonsi R, Mancuso M, Saran A, Lahm A, Di Marcotullio L, Steinkühler C, Pazzaglia S.

Mol Cancer Ther. 2016 Jun;15(6):1177-89. doi: 10.1158/1535-7163.MCT-15-0371. Epub 2016 Mar 9.

22.

The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint.

Di Magno L, Basile A, Coni S, Manni S, Sdruscia G, D'Amico D, Antonucci L, Infante P, De Smaele E, Cucchi D, Ferretti E, Di Marcotullio L, Screpanti I, Canettieri G.

Oncotarget. 2016 Feb 23;7(8):9538-49. doi: 10.18632/oncotarget.7070.

23.

Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth.

D'Amico D, Antonucci L, Di Magno L, Coni S, Sdruscia G, Macone A, Miele E, Infante P, Di Marcotullio L, De Smaele E, Ferretti E, Ciapponi L, Giangaspero F, Yates JR 3rd, Agostinelli E, Cardinali B, Screpanti I, Gulino A, Canettieri G.

Dev Cell. 2015 Oct 12;35(1):21-35. doi: 10.1016/j.devcel.2015.09.008.

24.

Insights into Gli Factors Ubiquitylation Methods.

Infante P, Alfonsi R, Di Marcotullio L.

Methods Mol Biol. 2015;1322:131-46. doi: 10.1007/978-1-4939-2772-2_12.

PMID:
26179045
25.

New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.

La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Verrico A, Miele A, Monti L, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Ricci B, Soriani A, Santoni A, Caraglia M, Porto S, Da Pozzo E, Martini C, Brancale A, Marinelli L, Novellino E, Vultaggio S, Varasi M, Mercurio C, Bigogno C, Dondio G, Hamel E, Lavia P, Silvestri R.

J Med Chem. 2015 Aug 13;58(15):5789-807. doi: 10.1021/acs.jmedchem.5b00310. Epub 2015 Jul 20.

26.

Digging a hole under Hedgehog: downstream inhibition as an emerging anticancer strategy.

Di Magno L, Coni S, Di Marcotullio L, Canettieri G.

Biochim Biophys Acta. 2015 Aug;1856(1):62-72. doi: 10.1016/j.bbcan.2015.06.003. Epub 2015 Jun 12. Review.

PMID:
26080084
27.

Targeting GLI factors to inhibit the Hedgehog pathway.

Infante P, Alfonsi R, Botta B, Mori M, Di Marcotullio L.

Trends Pharmacol Sci. 2015 Aug;36(8):547-58. doi: 10.1016/j.tips.2015.05.006. Epub 2015 Jun 10. Review.

PMID:
26072120
28.

The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress.

Petroni M, Sardina F, Heil C, Sahún-Roncero M, Colicchia V, Veschi V, Albini S, Fruci D, Ricci B, Soriani A, Di Marcotullio L, Screpanti I, Gulino A, Giannini G.

Cell Death Differ. 2016 Feb;23(2):197-206. doi: 10.1038/cdd.2015.81. Epub 2015 Jun 12.

29.

Cullin3-BTB interface: a novel target for stapled peptides.

de Paola I, Pirone L, Palmieri M, Balasco N, Esposito L, Russo L, Mazzà D, Di Marcotullio L, Di Gaetano S, Malgieri G, Vitagliano L, Pedone E, Zaccaro L.

PLoS One. 2015 Apr 7;10(4):e0121149. doi: 10.1371/journal.pone.0121149. eCollection 2015.

30.

Notch3/Jagged1 circuitry reinforces notch signaling and sustains T-ALL.

Pelullo M, Quaranta R, Talora C, Checquolo S, Cialfi S, Felli MP, te Kronnie G, Borga C, Besharat ZM, Palermo R, Di Marcotullio L, Capobianco AJ, Gulino A, Screpanti I, Bellavia D.

Neoplasia. 2014 Dec;16(12):1007-17. doi: 10.1016/j.neo.2014.10.004.

31.

Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth.

Di Magno L, Manzi D, D'Amico D, Coni S, Macone A, Infante P, Di Marcotullio L, De Smaele E, Ferretti E, Screpanti I, Agostinelli E, Gulino A, Canettieri G.

Cell Cycle. 2014;13(21):3404-13. doi: 10.4161/15384101.2014.952973.

32.

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.

Infante P, Mori M, Alfonsi R, Ghirga F, Aiello F, Toscano S, Ingallina C, Siler M, Cucchi D, Po A, Miele E, D'Amico D, Canettieri G, De Smaele E, Ferretti E, Screpanti I, Uccello Barretta G, Botta M, Botta B, Gulino A, Di Marcotullio L.

EMBO J. 2015 Jan 13;34(2):200-17. doi: 10.15252/embj.201489213. Epub 2014 Dec 4.

33.

Numb-dependent integration of pre-TCR and p53 function in T-cell precursor development.

Martin-Blanco NM, Checquolo S, Del Gaudio F, Palermo R, Franciosa G, Di Marcotullio L, Gulino A, Canelles M, Screpanti I.

Cell Death Dis. 2014 Oct 16;5:e1472. doi: 10.1038/cddis.2014.438.

34.

New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.

La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Sisinni L, Bolognesi A, Rensen WM, Miele A, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Brancale A, Novellino E, Dondio G, Vultaggio S, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R.

J Med Chem. 2014 Aug 14;57(15):6531-52. doi: 10.1021/jm500561a. Epub 2014 Jul 29.

35.

Yin-Yang strands of PCAF/Hedgehog axis in cancer control.

Infante P, Canettieri G, Gulino A, Di Marcotullio L.

Trends Mol Med. 2014 Aug;20(8):416-8. doi: 10.1016/j.molmed.2014.05.003. Epub 2014 Jun 4.

PMID:
24906555
36.

CNBP regulates wing development in Drosophila melanogaster by promoting IRES-dependent translation of dMyc.

Antonucci L, D'Amico D, Di Magno L, Coni S, Di Marcotullio L, Cardinali B, Gulino A, Ciapponi L, Canettieri G.

Cell Cycle. 2014;13(3):434-9. doi: 10.4161/cc.27268. Epub 2013 Nov 25.

37.

microRNA-17-92 cluster is a direct Nanog target and controls neural stem cell through Trp53inp1.

Garg N, Po A, Miele E, Campese AF, Begalli F, Silvano M, Infante P, Capalbo C, De Smaele E, Canettieri G, Di Marcotullio L, Screpanti I, Ferretti E, Gulino A.

EMBO J. 2013 Oct 30;32(21):2819-32. doi: 10.1038/emboj.2013.214. Epub 2013 Sep 27.

38.

PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress.

Mazzà D, Infante P, Colicchia V, Greco A, Alfonsi R, Siler M, Antonucci L, Po A, De Smaele E, Ferretti E, Capalbo C, Bellavia D, Canettieri G, Giannini G, Screpanti I, Gulino A, Di Marcotullio L.

Cell Death Differ. 2013 Dec;20(12):1688-97. doi: 10.1038/cdd.2013.120. Epub 2013 Sep 6.

39.

Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy.

Coni S, Antonucci L, D'Amico D, Di Magno L, Infante P, De Smaele E, Giannini G, Di Marcotullio L, Screpanti I, Gulino A, Canettieri G.

PLoS One. 2013 Jun 6;8(6):e65718. doi: 10.1371/journal.pone.0065718. Print 2013.

40.

Hedgehog/Gli control by ubiquitination/acetylation interplay.

Gulino A, Di Marcotullio L, Canettieri G, De Smaele E, Screpanti I.

Vitam Horm. 2012;88:211-27. doi: 10.1016/B978-0-12-394622-5.00009-2. Review.

PMID:
22391305
41.

Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma.

De Smaele E, Di Marcotullio L, Moretti M, Pelloni M, Occhione MA, Infante P, Cucchi D, Greco A, Pietrosanti L, Todorovic J, Coni S, Canettieri G, Ferretti E, Bei R, Maroder M, Screpanti I, Gulino A.

Neoplasia. 2011 Apr;13(4):374-85.

42.

Protected from the inside: endogenous histone deacetylase inhibitors and the road to cancer.

Di Marcotullio L, Canettieri G, Infante P, Greco A, Gulino A.

Biochim Biophys Acta. 2011 Apr;1815(2):241-52. doi: 10.1016/j.bbcan.2011.01.002. Epub 2011 Jan 26. Review.

PMID:
21277938
43.

Molecular organization of the cullin E3 ligase adaptor KCTD11.

Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazzà D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone EM.

Biochimie. 2011 Apr;93(4):715-24. doi: 10.1016/j.biochi.2010.12.014. Epub 2011 Jan 13.

PMID:
21237243
44.

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal.

Di Marcotullio L, Greco A, Mazzà D, Canettieri G, Pietrosanti L, Infante P, Coni S, Moretti M, De Smaele E, Ferretti E, Screpanti I, Gulino A.

Oncogene. 2011 Jan 6;30(1):65-76. doi: 10.1038/onc.2010.394. Epub 2010 Sep 6.

PMID:
20818436
45.

Hedgehog controls neural stem cells through p53-independent regulation of Nanog.

Po A, Ferretti E, Miele E, De Smaele E, Paganelli A, Canettieri G, Coni S, Di Marcotullio L, Biffoni M, Massimi L, Di Rocco C, Screpanti I, Gulino A.

EMBO J. 2010 Aug 4;29(15):2646-58. doi: 10.1038/emboj.2010.131. Epub 2010 Jun 25.

46.

Turning off the switch in medulloblastoma: the inhibitory acetylation of an oncogene.

Canettieri G, Di Marcotullio L, Coni S, Greco A, Gulino A.

Cell Cycle. 2010 Jun 1;9(11):2047-8. Epub 2010 Jun 1. No abstract available.

PMID:
20505339
47.

Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation.

Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone EM, Gallinari P, Giorgi A, Steinkühler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A.

Nat Cell Biol. 2010 Feb;12(2):132-42. doi: 10.1038/ncb2013. Epub 2010 Jan 17.

PMID:
20081843
48.

The multiple functions of Numb.

Gulino A, Di Marcotullio L, Screpanti I.

Exp Cell Res. 2010 Apr 1;316(6):900-6. doi: 10.1016/j.yexcr.2009.11.017. Epub 2009 Nov 26. Review.

PMID:
19944684
49.

MicroRNA profiling in human medulloblastoma.

Ferretti E, De Smaele E, Po A, Di Marcotullio L, Tosi E, Espinola MS, Di Rocco C, Riccardi R, Giangaspero F, Farcomeni A, Nofroni I, Laneve P, Gioia U, Caffarelli E, Bozzoni I, Screpanti I, Gulino A.

Int J Cancer. 2009 Feb 1;124(3):568-77. doi: 10.1002/ijc.23948.

50.

Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells.

Ferretti E, De Smaele E, Miele E, Laneve P, Po A, Pelloni M, Paganelli A, Di Marcotullio L, Caffarelli E, Screpanti I, Bozzoni I, Gulino A.

EMBO J. 2008 Oct 8;27(19):2616-27. doi: 10.1038/emboj.2008.172. Epub 2008 Aug 28.

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