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Changing surface grafting density has an effect on the activity of immobilized xylanase towards natural polysaccharides.

Montanier CY, Fanuel M, Rogniaux H, Ropartz D, Di Guilmi AM, Bouchoux A.

Sci Rep. 2019 Apr 8;9(1):5763. doi: 10.1038/s41598-019-42206-w.


One-Pot Two-Step Metabolic Labeling of Teichoic Acids and Direct Labeling of Peptidoglycan Reveals Tight Coordination of Both Polymers Inserted into Pneumococcus Cell Wall.

Bonnet J, Wong YS, Vernet T, Di Guilmi AM, Zapun A, Durmort C.

ACS Chem Biol. 2018 Aug 17;13(8):2010-2015. doi: 10.1021/acschembio.8b00559. Epub 2018 Jul 23.


The cell wall hydrolase Pmp23 is important for assembly and stability of the division ring in Streptococcus pneumoniae.

Jacq M, Arthaud C, Manuse S, Mercy C, Bellard L, Peters K, Gallet B, Galindo J, Doan T, Vollmer W, Brun YV, VanNieuwenhze MS, Di Guilmi AM, Vernet T, Grangeasse C, Morlot C.

Sci Rep. 2018 May 15;8(1):7591. doi: 10.1038/s41598-018-25882-y.


Single Molecule Force Spectroscopy Reveals Two-Domain Binding Mode of Pilus-1 Tip Protein RrgA of Streptococcus pneumoniae to Fibronectin.

Becke TD, Ness S, Gürster R, Schilling AF, di Guilmi AM, Sudhop S, Hilleringmann M, Clausen-Schaumann H.

ACS Nano. 2018 Jan 23;12(1):549-558. doi: 10.1021/acsnano.7b07247. Epub 2018 Jan 9.


Peptidoglycan O-acetylation is functionally related to cell wall biosynthesis and cell division in Streptococcus pneumoniae.

Bonnet J, Durmort C, Jacq M, Mortier-Barrière I, Campo N, VanNieuwenhze MS, Brun YV, Arthaud C, Gallet B, Moriscot C, Morlot C, Vernet T, Di Guilmi AM.

Mol Microbiol. 2017 Dec;106(5):832-846. doi: 10.1111/mmi.13849. Epub 2017 Oct 26.


Specific and spatial labeling of choline-containing teichoic acids in Streptococcus pneumoniae by click chemistry.

Di Guilmi AM, Bonnet J, Peiβert S, Durmort C, Gallet B, Vernet T, Gisch N, Wong YS.

Chem Commun (Camb). 2017 Sep 21;53(76):10572-10575. doi: 10.1039/c7cc05646j.


Autocatalytic association of proteins by covalent bond formation: a Bio Molecular Welding toolbox derived from a bacterial adhesin.

Bonnet J, Cartannaz J, Tourcier G, Contreras-Martel C, Kleman JP, Morlot C, Vernet T, Di Guilmi AM.

Sci Rep. 2017 Mar 2;7:43564. doi: 10.1038/srep43564.


Deciphering Key Residues Involved in the Virulence-promoting Interactions between Streptococcus pneumoniae and Human Plasminogen.

Moreau C, Terrasse R, Thielens NM, Vernet T, Gaboriaud C, Di Guilmi AM.

J Biol Chem. 2017 Feb 10;292(6):2217-2225. doi: 10.1074/jbc.M116.764209. Epub 2016 Dec 23.


Evidence for the Sialylation of PilA, the PI-2a Pilus-Associated Adhesin of Streptococcus agalactiae Strain NEM316.

Morello E, Mallet A, Konto-Ghiorghi Y, Chaze T, Mistou MY, Oliva G, Oliveira L, Di Guilmi AM, Trieu-Cuot P, Dramsi S.

PLoS One. 2015 Sep 25;10(9):e0138103. doi: 10.1371/journal.pone.0138103. eCollection 2015.


Remodeling of the Z-Ring Nanostructure during the Streptococcus pneumoniae Cell Cycle Revealed by Photoactivated Localization Microscopy.

Jacq M, Adam V, Bourgeois D, Moriscot C, Di Guilmi AM, Vernet T, Morlot C.

MBio. 2015 Aug 18;6(4). pii: e01108-15. doi: 10.1128/mBio.01108-15.


A structural snapshot of type II pilus formation in Streptococcus pneumoniae.

Shaik MM, Lombardi C, Maragno Trindade D, Fenel D, Schoehn G, Di Guilmi AM, Dessen A.

J Biol Chem. 2015 Sep 11;290(37):22581-92. doi: 10.1074/jbc.M115.647834. Epub 2015 Jul 21.


Streptococcus pneumoniae GAPDH Is Released by Cell Lysis and Interacts with Peptidoglycan.

Terrasse R, Amoroso A, Vernet T, Di Guilmi AM.

PLoS One. 2015 Apr 30;10(4):e0125377. doi: 10.1371/journal.pone.0125377. eCollection 2015.


Human L-ficolin recognizes phosphocholine moieties of pneumococcal teichoic acid.

Vassal-Stermann E, Lacroix M, Gout E, Laffly E, Pedersen CM, Martin L, Amoroso A, Schmidt RR, Zähringer U, Gaboriaud C, Di Guilmi AM, Thielens NM.

J Immunol. 2014 Dec 1;193(11):5699-708. doi: 10.4049/jimmunol.1400127. Epub 2014 Oct 24.


O-Glycosylation of the N-terminal region of the serine-rich adhesin Srr1 of Streptococcus agalactiae explored by mass spectrometry.

Chaze T, Guillot A, Valot B, Langella O, Chamot-Rooke J, Di Guilmi AM, Trieu-Cuot P, Dramsi S, Mistou MY.

Mol Cell Proteomics. 2014 Sep;13(9):2168-82. doi: 10.1074/mcp.M114.038075. Epub 2014 May 5.


Structural basis of pilus anchoring by the ancillary pilin RrgC of Streptococcus pneumoniae.

Shaik MM, Maccagni A, Tourcier G, Di Guilmi AM, Dessen A.

J Biol Chem. 2014 Jun 13;289(24):16988-97. doi: 10.1074/jbc.M114.555854. Epub 2014 Apr 21.


Interplay of the serine/threonine-kinase StkP and the paralogs DivIVA and GpsB in pneumococcal cell elongation and division.

Fleurie A, Manuse S, Zhao C, Campo N, Cluzel C, Lavergne JP, Freton C, Combet C, Guiral S, Soufi B, Macek B, Kuru E, VanNieuwenhze MS, Brun YV, Di Guilmi AM, Claverys JP, Galinier A, Grangeasse C.

PLoS Genet. 2014 Apr 10;10(4):e1004275. doi: 10.1371/journal.pgen.1004275. eCollection 2014 Apr.


Interaction of Penicillin-Binding Protein 2x and Ser/Thr protein kinase StkP, two key players in Streptococcus pneumoniae R6 morphogenesis.

Morlot C, Bayle L, Jacq M, Fleurie A, Tourcier G, Galisson F, Vernet T, Grangeasse C, Di Guilmi AM.

Mol Microbiol. 2013 Oct;90(1):88-102. doi: 10.1111/mmi.12348. Epub 2013 Aug 27.


Human and pneumococcal cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) proteins are both ligands of human C1q protein.

Terrasse R, Tacnet-Delorme P, Moriscot C, Pérard J, Schoehn G, Vernet T, Thielens NM, Di Guilmi AM, Frachet P.

J Biol Chem. 2012 Dec 14;287(51):42620-33. doi: 10.1074/jbc.M112.423731. Epub 2012 Oct 18.


PatA and PatB form a functional heterodimeric ABC multidrug efflux transporter responsible for the resistance of Streptococcus pneumoniae to fluoroquinolones.

Boncoeur E, Durmort C, Bernay B, Ebel C, Di Guilmi AM, Croizé J, Vernet T, Jault JM.

Biochemistry. 2012 Oct 2;51(39):7755-65. doi: 10.1021/bi300762p. Epub 2012 Sep 21.


Mutational dissection of the S/T-kinase StkP reveals crucial roles in cell division of Streptococcus pneumoniae.

Fleurie A, Cluzel C, Guiral S, Freton C, Galisson F, Zanella-Cleon I, Di Guilmi AM, Grangeasse C.

Mol Microbiol. 2012 Feb;83(4):746-58. doi: 10.1111/j.1365-2958.2011.07962.x. Epub 2012 Jan 11.


Association of RrgA and RrgC into the Streptococcus pneumoniae pilus by sortases C-2 and C-3.

El Mortaji L, Fenel D, Vernet T, Di Guilmi AM.

Biochemistry. 2012 Jan 10;51(1):342-52. doi: 10.1021/bi201591n. Epub 2011 Dec 7.


The full-length Streptococcus pneumoniae major pilin RrgB crystallizes in a fibre-like structure, which presents the D1 isopeptide bond and provides details on the mechanism of pilus polymerization.

El Mortaji L, Contreras-Martel C, Moschioni M, Ferlenghi I, Manzano C, Vernet T, Dessen A, Di Guilmi AM.

Biochem J. 2012 Feb 1;441(3):833-41. doi: 10.1042/BJ20111397.


Structural basis for the substrate specificity of a novel β-N-acetylhexosaminidase StrH protein from Streptococcus pneumoniae R6.

Jiang YL, Yu WL, Zhang JW, Frolet C, Di Guilmi AM, Zhou CZ, Vernet T, Chen Y.

J Biol Chem. 2011 Dec 16;286(50):43004-12. doi: 10.1074/jbc.M111.256578. Epub 2011 Oct 19.


Structural and enzymatic characterization of the streptococcal ATP/diadenosine polyphosphate and phosphodiester hydrolase Spr1479/SapH.

Jiang YL, Zhang JW, Yu WL, Cheng W, Zhang CC, Frolet C, Di Guilmi AM, Vernet T, Zhou CZ, Chen Y.

J Biol Chem. 2011 Oct 14;286(41):35906-14. doi: 10.1074/jbc.M111.228585. Epub 2011 Aug 23.


Biochemical characterization of the histidine triad protein PhtD as a cell surface zinc-binding protein of pneumococcus.

Loisel E, Chimalapati S, Bougault C, Imberty A, Gallet B, Di Guilmi AM, Brown J, Vernet T, Durmort C.

Biochemistry. 2011 May 3;50(17):3551-8. doi: 10.1021/bi200012f. Epub 2011 Apr 11.


Crystal structure of the mucin-binding domain of Spr1345 from Streptococcus pneumoniae.

Du Y, He YX, Zhang ZY, Yang YH, Shi WW, Frolet C, Di Guilmi AM, Vernet T, Zhou CZ, Chen Y.

J Struct Biol. 2011 Apr;174(1):252-7. doi: 10.1016/j.jsb.2010.10.016. Epub 2010 Nov 3.


New adhesin functions of surface-exposed pneumococcal proteins.

Frolet C, Beniazza M, Roux L, Gallet B, Noirclerc-Savoye M, Vernet T, Di Guilmi AM.

BMC Microbiol. 2010 Jul 12;10:190. doi: 10.1186/1471-2180-10-190.


Structural basis of host cell recognition by the pilus adhesin from Streptococcus pneumoniae.

Izoré T, Contreras-Martel C, El Mortaji L, Manzano C, Terrasse R, Vernet T, Di Guilmi AM, Dessen A.

Structure. 2010 Jan 13;18(1):106-15. doi: 10.1016/j.str.2009.10.019.


Stability and assembly of pilus subunits of Streptococcus pneumoniae.

El Mortaji L, Terrasse R, Dessen A, Vernet T, Di Guilmi AM.

J Biol Chem. 2010 Apr 16;285(16):12405-15. doi: 10.1074/jbc.M109.082776. Epub 2010 Feb 10.


A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology.

Durrant JD, Amaro RE, Xie L, Urbaniak MD, Ferguson MA, Haapalainen A, Chen Z, Di Guilmi AM, Wunder F, Bourne PE, McCammon JA.

PLoS Comput Biol. 2010 Jan 22;6(1):e1000648. doi: 10.1371/journal.pcbi.1000648.


Sortase activity is controlled by a flexible lid in the pilus biogenesis mechanism of gram-positive pathogens.

Manzano C, Izoré T, Job V, Di Guilmi AM, Dessen A.

Biochemistry. 2009 Nov 10;48(44):10549-57. doi: 10.1021/bi901261y.


Structure of the choline-binding domain of Spr1274 in Streptococcus pneumoniae.

Zhang Z, Li W, Frolet C, Bao R, di Guilmi AM, Vernet T, Chen Y.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Aug 1;65(Pt 8):757-61. doi: 10.1107/S1744309109025329. Epub 2009 Jul 21.


The ATPase activity of an 'essential' Bacillus subtilis enzyme, YdiB, is required for its cellular function and is modulated by oligomerization.

Karst JC, Foucher AE, Campbell TL, Di Guilmi AM, Stroebel D, Mangat CS, Brown ED, Jault JM.

Microbiology. 2009 Mar;155(Pt 3):944-56. doi: 10.1099/mic.0.021543-0.


The Inactivation of a New Peptidoglycan Hydrolase Pmp23 Leads to Abnormal Septum Formation in Streptococcus pneumoniae.

E P, B D, C F, O D, T V, Am DG.

Open Microbiol J. 2008;2:107-14. doi: 10.2174/1874285800802010107. Epub 2008 Aug 22.


Sortase-mediated pilus fiber biogenesis in Streptococcus pneumoniae.

Manzano C, Contreras-Martel C, El Mortaji L, Izoré T, Fenel D, Vernet T, Schoehn G, Di Guilmi AM, Dessen A.

Structure. 2008 Dec 10;16(12):1838-48. doi: 10.1016/j.str.2008.10.007.


The interaction of Streptococcus pneumoniae with plasmin mediates transmigration across endothelial and epithelial monolayers by intercellular junction cleavage.

Attali C, Durmort C, Vernet T, Di Guilmi AM.

Infect Immun. 2008 Nov;76(11):5350-6. doi: 10.1128/IAI.00184-08. Epub 2008 Aug 25.


AdcAII, a new pneumococcal Zn-binding protein homologous with ABC transporters: biochemical and structural analysis.

Loisel E, Jacquamet L, Serre L, Bauvois C, Ferrer JL, Vernet T, Di Guilmi AM, Durmort C.

J Mol Biol. 2008 Sep 5;381(3):594-606. doi: 10.1016/j.jmb.2008.05.068. Epub 2008 Jun 3.


Streptococcus pneumoniae choline-binding protein E interaction with plasminogen/plasmin stimulates migration across the extracellular matrix.

Attali C, Frolet C, Durmort C, Offant J, Vernet T, Di Guilmi AM.

Infect Immun. 2008 Feb;76(2):466-76. Epub 2007 Dec 10.


Crystal structure of penicillin-binding protein 1a (PBP1a) reveals a mutational hotspot implicated in beta-lactam resistance in Streptococcus pneumoniae.

Contreras-Martel C, Job V, Di Guilmi AM, Vernet T, Dideberg O, Dessen A.

J Mol Biol. 2006 Jan 27;355(4):684-96. Epub 2005 Nov 9.


Structure-based phylogeny of the metallo-beta-lactamases.

Garau G, Di Guilmi AM, Hall BG.

Antimicrob Agents Chemother. 2005 Jul;49(7):2778-84.


Active site restructuring regulates ligand recognition in class A penicillin-binding proteins.

Macheboeuf P, Di Guilmi AM, Job V, Vernet T, Dideberg O, Dessen A.

Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):577-82. Epub 2005 Jan 6.


Crystal structure of a peptidoglycan synthesis regulatory factor (PBP3) from Streptococcus pneumoniae.

Morlot C, Pernot L, Le Gouellec A, Di Guilmi AM, Vernet T, Dideberg O, Dessen A.

J Biol Chem. 2005 Apr 22;280(16):15984-91. Epub 2004 Dec 13.


Biochemical characterization of Streptococcus pneumoniae penicillin-binding protein 2b and its implication in beta-lactam resistance.

Pagliero E, Chesnel L, Hopkins J, Croizé J, Dideberg O, Vernet T, Di Guilmi AM.

Antimicrob Agents Chemother. 2004 May;48(5):1848-55.


Type III secretion proteins PcrV and PcrG from Pseudomonas aeruginosa form a 1:1 complex through high affinity interactions.

Nanao M, Ricard-Blum S, Di Guilmi AM, Lemaire D, Lascoux D, Chabert J, Attree I, Dessen A.

BMC Microbiol. 2003 Oct 18;3:21.


Oligomerization of type III secretion proteins PopB and PopD precedes pore formation in Pseudomonas.

Schoehn G, Di Guilmi AM, Lemaire D, Attree I, Weissenhorn W, Dessen A.

EMBO J. 2003 Oct 1;22(19):4957-67.


Structural studies of the transpeptidase domain of PBP1a from Streptococcus pneumoniae.

Job V, Di Guilmi AM, Martin L, Vernet T, Dideberg O, Dessen A.

Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):1067-9. Epub 2003 May 23.


Functional characterization of penicillin-binding protein 1b from Streptococcus pneumoniae.

Di Guilmi AM, Dessen A, Dideberg O, Vernet T.

J Bacteriol. 2003 Mar;185(5):1650-8.

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