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FSH Requirements for Follicle Growth During Controlled Ovarian Stimulation.

Abbara A, Patel A, Hunjan T, Clarke SA, Chia G, Eng PC, Phylactou M, Comninos AN, Lavery S, Trew GH, Salim R, Rai RS, Kelsey TW, Dhillo WS.

Front Endocrinol (Lausanne). 2019 Aug 27;10:579. doi: 10.3389/fendo.2019.00579. eCollection 2019.


Investigation and management of subfertility.

Thurston L, Abbara A, Dhillo WS.

J Clin Pathol. 2019 Sep;72(9):579-587. doi: 10.1136/jclinpath-2018-205579. Epub 2019 Jul 11. Review.


Combined GLP-1, Oxyntomodulin, and Peptide YY Improves Body Weight and Glycemia in Obesity and Prediabetes/Type 2 Diabetes: A Randomized, Single-Blinded, Placebo-Controlled Study.

Behary P, Tharakan G, Alexiadou K, Johnson N, Wewer Albrechtsen NJ, Kenkre J, Cuenco J, Hope D, Anyiam O, Choudhury S, Alessimii H, Poddar A, Minnion J, Doyle C, Frost G, Le Roux C, Purkayastha S, Moorthy K, Dhillo W, Holst JJ, Ahmed AR, Prevost AT, Bloom SR, Tan TM.

Diabetes Care. 2019 Aug;42(8):1446-1453. doi: 10.2337/dc19-0449. Epub 2019 Jun 8.


Determining the Relationship Between Hot Flushes and LH Pulses in Menopausal Women Using Mathematical Modeling.

Prague JK, Voliotis M, Clarke S, Comninos AN, Abbara A, Jayasena CN, Roberts RE, Yang L, Veldhuis JD, Tsaneva-Atanasova K, McArdle CA, Dhillo WS.

J Clin Endocrinol Metab. 2019 Sep 1;104(9):3628-3636. doi: 10.1210/jc.2018-02797.


Measuring luteinising hormone pulsatility with a robotic aptamer-enabled electrochemical reader.

Liang S, Kinghorn AB, Voliotis M, Prague JK, Veldhuis JD, Tsaneva-Atanasova K, McArdle CA, Li RHW, Cass AEG, Dhillo WS, Tanner JA.

Nat Commun. 2019 Feb 20;10(1):852. doi: 10.1038/s41467-019-08799-6.


Deregulation of miR-324/KISS1/kisspeptin in early ectopic pregnancy: mechanistic findings with clinical and diagnostic implications.

Romero-Ruiz A, Avendaño MS, Dominguez F, Lozoya T, Molina-Abril H, Sangiao-Alvarellos S, Gurrea M, Lara-Chica M, Fernandez-Sanchez M, Torres-Jimenez E, Perdices-Lopez C, Abbara A, Steffani L, Calzado MA, Dhillo WS, Pellicer A, Tena-Sempere M.

Am J Obstet Gynecol. 2019 May;220(5):480.e1-480.e17. doi: 10.1016/j.ajog.2019.01.228. Epub 2019 Jan 29.


Reduced Testicular Steroidogenesis and Increased Semen Oxidative Stress in Male Partners as Novel Markers of Recurrent Miscarriage.

Jayasena CN, Radia UK, Figueiredo M, Revill LF, Dimakopoulou A, Osagie M, Vessey W, Regan L, Rai R, Dhillo WS.

Clin Chem. 2019 Jan;65(1):161-169. doi: 10.1373/clinchem.2018.289348.


Neurokinin 3 Receptor Antagonism: A Novel Treatment for Menopausal Hot Flushes.

Modi M, Dhillo WS.

Neuroendocrinology. 2019;109(3):242-248. doi: 10.1159/000495889. Epub 2018 Nov 30. Review.


A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women.

Jayasena CN, Alkaabi FM, Liebers CS, Handley T, Franks S, Dhillo WS.

Clin Endocrinol (Oxf). 2019 Mar;90(3):391-414. doi: 10.1111/cen.13906. Epub 2019 Jan 14. Review.


Modulations of human resting brain connectivity by kisspeptin enhance sexual and emotional functions.

Comninos AN, Demetriou L, Wall MB, Shah AJ, Clarke SA, Narayanaswamy S, Nesbitt A, Izzi-Engbeaya C, Prague JK, Abbara A, Ratnasabapathy R, Yang L, Salem V, Nijher GM, Jayasena CN, Tanner M, Bassett P, Mehta A, McGonigle J, Rabiner EA, Bloom SR, Dhillo WS.

JCI Insight. 2018 Oct 18;3(20). pii: 121958. doi: 10.1172/jci.insight.121958.


Kisspeptin and the control of emotions, mood and reproductive behaviour

Mills EGA, Dhillo WS, Comninos AN.

J Endocrinol. 2018 Oct 1;239(1):R1–R12. doi: 10.1530/JOE-18-0269. Review.


Prevalence of abnormal semen analysis and levels of adherence with fertility preservation in men undergoing therapy for newly diagnosed cancer: A retrospective study in 2906 patients.

Jayasena CN, Luo R, Dimakopoulou A, Dearing C, Clarke H, Patel N, Stroud T, Seyani L, Ramsay J, Dhillo WS.

Clin Endocrinol (Oxf). 2018 Dec;89(6):798-804. doi: 10.1111/cen.13851. Epub 2018 Oct 10.


Clinical and biochemical characteristics of patients presenting with pituitary apoplexy.

Abbara A, Clarke S, Eng PC, Milburn J, Joshi D, Comninos AN, Ramli R, Mehta A, Jones B, Wernig F, Nair R, Mendoza N, Sam AH, Hatfield E, Meeran K, Dhillo WS, Martin NM.

Endocr Connect. 2018 Aug 23. pii: EC-18-0255. doi: 10.1530/EC-18-0255. [Epub ahead of print]


Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment.

Abbara A, Clarke SA, Dhillo WS.

Endocr Rev. 2018 Oct 1;39(5):593-628. doi: 10.1210/er.2017-00236. Review.


The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans.

Izzi-Engbeaya C, Comninos AN, Clarke SA, Jomard A, Yang L, Jones S, Abbara A, Narayanaswamy S, Eng PC, Papadopoulou D, Prague JK, Bech P, Godsland IF, Bassett P, Sands C, Camuzeaux S, Gomez-Romero M, Pearce JTM, Lewis MR, Holmes E, Nicholson JK, Tan T, Ratnasabapathy R, Hu M, Carrat G, Piemonti L, Bugliani M, Marchetti P, Johnson PR, Hughes SJ, James Shapiro AM, Rutter GA, Dhillo WS.

Diabetes Obes Metab. 2018 Dec;20(12):2800-2810. doi: 10.1111/dom.13460. Epub 2018 Aug 16.


Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis.

Ma Y, Ratnasabapathy R, Izzi-Engbeaya C, Nguyen-Tu MS, Richardson E, Hussain S, De Backer I, Holton C, Norton M, Carrat G, Schwappach B, Rutter GA, Dhillo WS, Gardiner J.

Diabetes Obes Metab. 2018 Sep;20(9):2246-2254. doi: 10.1111/dom.13359. Epub 2018 Jun 12.


Frequent falls and confusion: recurrent hypoglycemia in a patient with tuberous sclerosis complex.

Comninos AN, Yang L, Abbara A, Dhillo WS, Bassett JHD, Todd JF.

Clin Case Rep. 2018 Mar 24;6(5):904-909. doi: 10.1002/ccr3.1483. eCollection 2018 May.


Follicle Size on Day of Trigger Most Likely to Yield a Mature Oocyte.

Abbara A, Vuong LN, Ho VNA, Clarke SA, Jeffers L, Comninos AN, Salim R, Ho TM, Kelsey TW, Trew GH, Humaidan P, Dhillo WS.

Front Endocrinol (Lausanne). 2018 Apr 25;9:193. doi: 10.3389/fendo.2018.00193. eCollection 2018.


Author Correction: Intrinsic links among sex, emotion, and reproduction.

Yang L, Comninos AN, Dhillo WS.

Cell Mol Life Sci. 2018 Jul;75(13):2489. doi: 10.1007/s00018-018-2814-z.


Interpretation of Serum Gonadotropin Levels in Hyperprolactinaemia.

Abbara A, Clarke SA, Nesbitt A, Ali S, Comninos AN, Hatfield E, Martin NM, Sam AH, Meeran K, Dhillo WS.

Neuroendocrinology. 2018;107(2):105-113. doi: 10.1159/000489264. Epub 2018 Apr 16.


The 3rd World Conference on Kisspeptin, "Kisspeptin 2017: Brain and Beyond":Unresolved questions, challenges and future directions for the field.

Lehman MN, Coolen LM, Steiner RA, Neal-Perry G, Wang L, Moenter SM, Moore AM, Goodman RL, Hwa-Yeo S, Padilla SL, Kauffman AS, Garcia J, Kelly MJ, Clarkson J, Radovick S, Babwah AV, Leon S, Tena-Sempere M, Comninos A, Seminara S, Dhillo WS, Levine J, Terasawa E, Negron A, Herbison AE.

J Neuroendocrinol. 2018 Apr 14:e12600. doi: 10.1111/jne.12600. [Epub ahead of print] Review.


Intrinsic links among sex, emotion, and reproduction.

Yang L, Comninos AN, Dhillo WS.

Cell Mol Life Sci. 2018 Jun;75(12):2197-2210. doi: 10.1007/s00018-018-2802-3. Epub 2018 Mar 26. Review. Erratum in: Cell Mol Life Sci. 2018 Apr 17;:.


Hypothalamic Response to Kisspeptin-54 and Pituitary Response to Gonadotropin-Releasing Hormone Are Preserved in Healthy Older Men.

Abbara A, Narayanaswamy S, Izzi-Engbeaya C, Comninos AN, Clarke SA, Malik Z, Papadopoulou D, Clobentz A, Sarang Z, Bassett P, Jayasena CN, Dhillo WS.

Neuroendocrinology. 2018;106(4):401-410. doi: 10.1159/000488452. Epub 2018 Mar 15.


Neurokinin 3 receptor antagonism rapidly improves vasomotor symptoms with sustained duration of action.

Prague JK, Roberts RE, Comninos AN, Clarke S, Jayasena CN, Mohideen P, Lin VH, Stern TP, Panay N, Hunter MS, Webber LC, Dhillo WS.

Menopause. 2018 Aug;25(8):862-869. doi: 10.1097/GME.0000000000001090.


Clinical parameters of ovarian hyperstimulation syndrome following different hormonal triggers of oocyte maturation in IVF treatment.

Abbara A, Islam R, Clarke SA, Jeffers L, Christopoulos G, Comninos AN, Salim R, Lavery SA, Vuong TNL, Humaidan P, Kelsey TW, Trew GH, Dhillo WS.

Clin Endocrinol (Oxf). 2018 Jun;88(6):920-927. doi: 10.1111/cen.13569. Epub 2018 Mar 6.


Congenital hypogonadotropic hypogonadism and constitutional delay of growth and puberty have distinct genetic architectures.

Cassatella D, Howard SR, Acierno JS, Xu C, Papadakis GE, Santoni FA, Dwyer AA, Santini S, Sykiotis GP, Chambion C, Meylan J, Marino L, Favre L, Li J, Liu X, Zhang J, Bouloux PM, Geyter C, Paepe A, Dhillo WS, Ferrara JM, Hauschild M, Lang-Muritano M, Lemke JR, Flück C, Nemeth A, Phan-Hug F, Pignatelli D, Popovic V, Pekic S, Quinton R, Szinnai G, l'Allemand D, Konrad D, Sharif S, Iyidir ÖT, Stevenson BJ, Yang H, Dunkel L, Pitteloud N.

Eur J Endocrinol. 2018 Apr;178(4):377-388. doi: 10.1530/EJE-17-0568. Epub 2018 Feb 1.


Post mortem single-cell labeling with DiI and immunoelectron microscopy unveil the fine structure of kisspeptin neurons in humans.

Takács S, Bardóczi Z, Skrapits K, Göcz B, Váczi V, Maglóczky Z, Szűcs I, Rácz G, Matolcsy A, Dhillo WS, Watanabe M, Kádár A, Fekete C, Kalló I, Hrabovszky E.

Brain Struct Funct. 2018 Jun;223(5):2143-2156. doi: 10.1007/s00429-018-1610-8. Epub 2018 Jan 29.


Correction: Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo.

d'Anglemont de Tassigny X, Jayasena CN, Murphy KG, Dhillo WS, Colledge WH.

PLoS One. 2018 Jan 25;13(1):e0192014. doi: 10.1371/journal.pone.0192014. eCollection 2018.


Treating hot flushes with a neurokinin 3 receptor antagonist.

Prague JK, Dhillo WS.

Oncotarget. 2017 Nov 11;8(63):106153-106154. doi: 10.18632/oncotarget.22383. eCollection 2017 Dec 5. No abstract available.


The direct and indirect effects of kisspeptin-54 on granulosa lutein cell function.

Owens LA, Abbara A, Lerner A, O'floinn S, Christopoulos G, Khanjani S, Islam R, Hardy K, Hanyaloglu AC, Lavery SA, Dhillo WS, Franks S.

Hum Reprod. 2018 Feb 1;33(2):292-302. doi: 10.1093/humrep/dex357.


Reply: Clinical trial registry alone is not adequate: on the perception of possible endpoint switching and P-hacking.

Abbara A, Clarke S, Islam R, Prague JK, Comninos A, Narayanaswamy S, Papadopoulou DA, Roberts RE, Izzi-Engbeaya CN, Ratnasabapathy R, Nesbitt A, Vimalesvaran S, Salim R, Lavery SA, Bloom SR, Huson L, Trew GH, Dhillo WS.

Hum Reprod. 2018 Feb 1;33(2):342-344. doi: 10.1093/humrep/dex360. No abstract available.


Testosterone therapy for sexual dysfunction in men with Type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.

Algeffari M, Jayasena CN, MacKeith P, Thapar A, Dhillo WS, Oliver N.

Diabet Med. 2018 Feb;35(2):195-202. doi: 10.1111/dme.13553. Epub 2017 Dec 14.


Neurokinin 3 receptor antagonism - the magic bullet for hot flushes?

Prague JK, Dhillo WS.

Climacteric. 2017 Dec;20(6):505-509. doi: 10.1080/13697137.2017.1385598. Epub 2017 Oct 17. Review.


Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans.

Law J, Morris DE, Izzi-Engbeaya C, Salem V, Coello C, Robinson L, Jayasinghe M, Scott R, Gunn R, Rabiner E, Tan T, Dhillo WS, Bloom S, Budge H, Symonds ME.

J Nucl Med. 2018 Mar;59(3):516-522. doi: 10.2967/jnumed.117.190546. Epub 2017 Sep 14.


Kisspeptin Is a Novel Regulator of Human Fetal Adrenocortical Development and Function: A Finding With Important Implications for the Human Fetoplacental Unit.

Katugampola H, King PJ, Chatterjee S, Meso M, Duncan AJ, Achermann JC, Guasti L, Ghataore L, Taylor NF, Allen R, Marlene S, Aquilina J, Abbara A, Jaysena CN, Dhillo WS, Dunkel L, Sankilampi U, Storr HL.

J Clin Endocrinol Metab. 2017 Sep 1;102(9):3349-3359. doi: 10.1210/jc.2017-00763.


Emerging Roles of Kisspeptin in Sexual and Emotional Brain Processing.

Comninos AN, Dhillo WS.

Neuroendocrinology. 2018;106(2):195-202. doi: 10.1159/000481137. Epub 2017 Aug 31. Review.


A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trial.

Abbara A, Clarke S, Islam R, Prague JK, Comninos AN, Narayanaswamy S, Papadopoulou D, Roberts R, Izzi-Engbeaya C, Ratnasabapathy R, Nesbitt A, Vimalesvaran S, Salim R, Lavery SA, Bloom SR, Huson L, Trew GH, Dhillo WS.

Hum Reprod. 2017 Sep 1;32(9):1915-1924. doi: 10.1093/humrep/dex253.


Human brown adipose tissue-function and therapeutic potential in metabolic disease.

Bhatt PS, Dhillo WS, Salem V.

Curr Opin Pharmacol. 2017 Dec;37:1-9. doi: 10.1016/j.coph.2017.07.004. Epub 2017 Aug 8. Review.


Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight.

Hameed S, Patterson M, Dhillo WS, Rahman SA, Ma Y, Holton C, Gogakos A, Yeo GSH, Lam BYH, Polex-Wolf J, Fenske W, Bell J, Anastasovska J, Samarut J, Bloom SR, Bassett JHD, Williams GR, Gardiner JV.

Cell Rep. 2017 Jun 13;19(11):2202-2209. doi: 10.1016/j.celrep.2017.05.066.


Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo.

d'Anglemont de Tassigny X, Jayasena CN, Murphy KG, Dhillo WS, Colledge WH.

PLoS One. 2017 May 2;12(5):e0176821. doi: 10.1371/journal.pone.0176821. eCollection 2017. Erratum in: PLoS One. 2018 Jan 25;13(1):e0192014.


Using kisspeptin to assess GnRH function in an unusual case of primary amenorrhoea.

Vimalesvaran S, Narayanaswamy S, Yang L, Prague JK, Buckley A, Miras AD, Franks S, Meeran K, Dhillo WS.

Endocrinol Diabetes Metab Case Rep. 2017 Mar 27;2017. pii: 16-0117. doi: 10.1530/EDM-16-0117. eCollection 2017.


Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial.

Prague JK, Roberts RE, Comninos AN, Clarke S, Jayasena CN, Nash Z, Doyle C, Papadopoulou DA, Bloom SR, Mohideen P, Panay N, Hunter MS, Veldhuis JD, Webber LC, Huson L, Dhillo WS.

Lancet. 2017 May 6;389(10081):1809-1820. doi: 10.1016/S0140-6736(17)30823-1. Epub 2017 Apr 3.


Kisspeptin modulates sexual and emotional brain processing in humans.

Comninos AN, Wall MB, Demetriou L, Shah AJ, Clarke SA, Narayanaswamy S, Nesbitt A, Izzi-Engbeaya C, Prague JK, Abbara A, Ratnasabapathy R, Salem V, Nijher GM, Jayasena CN, Tanner M, Bassett P, Mehta A, Rabiner EA, Hönigsperger C, Silva MR, Brandtzaeg OK, Lundanes E, Wilson SR, Brown RC, Thomas SA, Bloom SR, Dhillo WS.

J Clin Invest. 2017 Feb 1;127(2):709-719. doi: 10.1172/JCI89519. Epub 2017 Jan 23.


Novel circulating placental markers prokineticin-1, soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor and association with late miscarriage.

Jayasena CN, Abbara A, Comninos AN, Narayanaswamy S, Gonzalez Maffe J, Izzi-Engbeaya C, Oldham J, Lee TT, Sarang Z, Malik Z, Dhanjal MK, Williamson C, Regan L, Bloom SR, Dhillo WS.

Hum Reprod. 2016 Dec;31(12):2681-2688. Epub 2016 Sep 22.


Randomised clinical study: inulin short-chain fatty acid esters for targeted delivery of short-chain fatty acids to the human colon.

Polyviou T, MacDougall K, Chambers ES, Viardot A, Psichas A, Jawaid S, Harris HC, Edwards CA, Simpson L, Murphy KG, Zac-Varghese SE, Blundell JE, Dhillo WS, Bloom SR, Frost GS, Preston T, Tedford MC, Morrison DJ.

Aliment Pharmacol Ther. 2016 Oct;44(7):662-72. doi: 10.1111/apt.13749. Epub 2016 Jul 28.


Investigating the KNDy Hypothesis in Humans by Coadministration of Kisspeptin, Neurokinin B, and Naltrexone in Men.

Narayanaswamy S, Prague JK, Jayasena CN, Papadopoulou DA, Mizamtsidi M, Shah AJ, Bassett P, Comninos AN, Abbara A, Bloom SR, Veldhuis JD, Dhillo WS.

J Clin Endocrinol Metab. 2016 Sep;101(9):3429-36. doi: 10.1210/jc.2016-1911. Epub 2016 Jul 5.


Kisspeptin across the human lifespan:evidence from animal studies and beyond.

Clarke SA, Dhillo WS.

J Endocrinol. 2016 Jun;229(3):R83-98. doi: 10.1530/JOE-15-0538. Review.


Increased peptide YY blood concentrations, not decreased acyl-ghrelin, are associated with reduced hunger and food intake in healthy older women: Preliminary evidence.

Hickson M, Moss C, Dhillo WS, Bottin J, Frost G.

Appetite. 2016 Oct 1;105:320-7. doi: 10.1016/j.appet.2016.06.002. Epub 2016 Jun 3.


Kisspeptin as a therapeutic target in reproduction.

Yang L, Dhillo W.

Expert Opin Ther Targets. 2016;20(5):567-75. doi: 10.1517/14728222.2016.1124858. Epub 2015 Dec 17. Review.


Subcutaneous infusion of kisspeptin-54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels.

Narayanaswamy S, Jayasena CN, Ng N, Ratnasabapathy R, Prague JK, Papadopoulou D, Abbara A, Comninos AN, Bassett P, Bloom SR, Veldhuis JD, Dhillo WS.

Clin Endocrinol (Oxf). 2016 Jun;84(6):939-45. doi: 10.1111/cen.12977. Epub 2015 Dec 17.

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