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N-acetyltransferase 2 genotypes amongst Zulu Speaking South Africans and isoniazid/N-acetyl-isoniazid pharmacokinetics during anti-tuberculosis treatment.

Mthiyane T, Millard J, Adamson J, Balakrishna Y, Connolly C, Owen A, Rustomjee R, Dheda K, McIlleron H, Pym AS.

Antimicrob Agents Chemother. 2020 Jan 21. pii: AAC.02376-19. doi: 10.1128/AAC.02376-19. [Epub ahead of print]


LTBI-associated Immuno-diagnostic Test Responses (Standardized IGRAs and the TST) as Biomarkers of Incipient TB: Fruitful or Futile?

Dheda K, Davids M.

Am J Respir Crit Care Med. 2020 Jan 17. doi: 10.1164/rccm.201912-2425ED. [Epub ahead of print] No abstract available.



Wasserman S, Huo S, Ky K, Malig YN, Esmail A, Dheda K, Bacchetti P, Gerona R, Maartens G, Gandhi M, Metcalfe J.

Antimicrob Agents Chemother. 2020 Jan 13. pii: AAC.02145-19. doi: 10.1128/AAC.02145-19. [Epub ahead of print]


Management of chronic obstructive pulmonary disease-A position statement of the South African Thoracic Society: 2019 update.

Abdool-Gaffar MS, Calligaro G, Wong ML, Smith C, Lalloo UG, Koegelenberg CFN, Dheda K, Allwood BW, Goolam-Mahomed A, van Zyl-Smit RN.

J Thorac Dis. 2019 Nov;11(11):4408-4427. doi: 10.21037/jtd.2019.10.65. Review. No abstract available.


A Human Lung Challenge Model to Evaluate the Safety and Immunogenicity of PPD and Live BCG.

Davids M, Pooran A, Hermann C, Mottay L, Thompson F, Cardenas J, Gu J, Koeuth T, Meldau R, Limberis J, Gina P, Srivastava S, Calder B, Esmail A, Tomasicchio M, Blackburn J, Gumbo T, Dheda K.

Am J Respir Crit Care Med. 2019 Dec 20. doi: 10.1164/rccm.201908-1580OC. [Epub ahead of print]


Recommendations for lung cancer screening in Southern Africa.

Koegelenberg CFN, Dorfman S, Schewitz I, Richards GA, Maasdorp S, Smith C, Dheda K; South African Thoracic Society.

J Thorac Dis. 2019 Sep;11(9):3696-3703. doi: 10.21037/jtd.2019.08.66. Review.


A regimen containing bedaquiline and delamanid compared to bedaquiline in patients with drug-resistant tuberculosis.

Olayanju O, Esmail A, Limberis J, Dheda K.

Eur Respir J. 2020 Jan 16;55(1). pii: 1901181. doi: 10.1183/13993003.01181-2019. Print 2020 Jan.


Guidance for Studies Evaluating the Accuracy of Biomarker-Based Nonsputum Tests to Diagnose Tuberculosis.

Drain PK, Gardiner J, Hannah H, Broger T, Dheda K, Fielding K, Walzl G, Kaforou M, Kranzer K, Joosten SA, Gilpin C, Weyer K, Denkinger CM, Schumacher SG.

J Infect Dis. 2019 Oct 8;220(Supplement_3):S108-S115. doi: 10.1093/infdis/jiz356.


Disrupting a cycle of mistrust: A constructivist grounded theory study on patient-provider trust in TB care.

Law S, Daftary A, Mitnick CD, Dheda K, Menzies D.

Soc Sci Med. 2019 Nov;240:112578. doi: 10.1016/j.socscimed.2019.112578. Epub 2019 Sep 26.


Urine lipoarabinomannan (LAM) and antimicrobial usage in seriously-ill HIV-infected patients with sputum smear-negative pulmonary tuberculosis.

Mthiyane T, Peter J, Allen J, Connolly C, Davids M, Rustomjee R, Holtz TH, Malinga L, Dheda K.

J Thorac Dis. 2019 Aug;11(8):3505-3514. doi: 10.21037/jtd.2019.07.69.


Palliative care and symptom relief for people affected by multidrug-resistant tuberculosis.

Krakauer EL, Dheda K, Kalsdorf B, Kuksa L, Nadkarni A, Nhung NV, Selwyn P, Shin S, Skrahina A, Jaramillo E.

Int J Tuberc Lung Dis. 2019 Aug 1;23(8):881-890. doi: 10.5588/ijtld.18.0428.


Management of drug-resistant tuberculosis.

Lange C, Dheda K, Chesov D, Mandalakas AM, Udwadia Z, Horsburgh CR Jr.

Lancet. 2019 Sep 14;394(10202):953-966. doi: 10.1016/S0140-6736(19)31882-3. Review.


The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis.

Dheda K, Gumbo T, Maartens G, Dooley KE, Murray M, Furin J, Nardell EA, Warren RM; Lancet Respiratory Medicine drug-resistant tuberculosis Commission group.

Lancet Respir Med. 2019 Sep;7(9):820-826. doi: 10.1016/S2213-2600(19)30263-2. Review.


Evaluating Latent Tuberculosis Infection Test Performance Using Latent Class Analysis in a TB and HIV Endemic Setting.

Adams S, Ehrlich R, Baatjies R, Dendukuri N, Wang Z, Dheda K.

Int J Environ Res Public Health. 2019 Aug 14;16(16). pii: E2912. doi: 10.3390/ijerph16162912.


Management of patients with multidrug-resistant tuberculosis.

Lange C, Aarnoutse RE, Alffenaar JWC, Bothamley G, Brinkmann F, Costa J, Chesov D, van Crevel R, Dedicoat M, Dominguez J, Duarte R, Grobbel HP, Günther G, Guglielmetti L, Heyckendorf J, Kay AW, Kirakosyan O, Kirk O, Koczulla RA, Kudriashov GG, Kuksa L, van Leth F, Magis-Escurra C, Mandalakas AM, Molina-Moya B, Peloquin CA, Reimann M, Rumetshofer R, Schaaf HS, Schön T, Tiberi S, Valda J, Yablonskii PK, Dheda K.

Int J Tuberc Lung Dis. 2019 Jun 1;23(6):645-662. doi: 10.5588/ijtld.18.0622.


Improving outcomes in patients with non-tuberculous mycobacterial disease: is there light at the end of the tunnel?

Dheda K.

Eur Respir J. 2019 Jul 11;54(1). pii: 1901149. doi: 10.1183/13993003.01149-2019. Print 2019 Jul. No abstract available.


Sleepiness Score-Specific Outcomes of a Novel Tongue Repositioning Procedure for the Treatment of Continuous Positive Airway Pressure-Resistant Obstructive Sleep Apnea.

Hendricks R, Davids M, Khalfey H, Landman HJ, Theron AE, Engela E, Dheda K.

Ann Maxillofac Surg. 2019 Jan-Jun;9(1):28-36. doi: 10.4103/ams.ams_151_18.


Same-Day Tools, Including Xpert Ultra and IRISA-TB, for Rapid Diagnosis of Pleural Tuberculosis: a Prospective Observational Study.

Meldau R, Randall P, Pooran A, Limberis J, Makambwa E, Dhansay M, Esmail A, Dheda K.

J Clin Microbiol. 2019 Aug 26;57(9). pii: e00614-19. doi: 10.1128/JCM.00614-19. Print 2019 Sep.


Challenges for dedicated smoking cessation services in developing countries.

Tadzimirwa GY, Day C, Esmail A, Cooper C, Kamkuemah M, Dheda K, Van Zyl-Smit RN.

S Afr Med J. 2019 May 31;109(6):431-436. doi: 10.7196/SAMJ.2019.v109i6.13631.


What is new in the WHO consolidated guidelines on drug-resistant tuberculosis treatment?

Sharma SK, Dheda K.

Indian J Med Res. 2019 Mar;149(3):309-312. doi: 10.4103/ijmr.IJMR_579_19. No abstract available.


Prospective Cohort Study on Performance of Cerebrospinal Fluid (CSF) Xpert MTB/RIF, CSF Lipoarabinomannan (LAM) Lateral Flow Assay (LFA), and Urine LAM LFA for Diagnosis of Tuberculous Meningitis in Zambia.

Siddiqi OK, Birbeck GL, Ghebremichael M, Mubanga E, Love S, Buback C, Kosloff B, Ayles H, Atadzhanov M, Dheda K, Koralnik IJ.

J Clin Microbiol. 2019 Jul 26;57(8). pii: e00652-19. doi: 10.1128/JCM.00652-19. Print 2019 Aug.


Linezolid interruption in patients with fluoroquinolone-resistant tuberculosis receiving a bedaquiline-based treatment regimen.

Olayanju O, Esmail A, Limberis J, Gina P, Dheda K.

Int J Infect Dis. 2019 Aug;85:74-79. doi: 10.1016/j.ijid.2019.04.028. Epub 2019 May 14.


IL-4 subverts mycobacterial containment in Mycobacterium tuberculosis-infected human macrophages.

Pooran A, Davids M, Nel A, Shoko A, Blackburn J, Dheda K.

Eur Respir J. 2019 Aug 8;54(2). pii: 1802242. doi: 10.1183/13993003.02242-2018. Print 2019 Aug.


Point of care Xpert MTB/RIF versus smear microscopy for tuberculosis diagnosis in southern African primary care clinics: a multicentre economic evaluation.

Pooran A, Theron G, Zijenah L, Chanda D, Clowes P, Mwenge L, Mutenherwa F, Lecesse P, Metcalfe J, Sohn H, Hoelscher M, Pym A, Peter J, Dowdy D, Dheda K.

Lancet Glob Health. 2019 Jun;7(6):e798-e807. doi: 10.1016/S2214-109X(19)30164-0. Erratum in: Lancet Glob Health. 2019 Sep;7(9):e1179.


Alone But Supported: A Qualitative Study of an HIV Self-testing App in an Observational Cohort Study in South Africa.

Janssen R, Engel N, Esmail A, Oelofse S, Krumeich A, Dheda K, Pai NP.

AIDS Behav. 2019 May 2. doi: 10.1007/s10461-019-02516-6. [Epub ahead of print]


Association of anti-tuberculosis drug concentrations in hair and treatment outcomes in MDR- and XDR-TB.

Metcalfe J, Bacchetti P, Gerona R, Esmail A, Dheda K, Gandhi M.

ERJ Open Res. 2019 Apr 26;5(2). pii: 00046-2019. doi: 10.1183/23120541.00046-2019. eCollection 2019 Apr.


Risk score for predicting mortality including urine lipoarabinomannan detection in hospital inpatients with HIV-associated tuberculosis in sub-Saharan Africa: Derivation and external validation cohort study.

Gupta-Wright A, Corbett EL, Wilson D, van Oosterhout JJ, Dheda K, Huerga H, Peter J, Bonnet M, Alufandika-Moyo M, Grint D, Lawn SD, Fielding K.

PLoS Med. 2019 Apr 5;16(4):e1002776. doi: 10.1371/journal.pmed.1002776. eCollection 2019 Apr.


Differential Targeting of c-Maf, Bach-1, and Elmo-1 by microRNA-143 and microRNA-365 Promotes the Intracellular Growth of Mycobacterium tuberculosis in Alternatively IL-4/IL-13 Activated Macrophages.

Tamgue O, Gcanga L, Ozturk M, Whitehead L, Pillay S, Jacobs R, Roy S, Schmeier S, Davids M, Medvedeva YA, Dheda K, Suzuki H, Brombacher F, Guler R.

Front Immunol. 2019 Mar 19;10:421. doi: 10.3389/fimmu.2019.00421. eCollection 2019.


Once-a-week tigecycline for the treatment of drug-resistant TB.

Deshpande D, Magombedze G, Srivastava S, Bendet P, Lee PS, Cirrincione KN, Martin KR, Dheda K, Gumbo T.

J Antimicrob Chemother. 2019 Jun 1;74(6):1607-1617. doi: 10.1093/jac/dkz061.


Predictors of discordant latent tuberculosis infection test results amongst South African health care workers.

Adams S, Ehrlich R, Baatjies R, Dendukuri N, Wang Z, Dheda K.

BMC Infect Dis. 2019 Feb 8;19(1):131. doi: 10.1186/s12879-019-3745-5.


Spatial Network Mapping of Pulmonary Multidrug-Resistant Tuberculosis Cavities Using RNA Sequencing.

Dheda K, Lenders L, Srivastava S, Magombedze G, Wainwright H, Raj P, Bush SJ, Pollara G, Steyn R, Davids M, Pooran A, Pennel T, Linegar A, McNerney R, Moodley L, Pasipanodya JG, Turner CT, Noursadeghi M, Warren RM, Wakeland E, Gumbo T.

Am J Respir Crit Care Med. 2019 Aug 1;200(3):370-380. doi: 10.1164/rccm.201807-1361OC.


Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis.

Di Tanna GL, Khaki AR, Theron G, McCarthy K, Cox H, Mupfumi L, Trajman A, Zijenah LS, Mason P, Bandason T, Durovni B, Bara W, Hoelscher M, Clowes P, Mangu C, Chanda D, Pym A, Mwaba P, Cobelens F, Nicol MP, Dheda K, Churchyard G, Fielding K, Metcalfe JZ.

Lancet Glob Health. 2019 Feb;7(2):e191-e199. doi: 10.1016/S2214-109X(18)30458-3. Erratum in: Lancet Glob Health. 2019 Apr;7(4):e419.


Linezolid Pharmacokinetics in South African Patients with Drug-Resistant Tuberculosis and a High Prevalence of HIV Coinfection.

Wasserman S, Denti P, Brust JCM, Abdelwahab M, Hlungulu S, Wiesner L, Norman J, Sirgel FA, Warren RM, Esmail A, Dheda K, Gandhi NR, Meintjes G, Maartens G.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e02164-18. doi: 10.1128/AAC.02164-18. Print 2019 Mar.


The Tuberculosis Network European Trials group (TBnet) ERS Clinical Research Collaboration: addressing drug-resistant tuberculosis through European cooperation.

van Leth F, Brinkmann F, Cirillo DM, Dheda K, Duarte R, Guglielmetti L, Kuksa L, Lange C, Mitnick C, Skrahina A, Zaman K, Bothamley G.

Eur Respir J. 2019 Jan 3;53(1). pii: 1802089. doi: 10.1183/13993003.02089-2018. Print 2019 Jan. No abstract available.


Minocycline Immunomodulates via Sonic Hedgehog Signaling and Apoptosis and Has Direct Potency Against Drug-Resistant Tuberculosis.

Deshpande D, Pasipanodya JG, Srivastava S, Martin KR, Athale S, van Zyl J, Antiabong J, Koeuth T, Lee PS, Dheda K, Gumbo T.

J Infect Dis. 2019 Feb 23;219(6):975-985. doi: 10.1093/infdis/jiy587.


Interaction between C-Tb and PPD given concomitantly in a split-body randomised controlled trial.

Aggerbeck H, Ruhwald M, Hoff ST, Tingskov PN, Hellstrom E, Malahleha M, Siebert M, Gani M, Diacon A, Novelijc Z, Andersen P, Dheda K.

Int J Tuberc Lung Dis. 2019 Jan 1;23(1):38-44. doi: 10.5588/ijtld.18.0137. Epub 2018 Dec 20.


Transmission of drug-resistant tuberculosis in HIV-endemic settings.

Khan PY, Yates TA, Osman M, Warren RM, van der Heijden Y, Padayatchi N, Nardell EA, Moore D, Mathema B, Gandhi N, Eldholm V, Dheda K, Hesseling AC, Mizrahi V, Rustomjee R, Pym A.

Lancet Infect Dis. 2019 Mar;19(3):e77-e88. doi: 10.1016/S1473-3099(18)30537-1. Epub 2018 Dec 13. Review. Erratum in: Lancet Infect Dis. 2019 Mar 6;:.


The Sterilizing Effect of Intermittent Tedizolid for Pulmonary Tuberculosis.

Srivastava S, Deshpande D, Nuermberger E, Lee PS, Cirrincione K, Dheda K, Gumbo T.

Clin Infect Dis. 2018 Nov 28;67(suppl_3):S336-S341. doi: 10.1093/cid/ciy626.


d-Cycloserine Pharmacokinetics/Pharmacodynamics, Susceptibility, and Dosing Implications in Multidrug-resistant Tuberculosis: A Faustian Deal.

Deshpande D, Alffenaar JC, Köser CU, Dheda K, Chapagain ML, Simbar N, Schön T, Sturkenboom MGG, McIlleron H, Lee PS, Koeuth T, Mpagama SG, Banu S, Foongladda S, Ogarkov O, Pholwat S, Houpt ER, Heysell SK, Gumbo T.

Clin Infect Dis. 2018 Nov 28;67(suppl_3):S308-S316. doi: 10.1093/cid/ciy624.


The Injectable Contraceptive Medroxyprogesterone Acetate Attenuates Mycobacterium tuberculosis-Specific Host Immunity Through the Glucocorticoid Receptor.

Tomasicchio M, Davids M, Pooran A, Theron G, Smith L, Semple L, Meldau R, Hapgood JP, Dheda K.

J Infect Dis. 2019 Apr 8;219(8):1329-1337. doi: 10.1093/infdis/jiy657.


Revising the definition of extensively drug-resistant tuberculosis.

Lange C, Chesov D, Furin J, Udwadia Z, Dheda K.

Lancet Respir Med. 2018 Dec;6(12):893-895. doi: 10.1016/S2213-2600(18)30428-4. Epub 2018 Nov 9. No abstract available.


Relationship between chest radiographic characteristics, sputum bacterial load, and treatment outcomes in patients with extensively drug-resistant tuberculosis.

Te Riele JB, Buser V, Calligaro G, Esmail A, Theron G, Lesosky M, Dheda K.

Int J Infect Dis. 2019 Feb;79:65-71. doi: 10.1016/j.ijid.2018.10.026. Epub 2018 Nov 3.


Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.

Ezewudo M, Borens A, Chiner-Oms Á, Miotto P, Chindelevitch L, Starks AM, Hanna D, Liwski R, Zignol M, Gilpin C, Niemann S, Kohl TA, Warren RM, Crook D, Gagneux S, Hoffner S, Rodrigues C, Comas I, Engelthaler DM, Alland D, Rigouts L, Lange C, Dheda K, Hasan R, McNerney R, Cirillo DM, Schito M, Rodwell TC, Posey J.

Sci Rep. 2018 Oct 18;8(1):15382. doi: 10.1038/s41598-018-33731-1.


An autologous dendritic cell vaccine polarizes a Th-1 response which is tumoricidal to patient-derived breast cancer cells.

Tomasicchio M, Semple L, Esmail A, Meldau R, Randall P, Pooran A, Davids M, Cairncross L, Anderson D, Downs J, Malherbe F, Novitzky N, Panieri E, Oelofse S, Londt R, Naiker T, Dheda K.

Cancer Immunol Immunother. 2019 Jan;68(1):71-83. doi: 10.1007/s00262-018-2238-5. Epub 2018 Oct 3.


C-Tb skin test to diagnose Mycobacterium tuberculosis infection in children and HIV-infected adults: A phase 3 trial.

Aggerbeck H, Ruhwald M, Hoff ST, Borregaard B, Hellstrom E, Malahleha M, Siebert M, Gani M, Seopela V, Diacon A, Lourens M, Andersen P, Dheda K.

PLoS One. 2018 Sep 24;13(9):e0204554. doi: 10.1371/journal.pone.0204554. eCollection 2018.


'Mind the gap': detecting the missing TB cases through active case finding.

Dheda K.

Int J Tuberc Lung Dis. 2018 Oct 1;22(10):1115. doi: 10.5588/ijtld.18.0583. No abstract available.


Erratum to South African guideline for the management of community-acquired pneumonia in adults.

Boyles TH, Brink A, Calligaro GL, Cohen C, Dheda K, Maartens G, Richards GA, van Zyl Smit R, Smith C, Wasserman S, Whitelaw AC, Feldman C; South African Thoracic Society; Federation of Infectious Diseases Societies of Southern Africa.

J Thorac Dis. 2018 Aug;10(8):E673-E675. doi: 10.21037/jtd.2018.07.137.


Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis.

Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment–2017, Ahmad N, Ahuja SD, Akkerman OW, Alffenaar JC, Anderson LF, Baghaei P, Bang D, Barry PM, Bastos ML, Behera D, Benedetti A, Bisson GP, Boeree MJ, Bonnet M, Brode SK, Brust JCM, Cai Y, Caumes E, Cegielski JP, Centis R, Chan PC, Chan ED, Chang KC, Charles M, Cirule A, Dalcolmo MP, D'Ambrosio L, de Vries G, Dheda K, Esmail A, Flood J, Fox GJ, Fréchet-Jachym M, Fregona G, Gayoso R, Gegia M, Gler MT, Gu S, Guglielmetti L, Holtz TH, Hughes J, Isaakidis P, Jarlsberg L, Kempker RR, Keshavjee S, Khan FA, Kipiani M, Koenig SP, Koh WJ, Kritski A, Kuksa L, Kvasnovsky CL, Kwak N, Lan Z, Lange C, Laniado-Laborín R, Lee M, Leimane V, Leung CC, Leung EC, Li PZ, Lowenthal P, Maciel EL, Marks SM, Mase S, Mbuagbaw L, Migliori GB, Milanov V, Miller AC, Mitnick CD, Modongo C, Mohr E, Monedero I, Nahid P, Ndjeka N, O'Donnell MR, Padayatchi N, Palmero D, Pape JW, Podewils LJ, Reynolds I, Riekstina V, Robert J, Rodriguez M, Seaworth B, Seung KJ, Schnippel K, Shim TS, Singla R, Smith SE, Sotgiu G, Sukhbaatar G, Tabarsi P, Tiberi S, Trajman A, Trieu L, Udwadia ZF, van der Werf TS, Veziris N, Viiklepp P, Vilbrun SC, Walsh K, Westenhouse J, Yew WW, Yim JJ, Zetola NM, Zignol M, Menzies D.

Lancet. 2018 Sep 8;392(10150):821-834. doi: 10.1016/S0140-6736(18)31644-1. Review.


Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance.

Kohli M, Schiller I, Dendukuri N, Dheda K, Denkinger CM, Schumacher SG, Steingart KR.

Cochrane Database Syst Rev. 2018 Aug 27;8:CD012768. doi: 10.1002/14651858.CD012768.pub2. Review.

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