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Items: 1 to 50 of 261

1.

Predictors of discordant latent tuberculosis infection test results amongst South African health care workers.

Adams S, Ehrlich R, Baatjies R, Dendukuri N, Wang Z, Dheda K.

BMC Infect Dis. 2019 Feb 8;19(1):131. doi: 10.1186/s12879-019-3745-5.

2.

Spatial Network Mapping of Pulmonary Multidrug-Resistant Tuberculosis Cavities Using RNA Sequencing.

Dheda K, Lenders L, Srivastava S, Magombedze G, Wainwright H, Raj P, Bush SJ, Pollara G, Steyn R, Davids M, Pooran A, Pennel T, Linegar A, McNerney R, Moodley L, Pasipanodya JG, Turner CT, Noursadeghi M, Warren RM, Wakeland E, Gumbo T.

Am J Respir Crit Care Med. 2019 Jan 29. doi: 10.1164/rccm.201807-1361OC. [Epub ahead of print]

PMID:
30694692
3.

Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis.

Di Tanna GL, Raza Khaki A, Theron G, McCarthy K, Cox H, Mupfumi L, Trajman A, Sodai Zijenah L, Mason P, Bandason T, Durovni B, Bara W, Hoelscher M, Clowes P, Mangu C, Chanda D, Pym A, Mwaba P, Cobelens F, Nicol MP, Dheda K, Churchyard G, Fielding K, Metcalfe JZ.

Lancet Glob Health. 2019 Feb;7(2):e191-e199. doi: 10.1016/S2214-109X(18)30458-3.

4.

Linezolid pharmacokinetics in South African patients with drug resistant tuberculosis and a high prevalence of HIV co-infection.

Wasserman S, Denti P, Brust JCM, Tareq M, Hlungulu S, Wiesner L, Norman J, Sirgel FA, Warren RM, Esmail A, Dheda K, Gandhi NR, Meintjes G, Maartens G.

Antimicrob Agents Chemother. 2019 Jan 7. pii: AAC.02164-18. doi: 10.1128/AAC.02164-18. [Epub ahead of print]

PMID:
30617089
5.

The Tuberculosis Network European Trials group (TBnet) ERS Clinical Research Collaboration: addressing drug-resistant tuberculosis through European cooperation.

van Leth F, Brinkmann F, Cirillo DM, Dheda K, Duarte R, Guglielmetti L, Kuksa L, Lange C, Mitnick C, Skrahina A, Zaman K, Bothamley G.

Eur Respir J. 2019 Jan 3;53(1). pii: 1802089. doi: 10.1183/13993003.02089-2018. Print 2019 Jan. No abstract available.

PMID:
30606765
6.

Minocycline Immunomodulates via Sonic Hedgehog Signaling and Apoptosis and Has Direct Potency Against Drug-Resistant Tuberculosis.

Deshpande D, Pasipanodya JG, Srivastava S, Martin KR, Athale S, van Zyl J, Antiabong J, Koeuth T, Lee PS, Dheda K, Gumbo T.

J Infect Dis. 2018 Dec 28. doi: 10.1093/infdis/jiy587. [Epub ahead of print]

PMID:
30597040
7.

Interaction between C-Tb and PPD given concomitantly in a split-body randomised controlled trial.

Aggerbeck H, Ruhwald M, Hoff ST, Tingskov PN, Hellstrom E, Malahleha M, Siebert M, Gani M, Diacon A, Novelijc Z, Andersen P, Dheda K.

Int J Tuberc Lung Dis. 2019 Jan 1;23(1):38-44. doi: 10.5588/ijtld.18.0137. Epub 2018 Dec 20.

PMID:
30572979
8.

Transmission of drug-resistant tuberculosis in HIV-endemic settings.

Khan PY, Yates TA, Osman M, Warren RM, van der Heijden Y, Padayatchi N, Nardell EA, Moore D, Mathema B, Gandhi N, Eldholm V, Dheda K, Hesseling AC, Mizrahi V, Rustomjee R, Pym A.

Lancet Infect Dis. 2018 Dec 13. pii: S1473-3099(18)30537-1. doi: 10.1016/S1473-3099(18)30537-1. [Epub ahead of print] Review.

PMID:
30554996
9.

The Sterilizing Effect of Intermittent Tedizolid for Pulmonary Tuberculosis.

Srivastava S, Deshpande D, Nuermberger E, Lee PS, Cirrincione K, Dheda K, Gumbo T.

Clin Infect Dis. 2018 Nov 28;67(suppl_3):S336-S341. doi: 10.1093/cid/ciy626.

PMID:
30496463
10.

d-Cycloserine Pharmacokinetics/Pharmacodynamics, Susceptibility, and Dosing Implications in Multidrug-resistant Tuberculosis: A Faustian Deal.

Deshpande D, Alffenaar JC, Köser CU, Dheda K, Chapagain ML, Simbar N, Schön T, Sturkenboom MGG, McIlleron H, Lee PS, Koeuth T, Mpagama SG, Banu S, Foongladda S, Ogarkov O, Pholwat S, Houpt ER, Heysell SK, Gumbo T.

Clin Infect Dis. 2018 Nov 28;67(suppl_3):S308-S316. doi: 10.1093/cid/ciy624.

PMID:
30496460
11.

The injectable contraceptive medroxyprogesterone acetate attenuates Mycobacterium tuberculosis-specific host immunity through the glucocorticoid receptor.

Tomasicchio M, Davids M, Pooran A, Theron G, Smith L, Semple L, Meldau R, Hapgood JP, Dheda K.

J Infect Dis. 2018 Nov 19. doi: 10.1093/infdis/jiy657. [Epub ahead of print]

PMID:
30452655
12.

Revising the definition of extensively drug-resistant tuberculosis.

Lange C, Chesov D, Furin J, Udwadia Z, Dheda K.

Lancet Respir Med. 2018 Dec;6(12):893-895. doi: 10.1016/S2213-2600(18)30428-4. Epub 2018 Nov 9. No abstract available.

PMID:
30420247
13.

Relationship between chest radiographic characteristics, sputum bacterial load, and treatment outcomes in patients with extensively drug-resistant tuberculosis.

Te Riele JB, Buser V, Calligaro G, Esmail A, Theron G, Lesosky M, Dheda K.

Int J Infect Dis. 2019 Feb;79:65-71. doi: 10.1016/j.ijid.2018.10.026. Epub 2018 Nov 3.

14.

Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.

Ezewudo M, Borens A, Chiner-Oms Á, Miotto P, Chindelevitch L, Starks AM, Hanna D, Liwski R, Zignol M, Gilpin C, Niemann S, Kohl TA, Warren RM, Crook D, Gagneux S, Hoffner S, Rodrigues C, Comas I, Engelthaler DM, Alland D, Rigouts L, Lange C, Dheda K, Hasan R, McNerney R, Cirillo DM, Schito M, Rodwell TC, Posey J.

Sci Rep. 2018 Oct 18;8(1):15382. doi: 10.1038/s41598-018-33731-1.

15.
16.

An autologous dendritic cell vaccine polarizes a Th-1 response which is tumoricidal to patient-derived breast cancer cells.

Tomasicchio M, Semple L, Esmail A, Meldau R, Randall P, Pooran A, Davids M, Cairncross L, Anderson D, Downs J, Malherbe F, Novitzky N, Panieri E, Oelofse S, Londt R, Naiker T, Dheda K.

Cancer Immunol Immunother. 2019 Jan;68(1):71-83. doi: 10.1007/s00262-018-2238-5. Epub 2018 Oct 3.

17.

C-Tb skin test to diagnose Mycobacterium tuberculosis infection in children and HIV-infected adults: A phase 3 trial.

Aggerbeck H, Ruhwald M, Hoff ST, Borregaard B, Hellstrom E, Malahleha M, Siebert M, Gani M, Seopela V, Diacon A, Lourens M, Andersen P, Dheda K.

PLoS One. 2018 Sep 24;13(9):e0204554. doi: 10.1371/journal.pone.0204554. eCollection 2018.

18.

'Mind the gap': detecting the missing TB cases through active case finding.

Dheda K.

Int J Tuberc Lung Dis. 2018 Oct 1;22(10):1115. doi: 10.5588/ijtld.18.0583. No abstract available.

PMID:
30236176
19.

Erratum to South African guideline for the management of community-acquired pneumonia in adults.

Boyles TH, Brink A, Calligaro GL, Cohen C, Dheda K, Maartens G, Richards GA, van Zyl Smit R, Smith C, Wasserman S, Whitelaw AC, Feldman C; South African Thoracic Society; Federation of Infectious Diseases Societies of Southern Africa.

J Thorac Dis. 2018 Aug;10(8):E673-E675. doi: 10.21037/jtd.2018.07.137.

20.

Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis.

Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment–2017, Ahmad N, Ahuja SD, Akkerman OW, Alffenaar JC, Anderson LF, Baghaei P, Bang D, Barry PM, Bastos ML, Behera D, Benedetti A, Bisson GP, Boeree MJ, Bonnet M, Brode SK, Brust JCM, Cai Y, Caumes E, Cegielski JP, Centis R, Chan PC, Chan ED, Chang KC, Charles M, Cirule A, Dalcolmo MP, D'Ambrosio L, de Vries G, Dheda K, Esmail A, Flood J, Fox GJ, Fréchet-Jachym M, Fregona G, Gayoso R, Gegia M, Gler MT, Gu S, Guglielmetti L, Holtz TH, Hughes J, Isaakidis P, Jarlsberg L, Kempker RR, Keshavjee S, Khan FA, Kipiani M, Koenig SP, Koh WJ, Kritski A, Kuksa L, Kvasnovsky CL, Kwak N, Lan Z, Lange C, Laniado-Laborín R, Lee M, Leimane V, Leung CC, Leung EC, Li PZ, Lowenthal P, Maciel EL, Marks SM, Mase S, Mbuagbaw L, Migliori GB, Milanov V, Miller AC, Mitnick CD, Modongo C, Mohr E, Monedero I, Nahid P, Ndjeka N, O'Donnell MR, Padayatchi N, Palmero D, Pape JW, Podewils LJ, Reynolds I, Riekstina V, Robert J, Rodriguez M, Seaworth B, Seung KJ, Schnippel K, Shim TS, Singla R, Smith SE, Sotgiu G, Sukhbaatar G, Tabarsi P, Tiberi S, Trajman A, Trieu L, Udwadia ZF, van der Werf TS, Veziris N, Viiklepp P, Vilbrun SC, Walsh K, Westenhouse J, Yew WW, Yim JJ, Zetola NM, Zignol M, Menzies D.

Lancet. 2018 Sep 8;392(10150):821-834. doi: 10.1016/S0140-6736(18)31644-1. Review.

PMID:
30215381
21.

Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance.

Kohli M, Schiller I, Dendukuri N, Dheda K, Denkinger CM, Schumacher SG, Steingart KR.

Cochrane Database Syst Rev. 2018 Aug 27;8:CD012768. doi: 10.1002/14651858.CD012768.pub2. Review.

PMID:
30148542
22.

Outcomes of patients with drug-resistant-tuberculosis treated with bedaquiline-containing regimens and undergoing adjunctive surgery.

Borisov SE, D'Ambrosio L, Centis R, Tiberi S, Dheda K, Alffenaar JW, Amale R, Belilowski E, Bruchfeld J, Canneto B, Denholm J, Duarte R, Esmail A, Filippov A, Davies Forsman L, Gaga M, Ganatra S, Igorevna GA, Lazaro Mastrapa B, Manfrin V, Manga S, Maryandyshev A, Massard G, González Montaner P, Mullerpattan J, Palmero DJ, Pontarelli A, Papavasileiou A, Pontali E, Romero Leyet R, Spanevello A, Udwadia ZF, Viggiani P, Visca D, Sotgiu G, Migliori GB.

J Infect. 2019 Jan;78(1):35-39. doi: 10.1016/j.jinf.2018.08.003. Epub 2018 Aug 7.

PMID:
30096332
23.

Incipient and Subclinical Tuberculosis: a Clinical Review of Early Stages and Progression of Infection.

Drain PK, Bajema KL, Dowdy D, Dheda K, Naidoo K, Schumacher SG, Ma S, Meermeier E, Lewinsohn DM, Sherman DR.

Clin Microbiol Rev. 2018 Jul 18;31(4). pii: e00021-18. doi: 10.1128/CMR.00021-18. Print 2018 Oct. Review.

PMID:
30021818
24.
25.

Impact of nicotine replacement therapy as an adjunct to anti-tuberculosis treatment and behaviour change counselling in newly diagnosed pulmonary tuberculosis patients: an open-label, randomised controlled trial.

Sharma SK, Mohan A, Singh AD, Mishra H, Jhanjee S, Pandey RM, Singh BK, Sharma R, Pallipamu PB, Pai M, Dheda K.

Sci Rep. 2018 Jun 11;8(1):8828. doi: 10.1038/s41598-018-26990-5.

26.

Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis.

Dheda K, Lenders L, Magombedze G, Srivastava S, Raj P, Arning E, Ashcraft P, Bottiglieri T, Wainwright H, Pennel T, Linegar A, Moodley L, Pooran A, Pasipanodya JG, Sirgel FA, van Helden PD, Wakeland E, Warren RM, Gumbo T.

Am J Respir Crit Care Med. 2018 Nov 1;198(9):1208-1219. doi: 10.1164/rccm.201711-2333OC.

PMID:
29877726
27.

M/XDR-TB treatment perspective: How to avoid mountains of pills via digital technologies - Reply.

Dheda K; all authors.

Respirology. 2018 Jun;23(6):637. doi: 10.1111/resp.13317. Epub 2018 Apr 27. No abstract available.

PMID:
29701301
28.

Long-term bedaquiline-related treatment outcomes in patients with extensively drug-resistant tuberculosis from South Africa.

Olayanju O, Limberis J, Esmail A, Oelofse S, Gina P, Pietersen E, Fadul M, Warren R, Dheda K.

Eur Respir J. 2018 May 30;51(5). pii: 1800544. doi: 10.1183/13993003.00544-2018. Print 2018 May.

PMID:
29700106
29.

Author Correction: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.

Coll F, Phelan J, Hill-Cawthorne GA, Nair MB, Mallard K, Ali S, Abdallah AM, Alghamdi S, Alsomali M, Ahmed AO, Portelli S, Oppong Y, Alves A, Bessa TB, Campino S, Caws M, Chatterjee A, Crampin AC, Dheda K, Furnham N, Glynn JR, Grandjean L, Ha DM, Hasan R, Hasan Z, Hibberd ML, Joloba M, Jones-López EC, Matsumoto T, Miranda A, Moore DJ, Mocillo N, Panaiotov S, Parkhill J, Penha C, Perdigão J, Portugal I, Rchiad Z, Robledo J, Sheen P, Shesha NT, Sirgel FA, Sola C, Sousa EO, Streicher EM, Van Helden P, Viveiros M, Warren RM, McNerney R, Pain A, Clark TG.

Nat Genet. 2018 May;50(5):764. doi: 10.1038/s41588-018-0074-3.

PMID:
29674744
30.

Drug-resistant tuberculosis: An update on disease burden, diagnosis and treatment.

Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, Dheda K.

Respirology. 2018 Jul;23(7):656-673. doi: 10.1111/resp.13304. Epub 2018 Apr 11. Review.

31.

Time to revise WHO-recommended definitions of MDR-TB treatment outcomes.

Lange C, van Leth F, Mitnick CD, Dheda K, Günther G.

Lancet Respir Med. 2018 Apr;6(4):246-248. doi: 10.1016/S2213-2600(18)30104-8. No abstract available.

PMID:
29595505
32.

Pan-tuberculosis regimens: an argument against.

Dheda K, Gumbo T, Lange C, Horsburgh CR Jr, Furin J.

Lancet Respir Med. 2018 Apr;6(4):240-242. doi: 10.1016/S2213-2600(18)30097-3. No abstract available.

PMID:
29595502
33.

Correlation of Xpert MTB/RIF with measures to assess Mycobacterium tuberculosis bacillary burden in high HIV burden areas of Southern Africa.

Beynon F, Theron G, Respeito D, Mambuque E, Saavedra B, Bulo H, Sanz S, Dheda K, Garcia-Basteiro AL.

Sci Rep. 2018 Mar 26;8(1):5201. doi: 10.1038/s41598-018-23066-2.

34.

Detection of tuberculosis by automatic cough sound analysis.

Botha GHR, Theron G, Warren RM, Klopper M, Dheda K, van Helden PD, Niesler TR.

Physiol Meas. 2018 Apr 26;39(4):045005. doi: 10.1088/1361-6579/aab6d0.

PMID:
29543189
35.

Regulatory T Cells Subvert Mycobacterial Containment in Patients Failing Extensively Drug-Resistant Tuberculosis Treatment.

Davids M, Pooran AS, Pietersen E, Wainwright HC, Binder A, Warren R, Dheda K.

Am J Respir Crit Care Med. 2018 Jul 1;198(1):104-116. doi: 10.1164/rccm.201707-1441OC.

PMID:
29425052
36.

Performance of the TB-LAMP diagnostic assay in reference laboratories: Results from a multicentre study.

Pham TH, Peter J, Mello FCQ, Parraga T, Lan NTN, Nabeta P, Valli E, Caceres T, Dheda K, Dorman SE, Hillemann D, Gray CM, Perkins MD.

Int J Infect Dis. 2018 Mar;68:44-49. doi: 10.1016/j.ijid.2018.01.005. Epub 2018 Feb 2.

37.

Tuberculous meningitis is associated with higher cerebrospinal HIV-1 viral loads compared to other HIV-1-associated meningitides.

Seipone ID, Singh R, Patel VB, Singh A, Gordon ML, Muema DM, Dheda K, Ndung'u T.

PLoS One. 2018 Feb 2;13(2):e0192060. doi: 10.1371/journal.pone.0192060. eCollection 2018.

38.

Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.

Coll F, Phelan J, Hill-Cawthorne GA, Nair MB, Mallard K, Ali S, Abdallah AM, Alghamdi S, Alsomali M, Ahmed AO, Portelli S, Oppong Y, Alves A, Bessa TB, Campino S, Caws M, Chatterjee A, Crampin AC, Dheda K, Furnham N, Glynn JR, Grandjean L, Minh Ha D, Hasan R, Hasan Z, Hibberd ML, Joloba M, Jones-López EC, Matsumoto T, Miranda A, Moore DJ, Mocillo N, Panaiotov S, Parkhill J, Penha C, Perdigão J, Portugal I, Rchiad Z, Robledo J, Sheen P, Shesha NT, Sirgel FA, Sola C, Oliveira Sousa E, Streicher EM, Helden PV, Viveiros M, Warren RM, McNerney R, Pain A, Clark TG.

Nat Genet. 2018 Feb;50(2):307-316. doi: 10.1038/s41588-017-0029-0. Epub 2018 Jan 22. Erratum in: Nat Genet. 2018 Apr 19;:.

39.

False-Positive Xpert MTB/RIF Results in Retested Patients with Previous Tuberculosis: Frequency, Profile, and Prospective Clinical Outcomes.

Theron G, Venter R, Smith L, Esmail A, Randall P, Sood V, Oelfese S, Calligaro G, Warren R, Dheda K.

J Clin Microbiol. 2018 Feb 22;56(3). pii: e01696-17. doi: 10.1128/JCM.01696-17. Print 2018 Mar.

40.

A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis.

Miotto P, Tessema B, Tagliani E, Chindelevitch L, Starks AM, Emerson C, Hanna D, Kim PS, Liwski R, Zignol M, Gilpin C, Niemann S, Denkinger CM, Fleming J, Warren RM, Crook D, Posey J, Gagneux S, Hoffner S, Rodrigues C, Comas I, Engelthaler DM, Murray M, Alland D, Rigouts L, Lange C, Dheda K, Hasan R, Ranganathan UDK, McNerney R, Ezewudo M, Cirillo DM, Schito M, Köser CU, Rodwell TC.

Eur Respir J. 2017 Dec 28;50(6). pii: 1701354. doi: 10.1183/13993003.01354-2017. Print 2017 Dec.

41.

Diagnosing tuberculosis in hospitalized HIV-infected individuals who cannot produce sputum: is urine lipoarabinomannan testing the answer?

Sabur NF, Esmail A, Brar MS, Dheda K.

BMC Infect Dis. 2017 Dec 28;17(1):803. doi: 10.1186/s12879-017-2914-7.

42.

Evaluation of a Urine-Based Rapid Molecular Diagnostic Test with Potential to Be Used at Point-of-Care for Pulmonary Tuberculosis: Cape Town Cohort.

Patel K, Nagel M, Wesolowski M, Dees S, Rivera-Milla E, Geldmacher C, Dheda K, Hoelscher M, Labugger I.

J Mol Diagn. 2018 Mar;20(2):215-224. doi: 10.1016/j.jmoldx.2017.11.005. Epub 2017 Dec 18.

PMID:
29269279
43.

Antibacterial and Sterilizing Effect of Benzylpenicillin in Tuberculosis.

Deshpande D, Srivastava S, Bendet P, Martin KR, Cirrincione KN, Lee PS, Pasipanodya JG, Dheda K, Gumbo T.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e02232-17. doi: 10.1128/AAC.02232-17. Print 2018 Feb.

44.

Designing and Evaluating Interventions to Halt the Transmission of Tuberculosis.

Dowdy DW, Grant AD, Dheda K, Nardell E, Fielding K, Moore DAJ.

J Infect Dis. 2017 Nov 3;216(suppl_6):S654-S661. doi: 10.1093/infdis/jix320. Review.

45.

Do digital innovations for HIV and sexually transmitted infections work? Results from a systematic review (1996-2017).

Daher J, Vijh R, Linthwaite B, Dave S, Kim J, Dheda K, Peter T, Pai NP.

BMJ Open. 2017 Nov 3;7(11):e017604. doi: 10.1136/bmjopen-2017-017604. Review.

46.

Ceftazidime-avibactam has potent sterilizing activity against highly drug-resistant tuberculosis.

Deshpande D, Srivastava S, Chapagain M, Magombedze G, Martin KR, Cirrincione KN, Lee PS, Koeuth T, Dheda K, Gumbo T.

Sci Adv. 2017 Aug 30;3(8):e1701102. doi: 10.1126/sciadv.1701102. eCollection 2017 Aug.

47.

Recent controversies about MDR and XDR-TB: Global implementation of the WHO shorter MDR-TB regimen and bedaquiline for all with MDR-TB?

Dheda K, Cox H, Esmail A, Wasserman S, Chang KC, Lange C.

Respirology. 2018 Jan;23(1):36-45. doi: 10.1111/resp.13143. Epub 2017 Aug 29. Review.

48.

The Multistep Tuberculosis Diagnostic Cascade. More Than Meets the Eye.

Dheda K.

Am J Respir Crit Care Med. 2017 Oct 1;196(7):809-811. doi: 10.1164/rccm.201708-1600ED. No abstract available.

PMID:
28846436
49.
50.

South African guideline for the management of community-acquired pneumonia in adults.

Boyles TH, Brink A, Calligaro GL, Cohen C, Dheda K, Maartens G, Richards GA, van Zyl Smit R, Smith C, Wasserman S, Whitelaw AC, Feldman C; South African Thoracic Society; Federation of Infectious Diseases Societies of Southern Africa.

J Thorac Dis. 2017 Jun;9(6):1469-1502. doi: 10.21037/jtd.2017.05.31. Review. No abstract available. Erratum in: J Thorac Dis. 2018 Aug;10(8):E673-E675.

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