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Local release of tacrolimus from hydrogel-based drug delivery system is controlled by inflammatory enzymes in vivo and can be monitored non-invasively using in vivo imaging.

Dzhonova D, Olariu R, Leckenby J, Dhayani A, Vemula PK, Prost JC, Banz Y, Taddeo A, Rieben R.

PLoS One. 2018 Aug 30;13(8):e0203409. doi: 10.1371/journal.pone.0203409. eCollection 2018.


Exploring membrane permeability of Tomatidine to enhance lipid mediated nucleic acid transfections.

Rangasami VK, Lohchania B, Voshavar C, Rachamalla HR, Banerjee R, Dhayani A, Thangavel S, Vemula PK, Marepally S.

Biochim Biophys Acta Biomembr. 2018 Jun 11. pii: S0005-2736(18)30178-0. doi: 10.1016/j.bbamem.2018.06.006. [Epub ahead of print]


Local Injections of Tacrolimus-loaded Hydrogel Reduce Systemic Immunosuppression-related Toxicity in Vascularized Composite Allotransplantation.

Dzhonova DV, Olariu R, Leckenby J, Banz Y, Prost JC, Dhayani A, Vemula PK, Voegelin E, Taddeo A, Rieben R.

Transplantation. 2018 Oct;102(10):1684-1694. doi: 10.1097/TP.0000000000002283.


A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft.

Gajanayake T, Olariu R, Leclère FM, Dhayani A, Yang Z, Bongoni AK, Banz Y, Constantinescu MA, Karp JM, Vemula PK, Rieben R, Vögelin E.

Sci Transl Med. 2014 Aug 13;6(249):249ra110. doi: 10.1126/scitranslmed.3008778.

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