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Items: 22


Big Data Needs Big Governance: Best Practices From Brain-CODE, the Ontario-Brain Institute's Neuroinformatics Platform.

Lefaivre S, Behan B, Vaccarino A, Evans K, Dharsee M, Gee T, Dafnas C, Mikkelsen T, Theriault E.

Front Genet. 2019 Mar 29;10:191. doi: 10.3389/fgene.2019.00191. eCollection 2019.


Plasma microRNA expression levels and their targeted pathways in patients with major depressive disorder who are responsive to duloxetine treatment.

Kim HK, Tyryshkin K, Elmi N, Dharsee M, Evans KR, Good J, Javadi M, McCormack S, Vaccarino AL, Zhang X, Andreazza AC, Feilotter H.

J Psychiatr Res. 2019 Mar;110:38-44. doi: 10.1016/j.jpsychires.2018.12.007. Epub 2018 Dec 8.


The CAMH Neuroinformatics Platform: A Hospital-Focused Brain-CODE Implementation.

Rotenberg DJ, Chang Q, Potapova N, Wang A, Hon M, Sanches M, Bogetic N, Frias N, Liu T, Behan B, El-Badrawi R, Strother SC, Evans SG, Mikkelsen J, Gee T, Dong F, Arnott SR, Laing S, Dharsee M, Vaccarino AL, Javadi M, Evans KR, Jankowicz D.

Front Neuroinform. 2018 Nov 6;12:77. doi: 10.3389/fninf.2018.00077. eCollection 2018.


Brain-CODE: A Secure Neuroinformatics Platform for Management, Federation, Sharing and Analysis of Multi-Dimensional Neuroscience Data.

Vaccarino AL, Dharsee M, Strother S, Aldridge D, Arnott SR, Behan B, Dafnas C, Dong F, Edgecombe K, El-Badrawi R, El-Emam K, Gee T, Evans SG, Javadi M, Jeanson F, Lefaivre S, Lutz K, MacPhee FC, Mikkelsen J, Mikkelsen T, Mirotchnick N, Schmah T, Studzinski CM, Stuss DT, Theriault E, Evans KR.

Front Neuroinform. 2018 May 23;12:28. doi: 10.3389/fninf.2018.00028. eCollection 2018.


Standardization of electroencephalography for multi-site, multi-platform and multi-investigator studies: insights from the canadian biomarker integration network in depression.

Farzan F, Atluri S, Frehlich M, Dhami P, Kleffner K, Price R, Lam RW, Frey BN, Milev R, Ravindran A, McAndrews MP, Wong W, Blumberger D, Daskalakis ZJ, Vila-Rodriguez F, Alonso E, Brenner CA, Liotti M, Dharsee M, Arnott SR, Evans KR, Rotzinger S, Kennedy SH.

Sci Rep. 2017 Aug 7;7(1):7473. doi: 10.1038/s41598-017-07613-x.


Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort.

Lam RW, Milev R, Rotzinger S, Andreazza AC, Blier P, Brenner C, Daskalakis ZJ, Dharsee M, Downar J, Evans KR, Farzan F, Foster JA, Frey BN, Geraci J, Giacobbe P, Feilotter HE, Hall GB, Harkness KL, Hassel S, Ismail Z, Leri F, Liotti M, MacQueen GM, McAndrews MP, Minuzzi L, Müller DJ, Parikh SV, Placenza FM, Quilty LC, Ravindran AV, Salomons TV, Soares CN, Strother SC, Turecki G, Vaccarino AL, Vila-Rodriguez F, Kennedy SH; CAN-BIND Investigator Team.

BMC Psychiatry. 2016 Apr 16;16:105. doi: 10.1186/s12888-016-0785-x.


miR-221/222 Are Involved in Response to Sunitinib Treatment in Metastatic Renal Cell Carcinoma.

Khella HWZ, Butz H, Ding Q, Rotondo F, Evans KR, Kupchak P, Dharsee M, Latif A, Pasic MD, Lianidou E, Bjarnason GA, Yousef GM.

Mol Ther. 2015 Nov;23(11):1748-1758. doi: 10.1038/mt.2015.129. Epub 2015 Jul 23.


Identification of the IGF1/PI3K/NF κB/ERK gene signalling networks associated with chemotherapy resistance and treatment response in high-grade serous epithelial ovarian cancer.

Koti M, Gooding RJ, Nuin P, Haslehurst A, Crane C, Weberpals J, Childs T, Bryson P, Dharsee M, Evans K, Feilotter HE, Park PC, Squire JA.

BMC Cancer. 2013 Nov 16;13:549. doi: 10.1186/1471-2407-13-549.


Exploring high dimensional data with Butterfly: a novel classification algorithm based on discrete dynamical systems.

Geraci J, Dharsee M, Nuin P, Haslehurst A, Koti M, Feilotter HE, Evans K.

Bioinformatics. 2014 Mar 1;30(5):712-8. doi: 10.1093/bioinformatics/btt602. Epub 2013 Oct 21.


MicroRNA signature helps distinguish early from late biochemical failure in prostate cancer.

Lichner Z, Fendler A, Saleh C, Nasser AN, Boles D, Al-Haddad S, Kupchak P, Dharsee M, Nuin PS, Evans KR, Jung K, Stephan C, Fleshner NE, Yousef GM.

Clin Chem. 2013 Nov;59(11):1595-603. doi: 10.1373/clinchem.2013.205450. Epub 2013 Aug 19.


Proteomics analyses of activated human optic nerve head lamina cribrosa cells following biomechanical strain.

Rogers R, Dharsee M, Ackloo S, Flanagan JG.

Invest Ophthalmol Vis Sci. 2012 Jun 20;53(7):3806-16. doi: 10.1167/iovs.11-8480.


EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer.

Haslehurst AM, Koti M, Dharsee M, Nuin P, Evans K, Geraci J, Childs T, Chen J, Li J, Weberpals J, Davey S, Squire J, Park PC, Feilotter H.

BMC Cancer. 2012 Mar 19;12:91. doi: 10.1186/1471-2407-12-91.


Proteomic analyses reveal high expression of decorin and endoplasmin (HSP90B1) are associated with breast cancer metastasis and decreased survival.

Cawthorn TR, Moreno JC, Dharsee M, Tran-Thanh D, Ackloo S, Zhu PH, Sardana G, Chen J, Kupchak P, Jacks LM, Miller NA, Youngson BJ, Iakovlev V, Guidos CJ, Vallis KA, Evans KR, McCready D, Leong WL, Done SJ.

PLoS One. 2012;7(2):e30992. doi: 10.1371/journal.pone.0030992. Epub 2012 Feb 20.


Proteomics analyses of human optic nerve head astrocytes following biomechanical strain.

Rogers RS, Dharsee M, Ackloo S, Sivak JM, Flanagan JG.

Mol Cell Proteomics. 2012 Feb;11(2):M111.012302. doi: 10.1074/mcp.M111.012302. Epub 2011 Nov 29.


Applying mass spectrometry based proteomic technology to advance the understanding of multiple myeloma.

Micallef J, Dharsee M, Chen J, Ackloo S, Evans K, Qiu L, Chang H.

J Hematol Oncol. 2010 Apr 7;3:13. doi: 10.1186/1756-8722-3-13. Review.


Multiple myeloma phosphotyrosine proteomic profile associated with FGFR3 expression, ligand activation, and drug inhibition.

St-Germain JR, Taylor P, Tong J, Jin LL, Nikolic A, Stewart II, Ewing RM, Dharsee M, Li Z, Trudel S, Moran MF.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20127-32. doi: 10.1073/pnas.0910957106. Epub 2009 Nov 9.


Rapid evolution of functional complexity in a domain family.

Ernst A, Sazinsky SL, Hui S, Currell B, Dharsee M, Seshagiri S, Bader GD, Sidhu SS.

Sci Signal. 2009 Sep 8;2(87):ra50. doi: 10.1126/scisignal.2000416.


Urinary protein profiles in a rat model for diabetic complications.

Schlatzer DM, Dazard JE, Dharsee M, Ewing RM, Ilchenko S, Stewart I, Christ G, Chance MR.

Mol Cell Proteomics. 2009 Sep;8(9):2145-58. doi: 10.1074/mcp.M800558-MCP200. Epub 2009 Jun 4.


Design and analysis of quantitative differential proteomics investigations using LC-MS technology.

Bukhman YV, Dharsee M, Ewing R, Chu P, Topaloglou T, Le Bihan T, Goh T, Duewel H, Stewart II, Wisniewski JR, Ng NF.

J Bioinform Comput Biol. 2008 Feb;6(1):107-23.


Large-scale mapping of human protein-protein interactions by mass spectrometry.

Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D.

Mol Syst Biol. 2007;3:89. Epub 2007 Mar 13.


Differential analysis of membrane proteins in mouse fore- and hindbrain using a label-free approach.

Le Bihan T, Goh T, Stewart II, Salter AM, Bukhman YV, Dharsee M, Ewing R, Wiśniewski JR.

J Proteome Res. 2006 Oct;5(10):2701-10.


The reproducible acquisition of comparative liquid chromatography/tandem mass spectrometry data from complex biological samples.

Stewart II, Zhao L, Le Bihan T, Larsen B, Scozzaro S, Figeys D, Mao GD, Ornatsky O, Dharsee M, Orsi C, Ewing R, Goh T.

Rapid Commun Mass Spectrom. 2004;18(15):1697-710.


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