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Items: 48

1.

Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists.

Lin H, Doebelin C, Patouret R, Garcia-Ordonez RD, Chang MR, Dharmarajan V, Bayona CR, Cameron MD, Griffin PR, Kamenecka TM.

Bioorg Med Chem Lett. 2018 May 1;28(8):1313-1319. doi: 10.1016/j.bmcl.2018.03.019. Epub 2018 Mar 8.

PMID:
29548571
2.

Biophysical Interactions of Direct AMPK Activators.

Kurumbail RG, West GM, Dharmarajan V, Borzilleri KA, Withka JM, Ward J, Reyes AR, Rajamohan F, Griffin PR, Calabrese MF.

Methods Mol Biol. 2018;1732:29-55. doi: 10.1007/978-1-4939-7598-3_3.

PMID:
29480467
3.

Structure of the full-length glucagon class B G-protein-coupled receptor.

Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Wu X, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Zhao Q, Jiang H, Wang MW, Wu B.

Nature. 2017 Jun 8;546(7657):259-264. doi: 10.1038/nature22363. Epub 2017 May 17.

4.

Corrigendum: Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, Griffin PR, Katzenellenbogen JA, Nettles KW.

Nat Chem Biol. 2017 May 17;13(6):691. doi: 10.1038/nchembio0617-691c. No abstract available.

PMID:
28514424
5.

Erratum: Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, Griffin PR, Katzenellenbogen JA, Nettles KW.

Nat Chem Biol. 2017 May 17;13(6):691. doi: 10.1038/nchembio0617-691b. No abstract available.

PMID:
28514419
6.

Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.

Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W, Tao H, Xu F.

Nat Commun. 2017 May 17;8:15383. doi: 10.1038/ncomms15383.

7.

Structure and Dynamics of the Liver Receptor Homolog 1-PGC1α Complex.

Mays SG, Okafor CD, Tuntland ML, Whitby RJ, Dharmarajan V, Stec J, Griffin PR, Ortlund EA.

Mol Pharmacol. 2017 Jul;92(1):1-11. doi: 10.1124/mol.117.108514. Epub 2017 Mar 31.

8.

N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists.

Doebelin C, Patouret R, Garcia-Ordonez RD, Chang MR, Dharmarajan V, Kuruvilla DS, Novick SJ, Lin L, Cameron MD, Griffin PR, Kamenecka TM.

ChemMedChem. 2016 Dec 6;11(23):2607-2620. doi: 10.1002/cmdc.201600491. Epub 2016 Nov 23.

9.

Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, Griffin PR, Katzenellenbogen JA, Nettles KW.

Nat Chem Biol. 2017 Jan;13(1):111-118. doi: 10.1038/nchembio.2236. Epub 2016 Nov 21. Erratum in: Nat Chem Biol. 2017 May 17;13(6):691. Nat Chem Biol. 2017 May 17;13(6):691.

10.

The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.

Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M.

ACS Chem Biol. 2016 May 20;11(5):1313-21. doi: 10.1021/acschembio.6b00167. Epub 2016 Mar 2.

11.

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.

Fanning SW, Mayne CG, Dharmarajan V, Carlson KE, Martin TA, Novick SJ, Toy W, Green B, Panchamukhi S, Katzenellenbogen BS, Tajkhorshid E, Griffin PR, Shen Y, Chandarlapaty S, Katzenellenbogen JA, Greene GL.

Elife. 2016 Feb 2;5. pii: e12792. doi: 10.7554/eLife.12792.

12.

Synthetic RORγt Agonists Enhance Protective Immunity.

Chang MR, Dharmarajan V, Doebelin C, Garcia-Ordonez RD, Novick SJ, Kuruvilla DS, Kamenecka TM, Griffin PR.

ACS Chem Biol. 2016 Apr 15;11(4):1012-8. doi: 10.1021/acschembio.5b00899. Epub 2016 Jan 25.

13.

Identification and function of conformational dynamics in the multidomain GTPase dynamin.

Srinivasan S, Dharmarajan V, Reed DK, Griffin PR, Schmid SL.

EMBO J. 2016 Feb 15;35(4):443-57. doi: 10.15252/embj.201593477. Epub 2016 Jan 18.

14.

A General Method for Insertion of Functional Proteins within Proteins via Combinatorial Selection of Permissive Junctions.

Peng Y, Zeng W, Ye H, Han KH, Dharmarajan V, Novick S, Wilson IA, Griffin PR, Friedman JM, Lerner RA.

Chem Biol. 2015 Aug 20;22(8):1134-43. doi: 10.1016/j.chembiol.2015.07.011. Epub 2015 Aug 13.

15.

Conformational states of the full-length glucagon receptor.

Yang L, Yang D, de Graaf C, Moeller A, West GM, Dharmarajan V, Wang C, Siu FY, Song G, Reedtz-Runge S, Pascal BD, Wu B, Potter CS, Zhou H, Griffin PR, Carragher B, Yang H, Wang MW, Stevens RC, Jiang H.

Nat Commun. 2015 Jul 31;6:7859. doi: 10.1038/ncomms8859.

16.

HDX-MS guided drug discovery: small molecules and biopharmaceuticals.

Marciano DP, Dharmarajan V, Griffin PR.

Curr Opin Struct Biol. 2014 Oct;28:105-11. doi: 10.1016/j.sbi.2014.08.007. Epub 2014 Aug 30. Review.

17.

A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.

Shkriabai N, Dharmarajan V, Slaughter A, Kessl JJ, Larue RC, Feng L, Fuchs JR, Griffin PR, Kvaratskhelia M.

J Biol Chem. 2014 Sep 19;289(38):26430-40. doi: 10.1074/jbc.M114.589572. Epub 2014 Aug 12.

18.

Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation.

Lewallen DM, Sreelatha A, Dharmarajan V, Madoux F, Chase P, Griffin PR, Orth K, Hodder P, Thompson PR.

ACS Chem Biol. 2014 Feb 21;9(2):433-42. doi: 10.1021/cb4006886. Epub 2013 Nov 25.

19.

Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.

Patel A, Vought VE, Swatkoski S, Viggiano S, Howard B, Dharmarajan V, Monteith KE, Kupakuwana G, Namitz KE, Shinsky SA, Cotter RJ, Cosgrove MS.

J Biol Chem. 2014 Jan 10;289(2):868-84. doi: 10.1074/jbc.M113.501064. Epub 2013 Nov 14.

20.

Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

Dharmarajan V, Lee JH, Patel A, Skalnik DG, Cosgrove MS.

J Biol Chem. 2012 Aug 10;287(33):27275-89. doi: 10.1074/jbc.M112.364125. Epub 2012 Jun 3.

21.

A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex.

Patel A, Vought VE, Dharmarajan V, Cosgrove MS.

J Biol Chem. 2011 Feb 4;286(5):3359-69. doi: 10.1074/jbc.M110.174524. Epub 2010 Nov 24. Erratum in: J Biol Chem. 2011 May 20;286(20):18344.

22.

On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.

Patel A, Dharmarajan V, Vought VE, Cosgrove MS.

J Biol Chem. 2009 Sep 4;284(36):24242-56. doi: 10.1074/jbc.M109.014498. Epub 2009 Jun 25.

23.

Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide.

Patel A, Dharmarajan V, Cosgrove MS.

J Biol Chem. 2008 Nov 21;283(47):32158-61. doi: 10.1074/jbc.C800164200. Epub 2008 Oct 1.

24.

A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex.

Patel A, Vought VE, Dharmarajan V, Cosgrove MS.

J Biol Chem. 2008 Nov 21;283(47):32162-75. doi: 10.1074/jbc.M806317200. Epub 2008 Oct 1.

25.
26.

A comparison of the sampling efficiencies of a range of atmosphere samplers when collecting polymeric diphenylmethane di-isocyanate (MDI) aerosols.

Hext PM, Booth K, Dharmarajan V, Karoly WJ, Parekh PP, Spence M.

Appl Occup Environ Hyg. 2003 May;18(5):346-57.

PMID:
12746078
27.
28.
29.

A new tool for sampling airborne isocyanates.

Dien Hillig KJ, Dharmarajan V.

Am Ind Hyg Assoc J. 1992 Feb;53(2):A78-9. No abstract available.

PMID:
1543125
30.

Evaluation of air-purifying respirators for protection against toluene diisocyanate vapors.

Dharmarajan V, Lingg RD, Hackathorn DR.

Am Ind Hyg Assoc J. 1986 Jul;47(7):393-8.

PMID:
3019117
31.

Five-year longitudinal study of workers employed in a new toluene diisocyanate manufacturing plant.

Diem JE, Jones RN, Hendrick DJ, Glindmeyer HW, Dharmarajan V, Butcher BT, Salvaggio JE, Weill H.

Am Rev Respir Dis. 1982 Sep;126(3):420-8.

PMID:
6289703
32.

Sampling of cotton dust for epidemiologic investigations.

Hammad YY, Dharmarajan V, Weill H.

Chest. 1981 Apr;79(4 Suppl):108S-113S. No abstract available.

PMID:
6894113
33.

Critical evaluation of continuous monitors for toluene diisocyanate.

Dharmarajan V, Rando RJ.

Am Ind Hyg Assoc J. 1980 Dec;41(12):869-78.

PMID:
6258418
34.

Dynamic calibration of a continuous organo-isocyanate monitor for hexamethylene diisocyanate.

Dharmarajan V, Rando RJ.

Am Ind Hyg Assoc J. 1980 Jun;41(6):437-41.

PMID:
6249110
35.

Mill effect and dose-response relationships in byssinosis.

Jones RN, Diem JE, Glindmeyer H, Dharmarajan V, Hammad YY, Carr J, Weill H.

Br J Ind Med. 1979 Nov;36(4):305-13.

36.

A new method for the generation of standard atmospheres of organo isocyanates.

Dharmarajan V, Rando RJ.

Am Ind Hyg Assoc J. 1979 Oct;40(10):870-6.

PMID:
230738
37.

Inhalation challenge and pharmacologic studies of toluene diisocyanate (TDI)-sensitive workers.

Butcher BT, Karr RM, O'Neil CE, Wilson MR, Dharmarajan V, Salvaggio JE, Weill H.

J Allergy Clin Immunol. 1979 Aug;64(2):146-52.

PMID:
222827
38.

A recommendation for modifying the standard analytical method for the determination of chlorine in air.

Dharmarajan V, Rando RJ.

Am Ind Hyg Assoc J. 1979 Feb;40(2):161-4. No abstract available.

PMID:
582878
39.

Physical state of airborne p, p'-diphenylmethane diisocyanate (MDI) and its measurement.

Dharmarajan V, Weill H.

Am Ind Hyg Assoc J. 1978 Sep;39(9):737-44.

PMID:
727121
40.

Environmental characterization of toluene diisocyanate (TDI) in a manufacturing plant.

Dharmarajan V, Weil H, Self CW.

Am Ind Hyg Assoc J. 1978 May;39(5):414-8. No abstract available. Erratum in: Am Ind Hyg Assoc J 1987 Feb;48(2):A109.

PMID:
209683
41.

Occupational asthma.

Karr RM, Davies RJ, Butcher BT, Lehrer SB, Wilson MR, Dharmarajan V, Salvaggio JE.

J Allergy Clin Immunol. 1978 Jan;61(1):54-65. No abstract available.

PMID:
618946
42.

Analysis of toluene diisocyanate (TDI) and p, p1-diphenylmethane diisocyanate (MDI) in air.

Dharmarajan V.

Am Ind Hyg Assoc J. 1977 Dec;38(12):725-6. No abstract available.

PMID:
201166
43.

Longitudinal study of workers employed in the manufacture of toluene-diisocyanate.

Butcher BT, Jones RN, O'Neil CE, Glindmeyer HW, Diem JE, Dharmarajan V, Weill H, Salvaggio JE.

Am Rev Respir Dis. 1977 Sep;116(3):411-21.

PMID:
71003
44.

Generation of standard metal oxide particulates in the respirable range.

Dharmarajan V, West PW.

Anal Chim Acta. 1976 Sep;85(2):399-402. No abstract available.

PMID:
962164
45.

Measurement of sulfuric acid aerosol, sulfur trioxide, and the total sulfate content of the ambient air.

Thomas RL, Dharmarajan V, Lundquist GL, West PW.

Anal Chem. 1976 Apr;48(4):639-42. No abstract available.

PMID:
1259160
46.

Sulfuric acid aerosol.

Dharmarajan V, Thomas RL, Maddalone RF, West PW.

Sci Total Environ. 1975 Sep;4(3):279-98. No abstract available.

PMID:
51510
47.

Microdetermination of cadmium airborne particulates by means of the ring-oven technique.

Dharmarajan V, West PW.

Anal Chim Acta. 1971 Dec;57(2):469-72. No abstract available.

PMID:
5132425
48.

Spanish moss, a sensor for lead.

Martinez JD, Mathany M, Dharmarajan V.

Nature. 1971 Oct 22;233(5321):564-5. No abstract available.

PMID:
4939986

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