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Mitochondrial fission causes cisplatin resistance under hypoxic conditions via ROS in ovarian cancer cells.

Han Y, Kim B, Cho U, Park IS, Kim SI, Dhanasekaran DN, Tsang BK, Song YS.

Oncogene. 2019 Aug 13. doi: 10.1038/s41388-019-0949-5. [Epub ahead of print]


Epigenetic targeting of autophagy for cancer prevention and treatment by natural compounds.

Vidoni C, Ferraresi A, Secomandi E, Vallino L, Dhanasekaran DN, Isidoro C.

Semin Cancer Biol. 2019 May 2. pii: S1044-579X(19)30010-0. doi: 10.1016/j.semcancer.2019.04.006. [Epub ahead of print] Review.


Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer.

Han Y, Jo H, Cho JH, Dhanasekaran DN, Song YS.

Int J Mol Sci. 2019 Feb 20;20(4). pii: E925. doi: 10.3390/ijms20040925. Review.


Activation of LXRɑ/β by cholesterol in malignant ascites promotes chemoresistance in ovarian cancer.

Kim S, Lee M, Dhanasekaran DN, Song YS.

BMC Cancer. 2018 Dec 10;18(1):1232. doi: 10.1186/s12885-018-5152-5.


Ovarian cancer cell-derived lysophosphatidic acid induces glycolytic shift and cancer-associated fibroblast-phenotype in normal and peritumoral fibroblasts.

Radhakrishnan R, Ha JH, Jayaraman M, Liu J, Moxley KM, Isidoro C, Sood AK, Song YS, Dhanasekaran DN.

Cancer Lett. 2019 Feb 1;442:464-474. doi: 10.1016/j.canlet.2018.11.023. Epub 2018 Nov 29.


A Non-invasive Liquid Biopsy Screening of Urine-Derived Exosomes for miRNAs as Biomarkers in Endometrial Cancer Patients.

Srivastava A, Moxley K, Ruskin R, Dhanasekaran DN, Zhao YD, Ramesh R.

AAPS J. 2018 Jul 9;20(5):82. doi: 10.1208/s12248-018-0220-y.


Tumour microenvironment on mitochondrial dynamics and chemoresistance in cancer.

Han Y, Cho U, Kim S, Park IS, Cho JH, Dhanasekaran DN, Song YS.

Free Radic Res. 2018 Dec;52(11-12):1271-1287. doi: 10.1080/10715762.2018.1459594. Epub 2018 Apr 19.


Cystathionine β-synthase regulates mitochondrial morphogenesis in ovarian cancer.

Chakraborty PK, Murphy B, Mustafi SB, Dey A, Xiong X, Rao G, Naz S, Zhang M, Yang D, Dhanasekaran DN, Bhattacharya R, Mukherjee P.

FASEB J. 2018 Aug;32(8):4145-4157. doi: 10.1096/fj.201701095R. Epub 2018 Mar 1.


LPA Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response.

Ha JH, Radhakrishnan R, Jayaraman M, Yan M, Ward JD, Fung KM, Moxley K, Sood AK, Isidoro C, Mukherjee P, Song YS, Dhanasekaran DN.

Cancer Res. 2018 Apr 15;78(8):1923-1934. doi: 10.1158/0008-5472.CAN-17-1624. Epub 2018 Jan 31.


JNK-signaling: A multiplexing hub in programmed cell death.

Dhanasekaran DN, Reddy EP.

Genes Cancer. 2017 Sep;8(9-10):682-694. doi: 10.18632/genesandcancer.155. Review.


Transition from androgenic to neurosteroidal action of 5α-androstane-3α, 17β-diol through the type A γ-aminobutyric acid receptor in prostate cancer progression.

Xia D, Lai DV, Wu W, Webb ZD, Yang Q, Zhao L, Yu Z, Thorpe JE, Disch BC, Ihnat MA, Jayaraman M, Dhanasekaran DN, Stratton KL, Cookson MS, Fung KM, Lin HK.

J Steroid Biochem Mol Biol. 2018 Apr;178:89-98. doi: 10.1016/j.jsbmb.2017.11.006. Epub 2017 Nov 21.


PGC1α induced by reactive oxygen species contributes to chemoresistance of ovarian cancer cells.

Kim B, Jung JW, Jung J, Han Y, Suh DH, Kim HS, Dhanasekaran DN, Song YS.

Oncotarget. 2017 Jul 10;8(36):60299-60311. doi: 10.18632/oncotarget.19140. eCollection 2017 Sep 1.


The protein restriction mimetic Resveratrol is an autophagy inducer stronger than amino acid starvation in ovarian cancer cells.

Ferraresi A, Titone R, Follo C, Castiglioni A, Chiorino G, Dhanasekaran DN, Isidoro C.

Mol Carcinog. 2017 Dec;56(12):2681-2691. doi: 10.1002/mc.22711. Epub 2017 Sep 7.


Identification of novel diagnostic and prognostic miRNA signatures in endometrial cancer.

Jayaraman M, Radhakrishnan R, Mathews CA, Yan M, Husain S, Moxley KM, Song YS, Dhanasekaran DN.

Genes Cancer. 2017 May;8(5-6):566-576. doi: 10.18632/genesandcancer.144.


Malignant ascites enhances migratory and invasive properties of ovarian cancer cells with membrane bound IL-6R in vitro.

Kim S, Gwak H, Kim HS, Kim B, Dhanasekaran DN, Song YS.

Oncotarget. 2016 Dec 13;7(50):83148-83159. doi: 10.18632/oncotarget.13074.


Lysophosphatidic acid stimulates epithelial to mesenchymal transition marker Slug/Snail2 in ovarian cancer cells via Gαi2, Src, and HIF1α signaling nexus.

Ha JH, Ward JD, Radhakrishnan R, Jayaraman M, Song YS, Dhanasekaran DN.

Oncotarget. 2016 Jun 21;7(25):37664-37679. doi: 10.18632/oncotarget.9224.


Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer.

Ha JH, Yan M, Gomathinayagam R, Jayaraman M, Husain S, Liu J, Mukherjee P, Reddy EP, Song YS, Dhanasekaran DN.

Oncotarget. 2016 Nov 8;7(45):72845-72859. doi: 10.18632/oncotarget.12069.


Adipose Stromal Cells from Visceral and Subcutaneous Fat Facilitate Migration of Ovarian Cancer Cells via IL-6/JAK2/STAT3 Pathway.

Kim B, Kim HS, Kim S, Haegeman G, Tsang BK, Dhanasekaran DN, Song YS.

Cancer Res Treat. 2017 Apr;49(2):338-349. doi: 10.4143/crt.2016.175. Epub 2016 Jul 18.


(Z)-3,5,4'-Trimethoxystilbene Limits Hepatitis C and Cancer Pathophysiology by Blocking Microtubule Dynamics and Cell-Cycle Progression.

Nguyen CB, Kotturi H, Waris G, Mohammed A, Chandrakesan P, May R, Sureban S, Weygant N, Qu D, Rao CV, Dhanasekaran DN, Bronze MS, Houchen CW, Ali N.

Cancer Res. 2016 Aug 15;76(16):4887-96. doi: 10.1158/0008-5472.CAN-15-2722. Epub 2016 Jun 10.


Metformin induces degradation of cyclin D1 via AMPK/GSK3β axis in ovarian cancer.

Gwak H, Kim Y, An H, Dhanasekaran DN, Song YS.

Mol Carcinog. 2017 Feb;56(2):349-358. doi: 10.1002/mc.22498. Epub 2016 Apr 29.


Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells.

Gwak H, Kim S, Dhanasekaran DN, Song YS.

Cancer Lett. 2016 Feb 28;371(2):347-53. doi: 10.1016/j.canlet.2015.11.032. Epub 2015 Dec 15.


Curcumin induces apoptosis by inhibiting sarco/endoplasmic reticulum Ca2+ ATPase activity in ovarian cancer cells.

Seo JA, Kim B, Dhanasekaran DN, Tsang BK, Song YS.

Cancer Lett. 2016 Feb 1;371(1):30-7. doi: 10.1016/j.canlet.2015.11.021. Epub 2015 Nov 23.


Determinant role for the gep oncogenes, Gα12/13, in ovarian cancer cell proliferation and xenograft tumor growth.

Ha JH, Gomathinayagam R, Yan M, Jayaraman M, Ramesh R, Dhanasekaran DN.

Genes Cancer. 2015 Jul;6(7-8):356-364.


Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases.

Ali N, Chandrakesan P, Nguyen CB, Husain S, Gillaspy AF, Huycke M, Berry WL, May R, Qu D, Weygant N, Sureban SM, Bronze MS, Dhanasekaran DN, Houchen CW.

Oncotarget. 2015 Aug 21;6(24):20327-44.


Ovarian cancer.

Song YS, Kim HS, Aoki D, Dhanasekaran DN, Tsang BK.

Biomed Res Int. 2014;2014:764323. doi: 10.1155/2014/764323. Epub 2014 Dec 21. No abstract available.


Gα13 Stimulates the Tyrosine Phosphorylation of Ric-8A.

Yan M, Ha JH, Dhanasekaran DN.

J Mol Signal. 2015 Jul 27;10:3. doi: 10.5334/1750-2187-10-3.


LPA-mediated migration of ovarian cancer cells involves translocalization of Gαi2 to invadopodia and association with Src and β-pix.

Ward JD, Ha JH, Jayaraman M, Dhanasekaran DN.

Cancer Lett. 2015 Jan 28;356(2 Pt B):382-91. doi: 10.1016/j.canlet.2014.09.030. Epub 2014 Oct 13.


Gα12 gep oncogene deregulation of p53-responsive microRNAs promotes epithelial-mesenchymal transition of hepatocellular carcinoma.

Yang YM, Lee WH, Lee CG, An J, Kim ES, Kim SH, Lee SK, Lee CH, Dhanasekaran DN, Moon A, Hwang S, Lee SJ, Park JW, Kim KM, Kim SG.

Oncogene. 2015 May 28;34(22):2910-21. doi: 10.1038/onc.2014.218. Epub 2014 Jul 28.


Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration.

Gomathinayagam R, Muralidharan J, Ha JH, Varadarajalu L, Dhanasekaran DN.

Genes Cancer. 2014 Mar;5(3-4):84-99.


JNK Signaling Network and Cancer.

Dhanasekaran DN.

Genes Cancer. 2013 Sep;4(9-10):332-3. doi: 10.1177/1947601913507949. No abstract available.


Monographs editor.

Dhanasekaran DN.

Genes Cancer. 2013 Sep;4(9-10):331. doi: 10.1177/1947601913507950. No abstract available.


The gep proto-oncogene Gα12 mediates LPA-stimulated activation of CREB in ovarian cancer cells.

Ha JH, Ward JD, Varadarajalu L, Kim SG, Dhanasekaran DN.

Cell Signal. 2014 Jan;26(1):122-32. doi: 10.1016/j.cellsig.2013.08.012. Epub 2013 Sep 19.


The gep proto-oncogene Gα13 mediates lysophosphatidic acid-mediated migration of pancreatic cancer cells.

Gardner JA, Ha JH, Jayaraman M, Dhanasekaran DN.

Pancreas. 2013 Jul;42(5):819-28. doi: 10.1097/MPA.0b013e318279c577.


LPA Stimulates the Phosphorylation of p130Cas via Gαi2 in Ovarian Cancer Cells.

Ward JD, Dhanasekaran DN.

Genes Cancer. 2012 Sep;3(9-10):578-91. doi: 10.1177/1947601913475360.


Lysophosphatidic Acid Stimulates the Proliferation of Ovarian Cancer Cells via the gep Proto-Oncogene Gα(12).

Goldsmith ZG, Ha JH, Jayaraman M, Dhanasekaran DN.

Genes Cancer. 2011 May;2(5):563-75. doi: 10.1177/1947601911419362.


Molecular and serum markers in hepatocellular carcinoma: predictive tools for prognosis and recurrence.

Singhal A, Jayaraman M, Dhanasekaran DN, Kohli V.

Crit Rev Oncol Hematol. 2012 May;82(2):116-40. doi: 10.1016/j.critrevonc.2011.05.005. Epub 2011 Jun 15. Review.


Neoplastic transformation induced by the gep oncogenes involves the scaffold protein JNK-interacting leucine zipper protein.

Kashef K, Radhakrishnan R, Lee CM, Reddy EP, Dhanasekaran DN.

Neoplasia. 2011 Apr;13(4):358-64.


Platelet protein kinase C-theta deficiency with human RUNX1 mutation: PRKCQ is a transcriptional target of RUNX1.

Jalagadugula G, Mao G, Kaur G, Dhanasekaran DN, Rao AK.

Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):921-7. doi: 10.1161/ATVBAHA.110.221879. Epub 2011 Jan 20.


Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency.

Jalagadugula G, Mao G, Kaur G, Goldfinger LE, Dhanasekaran DN, Rao AK.

Blood. 2010 Dec 23;116(26):6037-45. doi: 10.1182/blood-2010-06-289850. Epub 2010 Sep 27.


Requirement of Cdk4 for v-Ha-ras-Induced Breast Tumorigenesis and Activation of the v-ras-Induced Senescence Program by the R24C Mutation.

Reddy HK, Graña X, Dhanasekaran DN, Litvin J, Reddy EP.

Genes Cancer. 2010 Jan;1(1):69-80. doi: 10.1177/1947601909358105.


G(alpha)12/13 inhibition enhances the anticancer effect of bortezomib through PSMB5 downregulation.

Yang YM, Lee S, Nam CW, Ha JH, Jayaraman M, Dhanasekaran DN, Lee CH, Kwak MK, Kim SG.

Carcinogenesis. 2010 Jul;31(7):1230-7. doi: 10.1093/carcin/bgq097. Epub 2010 May 17.


Mitogenic Signaling by the gep Oncogene Involves the Upregulation of S-Phase Kinase-Associated Protein 2.

Radhakrishnan R, Ha JH, Dhanasekaran DN.

Genes Cancer. 2010 Oct;1(10):1033-43. doi: 10.1177/1947601910390516.


Heterologous expression of olfactory receptors for targeted chemosensing.

Dhanasekaran DN, Radhika V, Proikas-Cezanne T, Jayaraman M, Ha J.

Ann N Y Acad Sci. 2009 Jul;1170:157-60. doi: 10.1111/j.1749-6632.2009.04374.x.


Endothelial nitric oxide synthase inhibits G12/13 and rho-kinase activated by the angiotensin II type-1 receptor: implication in vascular migration.

Suzuki H, Kimura K, Shirai H, Eguchi K, Higuchi S, Hinoki A, Ishimaru K, Brailoiu E, Dhanasekaran DN, Stemmle LN, Fields TA, Frank GD, Autieri MV, Eguchi S.

Arterioscler Thromb Vasc Biol. 2009 Feb;29(2):217-24. doi: 10.1161/ATVBAHA.108.181024. Epub 2008 Dec 18.


JNK signaling in apoptosis.

Dhanasekaran DN, Reddy EP.

Oncogene. 2008 Oct 20;27(48):6245-51. doi: 10.1038/onc.2008.301. Review.


Scaffold proteins of MAP-kinase modules.

Dhanasekaran DN, Kashef K, Lee CM, Xu H, Reddy EP.

Oncogene. 2007 May 14;26(22):3185-202. Review.


G protein regulation of MAPK networks.

Goldsmith ZG, Dhanasekaran DN.

Oncogene. 2007 May 14;26(22):3122-42. Review.


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