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Items: 8

1.

Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1-S Checkpoint.

Zhu D, Xu S, Deyanat-Yazdi G, Peng SX, Barnes LA, Narla RK, Tran T, Mikolon D, Ning Y, Shi T, Jiang N, Raymon HK, Riggs JR, Boylan JF.

Mol Cancer Ther. 2018 Aug;17(8):1727-1738. doi: 10.1158/1535-7163.MCT-17-1084. Epub 2018 Jun 4.

2.

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.

Riggs JR, Nagy M, Elsner J, Erdman P, Cashion D, Robinson D, Harris R, Huang D, Tehrani L, Deyanat-Yazdi G, Narla RK, Peng X, Tran T, Barnes L, Miller T, Katz J, Tang Y, Chen M, Moghaddam MF, Bahmanyar S, Pagarigan B, Delker S, LeBrun L, Chamberlain PP, Calabrese A, Canan SS, Leftheris K, Zhu D, Boylan JF.

J Med Chem. 2017 Nov 9;60(21):8989-9002. doi: 10.1021/acs.jmedchem.7b01223. Epub 2017 Oct 27.

PMID:
28991472
3.

Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure.

Yamazaki Y, Tanaka K, Nicholson B, Deyanat-Yazdi G, Potts B, Yoshida T, Oda A, Kitagawa T, Orikasa S, Kiso Y, Yasui H, Akamatsu M, Chinen T, Usui T, Shinozaki Y, Yakushiji F, Miller BR, Neuteboom S, Palladino M, Kanoh K, Lloyd GK, Hayashi Y.

J Med Chem. 2012 Feb 9;55(3):1056-71. doi: 10.1021/jm2009088. Epub 2012 Jan 20.

PMID:
22185476
4.

Genomic analysis of multiple Roseophage SIO1 strains.

Angly F, Youle M, Nosrat B, Srinagesh S, Rodriguez-Brito B, McNairnie P, Deyanat-Yazdi G, Breitbart M, Rohwer F.

Environ Microbiol. 2009 Nov;11(11):2863-73. doi: 10.1111/j.1462-2920.2009.02021.x. Epub 2009 Jul 31.

PMID:
19659499
5.

Inhibition of protein kinase CK2 expression and activity blocks tumor cell growth.

Zhu D, Hensel J, Hilgraf R, Abbasian M, Pornillos O, Deyanat-Yazdi G, Hua XH, Cox S.

Mol Cell Biochem. 2010 Jan;333(1-2):159-67. doi: 10.1007/s11010-009-0216-0. Epub 2009 Jul 21.

PMID:
19629644
6.

Tubulin photoaffinity labeling with biotin-tagged derivatives of potent diketopiperazine antimicrotubule agents.

Yamazaki Y, Kohno K, Yasui H, Kiso Y, Akamatsu M, Nicholson B, Deyanat-Yazdi G, Neuteboom S, Potts B, Lloyd GK, Hayashi Y.

Chembiochem. 2008 Dec 15;9(18):3074-81. doi: 10.1002/cbic.200800317.

PMID:
19012291
7.

Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome.

Reed KA, Manam RR, Mitchell SS, Xu J, Teisan S, Chao TH, Deyanat-Yazdi G, Neuteboom ST, Lam KS, Potts BC.

J Nat Prod. 2007 Feb;70(2):269-76. Epub 2007 Jan 23.

PMID:
17243724
8.

Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor.

Macherla VR, Mitchell SS, Manam RR, Reed KA, Chao TH, Nicholson B, Deyanat-Yazdi G, Mai B, Jensen PR, Fenical WF, Neuteboom ST, Lam KS, Palladino MA, Potts BC.

J Med Chem. 2005 Jun 2;48(11):3684-7.

PMID:
15916417

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