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Fentanyl depression of respiration: comparison with heroin and morphine.

Hill R, Santhakumar R, Dewey W, Kelly E, Henderson G.

Br J Pharmacol. 2019 Sep 9. doi: 10.1111/bph.14860. [Epub ahead of print]


The Interplay of Nutrition, Physical Activity, Severity of Illness, and Mortality in Critically Ill Burn Patients: Is There a Connection?

Shields BA, Carpenter JN, Bustillos BD, Jordan AN, Cunningham KB, Vega SJ, Aden JK, Rowan MP, Rizzo JA, Dewey WS, Gurney JM, Ainsworth CR, Cancio LC.

J Burn Care Res. 2019 Oct 16;40(6):936-942. doi: 10.1093/jbcr/irz126.


Experimental Colitis Enhances the Rate of Antinociceptive Tolerance to Morphine via Peripheral Opioid Receptors.

Komla E, Stevens DL, Zheng Y, Zhang Y, Dewey WL, Akbarali HI.

J Pharmacol Exp Ther. 2019 Sep;370(3):504-513. doi: 10.1124/jpet.119.256941. Epub 2019 Jun 27.


Gastrointestinal motility, dysbiosis and opioid-induced tolerance: is there a link?

Akbarali HI, Dewey WL.

Nat Rev Gastroenterol Hepatol. 2019 Jun;16(6):323-324. doi: 10.1038/s41575-019-0150-x. Review. No abstract available.


Goniometric Measurement of Burn Scar Contracture: A Paradigm Shift Challenging the Standard.

Parry I, Richard R, Aden JK, Yelvington M, Ware L, Dewey W, Jacobson K, Caffrey J, Sen S.

J Burn Care Res. 2019 Jun 21;40(4):377-385. doi: 10.1093/jbcr/irz038.


Characterization of 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(indole-7-carboxamido)morphinan (NAN) as a Novel Opioid Receptor Modulator for Opioid Use Disorder Treatment.

Obeng S, Jali A, Zheng Y, Wang H, Schwienteck KL, Chen C, Stevens DL, Akbarali HI, Dewey WL, Banks ML, Liu-Chen LY, Selley DE, Zhang Y.

ACS Chem Neurosci. 2019 May 15;10(5):2518-2532. doi: 10.1021/acschemneuro.9b00038. Epub 2019 Feb 21.


Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands.

Zheng Y, Obeng S, Wang H, Jali AM, Peddibhotla B, Williams DA, Zou C, Stevens DL, Dewey WL, Akbarali HI, Selley DE, Zhang Y.

J Med Chem. 2019 Jan 24;62(2):561-574. doi: 10.1021/acs.jmedchem.8b01158. Epub 2019 Jan 11.


Analysis of carbenoxolone by ultra-high-performance liquid chromatography tandem mass spectrometry in mouse brain and blood after systemic administration.

Poklis JL, Gonek MM, Wolf CE, Akbarali HI, Dewey WL.

Biomed Chromatogr. 2019 Apr;33(4):e4465. doi: 10.1002/bmc.4465. Epub 2019 Jan 7.


Rehabilitation of Burn Injuries: An Update.

Young AW, Dewey WS, King BT.

Phys Med Rehabil Clin N Am. 2019 Feb;30(1):111-132. doi: 10.1016/j.pmr.2018.08.004. Epub 2018 Oct 31. Review.


Structure-Activity Relationship Studies of 6α- and 6β-Indolylacetamidonaltrexamine Derivatives as Bitopic Mu Opioid Receptor Modulators and Elaboration of the "Message-Address Concept" To Comprehend Their Functional Conversion.

Obeng S, Wang H, Jali A, Stevens DL, Akbarali HI, Dewey WL, Selley DE, Zhang Y.

ACS Chem Neurosci. 2019 Mar 20;10(3):1075-1090. doi: 10.1021/acschemneuro.8b00349. Epub 2018 Sep 7.


Methylation Products of 6β- N-Heterocyclic Substituted Naltrexamine Derivatives as Potential Peripheral Opioid Receptor Modulators.

Zheng Y, Obeng S, Wang H, Stevens DL, Komla E, Selley DE, Dewey WL, Akbarali HI, Zhang Y.

ACS Chem Neurosci. 2018 Dec 19;9(12):3028-3037. doi: 10.1021/acschemneuro.8b00234. Epub 2018 Jul 23.


Tolerance to Morphine-Induced Inhibition of TTX-R Sodium Channels in Dorsal Root Ganglia Neurons Is Modulated by Gut-Derived Mediators.

Mischel RA, Dewey WL, Akbarali HI.

iScience. 2018 Apr 27;2:193-209. doi: 10.1016/j.isci.2018.03.003.


The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception.

Hill R, Disney A, Conibear A, Sutcliffe K, Dewey W, Husbands S, Bailey C, Kelly E, Henderson G.

Br J Pharmacol. 2018 Jul;175(13):2653-2661. doi: 10.1111/bph.14224. Epub 2018 May 14.


Oxycodone-induced tolerance to respiratory depression: reversal by ethanol, pregabalin and protein kinase C inhibition.

Hill R, Dewey WL, Kelly E, Henderson G.

Br J Pharmacol. 2018 Jun;175(12):2492-2503. doi: 10.1111/bph.14219. Epub 2018 May 7.


Ethanol Reversal of Oxycodone Tolerance in Dorsal Root Ganglia Neurons.

Jacob JC, Sakakibara K, Mischel RA, Henderson G, Dewey WL, Akbarali HI.

Mol Pharmacol. 2018 May;93(5):417-426. doi: 10.1124/mol.117.110775. Epub 2018 Feb 21.


CCR5 mediates HIV-1 Tat-induced neuroinflammation and influences morphine tolerance, dependence, and reward.

Gonek M, McLane VD, Stevens DL, Lippold K, Akbarali HI, Knapp PE, Dewey WL, Hauser KF, Paris JJ.

Brain Behav Immun. 2018 Mar;69:124-138. doi: 10.1016/j.bbi.2017.11.006. Epub 2017 Nov 13.


The gut-brain interaction in opioid tolerance.

Akbarali HI, Dewey WL.

Curr Opin Pharmacol. 2017 Dec;37:126-130. doi: 10.1016/j.coph.2017.10.012. Epub 2017 Nov 13. Review.


Reversal of oxycodone and hydrocodone tolerance by diazepam.

Gonek M, Akbarali HI, Henderson G, Dewey WL.

Brain Res. 2017 Nov 1;1674:84-90. doi: 10.1016/j.brainres.2017.08.017. Epub 2017 Aug 19.


Ethanol Reversal of Tolerance to the Antinociceptive Effects of Oxycodone and Hydrocodone.

Jacob JC, Poklis JL, Akbarali HI, Henderson G, Dewey WL.

J Pharmacol Exp Ther. 2017 Jul;362(1):45-52. doi: 10.1124/jpet.117.241083. Epub 2017 Apr 25.


The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection.

Nelson EA, Dyall J, Hoenen T, Barnes AB, Zhou H, Liang JY, Michelotti J, Dewey WH, DeWald LE, Bennett RS, Morris PJ, Guha R, Klumpp-Thomas C, McKnight C, Chen YC, Xu X, Wang A, Hughes E, Martin S, Thomas C, Jahrling PB, Hensley LE, Olinger GG Jr, White JM.

PLoS Negl Trop Dis. 2017 Apr 12;11(4):e0005540. doi: 10.1371/journal.pntd.0005540. eCollection 2017 Apr.


Burn Hand or Finger Goniometric Measurements: Sum of the Isolated Parts and the Composite Whole.

Richard R, Parry IS, Santos A, Dewey WS.

J Burn Care Res. 2017 Nov/Dec;38(6):e960-e965. doi: 10.1097/BCR.0000000000000529.


Connexin-purinergic signaling in enteric glia mediates the prolonged effect of morphine on constipation.

Bhave S, Gade A, Kang M, Hauser KF, Dewey WL, Akbarali HI.

FASEB J. 2017 Jun;31(6):2649-2660. doi: 10.1096/fj.201601068R. Epub 2017 Mar 9.


The effect of gut microbiome on tolerance to morphine mediated antinociception in mice.

Kang M, Mischel RA, Bhave S, Komla E, Cho A, Huang C, Dewey WL, Akbarali HI.

Sci Rep. 2017 Feb 17;7:42658. doi: 10.1038/srep42658.


Effect of Tamoxifen and Brain-Penetrant Protein Kinase C and c-Jun N-Terminal Kinase Inhibitors on Tolerance to Opioid-Induced Respiratory Depression in Mice.

Withey SL, Hill R, Lyndon A, Dewey WL, Kelly E, Henderson G.

J Pharmacol Exp Ther. 2017 Apr;361(1):51-59. doi: 10.1124/jpet.116.238329. Epub 2017 Jan 27.


Nanoconjugated NAP as a Potent and Periphery Selective Mu Opioid Receptor Modulator To Treat Opioid-Induced Constipation.

Xu GG, Zolotarskaya OY, Williams DA, Yuan Y, Selley DE, Dewey WL, Akbarali HI, Yang H, Zhang Y.

ACS Med Chem Lett. 2016 Nov 21;8(1):78-83. doi: 10.1021/acsmedchemlett.6b00382. eCollection 2017 Jan 12.


Simvastatin promotes NPC1-mediated free cholesterol efflux from lysosomes through CYP7A1/LXRα signalling pathway in oxLDL-loaded macrophages.

Xu X, Zhang A, Halquist MS, Yuan X, Henderson SC, Dewey WL, Li PL, Li N, Zhang F.

J Cell Mol Med. 2017 Feb;21(2):364-374. doi: 10.1111/jcmm.12970. Epub 2016 Sep 15.


Profile of Patients Without Burn Scar Contracture Development.

Richard R, Santos-Lozada AR, Dewey WS, Chung KK.

J Burn Care Res. 2017 Jan/Feb;38(1):e62-e69. doi: 10.1097/BCR.0000000000000418.


HIV-1 Tat exacerbates lipopolysaccharide-induced cytokine release via TLR4 signaling in the enteric nervous system.

Guedia J, Brun P, Bhave S, Fitting S, Kang M, Dewey WL, Hauser KF, Akbarali HI.

Sci Rep. 2016 Aug 5;6:31203. doi: 10.1038/srep31203.


Substrate Ubiquitination Controls the Unfolding Ability of the Proteasome.

Reichard EL, Chirico GG, Dewey WJ, Nassif ND, Bard KE, Millas NE, Kraut DA.

J Biol Chem. 2016 Aug 26;291(35):18547-61. doi: 10.1074/jbc.M116.720151. Epub 2016 Jul 12.


6β-N-Heterocyclic Substituted Naltrexamine Derivative BNAP: A Peripherally Selective Mixed MOR/KOR Ligand.

Williams DA, Zheng Y, David BG, Yuan Y, Zaidi SA, Stevens DL, Scoggins KL, Selley DE, Dewey WL, Akbarali HI, Zhang Y.

ACS Chem Neurosci. 2016 Aug 17;7(8):1120-9. doi: 10.1021/acschemneuro.6b00075. Epub 2016 Jun 15.


Enhanced Sensitivity of α3β4 Nicotinic Receptors in Enteric Neurons after Long-Term Morphine: Implication for Opioid-Induced Constipation.

Gade AR, Kang M, Khan F, Grider JR, Damaj MI, Dewey WL, Akbarali HI.

J Pharmacol Exp Ther. 2016 Jun;357(3):520-8. doi: 10.1124/jpet.116.233304. Epub 2016 Apr 11.


Lysosomal cholesterol accumulation in macrophages leading to coronary atherosclerosis in CD38(-/-) mice.

Xu X, Yuan X, Li N, Dewey WL, Li PL, Zhang F.

J Cell Mol Med. 2016 Jun;20(6):1001-13. doi: 10.1111/jcmm.12788. Epub 2016 Jan 28.


The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.

Wilkerson JL, Niphakis MJ, Grim TW, Mustafa MA, Abdullah RA, Poklis JL, Dewey WL, Akbarali H, Banks ML, Wise LE, Cravatt BF, Lichtman AH.

J Pharmacol Exp Ther. 2016 Apr;357(1):145-56. doi: 10.1124/jpet.115.229971. Epub 2016 Jan 20.


17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4'-pyridylcarboxamido)morphinan (NAP) Modulating the Mu Opioid Receptor in a Biased Fashion.

Zhang Y, Williams DA, Zaidi SA, Yuan Y, Braithwaite A, Bilsky EJ, Dewey WL, Akbarali HI, Streicher JM, Selley DE.

ACS Chem Neurosci. 2016 Mar 16;7(3):297-304. doi: 10.1021/acschemneuro.5b00245. Epub 2016 Jan 8.


Morphine Tolerance and Physical Dependence Are Altered in Conditional HIV-1 Tat Transgenic Mice.

Fitting S, Stevens DL, Khan FA, Scoggins KL, Enga RM, Beardsley PM, Knapp PE, Dewey WL, Hauser KF.

J Pharmacol Exp Ther. 2016 Jan;356(1):96-105. doi: 10.1124/jpet.115.226407. Epub 2015 Nov 5.


Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.

Yuan Y, Zaidi SA, Stevens DL, Scoggins KL, Mosier PD, Kellogg GE, Dewey WL, Selley DE, Zhang Y.

Bioorg Med Chem. 2015 Apr 15;23(8):1701-15. doi: 10.1016/j.bmc.2015.02.055. Epub 2015 Mar 6.


Sensitization of enteric neurons to morphine by HIV-1 Tat protein.

Fitting S, Ngwainmbi J, Kang M, Khan FA, Stevens DL, Dewey WL, Knapp PE, Hauser KF, Akbarali HI.

Neurogastroenterol Motil. 2015 Apr;27(4):468-80. doi: 10.1111/nmo.12514. Epub 2015 Feb 19.


Effects of HIV-1 Tat on enteric neuropathogenesis.

Ngwainmbi J, De DD, Smith TH, El-Hage N, Fitting S, Kang M, Dewey WL, Hauser KF, Akbarali HI.

J Neurosci. 2014 Oct 22;34(43):14243-51. doi: 10.1523/JNEUROSCI.2283-14.2014.


Site and mechanism of morphine tolerance in the gastrointestinal tract.

Akbarali HI, Inkisar A, Dewey WL.

Neurogastroenterol Motil. 2014 Oct;26(10):1361-7. doi: 10.1111/nmo.12443. Review.


Morphine dependence in single enteric neurons from the mouse colon requires deletion of β-arrestin2.

Smith TH, Ngwainmbi J, Hashimoto A, Dewey WL, Akbarali HI.

Physiol Rep. 2014 Sep 4;2(9). pii: e12140. doi: 10.14814/phy2.12140. Print 2014 Sep 1.


Specific localization of β-Arrestin2 in myenteric plexus of mouse gastrointestinal tract.

Maguma HT, Datta De D, Bhave S, Dewey WL, Akbarali HI.

PLoS One. 2014 Aug 1;9(8):e103894. doi: 10.1371/journal.pone.0103894. eCollection 2014.


Design, synthesis, and biological evaluation of 14-heteroaromatic-substituted naltrexone derivatives: pharmacological profile switch from mu opioid receptor selectivity to mu/kappa opioid receptor dual selectivity.

Yuan Y, Zaidi SA, Elbegdorj O, Aschenbach LC, Li G, Stevens DL, Scoggins KL, Dewey WL, Selley DE, Zhang Y.

J Med Chem. 2013 Nov 27;56(22):9156-69. doi: 10.1021/jm4012214. Epub 2013 Nov 7.


An in-vitro preparation of isolated enteric neurons and glia from the myenteric plexus of the adult mouse.

Smith TH, Ngwainmbi J, Grider JR, Dewey WL, Akbarali HI.

J Vis Exp. 2013 Aug 7;(78). doi: 10.3791/50688.


Ethanol reversal of cellular tolerance to morphine in rat locus coeruleus neurons.

Llorente J, Withey S, Rivero G, Cunningham M, Cooke A, Saxena K, McPherson J, Oldfield S, Dewey WL, Bailey CP, Kelly E, Henderson G.

Mol Pharmacol. 2013 Aug;84(2):252-60. doi: 10.1124/mol.113.085936. Epub 2013 May 28.


Influence of upper extremity positioning on pain, paresthesia, and tolerance: advancing current practice.

Lester ME, Hazelton J, Dewey WS, Casey JC, Richard R.

J Burn Care Res. 2013 Nov-Dec;34(6):e342-50. doi: 10.1097/BCR.0b013e3182788f52.


Reversal of morphine analgesic tolerance by ethanol in the mouse.

Hull LC, Gabra BH, Bailey CP, Henderson G, Dewey WL.

J Pharmacol Exp Ther. 2013 Jun;345(3):512-9. doi: 10.1124/jpet.112.202184. Epub 2013 Mar 25.


Electrophysiological characteristics of enteric neurons isolated from the immortomouse.

Hawkins EG, Dewey WL, Anitha M, Srinivasan S, Grider JR, Akbarali HI.

Dig Dis Sci. 2013 Jun;58(6):1516-27. doi: 10.1007/s10620-013-2557-5. Epub 2013 Jan 31.


Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selective μ opioid receptor Agents.

Yuan Y, Elbegdorj O, Chen J, Akubathini SK, Zhang F, Stevens DL, Beletskaya IO, Scoggins KL, Zhang Z, Gerk PM, Selley DE, Akbarali HI, Dewey WL, Zhang Y.

J Med Chem. 2012 Nov 26;55(22):10118-29. doi: 10.1021/jm301247n. Epub 2012 Nov 9.


Morphine decreases enteric neuron excitability via inhibition of sodium channels.

Smith TH, Grider JR, Dewey WL, Akbarali HI.

PLoS One. 2012;7(9):e45251. doi: 10.1371/journal.pone.0045251. Epub 2012 Sep 21. Erratum in: PLoS One. 2013;8(5). doi: 10.1371/annotation/c2d0d839-3fea-4dfd-ad78-4e4fb1271b20.


Contribution of acid sphingomyelinase in the periaqueductal gray region to morphine-induced analgesia in mice.

Ritter JK, Fang Y, Xia M, Li PL, Dewey WL.

Neuroreport. 2012 Sep 12;23(13):780-5. doi: 10.1097/WNR.0b013e3283571757.

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