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Items: 1 to 50 of 147

1.

Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction.

Juncosa JI, Takaya K, Le HV, Moschitto MJ, Weerawarna PM, Mascarenhas R, Liu D, Dewey SL, Silverman RB.

J Am Chem Soc. 2018 Feb 14;140(6):2151-2164. doi: 10.1021/jacs.7b10965. Epub 2018 Jan 30.

2.

Levodopa-induced abnormal involuntary movements correlate with altered permeability of the blood-brain-barrier in the basal ganglia.

Lerner RP, Francardo V, Fujita K, Bimpisidis Z, Jourdain VA, Tang CC, Dewey SL, Chaly T, Cenci MA, Eidelberg D.

Sci Rep. 2017 Nov 22;7(1):16005. doi: 10.1038/s41598-017-16228-1.

3.

Imaging Sex Differences in Regional Brain Metabolism during Acute Opioid Withdrawal.

Santoro GC, Carrion J, Dewey SL.

J Alcohol Drug Depend. 2017 Apr;5(2). pii: 262. doi: 10.4172/2329-6488.1000262. Epub 2017 Apr 6.

4.

Sex Differences in Regional Brain Glucose Metabolism Following Opioid Withdrawal and Replacement.

Santoro GC, Carrion J, Patel K, Vilchez C, Veith J, Brodie JD, Dewey SL.

Neuropsychopharmacology. 2017 Aug;42(9):1841-1849. doi: 10.1038/npp.2017.69. Epub 2017 Apr 10.

5.

In vivo evaluation of IGF1R/IR PET ligand [18F]BMS-754807 in rodents.

Prabhakaran J, Dewey SL, McClure R, Simpson NR, Tantawy MN, Mann JJ, Pham W, Kumar JSD.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):941-943. doi: 10.1016/j.bmcl.2016.12.086. Epub 2017 Jan 7.

6.

A Novel Strategy for Attenuating Opioid Withdrawal in Neonates.

Santoro GC, Shukla S, Patel K, Kaczmarzyk J, Agorastos S, Scherrer S, Choi YY, Veith C, Carrion J, Silverman R, Mullin D, Ahmed M, Schiffer WK, Brodie JD, Dewey SL.

J Addict Res Ther. 2016 Aug;7(4). pii: 291. doi: 10.4172/2155-6105.1000291. Epub 2016 Aug 11.

7.

Dissociation of metabolic and hemodynamic levodopa responses in the 6-hydroxydopamine rat model.

Lerner RP, Bimpisidis Z, Agorastos S, Scherrer S, Dewey SL, Cenci MA, Eidelberg D.

Neurobiol Dis. 2016 Dec;96:31-37. doi: 10.1016/j.nbd.2016.08.010. Epub 2016 Aug 17.

8.

18FDG-microPET and MR DTI findings in Tor1a+/- heterozygous knock-out mice.

Vo A, Sako W, Dewey SL, Eidelberg D, Uluğ AM.

Neurobiol Dis. 2015 Jan;73:399-406. doi: 10.1016/j.nbd.2014.10.020. Epub 2014 Nov 4.

PMID:
25447231
9.

Regional brain metabolism in a murine systemic lupus erythematosus model.

Vo A, Volpe BT, Tang CC, Schiffer WK, Kowal C, Huerta PT, Uluğ AM, Dewey SL, Eidelberg D, Diamond B.

J Cereb Blood Flow Metab. 2014 Aug;34(8):1315-20. doi: 10.1038/jcbfm.2014.85. Epub 2014 May 14.

10.

(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction.

Pan Y, Gerasimov MR, Kvist T, Wellendorph P, Madsen KK, Pera E, Lee H, Schousboe A, Chebib M, Bräuner-Osborne H, Craft CM, Brodie JD, Schiffer WK, Dewey SL, Miller SR, Silverman RB.

J Med Chem. 2012 Jan 12;55(1):357-66. doi: 10.1021/jm201231w. Epub 2011 Dec 30.

11.

PET imaging of thin objects: measuring the effects of positron range and partial-volume averaging in the leaf of Nicotiana tabacum.

Alexoff DL, Dewey SL, Vaska P, Krishnamoorthy S, Ferrieri R, Schueller M, Schlyer DJ, Fowler JS.

Nucl Med Biol. 2011 Feb;38(2):191-200. doi: 10.1016/j.nucmedbio.2010.08.004. Epub 2010 Oct 27.

PMID:
21315274
12.

Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice.

Mirrione MM, Konomos DK, Gravanis I, Dewey SL, Aguzzi A, Heppner FL, Tsirka SE.

Neurobiol Dis. 2010 Jul;39(1):85-97. doi: 10.1016/j.nbd.2010.04.001. Epub 2010 Apr 9.

13.

Decreased serotonin levels associated with behavioral disinhibition in tissue plasminogen activator deficient (tPA-/-) mice.

Pothakos K, Robinson JK, Gravanis I, Marsteller DA, Dewey SL, Tsirka SE.

Brain Res. 2010 Apr 22;1326:135-42. doi: 10.1016/j.brainres.2009.12.095. Epub 2010 Feb 12.

14.

Randomized, double-blind, placebo-controlled trial of vigabatrin for the treatment of cocaine dependence in Mexican parolees.

Brodie JD, Case BG, Figueroa E, Dewey SL, Robinson JA, Wanderling JA, Laska EM.

Am J Psychiatry. 2009 Nov;166(11):1269-77. doi: 10.1176/appi.ajp.2009.08121811. Epub 2009 Aug 3.

PMID:
19651710
15.

Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents.

Schiffer WK, Liebling CN, Reiszel C, Hooker JM, Brodie JD, Dewey SL.

J Neurosci. 2009 May 13;29(19):6176-85. doi: 10.1523/JNEUROSCI.5221-08.2009.

16.

Racemic gamma vinyl-GABA (R,S-GVG) blocks methamphetamine-triggered reinstatement of conditioned place preference.

DeMarco A, Dalal RM, Pai J, Aquilina SD, Mullapudi U, Hammel C, Kothari SK, Kahanda M, Liebling CN, Patel V, Schiffer WK, Brodie JD, Dewey SL.

Synapse. 2009 Feb;63(2):87-94. doi: 10.1002/syn.20582.

17.

Subchronic racemic gamma vinyl-GABA produces weight loss in Sprague Dawley and Zucker fatty rats.

DeMarco A, Dalal RM, Kahanda M, Mullapudi U, Pai J, Hammel C, Liebling CN, Patel V, Brodie JD, Schiffer WK, Dewey SL, Aquilina SD.

Synapse. 2008 Nov;62(11):870-2. doi: 10.1002/syn.20555.

PMID:
18720383
18.

Imaging dopamine release with Positron Emission Tomography (PET) and (11)C-raclopride in freely moving animals.

Patel VD, Lee DE, Alexoff DL, Dewey SL, Schiffer WK.

Neuroimage. 2008 Jul 1;41(3):1051-66. doi: 10.1016/j.neuroimage.2008.02.065. Epub 2008 Mar 19.

PMID:
18442926
19.

Treatment of methamphetamine dependence.

Mendelson J, Rawson R, Newton T, Galloway G, de Wit H, Dewey SL, Hart CL, Epstein DH.

Mayo Clin Proc. 2008 Mar;83(3):369-70; author reply 370-1. doi: 10.4065/83.3.369-a. No abstract available.

PMID:
18316008
20.

The effects of inhaled acetone on place conditioning in adolescent rats.

Lee DE, Pai J, Mullapudui U, Alexoff DL, Ferrieri R, Dewey SL.

Pharmacol Biochem Behav. 2008 Mar;89(1):101-5. Epub 2007 Nov 22.

21.

Gamma-vinyl GABA inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats by a non-dopaminergic mechanism.

Peng XQ, Li X, Gilbert JG, Pak AC, Ashby CR Jr, Brodie JD, Dewey SL, Gardner EL, Xi ZX.

Drug Alcohol Depend. 2008 Oct 1;97(3):216-25. Epub 2007 Dec 11.

22.

Targeting the treatment of drug abuse with molecular imaging.

Schiffer WK, Liebling CN, Patel V, Dewey SL.

Nucl Med Biol. 2007 Oct;34(7):833-47. Epub 2007 Aug 9. Review.

PMID:
17921034
23.

PET studies of d-methamphetamine pharmacokinetics in primates: comparison with l-methamphetamine and ( --)-cocaine.

Fowler JS, Kroll C, Ferrieri R, Alexoff D, Logan J, Dewey SL, Schiffer W, Schlyer D, Carter P, King P, Shea C, Xu Y, Muench L, Benveniste H, Vaska P, Volkow ND.

J Nucl Med. 2007 Oct;48(10):1724-32. Epub 2007 Sep 14.

24.

A novel approach for imaging brain-behavior relationships in mice reveals unexpected metabolic patterns during seizures in the absence of tissue plasminogen activator.

Mirrione MM, Schiffer WK, Fowler JS, Alexoff DL, Dewey SL, Tsirka SE.

Neuroimage. 2007 Oct 15;38(1):34-42. Epub 2007 Jul 18.

25.

Brain metabolic changes following 4-week citalopram infusion: increased 18FDG uptake and gamma-amino butyric acid levels.

Marsteller DA, Barbarich-Marsteller NC, Patel VD, Dewey SL.

Synapse. 2007 Nov;61(11):877-81.

PMID:
17657806
26.

Optimizing experimental protocols for quantitative behavioral imaging with 18F-FDG in rodents.

Schiffer WK, Mirrione MM, Dewey SL.

J Nucl Med. 2007 Feb;48(2):277-87.

27.

Short-term treatment of cocaine and/or methamphetamine abuse with vigabatrin: ocular safety pilot results.

Fechtner RD, Khouri AS, Figueroa E, Ramirez M, Federico M, Dewey SL, Brodie JD.

Arch Ophthalmol. 2006 Sep;124(9):1257-62.

PMID:
16966620
28.

Metabolic correlates of toluene abuse: decline and recovery of function in adolescent animals.

Schiffer WK, Lee DE, Alexoff DL, Ferrieri R, Brodie JD, Dewey SL.

Psychopharmacology (Berl). 2006 Jun;186(2):159-67. Epub 2006 Apr 22.

PMID:
16703400
29.

Serial microPET measures of the metabolic reaction to a microdialysis probe implant.

Schiffer WK, Mirrione MM, Biegon A, Alexoff DL, Patel V, Dewey SL.

J Neurosci Methods. 2006 Sep 15;155(2):272-84. Epub 2006 Mar 7.

PMID:
16519945
30.

Reproducibility of intraperitoneal 2-deoxy-2-[18F]-fluoro-D-glucose cerebral uptake in rodents through time.

Marsteller DA, Barbarich-Marsteller NC, Fowler JS, Schiffer WK, Alexoff DL, Rubins DJ, Dewey SL.

Nucl Med Biol. 2006 Jan;33(1):71-9.

PMID:
16459261
31.

Therapeutic doses of amphetamine or methylphenidate differentially increase synaptic and extracellular dopamine.

Schiffer WK, Volkow ND, Fowler JS, Alexoff DL, Logan J, Dewey SL.

Synapse. 2006 Mar 15;59(4):243-51.

PMID:
16385551
32.

PET imaging of glucose metabolism in a mouse model of temporal lobe epilepsy.

Mirrione MM, Schiffer WK, Siddiq M, Dewey SL, Tsirka SE.

Synapse. 2006 Feb;59(2):119-21.

PMID:
16320304
33.

MicroPET imaging in an animal model of anorexia nervosa.

Barbarich-Marsteller NC, Marsteller DA, Alexoff DL, Fowler JS, Dewey SL.

Synapse. 2005 Aug;57(2):85-90.

PMID:
15906391
34.

Development of a simultaneous PET/microdialysis method to identify the optimal dose of 11C-raclopride for small animal imaging.

Schiffer WK, Alexoff DL, Shea C, Logan J, Dewey SL.

J Neurosci Methods. 2005 May 15;144(1):25-34. Epub 2004 Dec 8.

35.

Imaging addiction with PET: is insight in sight?

Schiffer WK, Lee DE, Brodie JD, Dewey SL.

Drug Discov Today. 2005 Apr 15;10(8):547-62. Review.

PMID:
15837598
36.

Safety and efficacy of gamma-vinyl GABA (GVG) for the treatment of methamphetamine and/or cocaine addiction.

Brodie JD, Figueroa E, Laska EM, Dewey SL.

Synapse. 2005 Feb;55(2):122-5.

PMID:
15543630
37.

Gamma-vinyl GABA (vigabatrin) blocks the expression of toluene-induced conditioned place preference (CPP).

Lee DE, Schiffer WK, Dewey SL.

Synapse. 2004 Dec 1;54(3):183-5. No abstract available.

PMID:
15459943
38.

PET Studies of the Effect of the Antidepressant Drugs Nefazodone or Paroxetine on [11C]Raclopride Binding in Human Brain.

Fowler JS, Wang GJ, Volkow ND, Ieni J, Logan J, Pappas N, Dewey SL.

Clin Positron Imaging. 1999 Jul;2(4):205-209.

PMID:
14516531
39.

Treating cocaine addiction: from preclinical to clinical trial experience with gamma-vinyl GABA.

Brodie JD, Figueroa E, Dewey SL.

Synapse. 2003 Dec 1;50(3):261-5. No abstract available.

PMID:
14515344
40.
41.

Sub-chronic low dose gamma-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine.

Schiffer WK, Marsteller D, Dewey SL.

Psychopharmacology (Berl). 2003 Jul;168(3):339-43. Epub 2003 Apr 9.

PMID:
12684739
42.

Selegiline potentiates cocaine-induced increases in rodent nucleus accumbens dopamine.

Schiffer WK, Azmoodeh M, Gerasimov M, Volkow ND, Fowler JS, Dewey SL.

Synapse. 2003 Apr;48(1):35-8.

PMID:
12557270
43.

Gamma-vinyl GABA, an irreversible inhibitor of GABA transaminase, alters the acquisition and expression of cocaine-induced sensitization in male rats.

Gardner EL, Schiffer WK, Horan BA, Highfield D, Dewey SL, Brodie JD, Ashby CR Jr.

Synapse. 2002 Dec 15;46(4):240-50.

PMID:
12373739
44.

Study of brain uptake and biodistribution of [11C]toluene in non-human primates and mice.

Gerasimov MR, Ferrieri RA, Schiffer WK, Logan J, Gatley SJ, Gifford AN, Alexoff DA, Marsteller DA, Shea C, Garza V, Carter P, King P, Ashby CR Jr, Vitkun S, Dewey SL.

Life Sci. 2002 Apr 26;70(23):2811-28.

PMID:
12269385
45.

Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortex.

Marsteller DA, Gerasimov MR, Schiffer WK, Geiger JM, Barnett CR, Schaich Borg J, Scott S, Ceccarelli J, Volkow ND, Molina PE, Alexoff DL, Dewey SL.

Neuropsychopharmacology. 2002 Aug;27(2):163-70.

46.

Effect of vehicle on brain uptake of [11C]toluene.

Gerasimov MR, Logan J, Ferrieri RA, Muller RD, Alexoff D, Dewey SL.

Nucl Med Biol. 2002 Jul;29(5):607-12.

PMID:
12088732
47.
48.

Toluene inhalation produces regionally specific changes in extracellular dopamine.

Gerasimov MR, Schiffer WK, Marstellar D, Ferrieri R, Alexoff D, Dewey SL.

Drug Alcohol Depend. 2002 Feb 1;65(3):243-51.

PMID:
11841896
49.

Topiramate selectively attenuates nicotine-induced increases in monoamine release.

Schiffer WK, Gerasimov MR, Marsteller DA, Geiger J, Barnett C, Alexoff DL, Dewey SL.

Synapse. 2001 Dec 1;42(3):196-8. No abstract available.

PMID:
11746717
50.

Gamma vinyl-GABA differentially modulates NMDA antagonist-induced increases in mesocortical versus mesolimbic DA transmission.

Schiffer WK, Gerasimov M, Hofmann L, Marsteller D, Ashby CR, Brodie JD, Alexoff DL, Dewey SL.

Neuropsychopharmacology. 2001 Nov;25(5):704-12.

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