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Items: 1 to 50 of 218

1.

Cell migration directionality and speed are independently regulated by RasG and Gβ in Dictyostelium cells in electrotaxis.

Jeon TJ, Gao R, Kim H, Lee A, Jeon P, Devreotes PN, Zhao M.

Biol Open. 2019 Jul 4;8(7). pii: bio042457. doi: 10.1242/bio.042457.

2.

Wave patterns organize cellular protrusions and control cortical dynamics.

Miao Y, Bhattacharya S, Banerjee T, Abubaker-Sharif B, Long Y, Inoue T, Iglesias PA, Devreotes PN.

Mol Syst Biol. 2019 Mar 11;15(3):e8585. doi: 10.15252/msb.20188585.

3.

Chemoattractant receptors activate, recruit and capture G proteins for wide range chemotaxis.

Miyanaga Y, Kamimura Y, Kuwayama H, Devreotes PN, Ueda M.

Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):304-310. doi: 10.1016/j.bbrc.2018.11.029. Epub 2018 Nov 17.

4.

Mutually inhibitory Ras-PI(3,4)P2 feedback loops mediate cell migration.

Li X, Edwards M, Swaney KF, Singh N, Bhattacharya S, Borleis J, Long Y, Iglesias PA, Chen J, Devreotes PN.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9125-E9134. doi: 10.1073/pnas.1809039115. Epub 2018 Sep 7. Erratum in: Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10286.

5.

Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation.

Neumann NM, Perrone MC, Veldhuis JH, Huebner RJ, Zhan H, Devreotes PN, Brodland GW, Ewald AJ.

Dev Cell. 2018 Apr 9;45(1):67-82.e6. doi: 10.1016/j.devcel.2018.03.011.

6.

Insight from the maximal activation of the signal transduction excitable network in Dictyostelium discoideum.

Edwards M, Cai H, Abubaker-Sharif B, Long Y, Lampert TJ, Devreotes PN.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3722-E3730. doi: 10.1073/pnas.1710480115. Epub 2018 Mar 30. Erratum in: Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6671.

7.

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation.

Artemenko Y, Devreotes PN.

J Vis Exp. 2017 Nov 9;(129). doi: 10.3791/56411.

8.

Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity.

Lampert TJ, Kamprad N, Edwards M, Borleis J, Watson AJ, Tarantola M, Devreotes PN.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7727-E7736. doi: 10.1073/pnas.1616600114. Epub 2017 Aug 28. Erratum in: Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6670.

9.

Excitable Signal Transduction Networks in Directed Cell Migration.

Devreotes PN, Bhattacharya S, Edwards M, Iglesias PA, Lampert T, Miao Y.

Annu Rev Cell Dev Biol. 2017 Oct 6;33:103-125. doi: 10.1146/annurev-cellbio-100616-060739. Epub 2017 Aug 9. Review.

10.

NKCC1 Regulates Migration Ability of Glioblastoma Cells by Modulation of Actin Dynamics and Interacting with Cofilin.

Schiapparelli P, Guerrero-Cazares H, Magaña-Maldonado R, Hamilla SM, Ganaha S, Goulin Lippi Fernandes E, Huang CH, Aranda-Espinoza H, Devreotes P, Quinones-Hinojosa A.

EBioMedicine. 2017 Jul;21:94-103. doi: 10.1016/j.ebiom.2017.06.020. Epub 2017 Jun 21.

11.

A Tunable Brake for HECT Ubiquitin Ligases.

Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel LM, Gabelli SB, Cole PA.

Mol Cell. 2017 May 4;66(3):345-357.e6. doi: 10.1016/j.molcel.2017.03.020.

12.

Altering the threshold of an excitable signal transduction network changes cell migratory modes.

Miao Y, Bhattacharya S, Edwards M, Cai H, Inoue T, Iglesias PA, Devreotes PN.

Nat Cell Biol. 2017 Apr;19(4):329-340. doi: 10.1038/ncb3495. Epub 2017 Mar 27.

13.

Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks.

Artemenko Y, Axiotakis L Jr, Borleis J, Iglesias PA, Devreotes PN.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7500-E7509. Epub 2016 Nov 7. Erratum in: Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6669.

14.

Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration.

Hoeller O, Toettcher JE, Cai H, Sun Y, Huang CH, Freyre M, Zhao M, Devreotes PN, Weiner OD.

PLoS Biol. 2016 Feb 18;14(2):e1002381. doi: 10.1371/journal.pbio.1002381. eCollection 2016 Feb.

15.

Signaling networks that regulate cell migration.

Devreotes P, Horwitz AR.

Cold Spring Harb Perspect Biol. 2015 Aug 3;7(8):a005959. doi: 10.1101/cshperspect.a005959. Review.

16.

Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN.

Nguyen HN, Yang JM, Miyamoto T, Itoh K, Rho E, Zhang Q, Inoue T, Devreotes PN, Sesaki H, Iijima M.

Sci Rep. 2015 Jul 28;5:12600. doi: 10.1038/srep12600.

17.

The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium.

Santhanam B, Cai H, Devreotes PN, Shaulsky G, Katoh-Kurasawa M.

Nat Commun. 2015 Jul 6;6:7551. doi: 10.1038/ncomms8551.

18.

Novel protein Callipygian defines the back of migrating cells.

Swaney KF, Borleis J, Iglesias PA, Devreotes PN.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3845-54. doi: 10.1073/pnas.1509098112. Epub 2015 Jun 30.

19.

A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum.

Gao R, Zhao S, Jiang X, Sun Y, Zhao S, Gao J, Borleis J, Willard S, Tang M, Cai H, Kamimura Y, Huang Y, Jiang J, Huang Z, Mogilner A, Pan T, Devreotes PN, Zhao M.

Sci Signal. 2015 May 26;8(378):ra50. doi: 10.1126/scisignal.aab0562.

20.

Engineering PTEN function: membrane association and activity.

Yang JM, Nguyen HN, Sesaki H, Devreotes PN, Iijima M.

Methods. 2015 May;77-78:119-24. doi: 10.1016/j.ymeth.2014.10.018. Epub 2014 Oct 22.

21.

The directional response of chemotactic cells depends on a balance between cytoskeletal architecture and the external gradient.

Wang MJ, Artemenko Y, Cai WJ, Iglesias PA, Devreotes PN.

Cell Rep. 2014 Nov 6;9(3):1110-21. doi: 10.1016/j.celrep.2014.09.047. Epub 2014 Oct 23.

22.

Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis.

Tang M, Wang M, Shi C, Iglesias PA, Devreotes PN, Huang CH.

Nat Commun. 2014 Oct 27;5:5175. doi: 10.1038/ncomms6175.

23.

A new class of cancer-associated PTEN mutations defined by membrane translocation defects.

Nguyen HN, Yang JM Jr, Rahdar M, Keniry M, Swaney KF, Parsons R, Park BH, Sesaki H, Devreotes PN, Iijima M.

Oncogene. 2015 Jul;34(28):3737-43. doi: 10.1038/onc.2014.293. Epub 2014 Sep 29.

24.

A unified nomenclature and amino acid numbering for human PTEN.

Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR.

Sci Signal. 2014 Jul 1;7(332):pe15. doi: 10.1126/scisignal.2005560.

25.

Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities.

Nguyen HN, Yang JM, Afkari Y, Park BH, Sesaki H, Devreotes PN, Iijima M.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2684-93. doi: 10.1073/pnas.1409433111. Epub 2014 Jun 16.

26.

Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes.

Artemenko Y, Lampert TJ, Devreotes PN.

Cell Mol Life Sci. 2014 Oct;71(19):3711-47. doi: 10.1007/s00018-014-1638-8. Epub 2014 May 21. Review.

27.

Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer.

Cai H, Katoh-Kurasawa M, Muramoto T, Santhanam B, Long Y, Li L, Ueda M, Iglesias PA, Shaulsky G, Devreotes PN.

Science. 2014 Mar 21;343(6177):1249531. doi: 10.1126/science.1249531.

28.

Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium.

Nguyen HN, Afkari Y, Senoo H, Sesaki H, Devreotes PN, Iijima M.

Oncogene. 2014 Dec 11;33(50):5688-96. doi: 10.1038/onc.2013.507. Epub 2013 Dec 2.

29.

An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration.

Huang CH, Tang M, Shi C, Iglesias PA, Devreotes PN.

Nat Cell Biol. 2013 Nov;15(11):1307-16. doi: 10.1038/ncb2859. Epub 2013 Oct 20.

30.

Multiple host kinases contribute to Akt activation during Salmonella infection.

Roppenser B, Kwon H, Canadien V, Xu R, Devreotes PN, Grinstein S, Brumell JH.

PLoS One. 2013 Aug 22;8(8):e71015. doi: 10.1371/journal.pone.0071015. eCollection 2013.

31.

Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells.

Shi C, Huang CH, Devreotes PN, Iglesias PA.

PLoS Comput Biol. 2013;9(7):e1003122. doi: 10.1371/journal.pcbi.1003122. Epub 2013 Jul 4.

32.

Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis.

Bolduc D, Rahdar M, Tu-Sekine B, Sivakumaren SC, Raben D, Amzel LM, Devreotes P, Gabelli SB, Cole P.

Elife. 2013 Jul 9;2:e00691. doi: 10.7554/eLife.00691.

33.

3D arrays for high throughput assay of cell migration and electrotaxis.

Zhao S, Gao R, Devreotes PN, Mogilner A, Zhao M.

Cell Biol Int. 2013 Sep;37(9):995-1002. doi: 10.1002/cbin.10116. Epub 2013 May 7. Erratum in: Cell Biol Int. 2014 Aug;38(8):987.

34.

Hippo on the move: tumor suppressor regulates adhesion and migration.

Artemenko Y, Devreotes PN.

Cell Cycle. 2013 Feb 15;12(4):535-6. doi: 10.4161/cc.23668. Epub 2013 Jan 31. No abstract available.

35.

Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion.

Artemenko Y, Batsios P, Borleis J, Gagnon Z, Lee J, Rohlfs M, Sanséau D, Willard SS, Schleicher M, Devreotes PN.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13632-7. doi: 10.1073/pnas.1211304109. Epub 2012 Jul 30.

36.

Quantitative characterization of the lipid encapsulation of quantum dots for biomedical applications.

Galloway JF, Winter A, Lee KH, Park JH, Dvoracek CM, Devreotes P, Searson PC.

Nanomedicine. 2012 Oct;8(7):1190-9. doi: 10.1016/j.nano.2011.12.002. Epub 2011 Dec 23.

37.

Biased excitable networks: how cells direct motion in response to gradients.

Iglesias PA, Devreotes PN.

Curr Opin Cell Biol. 2012 Apr;24(2):245-53. doi: 10.1016/j.ceb.2011.11.009. Epub 2011 Dec 10. Review.

38.

Analysis of chemotaxis in Dictyostelium.

Cai H, Huang CH, Devreotes PN, Iijima M.

Methods Mol Biol. 2012;757:451-68. doi: 10.1007/978-1-61779-166-6_26.

39.

Generation of cells that ignore the effects of PIP3 on cytoskeleton.

Tang M, Iijima M, Devreotes P.

Cell Cycle. 2011 Sep 1;10(17):2817-8. Epub 2011 Sep 1. No abstract available.

40.

Moving in the right direction: how eukaryotic cells migrate along chemical gradients.

Cai H, Devreotes PN.

Semin Cell Dev Biol. 2011 Oct;22(8):834-41. doi: 10.1016/j.semcdb.2011.07.020. Epub 2011 Jul 28. Review.

41.

Assessment of development and chemotaxis in Dictyostelium discoideum mutants.

Artemenko Y, Swaney KF, Devreotes PN.

Methods Mol Biol. 2011;769:287-309. doi: 10.1007/978-1-61779-207-6_20.

42.

Different roles of membrane potentials in electrotaxis and chemotaxis of dictyostelium cells.

Gao RC, Zhang XD, Sun YH, Kamimura Y, Mogilner A, Devreotes PN, Zhao M.

Eukaryot Cell. 2011 Sep;10(9):1251-6. doi: 10.1128/EC.05066-11. Epub 2011 Jul 8.

43.

Disrupting microtubule network immobilizes amoeboid chemotactic receptor in the plasma membrane.

de Keijzer S, Galloway J, Harms GS, Devreotes PN, Iglesias PA.

Biochim Biophys Acta. 2011 Jun;1808(6):1701-8. doi: 10.1016/j.bbamem.2011.02.009. Epub 2011 Feb 18.

44.

Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN.

Tang M, Iijima M, Kamimura Y, Chen L, Long Y, Devreotes P.

Mol Biol Cell. 2011 Feb 15;22(4):437-47. doi: 10.1091/mbc.E10-06-0522. Epub 2010 Dec 17.

45.

QnAs with Peter N. Devreotes. Interview by Prashant Nair.

Devreotes PN.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19613. doi: 10.1073/pnas.1014645107. Epub 2010 Oct 18. No abstract available.

46.

Cells navigate with a local-excitation, global-inhibition-biased excitable network.

Xiong Y, Huang CH, Iglesias PA, Devreotes PN.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17079-86. doi: 10.1073/pnas.1011271107. Epub 2010 Sep 23.

47.

Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis.

Cai H, Das S, Kamimura Y, Long Y, Parent CA, Devreotes PN.

J Cell Biol. 2010 Jul 26;190(2):233-45. doi: 10.1083/jcb.201001129.

48.

Automated characterization of cell shape changes during amoeboid motility by skeletonization.

Xiong Y, Kabacoff C, Franca-Koh J, Devreotes PN, Robinson DN, Iglesias PA.

BMC Syst Biol. 2010 Mar 24;4:33. doi: 10.1186/1752-0509-4-33.

49.

Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity.

Swaney KF, Huang CH, Devreotes PN.

Annu Rev Biophys. 2010;39:265-89. doi: 10.1146/annurev.biophys.093008.131228. Review.

50.

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