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Items: 1 to 50 of 89

1.

Assessment of Dried Blood Spots for Multi-Mycotoxin Biomarker Analysis in Pigs and Broiler Chickens.

Lauwers M, Croubels S, De Baere S, Sevastiyanova M, Romera Sierra EM, Letor B, Gougoulias C, Devreese M.

Toxins (Basel). 2019 Sep 18;11(9). pii: E541. doi: 10.3390/toxins11090541.

2.

Oral group medication in pig production: characterising medicated feed and drinking water systems.

Vandael F, Filippitzi ME, Dewulf J, Daeseleire E, Eeckhout M, Devreese M, Croubels S.

Vet Rec. 2019 Oct 5;185(13):405. doi: 10.1136/vr.105495. Epub 2019 Aug 19.

PMID:
31427411
3.

Alfaxalone total intravenous anaesthesia in dogs: pharmacokinetics, cardiovascular data and recovery characteristics.

Dehuisser V, Bosmans T, Devreese M, Gehring R, Croubels S, Duchateau L, Polis I.

Vet Anaesth Analg. 2019 Sep;46(5):605-612. doi: 10.1016/j.vaa.2019.04.014. Epub 2019 Jun 8.

PMID:
31395484
4.

In Vivo Metabolism of Ibuprofen in Growing Conventional Pigs: A Pharmacokinetic Approach.

Millecam J, De Baere S, Croubels S, Devreese M.

Front Pharmacol. 2019 Jun 27;10:712. doi: 10.3389/fphar.2019.00712. eCollection 2019.

5.

Gastrostomy tube placement via a laparotomic procedure in growing conventional piglets to perform multi-dose preclinical paediatric drug studies.

Millecam J, van Bergen T, Devreese M, Schauvliege S, Martens A, Chiers K, Croubels S, Antonissen G.

Lab Anim. 2019 Jun 26:23677219857106. doi: 10.1177/0023677219857106. [Epub ahead of print]

PMID:
31242071
6.

Characterization of Porcine Hepatic and Intestinal Drug Metabolizing CYP450: Comparison with Human Orthologues from A Quantitative, Activity and Selectivity Perspective.

Schelstraete W, Clerck L, Govaert E, Millecam J, Devreese M, Deforce D, Bocxlaer JV, Croubels S.

Sci Rep. 2019 Jun 25;9(1):9233. doi: 10.1038/s41598-019-45212-0.

7.

Pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs (Cavia porcellus).

Moeremans I, Devreese M, De Baere S, Croubels S, Hermans K.

Vet Anaesth Analg. 2019 Jul;46(4):548-555. doi: 10.1016/j.vaa.2018.11.011. Epub 2019 Mar 23.

PMID:
31153785
8.

Corrigendum to "Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of iohexol, p-aminohippuric acid and creatinine in porcine and broiler chicken plasma" [J. Chromatogr. B 1117 (2019) 77-85].

Dhondt L, Croubels S, De Cock P, De Paepe P, De Baere S, Devreese M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Aug 15;1124:375. doi: 10.1016/j.jchromb.2019.05.022. Epub 2019 May 29. No abstract available.

PMID:
31151834
9.

Developmental Pharmacokinetics and Safety of Ibuprofen and Its Enantiomers in the Conventional Pig as Potential Pediatric Animal Model.

Millecam J, van Bergen T, Schauvliege S, Antonissen G, Martens A, Chiers K, Gehring R, Gasthuys E, Vande Walle J, Croubels S, Devreese M.

Front Pharmacol. 2019 May 9;10:505. doi: 10.3389/fphar.2019.00505. eCollection 2019.

10.

Impact of Subacute Exposure to T-2 Toxin and Zearalenone on the Pharmacokinetics of Midazolam as CYP3A Probe Drug in a Porcine Animal Model: A Pilot Study.

Schelstraete W, Devreese M, Croubels S.

Front Pharmacol. 2019 Apr 16;10:399. doi: 10.3389/fphar.2019.00399. eCollection 2019.

11.

Use of non-steroidal anti-inflammatory drugs in porcine health management.

Schoos A, Devreese M, Maes DG.

Vet Rec. 2019 Aug 10;185(6):172. doi: 10.1136/vr.105170. Epub 2019 Apr 30. Review.

PMID:
31040220
12.

Quantitative risk model to estimate the level of antimicrobial residues that can be transferred to soil via manure, due to oral treatments of pigs.

Filippitzi ME, Devreese M, Broekaert K, Rasschaert G, Daeseleire E, Meirlaen J, Dewulf J.

Prev Vet Med. 2019 Jun 1;167:90-100. doi: 10.1016/j.prevetmed.2019.03.022. Epub 2019 Mar 28.

PMID:
31027728
13.

Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of iohexol, p-aminohippuric acid and creatinine in porcine and broiler chicken plasma.

Dhondt L, Croubels S, De Cock P, De Paepe P, De Baere S, Devreese M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jun 1;1117:77-85. doi: 10.1016/j.jchromb.2019.04.017. Epub 2019 Apr 8. Erratum in: J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Aug 15;1124:375.

PMID:
31004849
14.

Biomarkers for Exposure as A Tool for Efficacy Testing of A Mycotoxin Detoxifier in Broiler Chickens and Pigs.

Lauwers M, Croubels S, Letor B, Gougoulias C, Devreese M.

Toxins (Basel). 2019 Mar 28;11(4). pii: E187. doi: 10.3390/toxins11040187.

15.

Multi LC-MS/MS and LC-HRMS Methods for Determination of 24 Mycotoxins including Major Phase I and II Biomarker Metabolites in Biological Matrices from Pigs and Broiler Chickens.

Lauwers M, De Baere S, Letor B, Rychlik M, Croubels S, Devreese M.

Toxins (Basel). 2019 Mar 19;11(3). pii: E171. doi: 10.3390/toxins11030171.

16.

Insights into In Vivo Absolute Oral Bioavailability, Biotransformation, and Toxicokinetics of Zearalenone, α-Zearalenol, β-Zearalenol, Zearalenone-14-glucoside, and Zearalenone-14-sulfate in Pigs.

Catteuw A, Broekaert N, De Baere S, Lauwers M, Gasthuys E, Huybrechts B, Callebaut A, Ivanova L, Uhlig S, De Boevre M, De Saeger S, Gehring R, Devreese M, Croubels S.

J Agric Food Chem. 2019 Mar 27;67(12):3448-3458. doi: 10.1021/acs.jafc.8b05838. Epub 2019 Mar 13.

PMID:
30807145
17.

The role of roughage provision on the absorption and disposition of the mycotoxin deoxynivalenol and its acetylated derivatives in calves: from field observations to toxicokinetics.

Valgaeren B, Théron L, Croubels S, Devreese M, De Baere S, Van Pamel E, Daeseleire E, De Boevre M, De Saeger S, Vidal A, Di Mavungu JD, Fruhmann P, Adam G, Callebaut A, Bayrou C, Frisée V, Rao AS, Knapp E, Sartelet A, Pardon B, Deprez P, Antonissen G.

Arch Toxicol. 2019 Feb;93(2):293-310. doi: 10.1007/s00204-018-2368-8. Epub 2018 Dec 10.

18.

Similar Gastro-Intestinal Exposure to Florfenicol After Oral or Intramuscular Administration in Pigs, Leading to Resistance Selection in Commensal Escherichia coli.

De Smet J, Boyen F, Croubels S, Rasschaert G, Haesebrouck F, De Backer P, Devreese M.

Front Pharmacol. 2018 Nov 6;9:1265. doi: 10.3389/fphar.2018.01265. eCollection 2018.

19.

Development and validation of an LC-MS/MS method for the simultaneous determination of citrinin and ochratoxin a in a variety of feed and foodstuffs.

Meerpoel C, Vidal A, di Mavungu JD, Huybrechts B, Tangni EK, Devreese M, Croubels S, De Saeger S.

J Chromatogr A. 2018 Dec 14;1580:100-109. doi: 10.1016/j.chroma.2018.10.039. Epub 2018 Oct 22.

PMID:
30384965
20.

Comparative in vitro cytotoxicity of the emerging Fusarium mycotoxins beauvericin and enniatins to porcine intestinal epithelial cells.

Fraeyman S, Meyer E, Devreese M, Antonissen G, Demeyere K, Haesebrouck F, Croubels S.

Food Chem Toxicol. 2018 Nov;121:566-572. doi: 10.1016/j.fct.2018.09.053. Epub 2018 Sep 25.

PMID:
30266312
21.

In vitro model to assess the adsorption of oral veterinary drugs to mycotoxin binders in a feed- and aflatoxin B1-containing buffered matrix.

De Baere S, De Mil T, Antonissen G, Devreese M, Croubels S.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Sep;35(9):1728-1738. doi: 10.1080/19440049.2018.1501163. Epub 2018 Aug 6.

PMID:
30016205
22.

The Ontogeny of Cytochrome P450 Enzyme Activity and Protein Abundance in Conventional Pigs in Support of Preclinical Pediatric Drug Research.

Millecam J, De Clerck L, Govaert E, Devreese M, Gasthuys E, Schelstraete W, Deforce D, De Bock L, Van Bocxlaer J, Sys S, Croubels S.

Front Pharmacol. 2018 May 14;9:470. doi: 10.3389/fphar.2018.00470. eCollection 2018.

23.

Probabilistic risk model to assess the potential for resistance selection following the use of anti-microbial medicated feed in pigs.

Filippitzi ME, Chantziaras I, Devreese M, Dewulf J.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Jul;35(7):1266-1277. doi: 10.1080/19440049.2018.1461257. Epub 2018 May 30.

PMID:
29620436
24.

Population Pharmacokinetic Modeling of a Desmopressin Oral Lyophilisate in Growing Piglets as a Model for the Pediatric Population.

Gasthuys E, Vermeulen A, Croubels S, Millecam J, Schauvliege S, van Bergen T, De Bruyne P, Vande Walle J, Devreese M.

Front Pharmacol. 2018 Jan 31;9:41. doi: 10.3389/fphar.2018.00041. eCollection 2018.

25.

Comparative Toxicokinetics and Plasma Protein Binding of Ochratoxin A in Four Avian Species.

Devreese M, Croubels S, De Baere S, Gehring R, Antonissen G.

J Agric Food Chem. 2018 Mar 7;66(9):2129-2135. doi: 10.1021/acs.jafc.7b06048. Epub 2018 Feb 20.

PMID:
29417821
26.

Pharmacokinetics of florfenicol in turkey plasma, lung tissue, and pulmonary epithelial lining fluid after single oral bolus or continuous administration in the drinking water.

Watteyn A, Croubels S, De Baere S, De Backer P, Devreese M.

Poult Sci. 2018 Apr 1;97(4):1134-1140. doi: 10.3382/ps/pex416.

PMID:
29381781
27.

Chronic Dietary Intake of Enniatin B in Broiler Chickens Has Low Impact on Intestinal Morphometry and Hepatic Histology, and Shows Limited Transfer to Liver Tissue.

Fraeyman S, Croubels S, Devreese M, Ducatelle R, Rychlik M, Antonissen G.

Toxins (Basel). 2018 Jan 18;10(1). pii: E45. doi: 10.3390/toxins10010045.

28.

Storage stability study of porcine hepatic and intestinal cytochrome P450 isoenzymes by use of a newly developed and fully validated highly sensitive HPLC-MS/MS method.

Schelstraete W, Devreese M, Croubels S.

Anal Bioanal Chem. 2018 Feb;410(6):1833-1843. doi: 10.1007/s00216-017-0839-z. Epub 2018 Jan 11.

PMID:
29327113
29.

Pharmacokinetics and electrophysiological effects of sotalol hydrochloride in horses.

Broux B, De Clercq D, Decloedt A, Vera L, Devreese M, Gehring R, Croubels S, van Loon G.

Equine Vet J. 2018 May;50(3):377-383. doi: 10.1111/evj.12765. Epub 2017 Nov 1.

PMID:
29023952
30.

Role of mycotoxins in herds with and without problems with tail necrosis in neonatal pigs.

Van Limbergen T, Devreese M, Croubels S, Broekaert N, Michiels A, De Saeger S, Maes D.

Vet Rec. 2017 Nov 18;181(20):539. doi: 10.1136/vr.104385. Epub 2017 Oct 5.

PMID:
28982783
31.

Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus).

Dhondt L, Devreese M, Croubels S, De Baere S, Haesendonck R, Goessens T, Gehring R, De Backer P, Antonissen G.

Sci Rep. 2017 Sep 25;7(1):12043. doi: 10.1038/s41598-017-12159-z.

32.

Pharmacokinetic and urinary profiling reveals the prednisolone/cortisol ratio as a valid biomarker for prednisolone administration.

Van Meulebroek L, De Clercq N, Vanden Bussche J, Devreese M, Fichant E, Delahaut P, Croubels S, Vanhaecke L.

BMC Vet Res. 2017 Aug 14;13(1):236. doi: 10.1186/s12917-017-1158-5.

33.

Emerging Fusarium and Alternaria Mycotoxins: Occurrence, Toxicity and Toxicokinetics.

Fraeyman S, Croubels S, Devreese M, Antonissen G.

Toxins (Basel). 2017 Jul 18;9(7). pii: E228. doi: 10.3390/toxins9070228. Review.

34.

Postnatal Maturation of the Glomerular Filtration Rate in Conventional Growing Piglets As Potential Juvenile Animal Model for Preclinical Pharmaceutical Research.

Gasthuys E, Devreese M, Millecam J, Sys S, Vanderperren K, Delanghe J, Vande Walle J, Heyndrickx M, Croubels S.

Front Pharmacol. 2017 Jun 29;8:431. doi: 10.3389/fphar.2017.00431. eCollection 2017.

35.

Effect of administration route and dose alteration on sulfadiazine-trimethoprim plasma and intestinal concentrations in pigs.

De Smet J, Croubels S, De Backer P, Devreese M.

Int J Antimicrob Agents. 2017 Dec;50(6):707-714. doi: 10.1016/j.ijantimicag.2017.06.012. Epub 2017 Jun 28.

PMID:
28668685
36.

T-2 Toxin-3α-glucoside in Broiler Chickens: Toxicokinetics, Absolute Oral Bioavailability, and in Vivo Hydrolysis.

Broekaert N, Devreese M, De Boevre M, De Saeger S, Croubels S.

J Agric Food Chem. 2017 Jun 14;65(23):4797-4803. doi: 10.1021/acs.jafc.7b00698. Epub 2017 May 31.

PMID:
28520442
37.

Biotransformation of the mycotoxin enniatin B1 in pigs: A comparative in vitro and in vivo approach.

Ivanova L, Uhlig S, Devreese M, Croubels S, Fæste CK.

Food Chem Toxicol. 2017 Jul;105:506-517. doi: 10.1016/j.fct.2017.04.041. Epub 2017 May 2.

PMID:
28472676
38.

Repetitive urine and blood sampling in neonatal and weaned piglets for pharmacokinetic and pharmacodynamic modelling in drug discovery: a pilot study.

Gasthuys E, Schauvliege S, van Bergen T, Millecam J, Cerasoli I, Martens A, Gasthuys F, Vandecasteele T, Cornillie P, Van den Broeck W, Boyen F, Croubels S, Devreese M.

Lab Anim. 2017 Oct;51(5):498-508. doi: 10.1177/0023677217692372. Epub 2017 Feb 8.

PMID:
28178895
39.

Influence of mycotoxin binders on the oral bioavailability of tylosin, doxycycline, diclazuril, and salinomycin in fed broiler chickens.

De Mil T, Devreese M, Maes A, De Saeger S, De Backer P, Croubels S.

Poult Sci. 2017 Jul 1;96(7):2137-2144. doi: 10.3382/ps/pew503.

PMID:
28160001
40.

Impact of Fusarium mycotoxins on hepatic and intestinal mRNA expression of cytochrome P450 enzymes and drug transporters, and on the pharmacokinetics of oral enrofloxacin in broiler chickens.

Antonissen G, Devreese M, De Baere S, Martel A, Van Immerseel F, Croubels S.

Food Chem Toxicol. 2017 Mar;101:75-83. doi: 10.1016/j.fct.2017.01.006. Epub 2017 Jan 9.

PMID:
28082229
41.

The Impact of Deoxynivalenol on Pigeon Health: Occurrence in Feed, Toxicokinetics and Interaction with Salmonellosis.

Antonissen G, Haesendonck R, Devreese M, Broekaert N, Verbrugghe E, De Saeger S, Audenaert K, Haesebrouck F, Pasmans F, Ducatelle R, Croubels S, Martel A.

PLoS One. 2016 Dec 20;11(12):e0168205. doi: 10.1371/journal.pone.0168205. eCollection 2016.

42.

Residues of chlortetracycline, doxycycline and sulfadiazine-trimethoprim in intestinal content and feces of pigs due to cross-contamination of feed.

Peeters LE, Daeseleire E, Devreese M, Rasschaert G, Smet A, Dewulf J, Heyndrickx M, Imberechts H, Haesebrouck F, Butaye P, Croubels S.

BMC Vet Res. 2016 Sep 20;12:209. doi: 10.1186/s12917-016-0803-8.

43.

Comparative Oral Bioavailability, Toxicokinetics, and Biotransformation of Enniatin B1 and Enniatin B in Broiler Chickens.

Fraeyman S, Devreese M, Antonissen G, De Baere S, Rychlik M, Croubels S.

J Agric Food Chem. 2016 Sep 28;64(38):7259-64. doi: 10.1021/acs.jafc.6b02913. Epub 2016 Sep 15.

PMID:
27632250
44.

Feed contamination with Fusarium mycotoxins induces a corticosterone stress response in broiler chickens.

Antonissen G, De Baere S, Devreese M, Van Immerseel F, Martel A, Croubels S.

Poult Sci. 2017 Jan 1;96(1):14-17. Epub 2016 Sep 2.

PMID:
27591283
45.

GLP principles and their role in supporting pharmacokinetic and residue depletion studies for drug registration and licensing.

Croubels S, De Backer P, Devreese M.

Drug Test Anal. 2016 May;8(5-6):572-7. doi: 10.1002/dta.2009.

PMID:
27443213
46.

Comparative in vitro cytotoxicity of modified deoxynivalenol on porcine intestinal epithelial cells.

Broekaert N, Devreese M, Demeyere K, Berthiller F, Michlmayr H, Varga E, Adam G, Meyer E, Croubels S.

Food Chem Toxicol. 2016 Sep;95:103-9. doi: 10.1016/j.fct.2016.06.012. Epub 2016 Jun 21.

PMID:
27338712
47.

Efficacy of gamithromycin against Ornithobacterium rhinotracheale in turkey poults pre-infected with avian metapneumovirus.

Watteyn A, Devreese M, Plessers E, Wyns H, Garmyn A, Reddy VR, Pasmans F, Martel A, Haesebrouck F, De Backer P, Croubels S.

Avian Pathol. 2016 Oct;45(5):545-51. doi: 10.1080/03079457.2016.1183764.

PMID:
27171615
48.

In vivo contribution of deoxynivalenol-3-β-D-glucoside to deoxynivalenol exposure in broiler chickens and pigs: oral bioavailability, hydrolysis and toxicokinetics.

Broekaert N, Devreese M, van Bergen T, Schauvliege S, De Boevre M, De Saeger S, Vanhaecke L, Berthiller F, Michlmayr H, Malachová A, Adam G, Vermeulen A, Croubels S.

Arch Toxicol. 2017 Feb;91(2):699-712. doi: 10.1007/s00204-016-1710-2. Epub 2016 Apr 21.

PMID:
27100115
49.

The Potential Use of Piglets as Human Pediatric Surrogate for Preclinical Pharmacokinetic and Pharmacodynamic Drug Testing.

Gasthuys E, Vandecasteele T, De Bruyne P, Walle JV, De Backer P, Cornillie P, Devreese M, Croubels S.

Curr Pharm Des. 2016;22(26):4069-85. Review.

PMID:
26935702
50.

Influence of Mycotoxin Binders on the Oral Bioavailability of Doxycycline in Pigs.

De Mil T, Devreese M, De Saeger S, Eeckhout M, De Backer P, Croubels S.

J Agric Food Chem. 2016 Mar 16;64(10):2120-6. doi: 10.1021/acs.jafc.5b06084. Epub 2016 Mar 8.

PMID:
26902900

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