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Items: 16

1.

Biocatalysis in drug discovery and development.

Fryszkowska A, Devine PN.

Curr Opin Chem Biol. 2020 Mar 10;55:151-160. doi: 10.1016/j.cbpa.2020.01.012. [Epub ahead of print] Review.

PMID:
32169795
2.

Design of an in vitro biocatalytic cascade for the manufacture of islatravir.

Huffman MA, Fryszkowska A, Alvizo O, Borra-Garske M, Campos KR, Canada KA, Devine PN, Duan D, Forstater JH, Grosser ST, Halsey HM, Hughes GJ, Jo J, Joyce LA, Kolev JN, Liang J, Maloney KM, Mann BF, Marshall NM, McLaughlin M, Moore JC, Murphy GS, Nawrat CC, Nazor J, Novick S, Patel NR, Rodriguez-Granillo A, Robaire SA, Sherer EC, Truppo MD, Whittaker AM, Verma D, Xiao L, Xu Y, Yang H.

Science. 2019 Dec 6;366(6470):1255-1259. doi: 10.1126/science.aay8484.

PMID:
31806816
3.

Hemoprotein-Catalyzed Cyclopropanation En Route to the Chiral Cyclopropanol Fragment of Grazoprevir.

Kim T, Kassim AM, Botejue A, Zhang C, Forte J, Rozzell D, Huffman MA, Devine PN, McIntosh JA.

Chembiochem. 2019 May 2;20(9):1129-1132. doi: 10.1002/cbic.201800652. Epub 2019 Mar 6.

PMID:
30666768
4.

Asymmetric synthesis of cis-2,5-disubstituted pyrrolidine, the core scaffold of β3-AR agonists.

Xu F, Chung JY, Moore JC, Liu Z, Yoshikawa N, Hoerrner RS, Lee J, Royzen M, Cleator E, Gibson AG, Dunn R, Maloney KM, Alam M, Goodyear A, Lynch J, Yasuda N, Devine PN.

Org Lett. 2013 Mar 15;15(6):1342-5. doi: 10.1021/ol400252p. Epub 2013 Mar 1.

PMID:
23451898
5.

Synthesis of vaniprevir (MK-7009): lactamization to prepare a 20-membered [corrected] macrocycle.

Song ZJ, Tellers DM, Journet M, Kuethe JT, Lieberman D, Humphrey G, Zhang F, Peng Z, Waters MS, Zewge D, Nolting A, Zhao D, Reamer RA, Dormer PG, Belyk KM, Davies IW, Devine PN, Tschaen DM.

J Org Chem. 2011 Oct 7;76(19):7804-15. doi: 10.1021/jo2011494. Epub 2011 Aug 31. Erratum in: J Org Chem. 2011 Nov 18;76(22):9553.

PMID:
21838271
6.

Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture.

Savile CK, Janey JM, Mundorff EC, Moore JC, Tam S, Jarvis WR, Colbeck JC, Krebber A, Fleitz FJ, Brands J, Devine PN, Huisman GW, Hughes GJ.

Science. 2010 Jul 16;329(5989):305-9. doi: 10.1126/science.1188934. Epub 2010 Jun 17.

7.

Synthesis of a tertiary carbinamide via a novel Rh-catalyzed asymmetric hydrogenation.

Limanto J, Shultz CS, Dorner B, Desmond RA, Devine PN, Krska SW.

J Org Chem. 2008 Feb 15;73(4):1639-42. doi: 10.1021/jo702429u. Epub 2008 Jan 11.

PMID:
18186647
8.

Advances in the enzymatic reduction of ketones.

Moore JC, Pollard DJ, Kosjek B, Devine PN.

Acc Chem Res. 2007 Dec;40(12):1412-9. Epub 2007 Dec 4. Review.

PMID:
18052114
9.

Chemo- and enantioselective routes to chiral fluorinated hydroxyketones using ketoreductases.

Grau BT, Devine PN, DiMichele LN, Kosjek B.

Org Lett. 2007 Nov 22;9(24):4951-4. Epub 2007 Oct 31.

PMID:
17973397
10.

Diastereoselective reductive amination of aryl trifluoromethyl ketones and alpha-amino esters.

Hughes G, Devine PN, Naber JR, O'shea PD, Foster BS, McKay DJ, Volante RP.

Angew Chem Int Ed Engl. 2007;46(11):1839-42. No abstract available.

PMID:
17450610
11.

Palladium-catalyzed regioselective arylation of imidazo[1,2-b][1,2,4]triazine: synthesis of an alpha 2/3-selective GABA agonist.

Gauthier DR Jr, Limanto J, Devine PN, Desmond RA, Szumigala RH Jr, Foster BS, Volante RP.

J Org Chem. 2005 Jul 22;70(15):5938-45.

PMID:
16018689
12.

An efficient chemoenzymatic approach to (S)-gamma-fluoroleucine ethyl ester.

Limanto J, Shafiee A, Devine PN, Upadhyay V, Desmond RA, Foster BR, Gauthier DR Jr, Reamer RA, Volante RP.

J Org Chem. 2005 Mar 18;70(6):2372-5.

PMID:
15760235
13.

Facile synthesis of 2-bromo-3-fluorobenzonitrile: an application and study of the halodeboronation of aryl boronic acids.

Szumigala RH Jr, Devine PN, Gauthier DR Jr, Volante RP.

J Org Chem. 2004 Jan 23;69(2):566-9.

PMID:
14725476
14.

A regioselective approach to 5-substituted-3-amino-1,2,4-triazines.

Limanto J, Desmond RA, Gauthier DR Jr, Devine PN, Reamer RA, Volante RP.

Org Lett. 2003 Jun 26;5(13):2271-4.

PMID:
12816426
15.

Efficient synthesis of NK(1) receptor antagonist aprepitant using a crystallization-induced diastereoselective transformation.

Brands KM, Payack JF, Rosen JD, Nelson TD, Candelario A, Huffman MA, Zhao MM, Li J, Craig B, Song ZJ, Tschaen DM, Hansen K, Devine PN, Pye PJ, Rossen K, Dormer PG, Reamer RA, Welch CJ, Mathre DJ, Tsou NN, McNamara JM, Reider PJ.

J Am Chem Soc. 2003 Feb 26;125(8):2129-35.

PMID:
12590540
16.

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