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Items: 1 to 50 of 114

1.

Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.

Young-Baird SK, Lourenço MB, Elder MK, Klann E, Liebau S, Dever TE.

Mol Cell. 2019 Dec 3. pii: S1097-2765(19)30837-8. doi: 10.1016/j.molcel.2019.11.008. [Epub ahead of print]

PMID:
31836389
2.

Impaired EIF2S3 function associated with a novel phenotype of X-linked hypopituitarism with glucose dysregulation.

Gregory LC, Ferreira CB, Young-Baird SK, Williams HJ, Harakalova M, van Haaften G, Rahman SA, Gaston-Massuet C, Kelberman D, GOSgene, Qasim W, Camper SA, Dever TE, Shah P, Robinson ICAF, Dattani MT.

EBioMedicine. 2019 Apr;42:470-480. doi: 10.1016/j.ebiom.2019.03.013. Epub 2019 Mar 14.

3.

MEHMO syndrome mutation EIF2S3-I259M impairs initiator Met-tRNAiMet binding to eukaryotic translation initiation factor eIF2.

Young-Baird SK, Shin BS, Dever TE.

Nucleic Acids Res. 2019 Jan 25;47(2):855-867. doi: 10.1093/nar/gky1213.

4.

Roles of polyamines in translation.

Dever TE, Ivanov IP.

J Biol Chem. 2018 Nov 30;293(48):18719-18729. doi: 10.1074/jbc.TM118.003338. Epub 2018 Oct 15. Review.

5.

Polyamine Control of Translation Elongation Regulates Start Site Selection on Antizyme Inhibitor mRNA via Ribosome Queuing.

Ivanov IP, Shin BS, Loughran G, Tzani I, Young-Baird SK, Cao C, Atkins JF, Dever TE.

Mol Cell. 2018 Apr 19;70(2):254-264.e6. doi: 10.1016/j.molcel.2018.03.015.

6.

Translation Elongation and Recoding in Eukaryotes.

Dever TE, Dinman JD, Green R.

Cold Spring Harb Perspect Biol. 2018 Aug 1;10(8). pii: a032649. doi: 10.1101/cshperspect.a032649. Review.

7.

Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis.

Shin BS, Katoh T, Gutierrez E, Kim JR, Suga H, Dever TE.

Nucleic Acids Res. 2017 Aug 21;45(14):8392-8402. doi: 10.1093/nar/gkx532.

8.

eIF5A Functions Globally in Translation Elongation and Termination.

Schuller AP, Wu CC, Dever TE, Buskirk AR, Green R.

Mol Cell. 2017 Apr 20;66(2):194-205.e5. doi: 10.1016/j.molcel.2017.03.003. Epub 2017 Apr 6.

9.

EIF2S3 Mutations Associated with Severe X-Linked Intellectual Disability Syndrome MEHMO.

Skopkova M, Hennig F, Shin BS, Turner CE, Stanikova D, Brennerova K, Stanik J, Fischer U, Henden L, Müller U, Steinberger D, Leshinsky-Silver E, Bottani A, Kurdiova T, Ukropec J, Nyitrayova O, Kolnikova M, Klimes I, Borck G, Bahlo M, Haas SA, Kim JR, Lotspeich-Cole LE, Gasperikova D, Dever TE, Kalscheuer VM.

Hum Mutat. 2017 Apr;38(4):409-425. doi: 10.1002/humu.23170. Epub 2017 Jan 23.

10.

Molecular insights into protein synthesis with proline residues.

Melnikov S, Mailliot J, Rigger L, Neuner S, Shin BS, Yusupova G, Dever TE, Micura R, Yusupov M.

EMBO Rep. 2016 Dec;17(12):1776-1784. Epub 2016 Nov 8.

11.

Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome.

Melnikov S, Mailliot J, Shin BS, Rigger L, Yusupova G, Micura R, Dever TE, Yusupov M.

J Mol Biol. 2016 Sep 11;428(18):3570-3576. doi: 10.1016/j.jmb.2016.05.011. Epub 2016 May 16.

12.

Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae.

Dever TE, Kinzy TG, Pavitt GD.

Genetics. 2016 May;203(1):65-107. doi: 10.1534/genetics.115.186221. Review.

13.

Structural characterization of ribosome recruitment and translocation by type IV IRES.

Murray J, Savva CG, Shin BS, Dever TE, Ramakrishnan V, Fernández IS.

Elife. 2016 May 9;5. pii: e13567. doi: 10.7554/eLife.13567.

14.

Baculovirus protein PK2 subverts eIF2α kinase function by mimicry of its kinase domain C-lobe.

Li JJ, Cao C, Fixsen SM, Young JM, Ono C, Bando H, Elde NC, Katsuma S, Dever TE, Sicheri F.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4364-73. doi: 10.1073/pnas.1505481112. Epub 2015 Jul 27.

15.

Evidence That Base-pairing Interaction between Intron and mRNA Leader Sequences Inhibits Initiation of HAC1 mRNA Translation in Yeast.

Sathe L, Bolinger C, Mannan MA, Dever TE, Dey M.

J Biol Chem. 2015 Sep 4;290(36):21821-32. doi: 10.1074/jbc.M115.649335. Epub 2015 Jul 14.

16.

The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo.

Visweswaraiah J, Pittman Y, Dever TE, Hinnebusch AG.

Elife. 2015 Jul 2;4:e07939. doi: 10.7554/eLife.07939.

17.

An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α.

Rojas M, Vasconcelos G, Dever TE.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3466-75. doi: 10.1073/pnas.1501557112. Epub 2015 Jun 22.

18.

The hypusine-containing translation factor eIF5A.

Dever TE, Gutierrez E, Shin BS.

Crit Rev Biochem Mol Biol. 2014 Sep-Oct;49(5):413-25. doi: 10.3109/10409238.2014.939608. Epub 2014 Jul 17. Review.

19.

Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cells.

Lageix S, Rothenburg S, Dever TE, Hinnebusch AG.

PLoS Genet. 2014 May 8;10(5):e1004326. doi: 10.1371/journal.pgen.1004326. eCollection 2014 May.

20.

Protein phosphatase PP1/GLC7 interaction domain in yeast eIF2γ bypasses targeting subunit requirement for eIF2α dephosphorylation.

Rojas M, Gingras AC, Dever TE.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1344-53. doi: 10.1073/pnas.1400129111. Epub 2014 Mar 24.

21.

Variola virus E3L Zα domain, but not its Z-DNA binding activity, is required for PKR inhibition.

Thakur M, Seo EJ, Dever TE.

RNA. 2014 Feb;20(2):214-27. doi: 10.1261/rna.042341.113. Epub 2013 Dec 13.

22.

eIF5A promotes translation of polyproline motifs.

Gutierrez E, Shin BS, Woolstenhulme CJ, Kim JR, Saini P, Buskirk AR, Dever TE.

Mol Cell. 2013 Jul 11;51(1):35-45. doi: 10.1016/j.molcel.2013.04.021. Epub 2013 May 30.

23.

eIF2γ mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation.

Borck G, Shin BS, Stiller B, Mimouni-Bloch A, Thiele H, Kim JR, Thakur M, Skinner C, Aschenbach L, Smirin-Yosef P, Har-Zahav A, Nürnberg G, Altmüller J, Frommolt P, Hofmann K, Konen O, Nürnberg P, Munnich A, Schwartz CE, Gothelf D, Colleaux L, Dever TE, Kubisch C, Basel-Vanagaite L.

Mol Cell. 2012 Nov 30;48(4):641-6. doi: 10.1016/j.molcel.2012.09.005. Epub 2012 Oct 11.

24.

The elongation, termination, and recycling phases of translation in eukaryotes.

Dever TE, Green R.

Cold Spring Harb Perspect Biol. 2012 Jul 1;4(7):a013706. doi: 10.1101/cshperspect.a013706. Review.

25.

Molecular biology. A new start for protein synthesis.

Dever TE.

Science. 2012 Jun 29;336(6089):1645-6. doi: 10.1126/science.1224439. No abstract available.

PMID:
22745408
26.

PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium.

Zhang M, Mishra S, Sakthivel R, Rojas M, Ranjan R, Sullivan WJ Jr, Fontoura BM, Ménard R, Dever TE, Nussenzweig V.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3956-61. doi: 10.1073/pnas.1121567109. Epub 2012 Feb 21.

27.

Initiation factor eIF2γ promotes eIF2-GTP-Met-tRNAi(Met) ternary complex binding to the 40S ribosome.

Shin BS, Kim JR, Walker SE, Dong J, Lorsch JR, Dever TE.

Nat Struct Mol Biol. 2011 Oct 16;18(11):1227-34. doi: 10.1038/nsmb.2133.

28.

Characterization of a ranavirus inhibitor of the antiviral protein kinase PKR.

Rothenburg S, Chinchar VG, Dever TE.

BMC Microbiol. 2011 Mar 18;11:56. doi: 10.1186/1471-2180-11-56.

29.

Requirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51.

Dey M, Velyvis A, Li JJ, Chiu E, Chiovitti D, Kay LE, Sicheri F, Dever TE.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4316-21. doi: 10.1073/pnas.1014872108. Epub 2011 Feb 28.

30.

Structural integrity of {alpha}-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability.

Shin BS, Acker MG, Kim JR, Maher KN, Arefin SM, Lorsch JR, Dever TE.

RNA. 2011 Apr;17(4):687-96. doi: 10.1261/rna.2412511. Epub 2011 Feb 18.

31.

Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation.

Lorsch JR, Dever TE.

J Biol Chem. 2010 Jul 9;285(28):21203-7. doi: 10.1074/jbc.R110.119743. Epub 2010 May 5. Review.

32.

Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation.

Dev K, Santangelo TJ, Rothenburg S, Neculai D, Dey M, Sicheri F, Dever TE, Reeve JN, Hinnebusch AG.

J Mol Biol. 2009 Sep 25;392(3):701-22. doi: 10.1016/j.jmb.2009.07.030. Epub 2009 Jul 17.

33.

Hypusine-containing protein eIF5A promotes translation elongation.

Saini P, Eyler DE, Green R, Dever TE.

Nature. 2009 May 7;459(7243):118-21. doi: 10.1038/nature08034.

34.

A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2.

Gárriz A, Qiu H, Dey M, Seo EJ, Dever TE, Hinnebusch AG.

Mol Cell Biol. 2009 Mar;29(6):1592-607. doi: 10.1128/MCB.01446-08. Epub 2008 Dec 29.

35.

Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors.

Rothenburg S, Seo EJ, Gibbs JS, Dever TE, Dittmar K.

Nat Struct Mol Biol. 2009 Jan;16(1):63-70. doi: 10.1038/nsmb.1529. Epub 2008 Nov 30.

36.

rRNA suppressor of a eukaryotic translation initiation factor 5B/initiation factor 2 mutant reveals a binding site for translational GTPases on the small ribosomal subunit.

Shin BS, Kim JR, Acker MG, Maher KN, Lorsch JR, Dever TE.

Mol Cell Biol. 2009 Feb;29(3):808-21. doi: 10.1128/MCB.00896-08. Epub 2008 Nov 24.

37.

Kinetic analysis of late steps of eukaryotic translation initiation.

Acker MG, Shin BS, Nanda JS, Saini AK, Dever TE, Lorsch JR.

J Mol Biol. 2009 Jan 16;385(2):491-506. doi: 10.1016/j.jmb.2008.10.029. Epub 2008 Oct 19.

38.

Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein.

Seo EJ, Liu F, Kawagishi-Kobayashi M, Ung TL, Cao C, Dar AC, Sicheri F, Dever TE.

Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16894-9. doi: 10.1073/pnas.0805524105. Epub 2008 Oct 29.

39.

Translation initiation factor 2gamma mutant alters start codon selection independent of Met-tRNA binding.

Alone PV, Cao C, Dever TE.

Mol Cell Biol. 2008 Nov;28(22):6877-88. doi: 10.1128/MCB.01147-08. Epub 2008 Sep 15.

40.

Getting the message in protein synthesis. Keystone Symposium on Translational Regulatory Mechanisms.

Costa-Mattioli M, Bidinosti M, Dever TE.

EMBO Rep. 2008 Oct;9(10):954-9. doi: 10.1038/embor.2008.165. Epub 2008 Aug 29. Review. No abstract available.

41.
42.

Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing.

Lee KP, Dey M, Neculai D, Cao C, Dever TE, Sicheri F.

Cell. 2008 Jan 11;132(1):89-100. doi: 10.1016/j.cell.2007.10.057.

43.

Molecular genetic structure-function analysis of translation initiation factor eIF5B.

Shin BS, Dever TE.

Methods Enzymol. 2007;429:185-201.

PMID:
17913624
44.

Novel membrane-bound eIF2alpha kinase in the flagellar pocket of Trypanosoma brucei.

Moraes MC, Jesus TC, Hashimoto NN, Dey M, Schwartz KJ, Alves VS, Avila CC, Bangs JD, Dever TE, Schenkman S, Castilho BA.

Eukaryot Cell. 2007 Nov;6(11):1979-91. Epub 2007 Sep 14.

45.

Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining.

Fringer JM, Acker MG, Fekete CA, Lorsch JR, Dever TE.

Mol Cell Biol. 2007 Mar;27(6):2384-97. Epub 2007 Jan 22.

46.

Conserved intermolecular salt bridge required for activation of protein kinases PKR, GCN2, and PERK.

Dey M, Cao C, Sicheri F, Dever TE.

J Biol Chem. 2007 Mar 2;282(9):6653-60. Epub 2007 Jan 3.

47.

Intragenic suppressor mutations restore GTPase and translation functions of a eukaryotic initiation factor 5B switch II mutant.

Shin BS, Acker MG, Maag D, Kim JR, Lorsch JR, Dever TE.

Mol Cell Biol. 2007 Mar;27(5):1677-85. Epub 2006 Dec 22.

48.
49.

Interaction between eukaryotic initiation factors 1A and 5B is required for efficient ribosomal subunit joining.

Acker MG, Shin BS, Dever TE, Lorsch JR.

J Biol Chem. 2006 Mar 31;281(13):8469-75. Epub 2006 Feb 3.

50.

Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition.

Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F, Dever TE.

Cell. 2005 Sep 23;122(6):901-13.

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