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Items: 1 to 50 of 70

1.

Identification of Fatty Acid Binding Protein 5 Inhibitors Through Similarity-Based Screening.

Zhou Y, Elmes MW, Sweeney JM, Joseph OM, Che J, Hsu HC, Li H, Deutsch DG, Ojima I, Kaczocha M, Rizzo RC.

Biochemistry. 2019 Oct 22;58(42):4304-4316. doi: 10.1021/acs.biochem.9b00625. Epub 2019 Oct 11.

2.

Incarvillateine produces antinociceptive and motor suppressive effects via adenosine receptor activation.

Kim J, Bogdan DM, Elmes MW, Awwa M, Yan S, Che J, Lee G, Deutsch DG, Rizzo RC, Kaczocha M, Ojima I.

PLoS One. 2019 Jun 25;14(6):e0218619. doi: 10.1371/journal.pone.0218619. eCollection 2019.

3.

FABP1 controls hepatic transport and biotransformation of Δ9-THC.

Elmes MW, Prentis LE, McGoldrick LL, Giuliano CJ, Sweeney JM, Joseph OM, Che J, Carbonetti GS, Studholme K, Deutsch DG, Rizzo RC, Glynn SE, Kaczocha M.

Sci Rep. 2019 May 20;9(1):7588. doi: 10.1038/s41598-019-44108-3.

4.

SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins.

Yan S, Elmes MW, Tong S, Hu K, Awwa M, Teng GYH, Jing Y, Freitag M, Gan Q, Clement T, Wei L, Sweeney JM, Joseph OM, Che J, Carbonetti GS, Wang L, Bogdan DM, Falcone J, Smietalo N, Zhou Y, Ralph B, Hsu HC, Li H, Rizzo RC, Deutsch DG, Kaczocha M, Ojima I.

Eur J Med Chem. 2018 Jun 25;154:233-252. doi: 10.1016/j.ejmech.2018.04.050. Epub 2018 May 26.

5.

Fatty-acid-binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses.

Haj-Dahmane S, Shen RY, Elmes MW, Studholme K, Kanjiya MP, Bogdan D, Thanos PK, Miyauchi JT, Tsirka SE, Deutsch DG, Kaczocha M.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3482-3487. doi: 10.1073/pnas.1721339115. Epub 2018 Mar 12. Erratum in: Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4313.

6.

The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites.

Hsu HC, Tong S, Zhou Y, Elmes MW, Yan S, Kaczocha M, Deutsch DG, Rizzo RC, Ojima I, Li H.

Biochemistry. 2017 Jul 11;56(27):3454-3462. doi: 10.1021/acs.biochem.7b00194. Epub 2017 Jun 28.

7.

Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms.

Peng X, Studholme K, Kanjiya MP, Luk J, Bogdan D, Elmes MW, Carbonetti G, Tong S, Gary Teng YH, Rizzo RC, Li H, Deutsch DG, Ojima I, Rebecchi MJ, Puopolo M, Kaczocha M.

Mol Pain. 2017 Jan;13:1744806917697007. doi: 10.1177/1744806917697007.

9.

Fatty acid-binding proteins (FABPs) are intracellular carriers for Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD).

Elmes MW, Kaczocha M, Berger WT, Leung K, Ralph BP, Wang L, Sweeney JM, Miyauchi JT, Tsirka SE, Ojima I, Deutsch DG.

J Biol Chem. 2015 Apr 3;290(14):8711-21. doi: 10.1074/jbc.M114.618447. Epub 2015 Feb 9.

10.

Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia.

Kaczocha M, Rebecchi MJ, Ralph BP, Teng YH, Berger WT, Galbavy W, Elmes MW, Glaser ST, Wang L, Rizzo RC, Deutsch DG, Ojima I.

PLoS One. 2014 Apr 4;9(4):e94200. doi: 10.1371/journal.pone.0094200. eCollection 2014.

11.

Role of FAAH-like anandamide transporter in anandamide inactivation.

Leung K, Elmes MW, Glaser ST, Deutsch DG, Kaczocha M.

PLoS One. 2013 Nov 4;8(11):e79355. doi: 10.1371/journal.pone.0079355. eCollection 2013.

12.

Biosynthetic pathways of bioactive N-acylethanolamines in brain.

Tsuboi K, Ikematsu N, Uyama T, Deutsch DG, Tokumura A, Ueda N.

CNS Neurol Disord Drug Targets. 2013 Feb 1;12(1):7-16. Review.

PMID:
23394527
13.

Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugs.

Berger WT, Ralph BP, Kaczocha M, Sun J, Balius TE, Rizzo RC, Haj-Dahmane S, Ojima I, Deutsch DG.

PLoS One. 2012;7(12):e50968. doi: 10.1371/journal.pone.0050968. Epub 2012 Dec 7.

14.

Anandamide externally added to lipid vesicles containing trapped fatty acid amide hydrolase (FAAH) is readily hydrolyzed in a sterol-modulated fashion.

Kaczocha M, Lin Q, Nelson LD, McKinney MK, Cravatt BF, London E, Deutsch DG.

ACS Chem Neurosci. 2012 May 16;3(5):364-8. doi: 10.1021/cn300001w. Epub 2012 Jan 18.

15.

Fatty acid-binding proteins transport N-acylethanolamines to nuclear receptors and are targets of endocannabinoid transport inhibitors.

Kaczocha M, Vivieca S, Sun J, Glaser ST, Deutsch DG.

J Biol Chem. 2012 Jan 27;287(5):3415-24. doi: 10.1074/jbc.M111.304907. Epub 2011 Dec 14.

16.

Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways.

Tsuboi K, Okamoto Y, Ikematsu N, Inoue M, Shimizu Y, Uyama T, Wang J, Deutsch DG, Burns MP, Ulloa NM, Tokumura A, Ueda N.

Biochim Biophys Acta. 2011 Oct;1811(10):565-77. doi: 10.1016/j.bbalip.2011.07.009. Epub 2011 Jul 23.

PMID:
21801852
17.

Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice.

Wellner N, Tsuboi K, Madsen AN, Holst B, Diep TA, Nakao M, Tokumura A, Burns MP, Deutsch DG, Ueda N, Hansen HS.

Biochim Biophys Acta. 2011 Sep;1811(9):508-12. doi: 10.1016/j.bbalip.2011.06.020. Epub 2011 Jun 23.

PMID:
21723414
18.

Endocannabinoid tone versus constitutive activity of cannabinoid receptors.

Howlett AC, Reggio PH, Childers SR, Hampson RE, Ulloa NM, Deutsch DG.

Br J Pharmacol. 2011 Aug;163(7):1329-43. doi: 10.1111/j.1476-5381.2011.01364.x. Review.

19.

Unique pathway for anandamide synthesis and liver regeneration.

Izzo AA, Deutsch DG.

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6339-40. doi: 10.1073/pnas.1103566108. Epub 2011 Apr 13. No abstract available.

20.

Assessment of a spectrophotometric assay for monoacylglycerol lipase activity.

Ulloa NM, Deutsch DG.

AAPS J. 2010 Jun;12(2):197-201. doi: 10.1208/s12248-010-9180-6. Epub 2010 Feb 26. No abstract available.

21.

Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2.

Kaczocha M, Glaser ST, Chae J, Brown DA, Deutsch DG.

J Biol Chem. 2010 Jan 22;285(4):2796-806. doi: 10.1074/jbc.M109.058461. Epub 2009 Nov 19.

22.

Identification of intracellular carriers for the endocannabinoid anandamide.

Kaczocha M, Glaser ST, Deutsch DG.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6375-80. doi: 10.1073/pnas.0901515106. Epub 2009 Mar 23.

23.

2-Arachidonoylglycerol (2-AG) membrane transport: history and outlook.

Hermann A, Kaczocha M, Deutsch DG.

AAPS J. 2006;8(2):E409-12. Review.

24.

Endocannabinoids in the intact retina: 3 H-anandamide uptake, fatty acid amide hydrolase immunoreactivity and hydrolysis of anandamide.

Glaser ST, Deutsch DG, Studholme KM, Zimov S, Yazulla S.

Vis Neurosci. 2005 Nov-Dec;22(6):693-705.

PMID:
16469181
25.

Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase.

Kaczocha M, Hermann A, Glaser ST, Bojesen IN, Deutsch DG.

J Biol Chem. 2006 Apr 7;281(14):9066-75. Epub 2006 Feb 6.

26.

Toward an anandamide transporter.

Mechoulam R, Deutsch DG.

Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17541-2. Epub 2005 Nov 28. No abstract available.

27.

Design of on-target FAAH inhibitors.

Deutsch DG.

Chem Biol. 2005 Nov;12(11):1157-8.

28.

Anandamide transport: a critical review.

Glaser ST, Kaczocha M, Deutsch DG.

Life Sci. 2005 Aug 19;77(14):1584-604. Review.

PMID:
15979096
29.

Evidence against the presence of an anandamide transporter.

Glaser ST, Abumrad NA, Fatade F, Kaczocha M, Studholme KM, Deutsch DG.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4269-74. Epub 2003 Mar 24.

30.

The fatty acid amide hydrolase (FAAH).

Deutsch DG, Ueda N, Yamamoto S.

Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar;66(2-3):201-10. Review. Erratum in: Prostaglandins Leukot Essent Fatty Acids.2003 Jan;68(1):69..

PMID:
12052036
31.

Characterization of the 5'-sequence of the mouse fatty acid amide hydrolase.

Puffenbarger RA, Kapulina O, Howell JM, Deutsch DG.

Neurosci Lett. 2001 Nov 13;314(1-2):21-4.

PMID:
11698137
32.

Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide.

Day TA, Rakhshan F, Deutsch DG, Barker EL.

Mol Pharmacol. 2001 Jun;59(6):1369-75.

PMID:
11353795
33.

The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase.

Deutsch DG, Glaser ST, Howell JM, Kunz JS, Puffenbarger RA, Hillard CJ, Abumrad N.

J Biol Chem. 2001 Mar 9;276(10):6967-73. Epub 2000 Dec 15.

34.

The fatty acid amide hydrolase (FAAH).

Ueda N, Puffenbarger RA, Yamamoto S, Deutsch DG.

Chem Phys Lipids. 2000 Nov;108(1-2):107-21. Review.

PMID:
11106785
35.
36.

Cannabinoid properties of methylfluorophosphonate analogs.

Martin BR, Beletskaya I, Patrick G, Jefferson R, Winckler R, Deutsch DG, Di Marzo V, Dasse O, Mahadevan A, Razdan RK.

J Pharmacol Exp Ther. 2000 Sep;294(3):1209-18.

PMID:
10945879
37.

Immunocytochemical localization of cannabinoid CB1 receptor and fatty acid amide hydrolase in rat retina.

Yazulla S, Studholme KM, McIntosh HH, Deutsch DG.

J Comp Neurol. 1999 Dec 6;415(1):80-90.

PMID:
10540359
38.

Identification of two serine residues involved in catalysis by fatty acid amide hydrolase.

Omeir RL, Arreaza G, Deutsch DG.

Biochem Biophys Res Commun. 1999 Oct 22;264(2):316-20.

PMID:
10529361
39.
40.

Morphine and anandamide stimulate intracellular calcium transients in human arterial endothelial cells: coupling to nitric oxide release.

Fimiani C, Mattocks D, Cavani F, Salzet M, Deutsch DG, Pryor S, Bilfinger TV, Stefano GB.

Cell Signal. 1999 Mar;11(3):189-93.

PMID:
10353693
41.

Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry.

Tsou K, Nogueron MI, Muthian S, Sañudo-Pena MC, Hillard CJ, Deutsch DG, Walker JM.

Neurosci Lett. 1998 Oct 2;254(3):137-40.

PMID:
10214976
42.

Biochemistry of the endogenous ligands of cannabinoid receptors.

Di Marzo V, Deutsch DG.

Neurobiol Dis. 1998 Dec;5(6 Pt B):386-404. Review.

PMID:
9974173
43.

Pharmacological evidence for anandamide amidase in human cardiac and vascular tissues.

Bilfinger TV, Salzet M, Fimiani C, Deutsch DG, Tramu G, Stefano GB.

Int J Cardiol. 1998 Apr 30;64 Suppl 1:S15-22.

PMID:
9687088
44.

Anandamide amidase inhibition enhances anandamide-stimulated nitric oxide release in invertebrate neural tissues.

Stefano GB, Rialas CM, Deutsch DG, Salzet M.

Brain Res. 1998 May 18;793(1-2):341-5.

PMID:
9630717
45.

The cloned rat hydrolytic enzyme responsible for the breakdown of anandamide also catalyzes its formation via the condensation of arachidonic acid and ethanolamine.

Arreaza G, Devane WA, Omeir RL, Sajnani G, Kunz J, Cravatt BF, Deutsch DG.

Neurosci Lett. 1997 Sep 26;234(1):59-62.

PMID:
9347946
46.

Production and physiological actions of anandamide in the vasculature of the rat kidney.

Deutsch DG, Goligorsky MS, Schmid PC, Krebsbach RJ, Schmid HH, Das SK, Dey SK, Arreaza G, Thorup C, Stefano G, Moore LC.

J Clin Invest. 1997 Sep 15;100(6):1538-46.

47.

Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase.

Deutsch DG, Omeir R, Arreaza G, Salehani D, Prestwich GD, Huang Z, Howlett A.

Biochem Pharmacol. 1997 Feb 7;53(3):255-60.

PMID:
9065728
48.

Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor.

Deutsch DG, Lin S, Hill WA, Morse KL, Salehani D, Arreaza G, Omeir RL, Makriyannis A.

Biochem Biophys Res Commun. 1997 Feb 3;231(1):217-21.

PMID:
9070252
49.

Inhibitors of anandamide breakdown.

Deutsch DG, Makriyannis A.

NIDA Res Monogr. 1997;173:65-84. Review. No abstract available.

PMID:
9260184
50.

Arachidonoyl ethanolamide-[1,2-14C] as a substrate for anandamide amidase.

Omeir RL, Chin S, Hong Y, Ahern DG, Deutsch DG.

Life Sci. 1995;56(23-24):1999-2005.

PMID:
7776824

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