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Items: 1 to 50 of 105

1.

Deletion of CRH From GABAergic Forebrain Neurons Promotes Stress Resilience and Dampens Stress-Induced Changes in Neuronal Activity.

Dedic N, Kühne C, Gomes KS, Hartmann J, Ressler KJ, Schmidt MV, Deussing JM.

Front Neurosci. 2019 Sep 20;13:986. doi: 10.3389/fnins.2019.00986. eCollection 2019.

2.

Urocortin 3 signalling in the auditory brainstem aids recovery of hearing after reversible noise-induced threshold shift.

Fischl MJ, Ueberfuhr MA, Drexl M, Pagella S, Sinclair JL, Alexandrova O, Deussing JM, Kopp-Scheinpflug C.

J Physiol. 2019 Aug;597(16):4341-4355. doi: 10.1113/JP278132. Epub 2019 Jul 24.

PMID:
31270820
3.

Twenty-Seven Tamoxifen-Inducible iCre-Driver Mouse Strains for Eye and Brain, Including Seventeen Carrying a New Inducible-First Constitutive-Ready Allele.

Korecki AJ, Hickmott JW, Lam SL, Dreolini L, Mathelier A, Baker O, Kuehne C, Bonaguro RJ, Smith J, Tan CV, Zhou M, Goldowitz D, Deussing JM, Stewart AF, Wasserman WW, Holt RA, Simpson EM.

Genetics. 2019 Apr;211(4):1155-1177. doi: 10.1534/genetics.119.301984. Epub 2019 Feb 14.

4.

Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis.

Raftogianni A, Roth LC, García-González D, Bus T, Kühne C, Monyer H, Spergel DJ, Deussing JM, Grinevich V.

Front Mol Neurosci. 2018 Aug 30;11:305. doi: 10.3389/fnmol.2018.00305. eCollection 2018.

5.

The Corticotropin-Releasing Factor Family: Physiology of the Stress Response.

Deussing JM, Chen A.

Physiol Rev. 2018 Oct 1;98(4):2225-2286. doi: 10.1152/physrev.00042.2017. Review.

6.

P2X7 Receptor: A Potential Therapeutic Target for Depression?

Deussing JM, Arzt E.

Trends Mol Med. 2018 Sep;24(9):736-747. doi: 10.1016/j.molmed.2018.07.005. Epub 2018 Aug 6. Review.

PMID:
30093269
7.

The Role of m6A/m-RNA Methylation in Stress Response Regulation.

Engel M, Eggert C, Kaplick PM, Eder M, Röh S, Tietze L, Namendorf C, Arloth J, Weber P, Rex-Haffner M, Geula S, Jakovcevski M, Hanna JH, Leshkowitz D, Uhr M, Wotjak CT, Schmidt MV, Deussing JM, Binder EB, Chen A.

Neuron. 2018 Jul 25;99(2):389-403.e9. doi: 10.1016/j.neuron.2018.07.009.

8.

P2Y12 shRNA treatment decreases SGC activation to relieve diabetic neuropathic pain in type 2 diabetes mellitus rats.

Wang S, Wang Z, Li L, Zou L, Gong Y, Jia T, Zhao S, Yuan H, Shi L, Liu S, Wu B, Yi Z, Liu H, Gao Y, Li G, Deussing JM, Li M, Zhang C, Liang S.

J Cell Physiol. 2018 Dec;233(12):9620-9628. doi: 10.1002/jcp.26867. Epub 2018 Jun 26.

PMID:
29943819
9.

Stress peptides sensitize fear circuitry to promote passive coping.

Pliota P, Böhm V, Grössl F, Griessner J, Valenti O, Kraitsy K, Kaczanowska J, Pasieka M, Lendl T, Deussing JM, Haubensak W.

Mol Psychiatry. 2018 Jun 14. doi: 10.1038/s41380-018-0089-2. [Epub ahead of print]

10.

NPTX2 is a key component in the regulation of anxiety.

Chang S, Bok P, Tsai CY, Sun CP, Liu H, Deussing JM, Huang GJ.

Neuropsychopharmacology. 2018 Aug;43(9):1943-1953. doi: 10.1038/s41386-018-0091-z. Epub 2018 May 11.

11.

Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety.

Dedic N, Kühne C, Jakovcevski M, Hartmann J, Genewsky AJ, Gomes KS, Anderzhanova E, Pöhlmann ML, Chang S, Kolarz A, Vogl AM, Dine J, Metzger MW, Schmid B, Almada RC, Ressler KJ, Wotjak CT, Grinevich V, Chen A, Schmidt MV, Wurst W, Refojo D, Deussing JM.

Nat Neurosci. 2018 Jun;21(6):803-807. doi: 10.1038/s41593-018-0151-z. Epub 2018 May 21.

PMID:
29786085
12.

Chronic Stress Reduces Nectin-1 mRNA Levels and Disrupts Dendritic Spine Plasticity in the Adult Mouse Perirhinal Cortex.

Gong Q, Su YA, Wu C, Si TM, Deussing JM, Schmidt MV, Wang XD.

Front Cell Neurosci. 2018 Mar 13;12:67. doi: 10.3389/fncel.2018.00067. eCollection 2018.

13.

Mn2+ dynamics in manganese-enhanced MRI (MEMRI): Cav1.2 channel-mediated uptake and preferential accumulation in projection terminals.

Bedenk BT, Almeida-Corrêa S, Jurik A, Dedic N, Grünecker B, Genewsky AJ, Kaltwasser SF, Riebe CJ, Deussing JM, Czisch M, Wotjak CT.

Neuroimage. 2018 Apr 1;169:374-382. doi: 10.1016/j.neuroimage.2017.12.054. Epub 2017 Dec 19.

PMID:
29277401
14.

Dissociable Role of Corticotropin Releasing Hormone Receptor Subtype 1 on Dopaminergic and D1 Dopaminoceptive Neurons in Cocaine Seeking Behavior.

Bernardi RE, Broccoli L, Hirth N, Justice NJ, Deussing JM, Hansson AC, Spanagel R.

Front Behav Neurosci. 2017 Nov 13;11:221. doi: 10.3389/fnbeh.2017.00221. eCollection 2017.

15.

Heterozygosity for the Mood Disorder-Associated Variant Gln460Arg Alters P2X7 Receptor Function and Sleep Quality.

Metzger MW, Walser SM, Dedic N, Aprile-Garcia F, Jakubcakova V, Adamczyk M, Webb KJ, Uhr M, Refojo D, Schmidt MV, Friess E, Steiger A, Kimura M, Chen A, Holsboer F, Arzt E, Wurst W, Deussing JM.

J Neurosci. 2017 Nov 29;37(48):11688-11700. doi: 10.1523/JNEUROSCI.3487-16.2017. Epub 2017 Oct 27.

16.

Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood.

Dedic N, Pöhlmann ML, Richter JS, Mehta D, Czamara D, Metzger MW, Dine J, Bedenk BT, Hartmann J, Wagner KV, Jurik A, Almli LM, Lori A, Moosmang S, Hofmann F, Wotjak CT, Rammes G, Eder M, Chen A, Ressler KJ, Wurst W, Schmidt MV, Binder EB, Deussing JM.

Mol Psychiatry. 2018 Mar;23(3):533-543. doi: 10.1038/mp.2017.133. Epub 2017 Jul 11.

17.

Histone Modifications in Major Depressive Disorder and Related Rodent Models.

Deussing JM, Jakovcevski M.

Adv Exp Med Biol. 2017;978:169-183. doi: 10.1007/978-3-319-53889-1_9. Review.

PMID:
28523546
18.

cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells.

Inda C, Bonfiglio JJ, Dos Santos Claro PA, Senin SA, Armando NG, Deussing JM, Silberstein S.

Sci Rep. 2017 May 16;7(1):1944. doi: 10.1038/s41598-017-02021-7.

19.

Sequencing on the SOLiD 5500xl System - in-depth characterization of the GC bias.

Roeh S, Weber P, Rex-Haffner M, Deussing JM, Binder EB, Jakovcevski M.

Nucleus. 2017 Jul 4;8(4):370-380. doi: 10.1080/19491034.2017.1320461. Epub 2017 Apr 27.

20.

The CRF Family of Neuropeptides and their Receptors - Mediators of the Central Stress Response.

Dedic N, Chen A, Deussing JM.

Curr Mol Pharmacol. 2018;11(1):4-31. doi: 10.2174/1874467210666170302104053. Review.

21.

Involvement of GluN2B subunit containing N-methyl-d-aspartate (NMDA) receptors in mediating the acute and chronic synaptotoxic effects of oligomeric amyloid-beta (Aβ) in murine models of Alzheimer's disease (AD).

Rammes G, Mattusch C, Wulff M, Seeser F, Kreuzer M, Zhu K, Deussing JM, Herms J, Parsons CG.

Neuropharmacology. 2017 Sep 1;123:100-115. doi: 10.1016/j.neuropharm.2017.02.003. Epub 2017 Feb 4.

PMID:
28174113
22.

Differential Roles for L-Type Calcium Channel Subtypes in Alcohol Dependence.

Uhrig S, Vandael D, Marcantoni A, Dedic N, Bilbao A, Vogt MA, Hirth N, Broccoli L, Bernardi RE, Schönig K, Gass P, Bartsch D, Spanagel R, Deussing JM, Sommer WH, Carbone E, Hansson AC.

Neuropsychopharmacology. 2017 Apr;42(5):1058-1069. doi: 10.1038/npp.2016.266. Epub 2016 Dec 1.

23.

Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice.

Metzger MW, Walser SM, Aprile-Garcia F, Dedic N, Chen A, Holsboer F, Arzt E, Wurst W, Deussing JM.

Purinergic Signal. 2017 Jun;13(2):153-170. doi: 10.1007/s11302-016-9546-z. Epub 2016 Nov 17.

24.

Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics.

Shemesh Y, Forkosh O, Mahn M, Anpilov S, Sztainberg Y, Manashirov S, Shlapobersky T, Elliott E, Tabouy L, Ezra G, Adler ES, Ben-Efraim YJ, Gil S, Kuperman Y, Haramati S, Dine J, Eder M, Deussing JM, Schneidman E, Yizhar O, Chen A.

Nat Neurosci. 2016 Nov;19(11):1489-1496. doi: 10.1038/nn.4346. Epub 2016 Jul 18.

PMID:
27428651
25.

Prefrontal Cortex Corticotropin-Releasing Factor Receptor 1 Conveys Acute Stress-Induced Executive Dysfunction.

Uribe-Mariño A, Gassen NC, Wiesbeck MF, Balsevich G, Santarelli S, Solfrank B, Dournes C, Fries GR, Masana M, Labermeier C, Wang XD, Hafner K, Schmid B, Rein T, Chen A, Deussing JM, Schmidt MV.

Biol Psychiatry. 2016 Nov 15;80(10):743-753. doi: 10.1016/j.biopsych.2016.03.2106. Epub 2016 Apr 8.

PMID:
27318500
26.

Region-specific roles of the corticotropin-releasing factor-urocortin system in stress.

Henckens MJ, Deussing JM, Chen A.

Nat Rev Neurosci. 2016 Oct;17(10):636-51. doi: 10.1038/nrn.2016.94. Epub 2016 Sep 2. Review.

PMID:
27586075
27.

CRF receptor type 2 neurons in the posterior bed nucleus of the stria terminalis critically contribute to stress recovery.

Henckens MJAG, Printz Y, Shamgar U, Dine J, Lebow M, Drori Y, Kuehne C, Kolarz A, Eder M, Deussing JM, Justice NJ, Yizhar O, Chen A.

Mol Psychiatry. 2017 Dec;22(12):1691-1700. doi: 10.1038/mp.2016.133. Epub 2016 Aug 23.

PMID:
27550842
28.

Corrigendum: Local Optogenetic Induction of Fast (20-40 Hz) Pyramidal-Interneuron Network Oscillations in the In Vitro and In Vivo CA1 Hippocampus: Modulation by CRF and Enforcement of Perirhinal Theta Activity.

Dine J, Genewsky A, Hladky F, Wotjak CT, Deussing JM, Zieglgänsberger W, Chen A, Eder M.

Front Cell Neurosci. 2016 Jun 10;10:148. doi: 10.3389/fncel.2016.00148. eCollection 2016.

29.

Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor.

Hartmann J, Dedic N, Pöhlmann ML, Häusl A, Karst H, Engelhardt C, Westerholz S, Wagner KV, Labermaier C, Hoeijmakers L, Kertokarijo M, Chen A, Joëls M, Deussing JM, Schmidt MV.

Mol Psychiatry. 2017 Mar;22(3):466-475. doi: 10.1038/mp.2016.87. Epub 2016 May 31.

PMID:
27240530
30.

CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting.

Kuperman Y, Weiss M, Dine J, Staikin K, Golani O, Ramot A, Nahum T, Kühne C, Shemesh Y, Wurst W, Harmelin A, Deussing JM, Eder M, Chen A.

Cell Metab. 2016 Jun 14;23(6):1185-1199. doi: 10.1016/j.cmet.2016.04.017. Epub 2016 May 19.

31.

Local Optogenetic Induction of Fast (20-40 Hz) Pyramidal-Interneuron Network Oscillations in the In Vitro and In Vivo CA1 Hippocampus: Modulation by CRF and Enforcement of Perirhinal Theta Activity.

Dine J, Genewsky A, Hladky F, Wotjak CT, Deussing JM, Zieglgänsberger W, Chen A, Eder M.

Front Cell Neurosci. 2016 Apr 26;10:108. doi: 10.3389/fncel.2016.00108. eCollection 2016. Erratum in: Front Cell Neurosci. 2016;10:148.

32.

Beware of your Cre-Ation: lacZ expression impairs neuronal integrity and hippocampus-dependent memory.

Reichel JM, Bedenk BT, Gassen NC, Hafner K, Bura SA, Almeida-Correa S, Genewsky A, Dedic N, Giesert F, Agarwal A, Nave KA, Rein T, Czisch M, Deussing JM, Wotjak CT.

Hippocampus. 2016 Oct;26(10):1250-64. doi: 10.1002/hipo.22601. Epub 2016 May 24.

PMID:
27101945
33.

Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function.

Aprile-Garcia F, Metzger MW, Paez-Pereda M, Stadler H, Acuña M, Liberman AC, Senin SA, Gerez J, Hoijman E, Refojo D, Mitkovski M, Panhuysen M, Stühmer W, Holsboer F, Deussing JM, Arzt E.

PLoS One. 2016 Mar 17;11(3):e0151862. doi: 10.1371/journal.pone.0151862. eCollection 2016.

34.

Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function.

Gray JM, Wilson CD, Lee TT, Pittman QJ, Deussing JM, Hillard CJ, McEwen BS, Schulkin J, Karatsoreos IN, Patel S, Hill MN.

Psychoneuroendocrinology. 2016 Apr;66:151-8. doi: 10.1016/j.psyneuen.2016.01.004. Epub 2016 Jan 11.

35.

Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.

Bender J, Engeholm M, Ederer MS, Breu J, Møller TC, Michalakis S, Rasko T, Wanker EE, Biel M, Martinez KL, Wurst W, Deussing JM.

PLoS One. 2015 Sep 9;10(9):e0136768. doi: 10.1371/journal.pone.0136768. eCollection 2015.

36.

Evidence for the role of corticotropin-releasing factor in major depressive disorder.

Waters RP, Rivalan M, Bangasser DA, Deussing JM, Ising M, Wood SK, Holsboer F, Summers CH.

Neurosci Biobehav Rev. 2015 Nov;58:63-78. doi: 10.1016/j.neubiorev.2015.07.011. Epub 2015 Aug 10. Review.

37.

Roles of prefrontal cortex and paraventricular thalamus in affective and mechanical components of visceral nociception.

Jurik A, Auffenberg E, Klein S, Deussing JM, Schmid RM, Wotjak CT, Thoeringer CK.

Pain. 2015 Dec;156(12):2479-91. doi: 10.1097/j.pain.0000000000000318.

PMID:
26262826
38.

Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties.

Hartmann J, Wagner KV, Gaali S, Kirschner A, Kozany C, Rühter G, Dedic N, Häusl AS, Hoeijmakers L, Westerholz S, Namendorf C, Gerlach T, Uhr M, Chen A, Deussing JM, Holsboer F, Hausch F, Schmidt MV.

J Neurosci. 2015 Jun 17;35(24):9007-16. doi: 10.1523/JNEUROSCI.4024-14.2015.

39.

Adrenal and Ovarian Phenotype of a Tissue-Specific Urocortin 2-Overexpressing Mouse Model.

Spyroglou A, Riester A, Mueller-Peltzer K, Lu A, Rohde J, Hantel C, Kuehne C, Kulle A, Riepe F, Deussing JM, Beuschlein F.

Endocrinology. 2015 Jul;156(7):2646-56. doi: 10.1210/en.2014-1971. Epub 2015 May 5.

PMID:
25942073
40.

Cacna1c (Cav1.2) Modulates Electroencephalographic Rhythm and Rapid Eye Movement Sleep Recovery.

Kumar D, Dedic N, Flachskamm C, Voulé S, Deussing JM, Kimura M.

Sleep. 2015 Sep 1;38(9):1371-80. doi: 10.5665/sleep.4972.

41.

Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety.

Gray JM, Vecchiarelli HA, Morena M, Lee TT, Hermanson DJ, Kim AB, McLaughlin RJ, Hassan KI, Kühne C, Wotjak CT, Deussing JM, Patel S, Hill MN.

J Neurosci. 2015 Mar 4;35(9):3879-92. doi: 10.1523/JNEUROSCI.2737-14.2015.

42.

Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition.

Vogl AM, Brockmann MM, Giusti SA, Maccarrone G, Vercelli CA, Bauder CA, Richter JS, Roselli F, Hafner AS, Dedic N, Wotjak CT, Vogt-Weisenhorn DM, Choquet D, Turck CW, Stein V, Deussing JM, Refojo D.

Nat Neurosci. 2015 Feb;18(2):239-51. doi: 10.1038/nn.3912. Epub 2015 Jan 12.

PMID:
25581363
43.

Cell type-specific modifications of corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1) on startle behavior and sensorimotor gating.

Flandreau E, Risbrough V, Lu A, Ableitner M, Geyer MA, Holsboer F, Deussing JM.

Psychoneuroendocrinology. 2015 Mar;53:16-28. doi: 10.1016/j.psyneuen.2014.12.005. Epub 2014 Dec 11.

44.

MicroRNA-9 controls dendritic development by targeting REST.

Giusti SA, Vogl AM, Brockmann MM, Vercelli CA, Rein ML, Trümbach D, Wurst W, Cazalla D, Stein V, Deussing JM, Refojo D.

Elife. 2014 Nov 18;3. doi: 10.7554/eLife.02755.

45.

Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans.

Gassen NC, Hartmann J, Zschocke J, Stepan J, Hafner K, Zellner A, Kirmeier T, Kollmannsberger L, Wagner KV, Dedic N, Balsevich G, Deussing JM, Kloiber S, Lucae S, Holsboer F, Eder M, Uhr M, Ising M, Schmidt MV, Rein T.

PLoS Med. 2014 Nov 11;11(11):e1001755. doi: 10.1371/journal.pmed.1001755. eCollection 2014 Nov.

46.

Local CRH signaling promotes synaptogenesis and circuit integration of adult-born neurons.

Garcia I, Quast KB, Huang L, Herman AM, Selever J, Deussing JM, Justice NJ, Arenkiel BR.

Dev Cell. 2014 Sep 29;30(6):645-59. doi: 10.1016/j.devcel.2014.07.001. Epub 2014 Sep 4.

47.

Enriched environment impacts trimethylthiazoline-induced anxiety-related behavior and immediate early gene expression: critical role of Crhr1.

Sotnikov SV, Chekmareva NY, Schmid B, Harbich D, Malik V, Bauer S, Kuehne C, Markt PO, Deussing JM, Schmidt MV, Landgraf R.

Eur J Neurosci. 2014 Aug;40(4):2691-700. doi: 10.1111/ejn.12624. Epub 2014 May 20.

PMID:
24840018
48.

A robust and reliable non-invasive test for stress responsivity in mice.

Zimprich A, Garrett L, Deussing JM, Wotjak CT, Fuchs H, Gailus-Durner V, de Angelis MH, Wurst W, Hölter SM.

Front Behav Neurosci. 2014 Apr 15;8:125. doi: 10.3389/fnbeh.2014.00125. eCollection 2014.

49.

Behavioral phenotyping of Nestin-Cre mice: implications for genetic mouse models of psychiatric disorders.

Giusti SA, Vercelli CA, Vogl AM, Kolarz AW, Pino NS, Deussing JM, Refojo D.

J Psychiatr Res. 2014 Aug;55:87-95. doi: 10.1016/j.jpsychires.2014.04.002. Epub 2014 Apr 12.

PMID:
24768109
50.

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