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Early Scanning of Nascent Polypeptides inside the Ribosomal Tunnel by NAC.

Gamerdinger M, Kobayashi K, Wallisch A, Kreft SG, Sailer C, Schlömer R, Sachs N, Jomaa A, Stengel F, Ban N, Deuerling E.

Mol Cell. 2019 Sep 5;75(5):996-1006.e8. doi: 10.1016/j.molcel.2019.06.030. Epub 2019 Jul 31.


Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies.

Shen K, Gamerdinger M, Chan R, Gense K, Martin EM, Sachs N, Knight PD, Schlömer R, Calabrese AN, Stewart KL, Leiendecker L, Baghel A, Radford SE, Frydman J, Deuerling E.

Mol Cell. 2019 May 16;74(4):729-741.e7. doi: 10.1016/j.molcel.2019.03.012. Epub 2019 Apr 11.


Chaperone Interactions at the Ribosome.

Deuerling E, Gamerdinger M, Kreft SG.

Cold Spring Harb Perspect Biol. 2019 Nov 1;11(11). pii: a033977. doi: 10.1101/cshperspect.a033977. Review.


Neomycin-dependent hammerhead ribozymes for the direct control of gene expression in Saccharomyces cerevisiae.

Sack M, Stifel J, Kreft SG, Deuerling E, Hartig JS.

Methods. 2019 May 15;161:35-40. doi: 10.1016/j.ymeth.2019.01.004. Epub 2019 Jan 9.


Insights into the Aggregation Mechanism of PolyQ Proteins with Different Glutamine Repeat Lengths.

Yushchenko T, Deuerling E, Hauser K.

Biophys J. 2018 Apr 24;114(8):1847-1857. doi: 10.1016/j.bpj.2018.02.037.


Conformational flexibility within the nascent polypeptide-associated complex enables its interactions with structurally diverse client proteins.

Martin EM, Jackson MP, Gamerdinger M, Gense K, Karamonos TK, Humes JR, Deuerling E, Ashcroft AE, Radford SE.

J Biol Chem. 2018 Jun 1;293(22):8554-8568. doi: 10.1074/jbc.RA117.001568. Epub 2018 Apr 12.


Vms1: A Cytosolic CAT-Tailing Antagonist to Protect Mitochondria.

Kreft SG, Deuerling E.

Trends Cell Biol. 2018 Jan;28(1):3-5. doi: 10.1016/j.tcb.2017.11.003. Epub 2017 Dec 1.


Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction.

Hanebuth MA, Kityk R, Fries SJ, Jain A, Kriel A, Albanese V, Frickey T, Peter C, Mayer MP, Frydman J, Deuerling E.

Nat Commun. 2016 Dec 5;7:13695. doi: 10.1038/ncomms13695.


Ribosome Assembly as Antimicrobial Target.

Nikolay R, Schmidt S, Schlömer R, Deuerling E, Nierhaus KH.

Antibiotics (Basel). 2016 May 27;5(2). pii: E18. doi: 10.3390/antibiotics5020018.


Functional Dissection of the Nascent Polypeptide-Associated Complex in Saccharomyces cerevisiae.

Ott AK, Locher L, Koch M, Deuerling E.

PLoS One. 2015 Nov 30;10(11):e0143457. doi: 10.1371/journal.pone.0143457. eCollection 2015.


Not4-dependent translational repression is important for cellular protein homeostasis in yeast.

Preissler S, Reuther J, Koch M, Scior A, Bruderek M, Frickey T, Deuerling E.

EMBO J. 2015 Jul 14;34(14):1905-24. doi: 10.15252/embj.201490194. Epub 2015 May 13.


A comparison of the folding characteristics of free and ribosome-tethered polypeptide chains using limited proteolysis and mass spectrometry.

Rajabi K, Reuther J, Deuerling E, Radford SE, Ashcroft AE.

Protein Sci. 2015 Aug;24(8):1282-91. doi: 10.1002/pro.2702. Epub 2015 Jun 11.


Fluorescence-based monitoring of ribosome assembly landscapes.

Nikolay R, Schloemer R, Mueller S, Deuerling E.

BMC Mol Biol. 2015 Feb 25;16:3. doi: 10.1186/s12867-015-0031-y.


The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum.

Gamerdinger M, Hanebuth MA, Frickey T, Deuerling E.

Science. 2015 Apr 10;348(6231):201-7. doi: 10.1126/science.aaa5335.


Biochemistry. Trigger factor flexibility.

Gamerdinger M, Deuerling E.

Science. 2014 May 9;344(6184):590-1. doi: 10.1126/science.1254064. No abstract available.


Validation of a fluorescence-based screening concept to identify ribosome assembly defects in Escherichia coli.

Nikolay R, Schloemer R, Schmidt S, Mueller S, Heubach A, Deuerling E.

Nucleic Acids Res. 2014 Jul;42(12):e100. doi: 10.1093/nar/gku381. Epub 2014 May 3.


The nascent polypeptide-associated complex is a key regulator of proteostasis.

Kirstein-Miles J, Scior A, Deuerling E, Morimoto RI.

EMBO J. 2013 May 15;32(10):1451-68. doi: 10.1038/emboj.2013.87. Epub 2013 Apr 19.


Macrolides: the plug is out.

Gamerdinger M, Deuerling E.

Cell. 2012 Oct 26;151(3):469-71. doi: 10.1016/j.cell.2012.10.015.


Concerted action of the ribosome and the associated chaperone trigger factor confines nascent polypeptide folding.

Hoffmann A, Becker AH, Zachmann-Brand B, Deuerling E, Bukau B, Kramer G.

Mol Cell. 2012 Oct 12;48(1):63-74. doi: 10.1016/j.molcel.2012.07.018. Epub 2012 Aug 23.


High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system.

Basters A, Ketscher L, Deuerling E, Arkona C, Rademann J, Knobeloch KP, Fritz G.

BMC Biotechnol. 2012 Aug 23;12:56. doi: 10.1186/1472-6750-12-56.


Ribosome-associated chaperones as key players in proteostasis.

Preissler S, Deuerling E.

Trends Biochem Sci. 2012 Jul;37(7):274-83. doi: 10.1016/j.tibs.2012.03.002. Epub 2012 Apr 13. Review.


Directed PCR-free engineering of highly repetitive DNA sequences.

Scior A, Preissler S, Koch M, Deuerling E.

BMC Biotechnol. 2011 Sep 23;11:87. doi: 10.1186/1472-6750-11-87.


Cotranslational structure acquisition of nascent polypeptides monitored by NMR spectroscopy.

Eichmann C, Preissler S, Riek R, Deuerling E.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9111-6. doi: 10.1073/pnas.0914300107. Epub 2010 May 3.


A dual function for chaperones SSB-RAC and the NAC nascent polypeptide-associated complex on ribosomes.

Koplin A, Preissler S, Ilina Y, Koch M, Scior A, Erhardt M, Deuerling E.

J Cell Biol. 2010 Apr 5;189(1):57-68. doi: 10.1083/jcb.200910074.


Extra N-terminal residues have a profound effect on the aggregation properties of the potential yeast prion protein Mca1.

Erhardt M, Wegrzyn RD, Deuerling E.

PLoS One. 2010 Mar 29;5(3):e9929. doi: 10.1371/journal.pone.0009929.


Structural analysis of the ribosome-associated complex (RAC) reveals an unusual Hsp70/Hsp40 interaction.

Fiaux J, Horst J, Scior A, Preissler S, Koplin A, Bukau B, Deuerling E.

J Biol Chem. 2010 Jan 29;285(5):3227-34. doi: 10.1074/jbc.M109.075804. Epub 2009 Nov 17.


Molecular mechanism and structure of Trigger Factor bound to the translating ribosome.

Merz F, Boehringer D, Schaffitzel C, Preissler S, Hoffmann A, Maier T, Rutkowska A, Lozza J, Ban N, Bukau B, Deuerling E.

EMBO J. 2008 Jun 4;27(11):1622-32. doi: 10.1038/emboj.2008.89. Epub 2008 May 22.


Dynamics of trigger factor interaction with translating ribosomes.

Rutkowska A, Mayer MP, Hoffmann A, Merz F, Zachmann-Brand B, Schaffitzel C, Ban N, Deuerling E, Bukau B.

J Biol Chem. 2008 Feb 15;283(7):4124-32. Epub 2007 Nov 28.


Chaperone-based procedure to increase yields of soluble recombinant proteins produced in E. coli.

de Marco A, Deuerling E, Mogk A, Tomoyasu T, Bukau B.

BMC Biotechnol. 2007 Jun 12;7:32.


The C-terminal domain of Escherichia coli trigger factor represents the central module of its chaperone activity.

Merz F, Hoffmann A, Rutkowska A, Zachmann-Brand B, Bukau B, Deuerling E.

J Biol Chem. 2006 Oct 20;281(42):31963-71. Epub 2006 Aug 22.


Trigger factor forms a protective shield for nascent polypeptides at the ribosome.

Hoffmann A, Merz F, Rutkowska A, Zachmann-Brand B, Deuerling E, Bukau B.

J Biol Chem. 2006 Mar 10;281(10):6539-45. Epub 2006 Jan 5.


A conserved motif is prerequisite for the interaction of NAC with ribosomal protein L23 and nascent chains.

Wegrzyn RD, Hofmann D, Merz F, Nikolay R, Rauch T, Graf C, Deuerling E.

J Biol Chem. 2006 Feb 3;281(5):2847-57. Epub 2005 Nov 29.


Molecular guardians for newborn proteins: ribosome-associated chaperones and their role in protein folding.

Wegrzyn RD, Deuerling E.

Cell Mol Life Sci. 2005 Dec;62(23):2727-38. Review.


Low temperature of GroEL/ES overproduction permits growth of Escherichia coli cells lacking trigger factor DnaK.

Vorderwülbecke S, Kramer G, Merz F, Kurz TA, Rauch T, Zachmann-Brand B, Bukau B, Deuerling E.

FEBS Lett. 2005 Jun 13;579(15):181-7.


Dissecting functional similarities of ribosome-associated chaperones from Saccharomyces cerevisiae and Escherichia coli.

Rauch T, Hundley HA, Pfund C, Wegrzyn RD, Walter W, Kramer G, Kim SY, Craig EA, Deuerling E.

Mol Microbiol. 2005 Jul;57(2):357-65.


Elke Deuerling: winner of the 2005 FEBS Letters Award for Young Scientists [interview by Tine Walma].

Deuerling E.

FEBS Lett. 2005 Jun 13;579(15):3205. No abstract available.


A cradle for new proteins: trigger factor at the ribosome.

Maier T, Ferbitz L, Deuerling E, Ban N.

Curr Opin Struct Biol. 2005 Apr;15(2):204-12. Review.


Target-directed proteolysis at the ribosome.

Henrichs T, Mikhaleva N, Conz C, Deuerling E, Boyd D, Zelazny A, Bibi E, Ban N, Ehrmann M.

Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4246-51.


Chaperone-assisted folding of newly synthesized proteins in the cytosol.

Deuerling E, Bukau B.

Crit Rev Biochem Mol Biol. 2004 Sep-Dec;39(5-6):261-77. Review.


Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins.

Ferbitz L, Maier T, Patzelt H, Bukau B, Deuerling E, Ban N.

Nature. 2004 Sep 30;431(7008):590-6. Epub 2004 Aug 29.


DafA cycles between the DnaK chaperone system and translational machinery.

Dumitru GL, Groemping Y, Klostermeier D, Restle T, Deuerling E, Reinstein J.

J Mol Biol. 2004 Jun 18;339(5):1179-89.


Functional dissection of Escherichia coli trigger factor: unraveling the function of individual domains.

Kramer G, Rutkowska A, Wegrzyn RD, Patzelt H, Kurz TA, Merz F, Rauch T, Vorderwülbecke S, Deuerling E, Bukau B.

J Bacteriol. 2004 Jun;186(12):3777-84.


Trigger factor binds to ribosome-signal-recognition particle (SRP) complexes and is excluded by binding of the SRP receptor.

Buskiewicz I, Deuerling E, Gu SQ, Jöckel J, Rodnina MV, Bukau B, Wintermeyer W.

Proc Natl Acad Sci U S A. 2004 May 25;101(21):7902-6. Epub 2004 May 17.


Low temperature or GroEL/ES overproduction permits growth of Escherichia coli cells lacking trigger factor and DnaK.

Vorderwülbecke S, Kramer G, Merz F, Kurz TA, Rauch T, Zachmann-Brand B, Bukau B, Deuerling E.

FEBS Lett. 2004 Feb 13;559(1-3):181-7.


Trigger factor peptidyl-prolyl cis/trans isomerase activity is not essential for the folding of cytosolic proteins in Escherichia coli.

Kramer G, Patzelt H, Rauch T, Kurz TA, Vorderwülbecke S, Bukau B, Deuerling E.

J Biol Chem. 2004 Apr 2;279(14):14165-70. Epub 2004 Jan 16.


Small heat shock proteins, ClpB and the DnaK system form a functional triade in reversing protein aggregation.

Mogk A, Deuerling E, Vorderwülbecke S, Vierling E, Bukau B.

Mol Microbiol. 2003 Oct;50(2):585-95.


Essential Bacillus subtilis genes.

Kobayashi K, Ehrlich SD, Albertini A, Amati G, Andersen KK, Arnaud M, Asai K, Ashikaga S, Aymerich S, Bessieres P, Boland F, Brignell SC, Bron S, Bunai K, Chapuis J, Christiansen LC, Danchin A, Débarbouille M, Dervyn E, Deuerling E, Devine K, Devine SK, Dreesen O, Errington J, Fillinger S, Foster SJ, Fujita Y, Galizzi A, Gardan R, Eschevins C, Fukushima T, Haga K, Harwood CR, Hecker M, Hosoya D, Hullo MF, Kakeshita H, Karamata D, Kasahara Y, Kawamura F, Koga K, Koski P, Kuwana R, Imamura D, Ishimaru M, Ishikawa S, Ishio I, Le Coq D, Masson A, Mauël C, Meima R, Mellado RP, Moir A, Moriya S, Nagakawa E, Nanamiya H, Nakai S, Nygaard P, Ogura M, Ohanan T, O'Reilly M, O'Rourke M, Pragai Z, Pooley HM, Rapoport G, Rawlins JP, Rivas LA, Rivolta C, Sadaie A, Sadaie Y, Sarvas M, Sato T, Saxild HH, Scanlan E, Schumann W, Seegers JF, Sekiguchi J, Sekowska A, Séror SJ, Simon M, Stragier P, Studer R, Takamatsu H, Tanaka T, Takeuchi M, Thomaides HB, Vagner V, van Dijl JM, Watabe K, Wipat A, Yamamoto H, Yamamoto M, Yamamoto Y, Yamane K, Yata K, Yoshida K, Yoshikawa H, Zuber U, Ogasawara N.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4678-83. Epub 2003 Apr 7.


Trigger Factor and DnaK possess overlapping substrate pools and binding specificities.

Deuerling E, Patzelt H, Vorderwülbecke S, Rauch T, Kramer G, Schaffitzel E, Mogk A, Schulze-Specking A, Langen H, Bukau B.

Mol Microbiol. 2003 Mar;47(5):1317-28.


Three-state equilibrium of Escherichia coli trigger factor.

Patzelt H, Kramer G, Rauch T, Schönfeld HJ, Bukau B, Deuerling E.

Biol Chem. 2002 Oct;383(10):1611-9.


L23 protein functions as a chaperone docking site on the ribosome.

Kramer G, Rauch T, Rist W, Vorderwülbecke S, Patzelt H, Schulze-Specking A, Ban N, Deuerling E, Bukau B.

Nature. 2002 Sep 12;419(6903):171-4.


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