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Dissecting the Role of Thyrotropin in the DNA Damage Response in Human Thyrocytes after 131I, γ Radiation and H2O2.

Kyrilli A, Gacquer D, Detours V, Lefort A, Libert F, Twyffels L, Van Den Eeckhaute L, Strickaert A, Maenhaut C, De Deken X, Dumont JE, Miot F, Corvilain B.

J Clin Endocrinol Metab. 2020 Mar 1;105(3). pii: dgz185. doi: 10.1210/clinem/dgz185.


BRCA gene mutations do not shape the extent and organization of tumor infiltrating lymphocytes in triple negative breast cancer.

Solinas C, Marcoux D, Garaud S, Vitória JR, Van den Eynden G, de Wind A, De Silva P, Boisson A, Craciun L, Larsimont D, Piccart-Gebhart M, Detours V, t'Kint de Roodenbeke D, Willard-Gallo K.

Cancer Lett. 2019 May 28;450:88-97. doi: 10.1016/j.canlet.2019.02.027. Epub 2019 Feb 22.


Factors contributing to the resistance of the thyrocyte to hydrogen peroxide.

Ghaddhab C, Kyrilli A, Driessens N, Van Den Eeckhaute E, Hancisse O, De Deken X, Dumont JE, Detours V, Miot F, Corvilain B.

Mol Cell Endocrinol. 2019 Feb 5;481:62-70. doi: 10.1016/j.mce.2018.11.010. Epub 2018 Nov 23.


Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation.

Suzuki IK, Gacquer D, Van Heurck R, Kumar D, Wojno M, Bilheu A, Herpoel A, Lambert N, Cheron J, Polleux F, Detours V, Vanderhaeghen P.

Cell. 2018 May 31;173(6):1370-1384.e16. doi: 10.1016/j.cell.2018.03.067. Epub 2018 May 31.


Genomic hotspots but few recurrent fusion genes in breast cancer.

Fimereli D, Fumagalli D, Brown D, Gacquer D, Rothé F, Salgado R, Larsimont D, Sotiriou C, Detours V.

Genes Chromosomes Cancer. 2018 Jul;57(7):331-338. doi: 10.1002/gcc.22533. Epub 2018 Mar 22.


Distinctive Desmoplastic 3D Morphology Associated With BRAFV600E in Papillary Thyroid Cancers.

Tarabichi M, Antoniou A, Le Pennec S, Gacquer D, de Saint Aubain N, Craciun L, Cielen T, Laios I, Larsimont D, Andry G, Dumont JE, Maenhaut C, Detours V.

J Clin Endocrinol Metab. 2018 Mar 1;103(3):1102-1111. doi: 10.1210/jc.2017-02279.


Immune Checkpoint Molecules on Tumor-Infiltrating Lymphocytes and Their Association with Tertiary Lymphoid Structures in Human Breast Cancer.

Solinas C, Garaud S, De Silva P, Boisson A, Van den Eynden G, de Wind A, Risso P, Rodrigues Vitória J, Richard F, Migliori E, Noël G, Duvillier H, Craciun L, Veys I, Awada A, Detours V, Larsimont D, Piccart-Gebhart M, Willard-Gallo K.

Front Immunol. 2017 Oct 30;8:1412. doi: 10.3389/fimmu.2017.01412. eCollection 2017.


A research note regarding "Variation in cancer risk among tissues can be explained by the number of stem cell divisions".

Tarabichi M, Detours V.

Version 2. F1000Res. 2016 Aug 22 [revised 2016 Jan 1];5:2044. eCollection 2016.


miRNA expression and function in thyroid carcinomas: a comparative and critical analysis and a model for other cancers.

Saiselet M, Pita JM, Augenlicht A, Dom G, Tarabichi M, Fimereli D, Dumont JE, Detours V, Maenhaut C.

Oncotarget. 2016 Aug 9;7(32):52475-52492. doi: 10.18632/oncotarget.9655. Review.


Gene signature of the post-Chernobyl papillary thyroid cancer.

Handkiewicz-Junak D, Swierniak M, Rusinek D, Oczko-Wojciechowska M, Dom G, Maenhaut C, Unger K, Detours V, Bogdanova T, Thomas G, Likhtarov I, Jaksik R, Kowalska M, Chmielik E, Jarzab M, Swierniak A, Jarzab B.

Eur J Nucl Med Mol Imaging. 2016 Jul;43(7):1267-77. doi: 10.1007/s00259-015-3303-3. Epub 2016 Jan 26.


New global analysis of the microRNA transcriptome of primary tumors and lymph node metastases of papillary thyroid cancer.

Saiselet M, Gacquer D, Spinette A, Craciun L, Decaussin-Petrucci M, Andry G, Detours V, Maenhaut C.

BMC Genomics. 2015 Oct 21;16:828. doi: 10.1186/s12864-015-2082-3.


Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome.

Fumagalli D, Gacquer D, Rothé F, Lefort A, Libert F, Brown D, Kheddoumi N, Shlien A, Konopka T, Salgado R, Larsimont D, Polyak K, Willard-Gallo K, Desmedt C, Piccart M, Abramowicz M, Campbell PJ, Sotiriou C, Detours V.

Cell Rep. 2015 Oct 13;13(2):277-89. doi: 10.1016/j.celrep.2015.09.032. Epub 2015 Oct 1.


Revisiting the transcriptional analysis of primary tumours and associated nodal metastases with enhanced biological and statistical controls: application to thyroid cancer.

Tarabichi M, Saiselet M, Trésallet C, Hoang C, Larsimont D, Andry G, Maenhaut C, Detours V.

Br J Cancer. 2015 May 12;112(10):1665-74. doi: 10.1038/bjc.2014.665.


No significant viral transcription detected in whole breast cancer transcriptomes.

Fimereli D, Gacquer D, Fumagalli D, Salgado R, Rothé F, Larsimont D, Sotiriou C, Detours V.

BMC Cancer. 2015 Mar 18;15:147. doi: 10.1186/s12885-015-1176-2.


Intratumor heterogeneity and clonal evolution in an aggressive papillary thyroid cancer and matched metastases.

Le Pennec S, Konopka T, Gacquer D, Fimereli D, Tarabichi M, Tomás G, Savagner F, Decaussin-Petrucci M, Trésallet C, Andry G, Larsimont D, Detours V, Maenhaut C.

Endocr Relat Cancer. 2015 Apr;22(2):205-16. doi: 10.1530/ERC-14-0351. Epub 2015 Feb 17.


Transfer of clinically relevant gene expression signatures in breast cancer: from Affymetrix microarray to Illumina RNA-Sequencing technology.

Fumagalli D, Blanchet-Cohen A, Brown D, Desmedt C, Gacquer D, Michiels S, Rothé F, Majjaj S, Salgado R, Larsimont D, Ignatiadis M, Maetens M, Piccart M, Detours V, Sotiriou C, Haibe-Kains B.

BMC Genomics. 2014 Nov 21;15:1008. doi: 10.1186/1471-2164-15-1008.


Comparative analysis of the thyrocytes and T cells: responses to H2O2 and radiation reveals an H2O2-induced antioxidant transcriptional program in thyrocytes.

Versteyhe S, Driessens N, Ghaddhab C, Tarabichi M, Hoste C, Dumont JE, Miot F, Corvilain B, Detours V.

J Clin Endocrinol Metab. 2013 Oct;98(10):E1645-54. doi: 10.1210/jc.2013-1266. Epub 2013 May 10.


Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and "swarm intelligence".

Tarabichi M, Antoniou A, Saiselet M, Pita JM, Andry G, Dumont JE, Detours V, Maenhaut C.

Cancer Metastasis Rev. 2013 Dec;32(3-4):403-21. doi: 10.1007/s10555-013-9431-y. Review.


TriageTools: tools for partitioning and prioritizing analysis of high-throughput sequencing data.

Fimereli D, Detours V, Konopka T.

Nucleic Acids Res. 2013 Apr;41(7):e86. doi: 10.1093/nar/gkt094. Epub 2013 Feb 13.


A measure of the signal-to-noise ratio of microarray samples and studies using gene correlations.

Venet D, Detours V, Bersini H.

PLoS One. 2012;7(12):e51013. doi: 10.1371/journal.pone.0051013. Epub 2012 Dec 12.


Piecewise polynomial representations of genomic tracks.

Tarabichi M, Detours V, Konopka T.

PLoS One. 2012;7(11):e48941. doi: 10.1371/journal.pone.0048941. Epub 2012 Nov 15.


InSilico DB genomic datasets hub: an efficient starting point for analyzing genome-wide studies in GenePattern, Integrative Genomics Viewer, and R/Bioconductor.

Coletta A, Molter C, Duqué R, Steenhoff D, Taminau J, de Schaetzen V, Meganck S, Lazar C, Venet D, Detours V, Nowé A, Bersini H, Weiss Solís DY.

Genome Biol. 2012 Nov 18;13(11):R104. doi: 10.1186/gb-2012-13-11-r104.


A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas.

Dom G, Tarabichi M, Unger K, Thomas G, Oczko-Wojciechowska M, Bogdanova T, Jarzab B, Dumont JE, Detours V, Maenhaut C.

Br J Cancer. 2012 Sep 4;107(6):994-1000. doi: 10.1038/bjc.2012.302. Epub 2012 Jul 24.


A general method to derive robust organ-specific gene expression-based differentiation indices: application to thyroid cancer diagnostic.

Tomás G, Tarabichi M, Gacquer D, Hébrant A, Dom G, Dumont JE, Keutgen X, Fahey TJ 3rd, Maenhaut C, Detours V.

Oncogene. 2012 Oct 11;31(41):4490-8. doi: 10.1038/onc.2011.626. Epub 2012 Jan 23.


Most random gene expression signatures are significantly associated with breast cancer outcome.

Venet D, Dumont JE, Detours V.

PLoS Comput Biol. 2011 Oct;7(10):e1002240. doi: 10.1371/journal.pcbi.1002240. Epub 2011 Oct 20.


Genes expressed in specific areas of the human fetal cerebral cortex display distinct patterns of evolution.

Lambert N, Lambot MA, Bilheu A, Albert V, Englert Y, Libert F, Noel JC, Sotiriou C, Holloway AK, Pollard KS, Detours V, Vanderhaeghen P.

PLoS One. 2011 Mar 18;6(3):e17753. doi: 10.1371/journal.pone.0017753.


Gene expression profiles for radiation-induced thyroid cancer.

Maenhaut C, Detours V, Dom G, Handkiewicz-Junak D, Oczko-Wojciechowska M, Jarzab B.

Clin Oncol (R Coll Radiol). 2011 May;23(4):282-8. doi: 10.1016/j.clon.2011.01.509. Epub 2011 Mar 15. Review.


Human cancer cell lines: Experimental models for cancer cells in situ? For cancer stem cells?

van Staveren WC, Solís DY, Hébrant A, Detours V, Dumont JE, Maenhaut C.

Biochim Biophys Acta. 2009 Apr;1795(2):92-103. doi: 10.1016/j.bbcan.2008.12.004. Epub 2009 Jan 8. Review.


[Transcription markers of survival in breast neoplasms measuring the signals from the proliferation].

Detours V.

Bull Mem Acad R Med Belg. 2008;163(3-4):189-97; discussion 197-200. French.


Editorial comment should accompany hot papers online.

Detours V.

Nature. 2008 Oct 16;455(7215):861. doi: 10.1038/455861b. No abstract available.


Gene expression profiles of post-Chernobyl thyroid cancers.

Detours V, Versteyhe S, Dumont JE, Maenhaut C.

Curr Opin Endocrinol Diabetes Obes. 2008 Oct;15(5):440-5. doi: 10.1097/MED.0b013e32830eb874. Review.


Gene expression in RET/PTC3 and E7 transgenic mouse thyroids: RET/PTC3 but not E7 tumors are partial and transient models of human papillary thyroid cancers.

Burniat A, Jin L, Detours V, Driessens N, Goffard JC, Santoro M, Rothstein J, Dumont JE, Miot F, Corvilain B.

Endocrinology. 2008 Oct;149(10):5107-17. doi: 10.1210/en.2008-0531. Epub 2008 Jun 26.


Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype.

van Staveren WC, Solís DW, Delys L, Duprez L, Andry G, Franc B, Thomas G, Libert F, Dumont JE, Detours V, Maenhaut C.

Cancer Res. 2007 Sep 1;67(17):8113-20.


Genome-wide gene expression profiling suggests distinct radiation susceptibilities in sporadic and post-Chernobyl papillary thyroid cancers.

Detours V, Delys L, Libert F, Weiss Solís D, Bogdanova T, Dumont JE, Franc B, Thomas G, Maenhaut C.

Br J Cancer. 2007 Sep 17;97(6):818-25. Epub 2007 Aug 21.


Roles of hydrogen peroxide in thyroid physiology and disease.

Song Y, Driessens N, Costa M, De Deken X, Detours V, Corvilain B, Maenhaut C, Miot F, Van Sande J, Many MC, Dumont JE.

J Clin Endocrinol Metab. 2007 Oct;92(10):3764-73. Epub 2007 Jul 31. Review.


Gene expression and the biological phenotype of papillary thyroid carcinomas.

Delys L, Detours V, Franc B, Thomas G, Bogdanova T, Tronko M, Libert F, Dumont JE, Maenhaut C.

Oncogene. 2007 Dec 13;26(57):7894-903. Epub 2007 Jul 9.


Negative feedbacks in normal cell growth and their suppression in tumorigenesis.

van Staveren WC, Detours V, Dumont JE, Maenhaut C.

Cell Cycle. 2006 Mar;5(6):571-2. Epub 2006 Mar 15. Review. No abstract available.


Gene expression in human thyrocytes and autonomous adenomas reveals suppression of negative feedbacks in tumorigenesis.

van Staveren WC, Solís DW, Delys L, Venet D, Cappello M, Andry G, Dumont JE, Libert F, Detours V, Maenhaut C.

Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):413-8. Epub 2005 Dec 28.


Gene expression in thyroid autonomous adenomas provides insight into their physiopathology.

Wattel S, Mircescu H, Venet D, Burniat A, Franc B, Frank S, Andry G, Van Sande J, Rocmans P, Dumont JE, Detours V, Maenhaut C.

Oncogene. 2005 Oct 20;24(46):6902-16.


Absence of a specific radiation signature in post-Chernobyl thyroid cancers.

Detours V, Wattel S, Venet D, Hutsebaut N, Bogdanova T, Tronko MD, Dumont JE, Franc B, Thomas G, Maenhaut C.

Br J Cancer. 2005 Apr 25;92(8):1545-52.


Integration and cross-validation of high-throughput gene expression data: comparing heterogeneous data sets.

Detours V, Dumont JE, Bersini H, Maenhaut C.

FEBS Lett. 2003 Jul 3;546(1):98-102. Review.


Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type 1 (HIV-1) proteins reveal imprints of immune evasion on HIV-1 global variation.

Yusim K, Kesmir C, Gaschen B, Addo MM, Altfeld M, Brunak S, Chigaev A, Detours V, Korber BT.

J Virol. 2002 Sep;76(17):8757-68.


Prediction of proteasome cleavage motifs by neural networks.

Keşmir C, Nussbaum AK, Schild H, Detours V, Brunak S.

Protein Eng. 2002 Apr;15(4):287-96.


Evolutionary and immunological implications of contemporary HIV-1 variation.

Korber B, Gaschen B, Yusim K, Thakallapally R, Kesmir C, Detours V.

Br Med Bull. 2001;58:19-42. Review.


The paradox of alloreactivity and self MHC restriction: quantitative analysis and statistics.

Detours V, Perelson AS.

Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8479-83.


A quantitative theory of affinity-driven T cell repertoire selection.

Detours V, Mehr R, Perelson AS.

J Theor Biol. 1999 Oct 21;200(4):389-403.


Explaining high alloreactivity as a quantitative consequence of affinity-driven thymocyte selection.

Detours V, Perelson AS.

Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5153-8.


Size and connectivity of the idiotypic network are independent of the discreteness of the affinity distribution.

Detours V, Sulzer B, Perelson AS.

J Theor Biol. 1996 Dec 21;183(4):409-16.


Development of an idiotypic network in shape space.

Detours V, Bersini H, Stewart J, Varela F.

J Theor Biol. 1994 Oct 21;170(4):401-14.


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