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Items: 50

1.

Multiplexed assays by high-content imaging for assessment of GPCR activity.

Ross DA, Lee S, Reiser V, Xue J, Alves K, Vaidya S, Kreamer A, Mull R, Hudak E, Hare T, Detmers PA, Lingham R, Ferrer M, Strulovici B, Santini F.

J Biomol Screen. 2008 Jul;13(6):449-55. doi: 10.1177/1087057108317685. Epub 2008 Jun 2.

PMID:
18519922
2.

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).

Garcia-Calvo M, Lisnock J, Bull HG, Hawes BE, Burnett DA, Braun MP, Crona JH, Davis HR Jr, Dean DC, Detmers PA, Graziano MP, Hughes M, Macintyre DE, Ogawa A, O'neill KA, Iyer SP, Shevell DE, Smith MM, Tang YS, Makarewicz AM, Ujjainwalla F, Altmann SW, Chapman KT, Thornberry NA.

Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8132-7. Epub 2005 May 31.

3.

TLR2 recognizes a bacterial lipopeptide through direct binding.

Vasselon T, Detmers PA, Charron D, Haziot A.

J Immunol. 2004 Dec 15;173(12):7401-5.

4.

Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis.

Davis HR Jr, Zhu LJ, Hoos LM, Tetzloff G, Maguire M, Liu J, Yao X, Iyer SP, Lam MH, Lund EG, Detmers PA, Graziano MP, Altmann SW.

J Biol Chem. 2004 Aug 6;279(32):33586-92. Epub 2004 Jun 1.

5.

A small molecule alpha4beta1/alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence.

Egger LA, Cao J, McCallum C, Kidambi U, Van Riper G, McCauley E, Mumford RA, Lanza TJ, Lin LS, de Laszlo SE, Young DN, Yang G, Dean DC, Raab CE, Wallace MA, Jones AN, Hagmann WK, Schmidt JA, Pepinsky RB, Scott DM, Lee WC, Cornebise MA, Detmers PA.

J Pharmacol Exp Ther. 2003 Sep;306(3):903-13. Epub 2003 May 23.

PMID:
12766251
6.

Small molecule antagonists of complement receptor type 3 block adhesion and adhesion-dependent oxidative burst in human polymorphonuclear leukocytes.

Bansal VS, Vaidya S, Somers EP, Kanuga M, Shevell D, Weikel R, Detmers PA.

J Pharmacol Exp Ther. 2003 Mar;304(3):1016-24.

PMID:
12604677
7.

Simvastatin reduces neointimal thickening in low-density lipoprotein receptor-deficient mice after experimental angioplasty without changing plasma lipids.

Chen Z, Fukutomi T, Zago AC, Ehlers R, Detmers PA, Wright SD, Rogers C, Simon DI.

Circulation. 2002 Jul 2;106(1):20-3.

PMID:
12093764
8.

Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow.

Egger LA, Kidambi U, Cao J, Van Riper G, McCauley E, Mumford RA, Amo S, Lingham R, Lanza T, Lin LS, De Laszlo SE, Young DN, Kopka IE, Tong S, Pikounis B, Benson E, Warwood S, Bargatze RF, Hagmann WK, Schmidt JA, Detmers PA.

J Pharmacol Exp Ther. 2002 Jul;302(1):153-62. Erratum in: J Pharmacol Exp Ther. 2003 May;305(2):796.

PMID:
12065712
9.

Deficiency in sPLA(2) does not affect HDL levels or atherosclerosis in mice.

Burton CA, Patel S, Mundt S, Hassing H, Zhang D, Hermanowski-Vosatka A, Wright SD, Chao YS, Detmers PA, Sparrow CP.

Biochem Biophys Res Commun. 2002 May 31;294(1):88-94.

PMID:
12054745
10.

Toll-like receptor 2 (TLR2) mediates activation of stress-activated MAP kinase p38.

Vasselon T, Hanlon WA, Wright SD, Detmers PA.

J Leukoc Biol. 2002 Mar;71(3):503-10.

PMID:
11867688
11.

Toll receptors: a central element in innate immune responses.

Vasselon T, Detmers PA.

Infect Immun. 2002 Mar;70(3):1033-41. Review. No abstract available.

12.

ApoE(-/-) mice develop atherosclerosis in the absence of complement component C5.

Patel S, Thelander EM, Hernandez M, Montenegro J, Hassing H, Burton C, Mundt S, Hermanowski-Vosatka A, Wright SD, Chao YS, Detmers PA.

Biochem Biophys Res Commun. 2001 Aug 10;286(1):164-70.

PMID:
11485323
13.

Simvastatin has anti-inflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering.

Sparrow CP, Burton CA, Hernandez M, Mundt S, Hassing H, Patel S, Rosa R, Hermanowski-Vosatka A, Wang PR, Zhang D, Peterson L, Detmers PA, Chao YS, Wright SD.

Arterioscler Thromb Vasc Biol. 2001 Jan;21(1):115-21.

PMID:
11145942
14.

Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice.

Detmers PA, Hernandez M, Mudgett J, Hassing H, Burton C, Mundt S, Chun S, Fletcher D, Card DJ, Lisnock J, Weikel R, Bergstrom JD, Shevell DE, Hermanowski-Vosatka A, Sparrow CP, Chao YS, Rader DJ, Wright SD, Puré E.

J Immunol. 2000 Sep 15;165(6):3430-5.

15.

A target for cholesterol absorption inhibitors in the enterocyte brush border membrane.

Detmers PA, Patel S, Hernandez M, Montenegro J, Lisnock JM, Pikounis B, Steiner M, Kim D, Sparrow C, Chao YS, Wright SD.

Biochim Biophys Acta. 2000 Jul 19;1486(2-3):243-52.

PMID:
10903475
16.

Intestinal absorption of cholesterol is mediated by a saturable, inhibitable transporter.

Hernandez M, Montenegro J, Steiner M, Kim D, Sparrow C, Detmers PA, Wright SD, Chao YS.

Biochim Biophys Acta. 2000 Jul 19;1486(2-3):232-42.

PMID:
10903474
17.

Infectious agents are not necessary for murine atherogenesis.

Wright SD, Burton C, Hernandez M, Hassing H, Montenegro J, Mundt S, Patel S, Card DJ, Hermanowski-Vosatka A, Bergstrom JD, Sparrow CP, Detmers PA, Chao YS.

J Exp Med. 2000 Apr 17;191(8):1437-42.

18.

Activation of peroxisome proliferator-activated receptor gamma does not inhibit IL-6 or TNF-alpha responses of macrophages to lipopolysaccharide in vitro or in vivo.

Thieringer R, Fenyk-Melody JE, Le Grand CB, Shelton BA, Detmers PA, Somers EP, Carbin L, Moller DE, Wright SD, Berger J.

J Immunol. 2000 Jan 15;164(2):1046-54.

20.

A fluorescent cholesterol analog traces cholesterol absorption in hamsters and is esterified in vivo and in vitro.

Sparrow CP, Patel S, Baffic J, Chao YS, Hernandez M, Lam MH, Montenegro J, Wright SD, Detmers PA.

J Lipid Res. 1999 Oct;40(10):1747-57.

21.

Internalization of monomeric lipopolysaccharide occurs after transfer out of cell surface CD14.

Vasselon T, Hailman E, Thieringer R, Detmers PA.

J Exp Med. 1999 Aug 16;190(4):509-21.

22.

Role of stress-activated mitogen-activated protein kinase (p38) in beta 2-integrin-dependent neutrophil adhesion and the adhesion-dependent oxidative burst.

Detmers PA, Zhou D, Polizzi E, Thieringer R, Hanlon WA, Vaidya S, Bansal V.

J Immunol. 1998 Aug 15;161(4):1921-9.

23.

Sensitive responses of leukocytes to lipopolysaccharide require a protein distinct from CD14 at the cell surface.

Vasselon T, Pironkova R, Detmers PA.

J Immunol. 1997 Nov 1;159(9):4498-505.

PMID:
9379050
24.

Potential role of membrane internalization and vesicle fusion in adhesion of neutrophils in response to lipopolysaccharide and TNF.

Detmers PA, Thieblemont N, Vasselon T, Pironkova R, Miller DS, Wright SD.

J Immunol. 1996 Dec 15;157(12):5589-96.

PMID:
8955211
25.

U-73122: a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces and adhesion-related effector functions.

Smith RJ, Justen JM, McNab AR, Rosenbloom CL, Steele AN, Detmers PA, Anderson DC, Manning AM.

J Pharmacol Exp Ther. 1996 Jul;278(1):320-9.

PMID:
8764366
26.

Stimulation of macrophages and neutrophils by complexes of lipopolysaccharide and soluble CD14.

Hailman E, Vasselon T, Kelley M, Busse LA, Hu MC, Lichenstein HS, Detmers PA, Wright SD.

J Immunol. 1996 Jun 1;156(11):4384-90.

PMID:
8666811
27.

Endotoxin receptors (CD14) are found with CD16 (Fc gamma RIII) in an intracellular compartment of neutrophils that contains alkaline phosphatase.

Detmers PA, Zhou D, Powell D, Lichenstein H, Kelley M, Pironkova R.

J Immunol. 1995 Aug 15;155(4):2085-95.

PMID:
7543538
29.
30.

Differential effects of neutrophil-activating peptide 1/IL-8 and its homologues on leukocyte adhesion and phagocytosis.

Detmers PA, Powell DE, Walz A, Clark-Lewis I, Baggiolini M, Cohn ZA.

J Immunol. 1991 Dec 15;147(12):4211-7.

PMID:
1721641
31.

Cytoplasts from cytotoxic T lymphocytes are resistant to perforin-mediated lysis.

Ojcius DM, Jiang SB, Persechini PM, Detmers PA, Young JD.

Mol Immunol. 1991 Sep;28(9):1011-8.

PMID:
1922107
32.

Activation of the adhesive capacity of CR3 on neutrophils by endotoxin: dependence on lipopolysaccharide binding protein and CD14.

Wright SD, Ramos RA, Hermanowski-Vosatka A, Rockwell P, Detmers PA.

J Exp Med. 1991 May 1;173(5):1281-6.

33.

CD11c/CD18 on neutrophils recognizes a domain at the N terminus of the A alpha chain of fibrinogen.

Loike JD, Sodeik B, Cao L, Leucona S, Weitz JI, Detmers PA, Wright SD, Silverstein SC.

Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):1044-8.

34.
35.

CD18-deficient cells respond to lipopolysaccharide in vitro.

Wright SD, Detmers PA, Aida Y, Adamowski R, Anderson DC, Chad Z, Kabbash LG, Pabst MJ.

J Immunol. 1990 Apr 1;144(7):2566-71.

PMID:
1969452
36.
37.

Heterogeneity of granules of murine cytolytic T lymphocytes. Isolation of a homogeneous population of dense granules.

Persechini PM, Liu CC, Detmers PA, Young JD.

J Immunol Methods. 1989 Nov 13;124(1):7-15.

PMID:
2809230
38.
39.

Transient adhesion of neutrophils to endothelium.

Lo SK, Detmers PA, Levin SM, Wright SD.

J Exp Med. 1989 May 1;169(5):1779-93.

40.

Clustering of ligand on the surface of a particle enhances adhesion to receptor-bearing cells.

Hermanowski-Vosatka A, Detmers PA, Götze O, Silverstein SC, Wright SD.

J Biol Chem. 1988 Nov 25;263(33):17822-7.

41.

Adhesion-promoting receptors on leukocytes.

Detmers PA, Wright SD.

Curr Opin Immunol. 1988 Sep-Oct;1(1):10-5. Review. No abstract available.

PMID:
2908320
42.

Adhesion-promoting receptors on phagocytes.

Wright SD, Detmers PA.

J Cell Sci Suppl. 1988;9:99-120. Review.

PMID:
2978519
43.

Aggregation of complement receptors on human neutrophils in the absence of ligand.

Detmers PA, Wright SD, Olsen E, Kimball B, Cohn ZA.

J Cell Biol. 1987 Sep;105(3):1137-45.

44.
45.

Trifluoperazine and W-7 inhibit mating in Chlamydomonas at an early stage of gametic interaction.

Detmers PA, Condeelis J.

Exp Cell Res. 1986 Apr;163(2):317-26.

PMID:
3956581
46.

Elongation of cytoplasmic processes during gametic mating: models for actin-based motility.

Detmers PA.

Can J Biochem Cell Biol. 1985 Jun;63(6):599-607.

PMID:
4041963
47.

Localization of actin in Chlamydomonas using antiactin and NBD-phallacidin.

Detmers PA, Carboni JM, Condeelis J.

Cell Motil. 1985;5(5):415-30.

PMID:
2415259
49.
50.

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