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Items: 1 to 50 of 265

1.

Activation of the VEGFC/VEGFR3 pathway induces tumor immune escape in colorectal cancer.

Tacconi C, Ungaro F, Correale C, Arena V, Massimino L, Detmar M, Spinelli A, Carvello M, Mazzone M, Oliveira AI, Rubbino F, Garlatti V, Spanò S, Lugli E, Colombo FS, Malesci A, Peyrin-Biroulet L, Vetrano S, Danese S, D'Alessio S.

Cancer Res. 2019 Jun 25. pii: canres.3657.2018. doi: 10.1158/0008-5472.CAN-18-3657. [Epub ahead of print]

PMID:
31239267
2.

A Distinct Role of the Autonomic Nervous System in Modulating the Function of Lymphatic Vessels under Physiological and Tumor-Draining Conditions.

Bachmann SB, Gsponer D, Montoya-Zegarra JA, Schneider M, Scholkmann F, Tacconi C, Noerrelykke SF, Proulx ST, Detmar M.

Cell Rep. 2019 Jun 11;27(11):3305-3314.e13. doi: 10.1016/j.celrep.2019.05.050.

3.

Inflammation and Lymphatic Function.

Schwager S, Detmar M.

Front Immunol. 2019 Feb 26;10:308. doi: 10.3389/fimmu.2019.00308. eCollection 2019. Review.

4.

Differential effects of anaesthesia on the contractility of lymphatic vessels in vivo.

Bachmann SB, Proulx ST, He Y, Ries M, Detmar M.

J Physiol. 2019 Jun;597(11):2841-2852. doi: 10.1113/JP277254. Epub 2019 Mar 20.

PMID:
30829392
5.

Minimally invasive method for the point-of-care quantification of lymphatic vessel function.

Polomska AK, Proulx ST, Brambilla D, Fehr D, Bonmarin M, Brändli S, Meboldt M, Steuer C, Vasileva T, Reinke N, Leroux JC, Detmar M.

JCI Insight. 2019 Feb 21;4(4). pii: 126515. doi: 10.1172/jci.insight.126515. eCollection 2019 Feb 21.

6.

Mechanisms of Tumor-Induced Lymphovascular Niche Formation in Draining Lymph Nodes.

Commerford CD, Dieterich LC, He Y, Hell T, Montoya-Zegarra JA, Noerrelykke SF, Russo E, Röcken M, Detmar M.

Cell Rep. 2018 Dec 26;25(13):3554-3563.e4. doi: 10.1016/j.celrep.2018.12.002.

7.

Antibody-mediated delivery of VEGF-C potently reduces chronic skin inflammation.

Schwager S, Renner S, Hemmerle T, Karaman S, Proulx ST, Fetz R, Golding-Ochsenbein AM, Probst P, Halin C, Neri D, Detmar M.

JCI Insight. 2018 Dec 6;3(23). pii: 124850. doi: 10.1172/jci.insight.124850.

8.

AutoTube: a novel software for the automated morphometric analysis of vascular networks in tissues.

Montoya-Zegarra JA, Russo E, Runge P, Jadhav M, Willrodt AH, Stoma S, Nørrelykke SF, Detmar M, Halin C.

Angiogenesis. 2019 May;22(2):223-236. doi: 10.1007/s10456-018-9652-3. Epub 2018 Oct 28.

9.

Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain.

Ma Q, Ries M, Decker Y, Müller A, Riner C, Bücker A, Fassbender K, Detmar M, Proulx ST.

Acta Neuropathol. 2019 Jan;137(1):151-165. doi: 10.1007/s00401-018-1916-x. Epub 2018 Oct 10.

10.

Visualization and Measurement of Lymphatic Function In Vivo.

Bachmann SB, Detmar M, Proulx ST.

Methods Mol Biol. 2018;1846:197-211. doi: 10.1007/978-1-4939-8712-2_13.

PMID:
30242761
11.

Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors.

Ralvenius WT, Neumann E, Pagani M, Acuña MA, Wildner H, Benke D, Fischer N, Rostaher A, Schwager S, Detmar M, Frauenknecht K, Aguzzi A, Hubbs JL, Rudolph U, Favrot C, Zeilhofer HU.

Nat Commun. 2018 Aug 13;9(1):3230. doi: 10.1038/s41467-018-05709-0.

12.

Unexpected contribution of lymphatic vessels to promotion of distant metastatic tumor spread.

Ma Q, Dieterich LC, Ikenberg K, Bachmann SB, Mangana J, Proulx ST, Amann VC, Levesque MP, Dummer R, Baluk P, McDonald DM, Detmar M.

Sci Adv. 2018 Aug 8;4(8):eaat4758. doi: 10.1126/sciadv.aat4758. eCollection 2018 Aug.

13.

Light-sheet microscopy reveals site-specific 3-dimensional patterns of the cutaneous vasculature and pronounced rarefication in aged skin.

Kajiya K, Bise R, Commerford C, Sato I, Yamashita T, Detmar M.

J Dermatol Sci. 2018 Oct;92(1):3-5. doi: 10.1016/j.jdermsci.2018.07.006. Epub 2018 Jul 24. No abstract available.

PMID:
30076002
14.

Quantitative histological analyses and transcriptional profiling reveal structural and molecular changes of the dermal extracellular matrix in cellulite.

Yoshida Y, Kajiya K, Kishimoto J, Detmar M.

J Dermatol Sci. 2018 Oct;92(1):6-9. doi: 10.1016/j.jdermsci.2018.06.010. Epub 2018 Jun 30. No abstract available.

PMID:
30041986
15.

Lymphatic exosomes promote dendritic cell migration along guidance cues.

Brown M, Johnson LA, Leone DA, Majek P, Vaahtomeri K, Senfter D, Bukosza N, Schachner H, Asfour G, Langer B, Hauschild R, Parapatics K, Hong YK, Bennett KL, Kain R, Detmar M, Sixt M, Jackson DG, Kerjaschki D.

J Cell Biol. 2018 Jun 4;217(6):2205-2221. doi: 10.1083/jcb.201612051. Epub 2018 Apr 12.

16.

Multiple roles of lymphatic vessels in tumor progression.

Ma Q, Dieterich LC, Detmar M.

Curr Opin Immunol. 2018 Aug;53:7-12. doi: 10.1016/j.coi.2018.03.018. Epub 2018 Mar 30. Review.

PMID:
29605736
17.

Alternative transcription of a shorter, non-anti-angiogenic thrombospondin-2 variant in cancer-associated blood vessels.

Roudnicky F, Yoon SY, Poghosyan S, Schwager S, Poyet C, Vella G, Bachmann SB, Karaman S, Shin JW, Otto VI, Detmar M.

Oncogene. 2018 May;37(19):2573-2585. doi: 10.1038/s41388-018-0129-z. Epub 2018 Feb 22.

18.

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice.

Ma Q, Ineichen BV, Detmar M, Proulx ST.

Nat Commun. 2017 Nov 10;8(1):1434. doi: 10.1038/s41467-017-01484-6.

19.

Distinct transcriptional responses of lymphatic endothelial cells to VEGFR-3 and VEGFR-2 stimulation.

Dieterich LC, Ducoli L, Shin JW, Detmar M.

Sci Data. 2017 Aug 29;4:170106. doi: 10.1038/sdata.2017.106.

20.

FANTOM5 CAGE profiles of human and mouse samples.

Noguchi S, Arakawa T, Fukuda S, Furuno M, Hasegawa A, Hori F, Ishikawa-Kato S, Kaida K, Kaiho A, Kanamori-Katayama M, Kawashima T, Kojima M, Kubosaki A, Manabe RI, Murata M, Nagao-Sato S, Nakazato K, Ninomiya N, Nishiyori-Sueki H, Noma S, Saijyo E, Saka A, Sakai M, Simon C, Suzuki N, Tagami M, Watanabe S, Yoshida S, Arner P, Axton RA, Babina M, Baillie JK, Barnett TC, Beckhouse AG, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Carlisle AJ, Clevers HC, Davis CA, Detmar M, Dohi T, Edge ASB, Edinger M, Ehrlund A, Ekwall K, Endoh M, Enomoto H, Eslami A, Fagiolini M, Fairbairn L, Farach-Carson MC, Faulkner GJ, Ferrai C, Fisher ME, Forrester LM, Fujita R, Furusawa JI, Geijtenbeek TB, Gingeras T, Goldowitz D, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Hasegawa Y, Herlyn M, Heutink P, Hitchens KJ, Hume DA, Ikawa T, Ishizu Y, Kai C, Kawamoto H, Kawamura YI, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, Kitamura T, Klein S, Klinken SP, Knox AJ, Kojima S, Koseki H, Koyasu S, Lee W, Lennartsson A, Mackay-Sim A, Mejhert N, Mizuno Y, Morikawa H, Morimoto M, Moro K, Morris KJ, Motohashi H, Mummery CL, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nozaki T, Ogishima S, Ohkura N, Ohno H, Ohshima M, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov DA, Passier R, Patrikakis M, Pombo A, Pradhan-Bhatt S, Qin XY, Rehli M, Rizzu P, Roy S, Sajantila A, Sakaguchi S, Sato H, Satoh H, Savvi S, Saxena A, Schmidl C, Schneider C, Schulze-Tanzil GG, Schwegmann A, Sheng G, Shin JW, Sugiyama D, Sugiyama T, Summers KM, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tomoiu A, Toyoda H, van de Wetering M, van den Berg LM, Verardo R, Vijayan D, Wells CA, Winteringham LN, Wolvetang E, Yamaguchi Y, Yamamoto M, Yanagi-Mizuochi C, Yoneda M, Yonekura Y, Zhang PG, Zucchelli S, Abugessaisa I, Arner E, Harshbarger J, Kondo A, Lassmann T, Lizio M, Sahin S, Sengstag T, Severin J, Shimoji H, Suzuki M, Suzuki H, Kawai J, Kondo N, Itoh M, Daub CO, Kasukawa T, Kawaji H, Carninci P, Forrest ARR, Hayashizaki Y.

Sci Data. 2017 Aug 29;4:170112. doi: 10.1038/sdata.2017.112.

21.

An integrated expression atlas of miRNAs and their promoters in human and mouse.

de Rie D, Abugessaisa I, Alam T, Arner E, Arner P, Ashoor H, Åström G, Babina M, Bertin N, Burroughs AM, Carlisle AJ, Daub CO, Detmar M, Deviatiiarov R, Fort A, Gebhard C, Goldowitz D, Guhl S, Ha TJ, Harshbarger J, Hasegawa A, Hashimoto K, Herlyn M, Heutink P, Hitchens KJ, Hon CC, Huang E, Ishizu Y, Kai C, Kasukawa T, Klinken P, Lassmann T, Lecellier CH, Lee W, Lizio M, Makeev V, Mathelier A, Medvedeva YA, Mejhert N, Mungall CJ, Noma S, Ohshima M, Okada-Hatakeyama M, Persson H, Rizzu P, Roudnicky F, Sætrom P, Sato H, Severin J, Shin JW, Swoboda RK, Tarui H, Toyoda H, Vitting-Seerup K, Winteringham L, Yamaguchi Y, Yasuzawa K, Yoneda M, Yumoto N, Zabierowski S, Zhang PG, Wells CA, Summers KM, Kawaji H, Sandelin A, Rehli M; FANTOM Consortium, Hayashizaki Y, Carninci P, Forrest ARR, de Hoon MJL.

Nat Biotechnol. 2017 Sep;35(9):872-878. doi: 10.1038/nbt.3947. Epub 2017 Aug 21.

22.

An Important Role of VEGF-C in Promoting Lymphedema Development.

Gousopoulos E, Proulx ST, Bachmann SB, Dieterich LC, Scholl J, Karaman S, Bianchi R, Detmar M.

J Invest Dermatol. 2017 Sep;137(9):1995-2004. doi: 10.1016/j.jid.2017.04.033. Epub 2017 May 17.

23.

High-Fat Diet in the Absence of Obesity Does Not Aggravate Surgically Induced Lymphoedema in Mice.

Gousopoulos E, Karaman S, Proulx ST, Leu K, Buschle D, Detmar M.

Eur Surg Res. 2017;58(3-4):180-192. doi: 10.1159/000461579. Epub 2017 Mar 17.

PMID:
28301852
24.

High expression of insulin receptor on tumour-associated blood vessels in invasive bladder cancer predicts poor overall and progression-free survival.

Roudnicky F, Dieterich LC, Poyet C, Buser L, Wild P, Tang D, Camenzind P, Ho CH, Otto VI, Detmar M.

J Pathol. 2017 Jun;242(2):193-205. doi: 10.1002/path.4892. Epub 2017 May 3.

25.

Tumor-Associated Lymphatic Vessels Upregulate PDL1 to Inhibit T-Cell Activation.

Dieterich LC, Ikenberg K, Cetintas T, Kapaklikaya K, Hutmacher C, Detmar M.

Front Immunol. 2017 Feb 3;8:66. doi: 10.3389/fimmu.2017.00066. eCollection 2017.

26.

T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions.

Teijeira A, Hunter MC, Russo E, Proulx ST, Frei T, Debes GF, Coles M, Melero I, Detmar M, Rouzaut A, Halin C.

Cell Rep. 2017 Jan 24;18(4):857-865. doi: 10.1016/j.celrep.2016.12.078.

27.

Quantitative measurement of lymphatic function in mice by noninvasive near-infrared imaging of a peripheral vein.

Proulx ST, Ma Q, Andina D, Leroux JC, Detmar M.

JCI Insight. 2017 Jan 12;2(1):e90861. doi: 10.1172/jci.insight.90861.

28.

New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate.

Cui J, Hollmén M, Li L, Chen Y, Proulx ST, Reker D, Schneider G, Detmar M.

Oncotarget. 2017 Jan 3;8(1):1007-1022. doi: 10.18632/oncotarget.13537.

29.

Postnatal Deletion of Podoplanin in Lymphatic Endothelium Results in Blood Filling of the Lymphatic System and Impairs Dendritic Cell Migration to Lymph Nodes.

Bianchi R, Russo E, Bachmann SB, Proulx ST, Sesartic M, Smaadahl N, Watson SP, Buckley CD, Halin C, Detmar M.

Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):108-117. doi: 10.1161/ATVBAHA.116.308020. Epub 2016 Nov 3.

PMID:
27810998
30.

Multidisciplinary Consideration of Potential Pathophysiologic Mechanisms of Paradoxical Erythema with Topical Brimonidine Therapy.

Docherty JR, Steinhoff M, Lorton D, Detmar M, Schäfer G, Holmes A, Di Nardo A.

Adv Ther. 2016 Nov;33(11):1885-1895. Epub 2016 Aug 25. Review.

31.

Lymphatic endothelial cells attenuate inflammation via suppression of dendritic cell maturation.

Christiansen AJ, Dieterich LC, Ohs I, Bachmann SB, Bianchi R, Proulx ST, Hollmén M, Aebischer D, Detmar M.

Oncotarget. 2016 Jun 28;7(26):39421-39435. doi: 10.18632/oncotarget.9820.

32.

Regulatory T cell transfer ameliorates lymphedema and promotes lymphatic vessel function.

Gousopoulos E, Proulx ST, Bachmann SB, Scholl J, Dionyssiou D, Demiri E, Halin C, Dieterich LC, Detmar M.

JCI Insight. 2016 Oct 6;1(16):e89081. doi: 10.1172/jci.insight.89081.

33.

Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice.

Karaman S, Hollmén M, Yoon SY, Alkan HF, Alitalo K, Wolfrum C, Detmar M.

Sci Rep. 2016 Aug 11;6:31566. doi: 10.1038/srep31566.

34.

Regulation of lymphangiogenesis in the diaphragm by macrophages and VEGFR-3 signaling.

Ochsenbein AM, Karaman S, Proulx ST, Goldmann R, Chittazhathu J, Dasargyri A, Chong C, Leroux JC, Stanley ER, Detmar M.

Angiogenesis. 2016 Oct;19(4):513-24. doi: 10.1007/s10456-016-9523-8. Epub 2016 Jul 27.

35.

Prominent Lymphatic Vessel Hyperplasia with Progressive Dysfunction and Distinct Immune Cell Infiltration in Lymphedema.

Gousopoulos E, Proulx ST, Scholl J, Uecker M, Detmar M.

Am J Pathol. 2016 Aug;186(8):2193-2203. doi: 10.1016/j.ajpath.2016.04.006. Epub 2016 Jun 15.

36.

DeepCAGE transcriptomics identify HOXD10 as a transcription factor regulating lymphatic endothelial responses to VEGF-C.

Klein S, Dieterich LC, Mathelier A, Chong C, Sliwa-Primorac A, Hong YK, Shin JW, Lizio M, Itoh M, Kawaji H, Lassmann T, Daub CO, Arner E; FANTOM consortium, Carninci P, Hayashizaki Y, Forrest AR, Wasserman WW, Detmar M.

J Cell Sci. 2016 Jul 1;129(13):2573-85. doi: 10.1242/jcs.186767. Epub 2016 May 19.

37.

G-CSF regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer.

Hollmén M, Karaman S, Schwager S, Lisibach A, Christiansen AJ, Maksimow M, Varga Z, Jalkanen S, Detmar M.

Oncoimmunology. 2015 Nov 24;5(3):e1115177. eCollection 2016 Mar.

38.

Restoration of lymphatic function rescues obesity in Prox1-haploinsufficient mice.

Escobedo N, Proulx ST, Karaman S, Dillard ME, Johnson N, Detmar M, Oliver G.

JCI Insight. 2016 Feb 1;1(2). pii: e85096. Epub 2016 Feb 25.

39.

Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) Is Induced by Vascular Endothelial Growth Factor A (VEGF-A).

Nishida-Fukuda H, Araki R, Shudou M, Okazaki H, Tomono Y, Nakayama H, Fukuda S, Sakaue T, Shirakata Y, Sayama K, Hashimoto K, Detmar M, Higashiyama S, Hirakawa S.

J Biol Chem. 2016 May 13;291(20):10490-500. doi: 10.1074/jbc.M115.683201. Epub 2016 Mar 10.

40.

In vivo visualization and quantification of collecting lymphatic vessel contractility using near-infrared imaging.

Chong C, Scholkmann F, Bachmann SB, Luciani P, Leroux JC, Detmar M, Proulx ST.

Sci Rep. 2016 Mar 10;6:22930. doi: 10.1038/srep22930.

41.

Endothelial cell-derived semaphorin 3A inhibits filopodia formation by blood vascular tip cells.

Ochsenbein AM, Karaman S, Proulx ST, Berchtold M, Jurisic G, Stoeckli ET, Detmar M.

Development. 2016 Feb 15;143(4):589-94. doi: 10.1242/dev.127670.

42.

Findings questioning the involvement of Sigma-1 receptor in the uptake of anisamide-decorated particles.

Dasargyri A, Hervella P, Christiansen A, Proulx ST, Detmar M, Leroux JC.

J Control Release. 2016 Feb 28;224:229-238. doi: 10.1016/j.jconrel.2016.01.021. Epub 2016 Jan 13.

PMID:
26774218
43.

Microneedles for the Noninvasive Structural and Functional Assessment of Dermal Lymphatic Vessels.

Brambilla D, Proulx ST, Marschalkova P, Detmar M, Leroux JC.

Small. 2016 Feb 24;12(8):1053-61. doi: 10.1002/smll.201503093. Epub 2016 Jan 4.

PMID:
26727610
44.

Tumor lymphangiogenesis and new drug development.

Dieterich LC, Detmar M.

Adv Drug Deliv Rev. 2016 Apr 1;99(Pt B):148-160. doi: 10.1016/j.addr.2015.12.011. Epub 2015 Dec 17. Review.

PMID:
26705849
45.

Walking the Line: A Fibronectin Fiber-Guided Assay to Probe Early Steps of (Lymph)angiogenesis.

Mitsi M, Schulz MM, Gousopoulos E, Ochsenbein AM, Detmar M, Vogel V.

PLoS One. 2015 Dec 21;10(12):e0145210. doi: 10.1371/journal.pone.0145210. eCollection 2015.

46.

DeepCAGE Transcriptomics Reveal an Important Role of the Transcription Factor MAFB in the Lymphatic Endothelium.

Dieterich LC, Klein S, Mathelier A, Sliwa-Primorac A, Ma Q, Hong YK, Shin JW, Hamada M, Lizio M, Itoh M, Kawaji H, Lassmann T, Daub CO, Arner E, Carninci P, Hayashizaki Y, Forrest ARR, Wasserman WW, Detmar M.

Cell Rep. 2015 Nov 17;13(7):1493-1504. doi: 10.1016/j.celrep.2015.10.002. Epub 2015 Nov 5.

47.

Decline of lymphatic vessel density and function in murine skin during aging.

Karaman S, Buschle D, Luciani P, Leroux JC, Detmar M, Proulx ST.

Angiogenesis. 2015 Oct;18(4):489-98. doi: 10.1007/s10456-015-9479-0. Epub 2015 Aug 11.

PMID:
26260189
48.

Connexin 43 expression predicts poor progression-free survival in patients with non-muscle invasive urothelial bladder cancer.

Poyet C, Buser L, Roudnicky F, Detmar M, Hermanns T, Mannhard D, Höhn A, Rüschoff J, Zhong Q, Sulser T, Moch H, Wild PJ.

J Clin Pathol. 2015 Oct;68(10):819-24. doi: 10.1136/jclinpath-2015-202898. Epub 2015 Aug 6.

49.

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.

Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, Wiig H, Alitalo K.

J Exp Med. 2015 Jun 29;212(7):991-9. doi: 10.1084/jem.20142290. Epub 2015 Jun 15.

50.

Drug Pharmacokinetics Determined by Real-Time Analysis of Mouse Breath.

Li X, Martinez-Lozano Sinues P, Dallmann R, Bregy L, Hollmén M, Proulx S, Brown SA, Detmar M, Kohler M, Zenobi R.

Angew Chem Int Ed Engl. 2015 Jun 26;54(27):7815-8. doi: 10.1002/anie.201503312. Epub 2015 May 27.

PMID:
26015026

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